Published in Nat Genet on May 14, 2006
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet (2008) 7.71
Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. Am J Hum Genet (2008) 7.36
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet (2009) 5.75
The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol (2009) 5.21
Immune signaling by RIG-I-like receptors. Immunity (2011) 5.02
Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet (2009) 4.79
(2) Classification and diagnosis of diabetes. Diabetes Care (2015) 4.29
Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms. Am J Hum Genet (2008) 4.28
Autoimmune diseases: insights from genome-wide association studies. Hum Mol Genet (2008) 2.94
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88
Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat Rev Genet (2013) 2.85
To identify associations with rare variants, just WHaIT: Weighted haplotype and imputation-based tests. Am J Hum Genet (2010) 2.63
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes (2008) 2.51
The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants. Pediatr Diabetes (2011) 2.44
Recent advances in the genetics of autoimmune disease. Annu Rev Immunol (2009) 2.41
Copy number variants and common disorders: filling the gaps and exploring complexity in genome-wide association studies. PLoS Genet (2007) 2.32
Analysis of protein sequence and interaction data for candidate disease gene prediction. Nucleic Acids Res (2006) 2.30
Genome partitioning of genetic variation for height from 11,214 sibling pairs. Am J Hum Genet (2007) 2.27
IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells. Hum Mol Genet (2008) 2.27
Polymorphisms in melanoma differentiation-associated gene 5 link protein function to clearance of hepatitis C virus. Hepatology (2015) 2.11
Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. Mol Psychiatry (2009) 2.09
Assessing batch effects of genotype calling algorithm BRLMM for the Affymetrix GeneChip Human Mapping 500 K array set using 270 HapMap samples. BMC Bioinformatics (2008) 1.98
Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study. Lancet Neurol (2006) 1.92
Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host. Nat Rev Endocrinol (2010) 1.85
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. Nat Genet (2012) 1.81
Meta-analysis in genome-wide association datasets: strategies and application in Parkinson disease. PLoS One (2007) 1.69
Whole genome association mapping by incompatibilities and local perfect phylogenies. BMC Bioinformatics (2006) 1.68
Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev (2008) 1.66
Understanding type 1 diabetes through genetics: advances and prospects. Nat Rev Genet (2011) 1.64
Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetes. J Biol Chem (2009) 1.62
Genome-wide association studies: a new window into immune-mediated diseases. Nat Rev Immunol (2008) 1.59
Influence of microbial environment on autoimmunity. Nat Immunol (2009) 1.59
Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus. PLoS Genet (2011) 1.59
Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. Diabetes (2008) 1.56
Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden. Am J Hum Genet (2006) 1.50
Assembly of inflammation-related genes for pathway-focused genetic analysis. PLoS One (2007) 1.46
Genome-wide association studies: progress and potential for drug discovery and development. Nat Rev Drug Discov (2008) 1.45
Enteroviruses in the pathogenesis of type 1 diabetes. Semin Immunopathol (2010) 1.43
Allelic variant in CTLA4 alters T cell phosphorylation patterns. Proc Natl Acad Sci U S A (2007) 1.42
Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families. Genes Immun (2009) 1.42
Aicardi-Goutières syndrome is caused by IFIH1 mutations. Am J Hum Genet (2014) 1.41
Genome-virome interactions: examining the role of common viral infections in complex disease. Nat Rev Microbiol (2011) 1.38
Genetics of type 1 diabetes. Clin Chem (2011) 1.37
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity. Pharmacol Ther (2009) 1.37
Technical reproducibility of genotyping SNP arrays used in genome-wide association studies. PLoS One (2012) 1.36
Recent advances in the genetics of systemic lupus erythematosus. Expert Rev Clin Immunol (2010) 1.35
Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients. J Immunol (2011) 1.34
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. Nat Genet (2010) 1.32
Bench-to-bedside review: Association of genetic variation with sepsis. Crit Care (2009) 1.31
Admixture mapping provides evidence of association of the VNN1 gene with hypertension. PLoS One (2007) 1.31
MDA5 and MAVS mediate type I interferon responses to coxsackie B virus. J Virol (2010) 1.28
A comprehensive review of the genetics of juvenile idiopathic arthritis. Pediatr Rheumatol Online J (2008) 1.27
Enterovirus RNA in blood is linked to the development of type 1 diabetes. Diabetes (2010) 1.26
PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim. Diabetes (2011) 1.26
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. Hum Mol Genet (2010) 1.25
Reduced expression of IFIH1 is protective for type 1 diabetes. PLoS One (2010) 1.18
Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population. Genes Immun (2011) 1.18
Collapsing SNP genotypes in case-control genome-wide association studies increases the type I error rate and power. Stat Appl Genet Mol Biol (2008) 1.17
A specific IFIH1 gain-of-function mutation causes Singleton-Merten syndrome. Am J Hum Genet (2015) 1.17
Evidence for association of the TCF7 locus with type I diabetes. Genes Immun (2009) 1.15
When the human viral infectome and diseasome networks collide: towards a systems biology platform for the aetiology of human diseases. BMC Syst Biol (2011) 1.15
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet (2013) 1.14
The genetics of lupus: a functional perspective. Arthritis Res Ther (2012) 1.12
PADB: published association database. BMC Bioinformatics (2007) 1.12
Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides. PLoS One (2013) 1.11
Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk. Hum Hered (2010) 1.10
Detection of enteroviruses in the intestine of type 1 diabetic patients. Clin Exp Immunol (2007) 1.10
Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'. Trends Genet (2014) 1.10
The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes. BMC Med Genet (2007) 1.10
A generalizable hypothesis for the genetic architecture of disease: pleomorphic risk loci. Hum Mol Genet (2011) 1.10
Approaches in type 1 diabetes research: A status report. Int J Diabetes Dev Ctries (2009) 1.08
Psoriasis and other complex trait dermatoses: from Loci to functional pathways. J Invest Dermatol (2011) 1.07
Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response. PLoS One (2009) 1.07
Local phylogeny mapping of quantitative traits: higher accuracy and better ranking than single-marker association in genomewide scans. Genetics (2008) 1.07
Direct inference of SNP heterozygosity rates and resolution of LOH detection. PLoS Comput Biol (2007) 1.06
Connections between antiviral defense and autoimmunity. Curr Opin Immunol (2009) 1.05
RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice. J Clin Invest (2011) 1.04
Immunopathology of the human pancreas in type-I diabetes. Semin Immunopathol (2010) 1.04
Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma. Clin Exp Immunol (2012) 1.03
An interferon-induced helicase (IFIH1) gene polymorphism associates with different rates of progression from autoimmunity to type 1 diabetes. Diabetes (2011) 1.02
The imprinted gene neuronatin is regulated by metabolic status and associated with obesity. Obesity (Silver Spring) (2009) 1.02
Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development. Immunity (2015) 1.01
Current aspects of vitiligo genetics. Postepy Dermatol Alergol (2014) 1.01
Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1). Diabetes (2008) 1.01
Extreme genetic risk for type 1A diabetes in the post-genome era. J Autoimmun (2008) 1.00
Assessing sources of inconsistencies in genotypes and their effects on genome-wide association studies with HapMap samples. Pharmacogenomics J (2010) 1.00
The immunogenetic architecture of autoimmune disease. Cold Spring Harb Perspect Biol (2012) 1.00
Innate receptors and microbes in induction of autoimmunity. Curr Opin Immunol (2009) 1.00
The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis. Arthritis Res Ther (2007) 0.99
Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes. PLoS Pathog (2013) 0.99
The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome. Genes Immun (2009) 0.98
Effective sample size: Quick estimation of the effect of related samples in genetic case-control association analyses. Comput Biol Chem (2011) 0.98
Genetic Basis of Type 1 Diabetes: Similarities and Differences between East and West. Rev Diabet Stud (2008) 0.98
Biomarkers for type 1 diabetes. Int J Clin Exp Med (2008) 0.98
Carriers of rare missense variants in IFIH1 are protected from psoriasis. J Invest Dermatol (2010) 0.97
Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat Genet (2005) 25.34
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum Hered (2003) 14.37
Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet (2005) 14.30
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature (2003) 13.00
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Prepublication data sharing. Nature (2009) 12.24
Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. Am J Hum Genet (2001) 8.47
Control of confounding of genetic associations in stratified populations. Am J Hum Genet (2003) 7.99
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet (2008) 7.71
Vascular risk factors and diabetic neuropathy. N Engl J Med (2005) 7.69
Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med (2008) 7.66
Genetically distinct subsets within ANCA-associated vasculitis. N Engl J Med (2012) 6.93
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature (2007) 6.67
Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial. Lancet (2010) 6.50
Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med (2007) 6.47
Summary and recommendations of the Fifth International Workshop-Conference on Gestational Diabetes Mellitus. Diabetes Care (2007) 6.38
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet (2007) 6.11
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res (2010) 6.03
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet (2007) 5.68
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes (2008) 4.94
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes (2004) 4.81
A method to address differential bias in genotyping in large-scale association studies. PLoS Genet (2007) 4.51
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet (2005) 4.36
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet (2009) 3.59
A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science (2004) 3.54
Early insulin therapy in very-low-birth-weight infants. N Engl J Med (2008) 3.51
Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing. Hum Mol Genet (2010) 3.50
Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects. Genet Epidemiol (2004) 3.39
Betting odds and genetic associations. J Natl Cancer Inst (2004) 3.39
Overnight closed loop insulin delivery (artificial pancreas) in adults with type 1 diabetes: crossover randomised controlled studies. BMJ (2011) 3.36
Genetic association studies. Lancet (2005) 3.35
Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J Natl Cancer Inst (2002) 3.32
Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31