Published in PLoS Genet on March 20, 2009
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A quest for the mechanism regulating global planar cell polarity of tissues. Trends Cell Biol (2009) 1.60
Vertebrate intestinal endoderm development. Dev Dyn (2011) 1.41
Down-regulation of the canonical Wnt β-catenin pathway in the airway epithelium of healthy smokers and smokers with COPD. PLoS One (2011) 1.13
Regulation of NMDA-receptor synaptic transmission by Wnt signaling. J Neurosci (2011) 1.12
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Planar cell polarity genes control the connectivity of enteric neurons. J Clin Invest (2013) 1.03
Serrano (sano) functions with the planar cell polarity genes to control tracheal tube length. PLoS Genet (2009) 1.01
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Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gut. Development (2010) 0.98
Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2. Dev Cell (2013) 0.96
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Multiparametric image analysis of lung-branching morphogenesis. Dev Dyn (2013) 0.92
The complex roles of Wnt antagonists in RCC. Nat Rev Urol (2011) 0.89
Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration. Elife (2015) 0.85
Sfrp5 modulates both Wnt and BMP signaling and regulates gastrointestinal organogenesis [corrected] in the zebrafish, Danio rerio. PLoS One (2013) 0.85
The immunohistochemistry of invasive and proliferative phenotype switching in melanoma: a case report. Melanoma Res (2010) 0.85
Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development. EMBO J (2017) 0.84
Inhibition of phosphodiesterase 5 reduces bone mass by suppression of canonical Wnt signaling. Cell Death Dis (2014) 0.83
Jun N-terminal kinase maintains tissue integrity during cell rearrangement in the gut. Development (2013) 0.81
Involvement of Wnt signaling pathways in the metamorphosis of the bryozoan Bugula neritina. PLoS One (2012) 0.81
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GATA4 regulates epithelial cell proliferation to control intestinal growth and development in mice. Cell Mol Gastroenterol Hepatol (2016) 0.80
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Comparative study of efficacy of dopaminergic neuron differentiation between embryonic stem cell and protein-based induced pluripotent stem cell. PLoS One (2014) 0.79
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Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I. PLoS Genet (2016) 0.78
Novel mechanisms of tube-size regulation revealed by the Drosophila trachea. Cell Tissue Res (2013) 0.78
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Stomach development, stem cells and disease. Development (2016) 0.77
Frogs as integrative models for understanding digestive organ development and evolution. Semin Cell Dev Biol (2016) 0.76
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Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature (2003) 4.56
Shaping the vertebrate body plan by polarized embryonic cell movements. Science (2002) 4.35
The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells (2003) 4.11
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility. Nat Rev Genet (2007) 3.88
Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature (2006) 3.80
JNK phosphorylates paxillin and regulates cell migration. Nature (2003) 3.60
The orientation of cell divisions determines the shape of Drosophila organs. Curr Biol (2005) 3.58
The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J Neurosci (2006) 3.36
Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation. Nature (2004) 3.29
Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J Cell Sci (2008) 3.21
JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep (2001) 3.08
Cdx1 and cdx2 expression during intestinal development. Gastroenterology (2000) 3.03
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development (2006) 2.96
Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res (2006) 2.86
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The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech Dev (2003) 2.31
Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway. Dev Cell (2007) 2.25
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Regulation of cadherin function by Rho and Rac: modulation by junction maturation and cellular context. Mol Biol Cell (1999) 1.94
Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes. Mol Biol Cell (2000) 1.79
Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis. Cancer Res (2005) 1.77
Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues. Gene Expr Patterns (2004) 1.75
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The bicoid-related homeoprotein Ptx1 defines the most anterior domain of the embryo and differentiates posterior from anterior lateral mesoderm. Development (1997) 1.50
Regulation of Lethal giant larvae by Dishevelled. Nature (2005) 1.47
Wnt signaling during development of the gastrointestinal tract. Dev Biol (2003) 1.44
Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomach. Mech Dev (1995) 1.42
Differential inhibition of Wnt-3a by Sfrp-1, Sfrp-2, and Sfrp-3. Dev Dyn (2006) 1.38
Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity. PLoS Biol (2004) 1.33
Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation. Gene Expr Patterns (2006) 1.33
Expression patterns of Wnt genes in mouse gut development. Mech Dev (2001) 1.27
Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development (2006) 1.25
FGF10 signaling controls stomach morphogenesis. Dev Biol (2006) 1.23
Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse. Genesis (2008) 1.21
Region-specific gastrointestinal Hox code during murine embryonal gut development. Dev Growth Differ (2002) 1.19
Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development. Gene Expr Patterns (2005) 1.12
Distinctions in meiotic spindle structure and assembly during in vitro and in vivo maturation of mouse oocytes. Biol Reprod (2003) 1.11
Isolation of novel cDNAs by subtractions between the anterior mesendoderm of single mouse gastrula stage embryos. Dev Biol (1999) 0.89
The mouse secreted frizzled-related protein 5 gene is expressed in the anterior visceral endoderm and foregut endoderm during early post-implantation development. Gene Expr Patterns (2003) 0.89
Region-specific expression of murine Hox genes implies the Hox code-mediated patterning of the digestive tract. Genes Cells (1998) 0.87
Sfrp5 is not essential for axis formation in the mouse. Genesis (2006) 0.84
Susceptibility of epithelia to directive influences of mesenchymes during organogenesis: uncoupling of morphogenesis and cytodifferentiation. Cell Differ Dev (1990) 0.82
Distribution pattern of HNF-3beta proteins in developing embryos of two mammalian species, the house shrew and the mouse. Dev Growth Differ (1997) 0.79
Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science (2010) 4.15
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity (2003) 3.73
Bcl11b is required for differentiation and survival of alphabeta T lymphocytes. Nat Immunol (2003) 3.42
Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity. Cell (2008) 3.32
Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. Nat Neurosci (2003) 3.08
Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture. Cell (2013) 2.92
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. J Clin Invest (2007) 2.81
Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. Cell (2005) 2.61
MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. J Neurosci (2011) 2.03
Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification. Development (2003) 1.90
Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol (2013) 1.86
A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions. Cancer Cell (2011) 1.86
MicroRNA-9 modulates Cajal-Retzius cell differentiation by suppressing Foxg1 expression in mouse medial pallium. J Neurosci (2008) 1.77
A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nat Neurosci (2007) 1.76
Establishment of conditional reporter mouse lines at ROSA26 locus for live cell imaging. Genesis (2011) 1.54
Angiomotin regulates endothelial cell migration during embryonic angiogenesis. Genes Dev (2007) 1.49
Functional roles of Otx2 transcription factor in postnatal mouse retinal development. Mol Cell Biol (2007) 1.46
New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Sci Signal (2010) 1.43
Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm. Dev Cell (2005) 1.43
The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. J Neurosci (2006) 1.40
b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. J Biol Chem (2001) 1.38
Three inhibitors of FGF receptor, ERK, and GSK3 establishes germline-competent embryonic stem cells of C57BL/6N mouse strain with high efficiency and stability. Genesis (2010) 1.34
Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus. Nat Commun (2011) 1.34
Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells. Hum Mol Genet (2006) 1.32
The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis. Sci Signal (2013) 1.25
Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development (2006) 1.25
EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J Cell Biol (2008) 1.24
Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture. Dev Biol (2008) 1.21
Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse. Genesis (2008) 1.21
Targeted disruption of the mouse ELYS gene results in embryonic death at peri-implantation development. Genes Cells (2004) 1.17
Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development (2004) 1.17
ang is a novel gene expressed in early neuroectoderm, but its null mutant exhibits no obvious phenotype. Gene Expr Patterns (2004) 1.16
Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter. Development (2012) 1.13
Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm. Development (2004) 1.13
Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells. Cell Stem Cell (2009) 1.10
Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury. Circulation (2003) 1.09
Dkk3-Cre BAC transgenic mouse line: a tool for highly efficient gene deletion in retinal progenitor cells. Genesis (2007) 1.08
Evolutionary constraint on Otx2 neuroectoderm enhancers-deep conservation from skate to mouse and unique divergence in teleost. Proc Natl Acad Sci U S A (2006) 1.06
SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis. Nat Neurosci (2011) 1.06
An essential role for RAX homeoprotein and NOTCH-HES signaling in Otx2 expression in embryonic retinal photoreceptor cell fate determination. J Neurosci (2011) 1.05
Sfrp1 and Sfrp2 are required for normal male sexual development in mice. Dev Biol (2008) 1.04
Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice. Development (2002) 1.02
Otx2 is required to respond to signals from anterior neural ridge for forebrain specification. Dev Biol (2002) 1.01
Emx1 and Emx2 cooperate in initial phase of archipallium development. Mech Dev (2004) 1.00
Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double mutant cerebral cortex. Development (2002) 0.98
Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium. J Neurosci (2005) 0.97
Overview of the transcriptome profiles identified in hagfish, shark, and bichir: current issues arising from some nonmodel vertebrate taxa. J Exp Zool B Mol Dev Evol (2011) 0.97
Secreted frizzled-related proteins are required for Wnt/β-catenin signalling activation in the vertebrate optic cup. Development (2011) 0.96
Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses. Proc Natl Acad Sci U S A (2004) 0.95
A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis. EMBO J (2005) 0.93
A mouse reporter line to conditionally mark nuclei and cell membranes for in vivo live-imaging. Genesis (2011) 0.92
Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes. Proc Natl Acad Sci U S A (2007) 0.92
Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Dev Biol (2012) 0.91
Characterization of newly established clonal oviductal cell lines and differential hormonal regulation of gene expression. In Vitro Cell Dev Biol Anim (2003) 0.90
SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells. Stem Cells (2012) 0.90
Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization. Dev Biol (2010) 0.89
Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice. J Biol Chem (2002) 0.87
Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality. Mech Dev (2008) 0.87
Acetylated YY1 regulates Otx2 expression in anterior neuroectoderm at two cis-sites 90 kb apart. EMBO J (2007) 0.86
Functional analysis of the p53 gene in apoptosis induced by heat stress or loss of stem cell factor signaling in mouse male germ cells. Biol Reprod (2003) 0.86
The genus Polypterus (bichirs): a fish group diverged at the stem of ray-finned fishes (Actinopterygii). Cold Spring Harb Protoc (2009) 0.85
Impaired spermatogenesis and male fertility defects in CIZ/Nmp4-disrupted mice. Genes Cells (2004) 0.85
The same enhancer regulates the earliest Emx2 expression in caudal forebrain primordium, subsequent expression in dorsal telencephalon and later expression in the cortical ventricular zone. Development (2010) 0.85
Mice deficient in Sfrp1 exhibit increased adiposity, dysregulated glucose metabolism, and enhanced macrophage infiltration. PLoS One (2013) 0.84
cfm is a novel gene uniquely expressed in developing forebrain and midbrain, but its null mutant exhibits no obvious phenotype. Gene Expr Patterns (2005) 0.84
Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Dev Biol (2007) 0.84
Contrasting and brain region-specific roles of neurogenin2 and mash1 in GABAergic neuron differentiation in vitro. Exp Cell Res (2007) 0.84
A new serine/threonine protein kinase, Omphk1, essential to ventral body wall formation. Dev Dyn (2006) 0.84
Application of ES cells for generation of respiration-deficient mice carrying mtDNA with a large-scale deletion. Biochem Biophys Res Commun (2005) 0.83
BCR signal through alpha 4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation. Int Immunol (2002) 0.83
A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad. Genes Cells (2005) 0.83
Loss of SFRP1 promotes ductal branching in the murine mammary gland. BMC Dev Biol (2012) 0.83
Shisa2 promotes the maturation of somitic precursors and transition to the segmental fate in Xenopus embryos. Development (2006) 0.82
Gbx2 directly restricts Otx2 expression to forebrain and midbrain, competing with class III POU factors. Mol Cell Biol (2012) 0.82
Germ layer patterning in bichir and lamprey; an insight into its evolution in vertebrates. Dev Biol (2009) 0.81
Evolution of Otx paralogue usages in early patterning of the vertebrate head. Dev Biol (2008) 0.81
Establishment and characterization of clonal cell lines from the vagina of p53-deficient young mice. In Vitro Cell Dev Biol Anim (2003) 0.80
Establishment of framework of the cortical area is influenced by Otx1. Neurosci Res (2008) 0.80
Abnormal epithelial cell polarity and ectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads. Endocrinology (2010) 0.80
Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream. Nat Neurosci (2013) 0.80
Increased serum leptin protects from adiposity despite the increased glucose uptake in white adipose tissue in mice lacking p85alpha phosphoinositide 3-kinase. Diabetes (2004) 0.80
Expression of Tom34 splicing isoforms in mouse testis and knockout of Tom34 in mice. J Biochem (2003) 0.79
Neural tube defects by NUAK1 and NUAK2 double mutation. Dev Dyn (2012) 0.79
Sfrp1 and Sfrp2 are not involved in Wnt/β-catenin signal silencing during lens induction but are required for maintenance of Wnt/β-catenin signaling in lens epithelial cells. Dev Biol (2013) 0.78
beta-Catenin in early development of the lancelet embryo indicates specific determination of embryonic polarity. Dev Growth Differ (2002) 0.77
The embryonic mouse gut tube as a model for analysis of epithelial polarity. Methods Mol Biol (2012) 0.76
Characterization of Opr deficiency in mouse brain: subtle defects in dorsomedial telencephalon and medioventral forebrain. Dev Dyn (2005) 0.76
Role of the liver in glucose homeostasis in PI 3-kinase p85alpha-deficient mice. Am J Physiol Endocrinol Metab (2009) 0.76
Expression and roles of a xenopus head-forming gene homologue in human cancer cell lines. Nagoya J Med Sci (2008) 0.76
Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm. Dev Biol (2010) 0.76
The effects of diet induced obesity on breast cancer associated pathways in mice deficient in SFRP1. Mol Cancer (2014) 0.75
An interview with Shinichi Aizawa: President of the Japanese Society of Developmental Biologists. Interview by Eva Amsen. Development (2010) 0.75
Whole-mount in situ hybridization of bichir (Polypterus) embryos. Cold Spring Harb Protoc (2009) 0.75
Live imaging of early mouse embryos using fluorescently labeled transgenic mice. Methods Mol Biol (2013) 0.75
Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein. Mol Pharmacol (2013) 0.75
A lineage specific enhancer drives Otx2 expression in teleost organizer tissues. Mech Dev (2011) 0.75
Microinjection of bichir (Polypterus) embryos. Cold Spring Harb Protoc (2009) 0.75