Published in EMBO J on February 01, 1995
Regulated antisense RNA eliminates alpha-toxin virulence in Staphylococcus aureus infection. J Bacteriol (1999) 1.88
Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. J Cell Biol (1997) 1.82
Dynamic effects of acid on Barrett's esophagus. An ex vivo proliferation and differentiation model. J Clin Invest (1996) 1.81
In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush borders. J Cell Biol (1999) 1.69
Ezrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epithelium. J Cell Biol (1999) 1.46
Inhibition of laminin alpha 1-chain expression leads to alteration of basement membrane assembly and cell differentiation. J Cell Biol (1996) 1.34
Rotavirus infection induces an increase in intracellular calcium concentration in human intestinal epithelial cells: role in microvillar actin alteration. J Virol (2000) 1.34
Rotavirus infection reduces sucrase-isomaltase expression in human intestinal epithelial cells by perturbing protein targeting and organization of microvillar cytoskeleton. J Virol (1998) 1.33
The apical submembrane cytoskeleton participates in the organization of the apical pole in epithelial cells. J Cell Biol (1997) 1.31
Adherence of Salmonella typhimurium to Caco-2 cells: identification of a glycoconjugate receptor. Infect Immun (1996) 1.27
Bacteroides fragilis toxin exhibits polar activity on monolayers of human intestinal epithelial cells (T84 cells) in vitro. Infect Immun (1997) 1.26
Optimizing culture conditions of a porcine epithelial cell line IPEC-J2 through a histological and physiological characterization. Cytotechnology (2011) 1.10
Dynamical control of the shape and size of stereocilia and microvilli. Biophys J (2007) 1.09
Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium. Mol Biol Cell (2009) 1.06
Intestinal mucosal atrophy and adaptation. World J Gastroenterol (2012) 1.06
Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells. Mol Biol Cell (2003) 1.02
Actin filaments and microtubules are involved in different membrane traffic pathways that transport sphingolipids to the apical surface of polarized HepG2 cells. Mol Biol Cell (1998) 1.02
A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Mol Biol Cell (2011) 1.00
Rotavirus infection induces cytoskeleton disorganization in human intestinal epithelial cells: implication of an increase in intracellular calcium concentration. J Virol (2000) 0.98
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. PLoS One (2010) 0.97
Unsolved mysteries of intestinal M cells. Gut (2000) 0.96
Structural and functional lesions in brush border of human polarized intestinal Caco-2/TC7 cells infected by members of the Afa/Dr diffusely adhering family of Escherichia coli. Infect Immun (2000) 0.96
The role of actin bundling proteins in the assembly of filopodia in epithelial cells. Cell Adh Migr (2011) 0.94
Villin severing activity enhances actin-based motility in vivo. Mol Biol Cell (2006) 0.89
Pathogenesis of human enterovirulent bacteria: lessons from cultured, fully differentiated human colon cancer cell lines. Microbiol Mol Biol Rev (2013) 0.87
Villin expression is frequently lost in poorly differentiated colon cancer. Am J Pathol (2012) 0.86
Antigen transport and cytoskeletal characteristics of a distinct enterocyte population in inflammatory bowel diseases. Am J Pathol (2004) 0.82
Regulation of villin by wnt5a/ror2 signaling in human intestinal cells. Front Physiol (2011) 0.81
Vectorial function of major histocompatibility complex class II in a human intestinal cell line. Immunology (1999) 0.81
Extracellular nucleotides inhibit oxalate transport by human intestinal Caco-2-BBe cells through PKC-δ activation. Am J Physiol Cell Physiol (2013) 0.80
Plasticity of the brush border - the yin and yang of intestinal homeostasis. Nat Rev Gastroenterol Hepatol (2016) 0.79
Atomic force microscopy as analytical tool to study physico-mechanical properties of intestinal cells. Beilstein J Nanotechnol (2015) 0.77
Giardia duodenalis Surface Cysteine Proteases Induce Cleavage of the Intestinal Epithelial Cytoskeletal Protein Villin via Myosin Light Chain Kinase. PLoS One (2015) 0.77
Medaka villin 1-like protein (VILL) is associated with the formation of microvilli induced by decreasing salinities in the absorptive ionocytes. Front Zool (2014) 0.76
Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem (1981) 71.15
Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci U S A (1987) 18.91
Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells. Nature (1985) 14.39
Antisense RNA inactivation of myosin heavy chain gene expression in Dictyostelium discoideum. Science (1987) 6.13
INFECTION OF HUMAN AND SIMIAN TISSUE CULTURES WITH ROUS SARCOMA VIRUS. Proc Natl Acad Sci U S A (1964) 5.60
Interaction of cytoskeletal proteins on the human erythrocyte membrane. Cell (1981) 5.13
A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene. Proc Natl Acad Sci U S A (1984) 5.08
Apical membrane aminopeptidase appears at site of cell-cell contact in cultured kidney epithelial cells. Proc Natl Acad Sci U S A (1980) 4.63
Cytoskeleton--plasma membrane interactions. Science (1992) 4.44
Stable reduction of thymidine kinase activity in cells expressing high levels of anti-sense RNA. Cell (1985) 4.31
Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity. Cell (1990) 3.75
Constitutive and conditional suppression of exogenous and endogenous genes by anti-sense RNA. Science (1985) 3.71
Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cells. J Cell Biol (1985) 3.14
Characterization of an integral membrane glycoprotein associated with the microfilaments of pig intestinal microvilli. EMBO J (1983) 2.95
Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2. J Cell Sci (1992) 2.80
Microfilament structure and function in the cortical cytoskeleton. Annu Rev Cell Biol (1991) 2.56
The spectrin-actin junction of erythrocyte membrane skeletons. Biochim Biophys Acta (1989) 2.50
Sorting of endogenous plasma membrane proteins occurs from two sites in cultured human intestinal epithelial cells (Caco-2). Cell (1990) 2.49
Glycophospholipid membrane anchoring provides clues to the mechanism of protein sorting in polarized epithelial cells. Trends Biochem Sci (1990) 2.27
Villin induces microvilli growth and actin redistribution in transfected fibroblasts. Cell (1989) 2.19
Biogenetic pathways of plasma membrane proteins in Caco-2, a human intestinal epithelial cell line. J Cell Biol (1990) 2.02
An actin-binding site containing a conserved motif of charged amino acid residues is essential for the morphogenic effect of villin. Cell (1992) 2.01
ZO-1 mRNA and protein expression during tight junction assembly in Caco-2 cells. J Cell Biol (1989) 1.92
Can villin be used to identify malignant and undifferentiated normal digestive epithelial cells? Proc Natl Acad Sci U S A (1985) 1.83
The Dictyostelium essential light chain is required for myosin function. Cell (1992) 1.82
Nocodazole, a microtubule-active drug, interferes with apical protein delivery in cultured intestinal epithelial cells (Caco-2). J Cell Biol (1989) 1.76
Suppression of vinculin expression by antisense transfection confers changes in cell morphology, motility, and anchorage-dependent growth of 3T3 cells. J Cell Biol (1993) 1.61
An in vitro model for the analysis of intestinal brush border assembly. I. Ultrastructural analysis of cell contact-induced brush border assembly in Caco-2BBe cells. J Cell Sci (1993) 1.54
Conversion of normal behavior to shiverer by myelin basic protein antisense cDNA in transgenic mice. Science (1988) 1.53
Sequence of human villin: a large duplicated domain homologous with other actin-severing proteins and a unique small carboxy-terminal domain related to villin specificity. J Cell Biol (1988) 1.49
Assembly of the intestinal brush border: appearance and redistribution of microvillar core proteins in developing chick enterocytes. J Cell Biol (1987) 1.48
Differential localization of villin and fimbrin during development of the mouse visceral endoderm and intestinal epithelium. Development (1989) 1.47
Suppression by antisense mRNA demonstrates a requirement for the glial fibrillary acidic protein in the formation of stable astrocytic processes in response to neurons. J Cell Biol (1991) 1.41
Reassociation of microvillar core proteins: making a microvillar core in vitro. J Cell Biol (1989) 1.40
Use of immunocytochemical techniques in studying the biogenesis of cell surfaces in polarized epithelia. Methods Enzymol (1983) 1.39
A human villin cDNA clone to investigate the differentiation of intestinal and kidney cells in vivo and in culture. EMBO J (1986) 1.35
Changes in villin synthesis and subcellular distribution during intestinal differentiation of HT29-18 clones. J Cell Biol (1987) 1.33
Congenital microvillous atrophy: specific diagnostic features. Arch Dis Child (1985) 1.30
Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I. Proc Natl Acad Sci U S A (1992) 1.29
Spectrin and related molecules. CRC Crit Rev Biochem (1988) 1.27
Assembly of the intestinal brush border cytoskeleton. Curr Top Dev Biol (1992) 1.26
Sucrase-isomaltase deficiency in humans. Different mutations disrupt intracellular transport, processing, and function of an intestinal brush border enzyme. J Clin Invest (1988) 1.08
Antisense strategies in cell and developmental biology. J Cell Sci (1990) 1.07
A study of the molecular pathology of sucrase-isomaltase deficiency. A defect in the intracellular processing of the enzyme. N Engl J Med (1987) 1.03
Antisense RNA inhibits expression of membrane skeleton protein 4.1 during embryonic development of Xenopus. Cell (1988) 1.03
Mutations of the red blood cell membrane proteins: from clinical evaluation to detection of the underlying genetic defect. Blood (1992) 0.96
Regulatory sequences on the human villin gene trigger the expression of a reporter gene in a differentiating HT29 intestinal cell line. J Biol Chem (1993) 0.95
Structure of the human villin gene. Proc Natl Acad Sci U S A (1991) 0.92
Differential distribution of villin and villin MRNA in mouse intestinal epithelial cells. Differentiation (1988) 0.83
Comparative analysis of neutral endopeptidase (NEP) and villin gene expression during mouse embryogenesis and enterocyte maturation. Differentiation (1994) 0.83
Development of the chicken intestinal epithelium. Curr Top Dev Biol (1992) 0.78
Antibodies to the Golgi complex and the rough endoplasmic reticulum. J Cell Biol (1982) 7.02
A monoclonal antibody against a 135-K Golgi membrane protein. EMBO J (1982) 4.89
Apical membrane aminopeptidase appears at site of cell-cell contact in cultured kidney epithelial cells. Proc Natl Acad Sci U S A (1980) 4.63
Passage of viral membrane proteins through the Golgi complex. J Mol Biol (1981) 4.48
SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane. J Biol Chem (1991) 4.48
Antibody-induced linkages of plasma membrane proteins to intracellular actomyosin-containing filaments in cultured fibroblasts. Proc Natl Acad Sci U S A (1977) 4.23
Polarization of the Golgi apparatus and the microtubule-organizing center in cultured fibroblasts at the edge of an experimental wound. Proc Natl Acad Sci U S A (1982) 4.17
Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker. J Cell Biol (1993) 3.96
Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria. Science (1997) 3.65
Uvomorulin: a nonintegral membrane protein of early mouse embryo. Proc Natl Acad Sci U S A (1983) 3.42
Viral membrane proteins acquire galactose in trans Golgi cisternae during intracellular transport. J Cell Biol (1982) 3.18
Characterization of an integral membrane glycoprotein associated with the microfilaments of pig intestinal microvilli. EMBO J (1983) 2.95
Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border. J Cell Biol (1985) 2.73
Inhibition of coated pit formation in Hep2 cells blocks the cytotoxicity of diphtheria toxin but not that of ricin toxin. J Cell Biol (1985) 2.71
The aminopeptidase from hog intestinal brush border. Biochim Biophys Acta (1973) 2.57
Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells. J Cell Biol (1997) 2.51
Characterization of antigens recognized by monoclonal and polyclonal antibodies directed against uvomorulin. Proc Natl Acad Sci U S A (1985) 2.47
Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane. J Cell Biol (2000) 2.45
Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A (1999) 2.21
Villin induces microvilli growth and actin redistribution in transfected fibroblasts. Cell (1989) 2.19
Regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of small and large intestines. J Biol Chem (1999) 2.15
Antigen sampling across epithelial barriers and induction of mucosal immune responses. Annu Rev Immunol (1996) 2.11
A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. Mol Biol Cell (1998) 2.11
Transepithelial transport of a viral membrane glycoprotein implanted into the apical plasma membrane of Madin-Darby canine kidney cells. I. Morphological evidence. J Cell Biol (1983) 2.07
Growing an actin gel on spherical surfaces. Biophys J (2000) 2.06
Absorptive and mucus-secreting subclones isolated from a multipotent intestinal cell line (HT-29) provide new models for cell polarity and terminal differentiation. J Cell Biol (1987) 2.03
An actin-binding site containing a conserved motif of charged amino acid residues is essential for the morphogenic effect of villin. Cell (1992) 2.01
Raft association of SNAP receptors acting in apical trafficking in Madin-Darby canine kidney cells. Proc Natl Acad Sci U S A (1999) 1.95
The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts. Proc Natl Acad Sci U S A (1996) 1.95
A monoclonal antibody to the heavy chain of clathrin. EMBO J (1983) 1.94
Membrane-actin microfilament connections: an increasing diversity of players related to band 4.1. Curr Opin Cell Biol (1994) 1.86
Assembled and unassembled pools of clathrin: a quantitative study using an enzyme immunoassay. J Cell Biol (1985) 1.84
Actin filaments facilitate two steps of endocytosis. J Cell Sci (1996) 1.83
Can villin be used to identify malignant and undifferentiated normal digestive epithelial cells? Proc Natl Acad Sci U S A (1985) 1.83
Role of tetanus neurotoxin insensitive vesicle-associated membrane protein (TI-VAMP) in vesicular transport mediating neurite outgrowth. J Cell Biol (2000) 1.82
A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells. J Cell Biol (1994) 1.80
A monoclonal anti-DNA antibody also binds to cell-surface protein(s). Proc Natl Acad Sci U S A (1984) 1.75
In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush borders. J Cell Biol (1999) 1.69
LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity. Mol Biol Cell (2000) 1.62
Antibodies against lysosomal membranes reveal a 100,000-mol-wt protein that cross-reacts with purified H+,K+ ATPase from gastric mucosa. J Cell Biol (1984) 1.59
Characterization of molecules involved in protein translocation using a specific antibody. J Cell Biol (1982) 1.58
Actin filaments and myosin I alpha cooperate with microtubules for the movement of lysosomes. Mol Biol Cell (2001) 1.56
Lysosomes are associated with microtubules and not with intermediate filaments in cultured fibroblasts. Proc Natl Acad Sci U S A (1984) 1.56
Cytosolic distribution of villin in M cells from mouse Peyer's patches correlates with the absence of a brush border. Gastroenterology (1996) 1.55
On the preparation and some properties of closed membrane vesicles from hog duodenal and jejunal brush border. Biochim Biophys Acta (1973) 1.54
Clathrin-immunoreactive sites in the Golgi apparatus are concentrated at the trans pole in polypeptide hormone-secreting cells. Proc Natl Acad Sci U S A (1985) 1.54
Targeting of zyxin to sites of actin membrane interaction and to the nucleus. J Biol Chem (2001) 1.52
Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. J Biol Chem (2000) 1.51
Transimmortalized mouse intestinal cells (m-ICc12) that maintain a crypt phenotype. Am J Physiol (1996) 1.51
Topological studies on the hydrolases bound to the intestinal brush border membrane. I. Solubilization by papain and Triton X-100. Biochim Biophys Acta (1975) 1.51
Sequence of human villin: a large duplicated domain homologous with other actin-severing proteins and a unique small carboxy-terminal domain related to villin specificity. J Cell Biol (1988) 1.49
Human fetal enterocytes in vitro: modulation of the phenotype by extracellular matrix. Proc Natl Acad Sci U S A (1996) 1.49
On the hydrophobic part of aminopeptidase and maltases which bind the enzyme to the intestinal brush border membrane. Biochim Biophys Acta (1976) 1.48
Na+-H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3. J Physiol (2001) 1.47
Targeting of Listeria monocytogenes ActA protein to the plasma membrane as a tool to dissect both actin-based cell morphogenesis and ActA function. EMBO J (1995) 1.46
ActA and human zyxin harbour Arp2/3-independent actin-polymerization activity. Nat Cell Biol (2001) 1.46
Transmembrane interactions and the mechanisms of transport of proteins across membranes. J Supramol Struct (1978) 1.44
The brush-border intestinal aminopeptidase, a transmembrane protein as probed by macromolecular photolabelling. J Mol Biol (1976) 1.42
Tight junction, a platform for trafficking and signaling protein complexes. J Cell Biol (2000) 1.41
Functional differences between L- and T-plastin isoforms. J Cell Biol (1994) 1.41
Immunolocalization of the 110,000 molecular weight cytoskeletal protein of intestinal microvilli. J Mol Biol (1981) 1.41
Use of immunocytochemical techniques in studying the biogenesis of cell surfaces in polarized epithelia. Methods Enzymol (1983) 1.39
Structural and topological homology between porcine intestinal and renal brush border aminopeptidase. Biochim Biophys Acta (1976) 1.37
A human villin cDNA clone to investigate the differentiation of intestinal and kidney cells in vivo and in culture. EMBO J (1986) 1.35
Src-dependent ezrin phosphorylation in adhesion-mediated signaling. Mol Biol Cell (2005) 1.35
Changes in villin synthesis and subcellular distribution during intestinal differentiation of HT29-18 clones. J Cell Biol (1987) 1.33
I-SceI-induced gene replacement at a natural locus in embryonic stem cells. Mol Cell Biol (1998) 1.32
A common exocytotic mechanism mediates axonal and dendritic outgrowth. J Neurosci (2001) 1.31
Binding of a monoclonal anti-DNA autoantibody to identical protein(s) present at the surface of several human cell types involved in lupus pathogenesis. J Clin Invest (1985) 1.31
Subcellular localization of tetanus neurotoxin-insensitive vesicle-associated membrane protein (VAMP)/VAMP7 in neuronal cells: evidence for a novel membrane compartment. J Neurosci (1999) 1.30
From the structure to the function of villin, an actin-binding protein of the brush border. Bioessays (1990) 1.29
Association of myosin I alpha with endosomes and lysosomes in mammalian cells. Mol Biol Cell (1999) 1.28
Partial deduced sequence of the 110-kD-calmodulin complex of the avian intestinal microvillus shows that this mechanoenzyme is a member of the myosin I family. J Cell Biol (1989) 1.23
On porcine enterokinase. Further purification and some molecular properties. Biochim Biophys Acta (1973) 1.21
Developmental regulation of villin gene expression in the epithelial cell lineages of mouse digestive and urogenital tracts. Development (1992) 1.21
Villin-like actin-binding proteins are expressed ubiquitously in Arabidopsis. Plant Physiol (2000) 1.19
Human intestinal goblet cells in monolayer culture: characterization of a mucus-secreting subclone derived from the HT29 colon adenocarcinoma cell line. Gastroenterology (1988) 1.19
Brush border myosin-I truncated in the motor domain impairs the distribution and the function of endocytic compartments in an hepatoma cell line. Proc Natl Acad Sci U S A (1996) 1.19
Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance. EMBO J (1992) 1.17
Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion. J Biol Chem (2001) 1.17
Polarized secretion of lysosomal enzymes: co-distribution of cation-independent mannose-6-phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathway. J Cell Biol (1988) 1.16
Association of an aminoacyl-tRNA synthetase complex and of phenylalanyl-tRNA synthetase with the cytoskeletal framework fraction from mammalian cells. Exp Cell Res (1985) 1.15
Vimentin filaments in fibroblasts are a reservoir for SNAP23, a component of the membrane fusion machinery. Mol Biol Cell (2000) 1.15
Villin: a cytoskeletal protein and a differentiation marker expressed in some human adenocarcinomas. Virchows Arch B Cell Pathol Incl Mol Pathol (1987) 1.12
Surface and cytoplasmic domains in polarized epithelial cells. Prog Clin Biol Res (1982) 1.11
Truncated brush border myosin I affects membrane traffic in polarized epithelial cells. Traffic (2000) 1.10
Changes in the distribution of membranous organelles during mouse early development. J Embryol Exp Morphol (1985) 1.09
Adhesion of Helicobacter pylori to polarized T84 human intestinal cell monolayers is pH dependent. Infect Immun (1996) 1.08