Published in Proc Natl Acad Sci U S A on February 27, 2009
Wnt signaling in cancer. Cold Spring Harb Perspect Biol (2012) 2.75
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci U S A (2009) 2.63
Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev Res (Phila) (2011) 2.62
Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci U S A (2011) 2.54
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update. Nat Rev Clin Oncol (2015) 2.02
Denervation suppresses gastric tumorigenesis. Sci Transl Med (2014) 1.96
NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res (2010) 1.85
The Hippo signaling pathway and stem cell biology. Trends Cell Biol (2012) 1.84
From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell (2014) 1.70
FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. J Exp Med (2011) 1.62
JNK-induced apoptosis, compensatory growth, and cancer stem cells. Cancer Res (2012) 1.52
Notch and disease: a growing field. Semin Cell Dev Biol (2012) 1.48
Targeting the Notch pathway: A potential therapeutic approach for desmoid tumors. Cancer (2015) 1.42
Delta-like 4/Notch signaling promotes Apc (Min/+) tumor initiation through angiogenic and non-angiogenic related mechanisms. BMC Cancer (2017) 1.38
Non-canonical Notch signaling: emerging role and mechanism. Trends Cell Biol (2012) 1.37
YAP oncogene overexpression supercharges colon cancer proliferation. Cell Cycle (2012) 1.34
Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis. Gut (2011) 1.33
Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice. PLoS One (2011) 1.24
Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression. J Biol Chem (2011) 1.24
Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system. PLoS One (2011) 1.24
Notch signaling in stomach epithelial stem cell homeostasis. J Exp Med (2011) 1.20
Antimicrobial peptides and gut microbiota in homeostasis and pathology. EMBO Mol Med (2013) 1.17
Honokiol in combination with radiation targets notch signaling to inhibit colon cancer stem cells. Mol Cancer Ther (2012) 1.13
Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer. J Clin Invest (2012) 1.10
Krüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine. Gastroenterology (2011) 1.10
Preclinical analysis of the γ-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia. Mol Cancer Ther (2012) 1.09
Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure. Nature (2015) 1.08
The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nat Commun (2011) 1.07
Notch3 marks clonogenic mammary luminal progenitor cells in vivo. J Cell Biol (2013) 1.06
Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancer. Mol Ther (2011) 1.05
Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila. EMBO J (2012) 1.05
Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival. BMC Med Genomics (2011) 1.04
Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut. Nat Commun (2014) 1.04
Notch: architect, landscaper, and guardian of the intestine. Gastroenterology (2011) 1.03
The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer. J Clin Invest (2014) 1.00
MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress. PLoS Genet (2011) 1.00
Notch signaling proteins: legitimate targets for cancer therapy. Curr Protein Pept Sci (2010) 0.98
The Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cells. PLoS One (2011) 0.97
Colon cancer progression is driven by APEX1-mediated upregulation of Jagged. J Clin Invest (2013) 0.96
Regenerative inflammation: lessons from Drosophila intestinal epithelium in health and disease. Pathogens (2013) 0.96
Notch signaling in diabetic nephropathy. Exp Cell Res (2012) 0.95
MicroRNA-449a overexpression, reduced NOTCH1 signals and scarce goblet cells characterize the small intestine of celiac patients. PLoS One (2011) 0.95
Hes1 is involved in the self-renewal and tumourigenicity of stem-like cancer cells in colon cancer. Sci Rep (2014) 0.95
ADAM10 regulates Notch function in intestinal stem cells of mice. Gastroenterology (2014) 0.95
Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/β-catenin pathway in colorectal cancer. Cancer Res (2013) 0.95
Targeting the WNT Signaling Pathway in Cancer Therapeutics. Oncologist (2015) 0.92
Wnt signaling during cochlear development. Semin Cell Dev Biol (2013) 0.91
Epigenetic silencing of Notch signaling in gastrointestinal cancers. Cell Cycle (2012) 0.91
The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies. Lab Invest (2015) 0.91
Critical roles of Notch and Wnt/β-catenin pathways in the regulation of hyperplasia and/or colitis in response to bacterial infection. Infect Immun (2012) 0.90
Suppression of colon carcinogenesis by targeting Notch signaling. Carcinogenesis (2013) 0.90
Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease. EMBO Rep (2015) 0.89
Evidence of the cross talk between Wnt and Notch signaling pathways in non-small-cell lung cancer (NSCLC): Notch3-siRNA weakens the effect of LiCl on the cell cycle of NSCLC cell lines. J Cancer Res Clin Oncol (2010) 0.87
Notch signaling in serous ovarian cancer. J Ovarian Res (2014) 0.87
Agonism of Wnt-β-catenin signalling promotes mesenchymal stem cell (MSC) expansion. J Tissue Eng Regen Med (2013) 0.86
ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways. PLoS One (2015) 0.86
NOTCH Signaling and ATOH1 in Colorectal Cancers. Curr Colorectal Cancer Rep (2011) 0.86
Increased LEF1 expression and decreased Notch2 expression are strong predictors of poor outcomes in colorectal cancer patients. Dis Markers (2013) 0.85
The CSF-1 receptor fashions the intestinal stem cell niche. Stem Cell Res (2012) 0.85
The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids. Nat Commun (2015) 0.85
Trp53 regulates Notch 4 signaling through Mdm2. J Cell Sci (2011) 0.84
Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms. Am J Physiol Cell Physiol (2015) 0.84
Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling. PLoS One (2013) 0.83
Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia. BMC Genomics (2013) 0.83
Major signaling pathways in intestinal stem cells. Biochim Biophys Acta (2012) 0.83
Independent pathways can transduce the life-cycle differentiation signal in Trypanosoma brucei. PLoS Pathog (2013) 0.83
The roles of Notch3 on the cell proliferation and apoptosis induced by CHIR99021 in NSCLC cell lines: a functional link between Wnt and Notch signaling pathways. PLoS One (2013) 0.82
Knockdown of lymphoid enhancer factor 1 inhibits colon cancer progression in vitro and in vivo. PLoS One (2013) 0.81
ADAM Proteases and Gastrointestinal Function. Annu Rev Physiol (2015) 0.81
Androgens up-regulate transcription of the Notch inhibitor Numb in C2C12 myoblasts via Wnt/β-catenin signaling to T cell factor elements in the Numb promoter. J Biol Chem (2013) 0.80
Muscle niche-driven Insulin-Notch-Myc cascade reactivates dormant Adult Muscle Precursors in Drosophila. Elife (2015) 0.80
Hes1 promotes cell proliferation and migration by activating Bmi-1 and PTEN/Akt/GSK3β pathway in human colon cancer. Oncotarget (2015) 0.79
Citrobacter Infection and Wnt signaling. Curr Colorectal Cancer Rep (2012) 0.79
Targeting Notch Signaling in Colorectal Cancer. Curr Colorectal Cancer Rep (2014) 0.79
Multi-level interactions between the nuclear receptor TRα1 and the WNT effectors β-catenin/Tcf4 in the intestinal epithelium. PLoS One (2012) 0.79
Hypothesis: cell signalling influences age-related risk of colorectal cancer. J Cell Mol Med (2014) 0.79
Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer. Proc Natl Acad Sci U S A (2014) 0.78
Notch regulation of gastrointestinal stem cells. J Physiol (2016) 0.78
Dampening the signals transduced through hedgehog via microRNA miR-7 facilitates notch-induced tumourigenesis. PLoS Biol (2013) 0.78
Differential roles of Hath1, MUC2 and P27Kip1 in relation with gamma-secretase inhibition in human colonic carcinomas: a translational study. PLoS One (2013) 0.78
Epigenetic regulation of the intestinal epithelium. Cell Mol Life Sci (2015) 0.78
Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles. Sci Rep (2016) 0.78
Pin1-mediated Modification Prolongs the Nuclear Retention of β-Catenin in Wnt3a-induced Osteoblast Differentiation. J Biol Chem (2016) 0.77
Loss of Hes1 Differentiates Sessile Serrated Adenoma/Polyp From Hyperplastic Polyp. Am J Surg Pathol (2016) 0.77
NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells. Cancer Res (2016) 0.77
Kynurenic acid inhibits colon cancer proliferation in vitro: effects on signaling pathways. Amino Acids (2014) 0.77
Distinct human stem cell populations in small and large intestine. PLoS One (2015) 0.77
Disruption of cell-cell contact-mediated notch signaling via hydrogel encapsulation reduces mesenchymal stem cell chondrogenic potential: winner of the Society for Biomaterials Student Award in the Undergraduate Category, Charlotte, NC, April 15 to 18, 2015. J Biomed Mater Res A (2014) 0.76
The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development. Curr Colorectal Cancer Rep (2012) 0.76
Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination. Oncotarget (2015) 0.76
Notch signaling promotes intestinal crypt fission in the infant rat. Dig Dis Sci (2012) 0.76
Notch1 directly induced CD133 expression in human diffuse type gastric cancers. Oncotarget (2016) 0.76
Targeting the Notch signaling pathway in cancer therapeutics. Thorac Cancer (2014) 0.75
Stem cell competition in the gut: insights from multi-scale computational modelling. J R Soc Interface (2016) 0.75
Myeloid translocation genes differentially regulate colorectal cancer programs. Oncogene (2016) 0.75
ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer. Clin Cancer Res (2016) 0.75
Early commitment and robust differentiation in colonic crypts. Mol Syst Biol (2017) 0.75
Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways. Nat Commun (2016) 0.75
STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway. Cancer Res (2017) 0.75
Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc (2008) 62.52
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science (1997) 22.80
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
Identification and characterization of the familial adenomatous polyposis coli gene. Cell (1991) 14.46
Hereditary colorectal cancer. N Engl J Med (2003) 11.86
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet (1998) 10.51
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell (1991) 10.06
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science (1991) 9.89
A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac. Nat Genet (2004) 8.55
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell (1997) 8.23
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis (2004) 6.83
Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A (2003) 6.55
Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci U S A (1996) 6.48
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev (2003) 6.27
Notch signals control the fate of immature progenitor cells in the intestine. Nature (2005) 6.13
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat Rev Genet (2006) 4.82
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci U S A (2003) 4.76
Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc Natl Acad Sci U S A (1995) 3.33
A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci U S A (1994) 3.33
Landscaping the cancer terrain. Science (1998) 2.93
Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine. Development (2005) 2.56
An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature (1993) 2.49
Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol Cell Biol (1997) 2.48
Site- and time-specific gene targeting in the mouse. Methods (2001) 2.42
Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J (2000) 2.41
Uncoupling cell fate determination from patterned cell division in the Drosophila eye. Science (1995) 2.32
Crossing paths with Notch in the hyper-network. Curr Opin Cell Biol (2007) 2.20
Negative regulation of Armadillo, a Wingless effector in Drosophila. Development (1997) 2.09
Cell proliferation control by Notch signaling in Drosophila development. Development (1998) 1.98
The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene (1997) 1.81
Control of cell proliferation in the Drosophila eye by Notch signaling. Dev Cell (2005) 1.79
Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision. J Gastroenterol (2007) 1.75
Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt. Virology (2001) 1.63
Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium. Am J Pathol (2004) 1.59
Multistep carcinogenesis of the colon in Apc(Min/+) mouse. Cancer Sci (2007) 1.32
Accessing the Exelixis collection. Nat Genet (2004) 1.06
Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes. Methods Enzymol (2003) 0.95
Interactions between Wingless and Notch during the assignment of cell fates in Drosophila. Int J Dev Biol (1998) 0.90
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis (2004) 6.83
Notch signals control the fate of immature progenitor cells in the intestine. Nature (2005) 6.13
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab (2005) 5.32
Notch signalling in vertebrate neural development. Nat Rev Neurosci (2006) 4.97
Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma. J Clin Oncol (2010) 4.93
Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium. J Cell Biol (2007) 4.52
A protein complex network of Drosophila melanogaster. Cell (2011) 3.31
Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Mol Cell Biol (2007) 3.06
Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin. J Cell Biol (2004) 3.03
Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc Natl Acad Sci U S A (2006) 2.92
The Notch signalling system: recent insights into the complexity of a conserved pathway. Nat Rev Genet (2012) 2.77
Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis. Cancer Cell (2004) 2.66
Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia. J Cell Biol (2010) 2.62
Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine. Development (2005) 2.56
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest (2005) 2.45
Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling. Cancer Cell (2011) 2.45
Nanocourses: a short course format as an educational tool in a biological sciences graduate curriculum. CBE Life Sci Educ (2008) 2.39
Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. Cancer Res (2007) 2.26
APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. Gastroenterology (2006) 2.25
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol (2011) 2.21
Crossing paths with Notch in the hyper-network. Curr Opin Cell Biol (2007) 2.20
IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A (2004) 2.12
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A (2010) 2.10
The co-workers of actin filaments: from cell structures to signals. Nat Rev Mol Cell Biol (2004) 2.01
Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis. Cancer Cell (2010) 1.93
TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res (2007) 1.93
Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A (2008) 1.90
A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Nat Cell Biol (2004) 1.88
ERM proteins in epithelial cell organization and functions. Biochim Biophys Acta (2006) 1.80
The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr Biol (2004) 1.80
Regulation of Notch signalling by non-visual beta-arrestin. Nat Cell Biol (2005) 1.79
The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells. Breast Cancer Res (2005) 1.76
Notch signaling at a glance. J Cell Sci (2013) 1.76
Molecular analysis of microscopic ezrin dynamics by two-photon FRAP. Proc Natl Acad Sci U S A (2002) 1.73
Modeling spinal muscular atrophy in Drosophila. PLoS One (2008) 1.71
c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium. Mol Cell Biol (2005) 1.70
Translocation carcinomas of the kidney after chemotherapy in childhood. J Clin Oncol (2006) 1.69
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol (2008) 1.68
Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation. Mol Biol Cell (2003) 1.67
ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling. Curr Opin Cell Biol (2002) 1.61
Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process. Development (2003) 1.61
Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium. Am J Pathol (2004) 1.59
Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis. Gastroenterology (2007) 1.58
Management of phyllodes breast tumors. Breast J (2011) 1.58
Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice. Gastroenterology (2002) 1.57
Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR. Am J Surg Pathol (2005) 1.54
Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis. Ann Surg (2013) 1.53
Different microtubule motors move early and late endocytic compartments. Traffic (2008) 1.50
Colorectal cancer surgery remains effective with rising patient age. Int J Colorectal Dis (2014) 1.49
Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras. Int J Cancer (2008) 1.48
Notch and disease: a growing field. Semin Cell Dev Biol (2012) 1.48
Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells. Eur J Immunol (2008) 1.46
Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency. J Biol Chem (2005) 1.43
A genetic study of the role of the Wnt/beta-catenin signalling in Paneth cell differentiation. Dev Biol (2008) 1.42
Down-regulation of Delta by proteolytic processing. J Cell Biol (2002) 1.37
Analyzing protein complexes in Drosophila with tandem affinity purification-mass spectrometry. Dev Dyn (2005) 1.36
The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells. Mol Biol Cell (2002) 1.35
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal. Mol Cell Biol (2012) 1.34
Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium. Mol Cell Biol (2009) 1.33
Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival. Int J Colorectal Dis (2010) 1.31
Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas. Cancer Res (2010) 1.28
Linking Notch signaling to ischemic stroke. Proc Natl Acad Sci U S A (2008) 1.28
Integrative marker analysis allows risk assessment for metastasis in stage II colon cancer. Ann Surg (2012) 1.25
Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice. PLoS One (2011) 1.24
Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages. Nat Cell Biol (2013) 1.24
Rab13 regulates PKA signaling during tight junction assembly. J Cell Biol (2004) 1.24
Independent validation of a prognostic genomic signature (ColoPrint) for patients with stage II colon cancer. Ann Surg (2013) 1.23
Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium. Development (2010) 1.22
KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. Mod Pathol (2005) 1.21
Gastric metastasis of breast cancer: a single centre retrospective study. Dig Liver Dis (2011) 1.21
Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector. Genetics (2007) 1.19
Prediction of prognosis is not improved by the seventh and latest edition of the TNM classification for colorectal cancer in a single-center collective. Ann Surg (2011) 1.19
Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival. J Clin Invest (2010) 1.18
Myosin 1b promotes the formation of post-Golgi carriers by regulating actin assembly and membrane remodelling at the trans-Golgi network. Nat Cell Biol (2011) 1.16
Microarray-based prediction of tumor response to neoadjuvant radiochemotherapy of patients with locally advanced rectal cancer. Clin Gastroenterol Hepatol (2008) 1.16
Oral health-related KAP among 11- to 12-year-old school children in a government-aided missionary school of Bangalore city. Indian J Dent Res (2008) 1.14
Expression of osteopontin, a target gene of de-regulated Wnt signaling, predicts survival in colon cancer. Int J Cancer (2007) 1.13
Myosin Ib modulates the morphology and the protein transport within multi-vesicular sorting endosomes. J Cell Sci (2005) 1.13
Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells. Mol Biol Cell (2007) 1.12
Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol (2011) 1.11
Identification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: focus on MYCN as a biologically relevant target. Genes Chromosomes Cancer (2008) 1.10
Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer. Int J Cancer (2007) 1.09
Free Brick1 is a trimeric precursor in the assembly of a functional wave complex. PLoS One (2008) 1.09
Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proc Natl Acad Sci U S A (2011) 1.08
Conserved genes act as modifiers of invertebrate SMN loss of function defects. PLoS Genet (2010) 1.07