Published in Mol Biol Cell on March 25, 2009
Cytoskeletal regulation of epithelial barrier function during inflammation. Am J Pathol (2010) 1.73
The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice. J Neurosci (2010) 1.54
Non-lytic, actin-based exit of intracellular parasites from C. elegans intestinal cells. PLoS Pathog (2011) 1.05
A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Mol Biol Cell (2011) 1.00
Shaping the intestinal brush border. J Cell Biol (2014) 0.99
Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion. Cell (2014) 0.99
Proteomic analysis of the enterocyte brush border. Am J Physiol Gastrointest Liver Physiol (2011) 0.98
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. PLoS One (2010) 0.97
Plastin family of actin-bundling proteins: its functions in leukocytes, neurons, intestines, and cancer. Int J Cell Biol (2012) 0.96
Seven kinds of intermediate filament networks in the cytoplasm of polarized cells: structure and function. Acta Histochem Cytochem (2010) 0.89
Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice. Hum Mol Genet (2014) 0.88
Cordon Bleu serves as a platform at the basal region of microvilli, where it regulates microvillar length through its WH2 domains. Mol Biol Cell (2014) 0.86
Desmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium. Mol Biol Cell (2012) 0.85
Keratin 8 modulates β-cell stress responses and normoglycaemia. J Cell Sci (2013) 0.83
The novel intestinal filament organizer IFO-1 contributes to epithelial integrity in concert with ERM-1 and DLG-1. Development (2012) 0.82
Plasticity of the brush border - the yin and yang of intestinal homeostasis. Nat Rev Gastroenterol Hepatol (2016) 0.79
Generation of intestinal surface: an absorbing tale. Development (2016) 0.77
Intermediate Filaments and Polarization in the Intestinal Epithelium. Cells (2016) 0.77
Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain. Histochem Cell Biol (2014) 0.76
Plastins regulate ectoplasmic specialization via its actin bundling activity on microfilaments in the rat testis. Asian J Androl (2016) 0.76
MyTH4-FERM myosins in the assembly and maintenance of actin-based protrusions. Curr Opin Cell Biol (2016) 0.75
A novel function for the MAP kinase SMA-5 in intestinal tube stability. Mol Biol Cell (2016) 0.75
Multiple roles for keratin intermediate filaments in the regulation of epithelial barrier function and apico-basal polarity. Tissue Barriers (2016) 0.75
Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration. J Immunol (2016) 0.75
The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512. Mol Metab (2016) 0.75
Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid. J Cell Biol (2016) 0.75
Simplified mammalian DNA isolation procedure. Nucleic Acids Res (1991) 12.56
Organization of an actin filament-membrane complex. Filament polarity and membrane attachment in the microvilli of intestinal epithelial cells. J Cell Biol (1975) 8.97
Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. J Biol Chem (1973) 6.99
Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin Exp Immunol (1998) 5.77
Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat Rev Genet (2006) 4.82
Identification and organization of the components in the isolated microvillus cytoskeleton. J Cell Biol (1979) 4.12
Localization of actin and microfilament-associated proteins in the microvilli and terminal web of the intestinal brush border by immunofluorescence microscopy. J Cell Biol (1978) 3.98
Fimbrin, a new microfilament-associated protein present in microvilli and other cell surface structures. J Cell Biol (1980) 3.93
Organization, chemistry, and assembly of the cytoskeletal apparatus of the intestinal brush border. Annu Rev Cell Biol (1985) 3.68
Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine. Dev Cell (2004) 3.33
Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science (1996) 3.32
Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion. Science (2005) 3.32
Villin: the major microfilament-associated protein of the intestinal microvillus. Proc Natl Acad Sci U S A (1979) 3.27
Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells. J Cell Biol (1983) 3.03
An F-actin- and calmodulin-binding protein from isolated intestinal brush borders has a morphology related to spectrin. Cell (1982) 2.89
The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins. Cell (2000) 2.82
F-actin binding and bundling properties of fimbrin, a major cytoskeletal protein of microvillus core filaments. J Biol Chem (1981) 2.72
Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. Genes Dev (1994) 2.51
Actin filaments, stereocilia, and hair cells: how cells count and measure. Annu Rev Cell Biol (1992) 2.44
Myosin-1a is critical for normal brush border structure and composition. Mol Biol Cell (2005) 2.44
Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo. J Cell Biol (2003) 2.31
Effects of gender and sex steroids on the immune response. J Steroid Biochem (1990) 2.20
Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli. J Cell Biol (1998) 2.06
Intermediate filaments mediate cytoskeletal crosstalk. Nat Rev Mol Cell Biol (2004) 2.02
An actin-binding site containing a conserved motif of charged amino acid residues is essential for the morphogenic effect of villin. Cell (1992) 2.01
Organization of actin, myosin, and intermediate filaments in the brush border of intestinal epithelial cells. J Cell Biol (1982) 1.79
Preliminary biochemical characterization of the stereocilia and cuticular plate of hair cells of the chick cochlea. J Cell Biol (1989) 1.74
Location of a protein of the fodrin-spectrin-TW260/240 family in the mouse intestinal brush border. Cell (1983) 1.73
In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush borders. J Cell Biol (1999) 1.69
Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates. J Cell Biol (1998) 1.65
Integrating the actin and vimentin cytoskeletons. adhesion-dependent formation of fimbrin-vimentin complexes in macrophages. J Cell Biol (1999) 1.52
Gastrointestinal nematode expulsion in IL-4 knockout mice is IL-13 dependent. Eur J Immunol (2000) 1.52
Targeted disruption of the mouse villin gene does not impair the morphogenesis of microvilli. Dev Dyn (1998) 1.51
Cytokeratins 8 and 19 in the mouse placental development. J Cell Biol (2000) 1.49
Differential localization of villin and fimbrin during development of the mouse visceral endoderm and intestinal epithelium. Development (1989) 1.47
Actin filament turnover regulated by cross-linking accounts for the size, shape, location, and number of actin bundles in Drosophila bristles. Mol Biol Cell (2003) 1.46
Plastins: versatile modulators of actin organization in (patho)physiological cellular processes. Acta Pharmacol Sin (2005) 1.44
Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. J Biol Chem (1993) 1.43
Multiple unconventional myosin domains of the intestinal brush border cytoskeleton. J Cell Sci (1994) 1.43
Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts. Mol Cell Biol (1988) 1.42
Functional differences between L- and T-plastin isoforms. J Cell Biol (1994) 1.41
Myosin-1a powers the sliding of apical membrane along microvillar actin bundles. J Cell Biol (2007) 1.37
Suppression of villin expression by antisense RNA impairs brush border assembly in polarized epithelial intestinal cells. EMBO J (1995) 1.36
Tropomyosin stabilizes the pointed end of actin filaments by slowing depolymerization. Biochemistry (1989) 1.36
The apical submembrane cytoskeleton participates in the organization of the apical pole in epithelial cells. J Cell Biol (1997) 1.31
Role of fimbrin and villin in determining the interfilament distances of actin bundles. Nature (1983) 1.31
Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. Mol Cell Biol (1994) 1.30
From the structure to the function of villin, an actin-binding protein of the brush border. Bioessays (1990) 1.29
Role of myosin in terminal web contraction in isolated intestinal epithelial brush borders. J Cell Biol (1985) 1.28
Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading. Immunity (2003) 1.21
Anomalous apical plasma membrane phenotype in CK8-deficient mice indicates a novel role for intermediate filaments in the polarization of simple epithelia. J Cell Sci (2001) 1.18
Transient expression of the t-isoform of plastins/fimbrin in the stereocilia of developing auditory hair cells. Cell Motil Cytoskeleton (2002) 1.13
Inhibition of actin filament depolymerization by the Dictyostelium 30,000-D actin-bundling protein. J Cell Biol (1992) 1.12
A novel role for villin in intestinal epithelial cell survival and homeostasis. J Biol Chem (2008) 1.12
Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19. Mol Biol Cell (2005) 1.10
Dynamical control of the shape and size of stereocilia and microvilli. Biophys J (2007) 1.09
Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton. Mol Biol Cell (2001) 1.08
Sorting of tropomyosin isoforms in synchronised NIH 3T3 fibroblasts: evidence for distinct microfilament populations. Cell Motil Cytoskeleton (2000) 1.04
Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement. J Cell Sci (2005) 1.00
Cytoskeletal protein and mRNA accumulation during brush border formation in adult chicken enterocytes. Development (1990) 0.97
The epithelial cell cytoskeleton and intracellular trafficking. III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells? Am J Physiol Gastrointest Liver Physiol (2002) 0.96
Intermediate filaments interact with dormant ezrin in intestinal epithelial cells. Mol Biol Cell (2005) 0.91
Polarization of specific tropomyosin isoforms in gastrointestinal epithelial cells and their impact on CFTR at the apical surface. Mol Biol Cell (2003) 0.89
Roles for Drosophila melanogaster myosin IB in maintenance of enterocyte brush-border structure and resistance to the bacterial pathogen Pseudomonas entomophila. Mol Biol Cell (2007) 0.86
Sequential expression and differential localization of I-, L-, and T-fimbrin during differentiation of the mouse intestine and yolk sac. Dev Dyn (1995) 0.85
Recruitment of cells in the small intestine into rapid cell cycle by small doses of external gamma or internal beta-radiation. Int J Radiat Biol Relat Stud Phys Chem Med (1985) 0.78
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis (2004) 6.83
Notch signals control the fate of immature progenitor cells in the intestine. Nature (2005) 6.13
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab (2005) 5.32
Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium. J Cell Biol (2007) 4.52
Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Mol Cell Biol (2007) 3.06
Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin. J Cell Biol (2004) 3.03
Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia. J Cell Biol (2010) 2.62
Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes. Mol Biol Cell (2005) 2.56
Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine. Development (2005) 2.56
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest (2005) 2.45
Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling. Cancer Cell (2011) 2.45
Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci U S A (2009) 2.34
Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation. J Cell Biol (2002) 2.34
A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis. Dev Cell (2006) 2.29
Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. Cancer Res (2007) 2.26
APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. Gastroenterology (2006) 2.25
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol (2011) 2.21
Preemptive ramipril therapy delays renal failure and reduces renal fibrosis in COL4A3-knockout mice with Alport syndrome. Kidney Int (2003) 2.20
IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A (2004) 2.12
The co-workers of actin filaments: from cell structures to signals. Nat Rev Mol Cell Biol (2004) 2.01
AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis. J Cell Biol (2009) 1.99
Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis. Cancer Cell (2010) 1.93
Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A (2008) 1.90
ERM proteins in epithelial cell organization and functions. Biochim Biophys Acta (2006) 1.80
The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells. Breast Cancer Res (2005) 1.76
Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis. J Exp Med (2002) 1.75
Molecular analysis of microscopic ezrin dynamics by two-photon FRAP. Proc Natl Acad Sci U S A (2002) 1.73
Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum. Genome Biol (2011) 1.72
TI-VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages. EMBO J (2004) 1.71
c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium. Mol Cell Biol (2005) 1.70
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol (2008) 1.68
Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation. Mol Biol Cell (2003) 1.67
Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. J Biol Chem (2002) 1.66
ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling. Curr Opin Cell Biol (2002) 1.61
Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis. Gastroenterology (2007) 1.58
Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice. Gastroenterology (2002) 1.57
Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J (2004) 1.56
Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication. Genome Res (2011) 1.53
Potential for preventive effects of cocoa and cocoa polyphenols in cancer. Food Chem Toxicol (2013) 1.50
Different microtubule motors move early and late endocytic compartments. Traffic (2008) 1.50
Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras. Int J Cancer (2008) 1.48
Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein. Genesis (2004) 1.48
Use of granules of biphasic ceramic in rehabilitation of canal wall down mastoidectomy. Eur Arch Otorhinolaryngol (2013) 1.43
Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency. J Biol Chem (2005) 1.43
A genetic study of the role of the Wnt/beta-catenin signalling in Paneth cell differentiation. Dev Biol (2008) 1.42
Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice. Mol Cell Biol (2005) 1.40
Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development. Development (2002) 1.39
Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1. J Cell Sci (2007) 1.39
The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells. Mol Biol Cell (2002) 1.35
Development of skin tumors in mice transgenic for early genes of human papillomavirus type 8. Cancer Res (2005) 1.34
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal. Mol Cell Biol (2012) 1.34
Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium. Mol Cell Biol (2009) 1.33
Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2). J Nutr (2006) 1.32
Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas. Cancer Res (2010) 1.28
N-terminal domains elicit formation of functional Pmel17 amyloid fibrils. J Biol Chem (2009) 1.28
Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability. Traffic (2008) 1.26
Calponin homology domains at a glance. J Cell Sci (2002) 1.26
Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice. PLoS One (2011) 1.24
Rab13 regulates PKA signaling during tight junction assembly. J Cell Biol (2004) 1.24
Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration. FEBS J (2011) 1.23
Characterization of SMOC-1, a novel modular calcium-binding protein in basement membranes. J Biol Chem (2002) 1.23
Binding of netrin-4 to laminin short arms regulates basement membrane assembly. J Biol Chem (2007) 1.22
Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium. Development (2010) 1.22
Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress. Application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antioxidants from fruits. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 1.20
Pathophysiology of diabetic macular edema. Dev Ophthalmol (2007) 1.20
Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival. J Clin Invest (2010) 1.18
Disturbances in glucose-tolerance, insulin-release, and stress-induced hyperglycemia upon disruption of the Ca(v)2.3 (alpha 1E) subunit of voltage-gated Ca(2+) channels. Mol Endocrinol (2002) 1.17
Myosin 1b promotes the formation of post-Golgi carriers by regulating actin assembly and membrane remodelling at the trans-Golgi network. Nat Cell Biol (2011) 1.16
DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria. Kidney Int (2004) 1.15
The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor. J Biol Chem (2004) 1.15
Cardiovascular and thromboembolic risk factors in idiopathic sudden sensorineural hearing loss: a case-control study. Audiol Neurootol (2010) 1.14
Nidogens-Extracellular matrix linker molecules. Microsc Res Tech (2008) 1.13
Myosin Ib modulates the morphology and the protein transport within multi-vesicular sorting endosomes. J Cell Sci (2005) 1.13
Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells. Mol Biol Cell (2007) 1.12
Assessing the localization of centrosomal proteins by PALM/STORM nanoscopy. Cytoskeleton (Hoboken) (2011) 1.11
Response of the antioxidant defense system to tert-butyl hydroperoxide and hydrogen peroxide in a human hepatoma cell line (HepG2). J Biochem Mol Toxicol (2005) 1.11
Speech performance and sound localization in a complex noisy environment in bilaterally implanted adult patients. Audiol Neurootol (2008) 1.09
Rho GTPase signaling in Dictyostelium discoideum: insights from the genome. Eur J Cell Biol (2006) 1.09
Free Brick1 is a trimeric precursor in the assembly of a functional wave complex. PLoS One (2008) 1.09
Dictyostelium PAKc is required for proper chemotaxis. Mol Biol Cell (2004) 1.09
Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide. Toxicol Appl Pharmacol (2005) 1.07
Bloom's syndrome and PICH helicases cooperate with topoisomerase IIα in centromere disjunction before anaphase. PLoS One (2012) 1.06
Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium. J Biol Chem (2006) 1.05
Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB. Gastroenterology (2008) 1.05
Mixed chimerism of cardiomyocytes and vessels after allogeneic bone marrow and stem-cell transplantation in comparison with cardiac allografts. Transplantation (2004) 1.04
Functional melanocytes derived from human pluripotent stem cells engraft into pluristratified epidermis. Proc Natl Acad Sci U S A (2011) 1.04
BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells. Proc Natl Acad Sci U S A (2013) 1.04
Chloride transport in nasal ciliated cells of cystic fibrosis heterozygotes. Am J Respir Crit Care Med (2005) 1.03
Notch signaling in intestinal homeostasis across species: the cases of Drosophila, Zebrafish and the mouse. Exp Cell Res (2011) 1.03
Electrocorticographic and deep intracerebral EEG recording in mice using a telemetry system. Brain Res Brain Res Protoc (2005) 1.03