MicroRNA-based therapeutics for cancer.

The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol (2010) 2.53

Molecular classification and novel targets in hepatocellular carcinoma: recent advancements. Semin Liver Dis (2010) 2.46

Targeting long non-coding RNA to therapeutically upregulate gene expression. Nat Rev Drug Discov (2013) 1.82

MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a. Gastroenterology (2011) 1.77

MicroRNAs, cancer and cancer stem cells. Cancer Lett (2010) 1.65

MicroRNA reexpression as differentiation therapy in cancer. J Clin Invest (2009) 1.38

Diagnostic, prognostic and therapeutic implications of microRNAs in urologic tumors. Nat Rev Urol (2010) 1.28

Four microRNAs promote prostate cell proliferation with regulation of PTEN and its downstream signals in vitro. PLoS One (2013) 1.11

MicroRNA-21 as a potential colon and rectal cancer biomarker. World J Gastroenterol (2013) 1.10

Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing. Nucleic Acids Res (2010) 1.04

MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma. Curr Opin Pharmacol (2009) 1.02

MicroRNAs: exploring a new dimension in the pathogenesis of kidney cancer. BMC Med (2010) 1.00

Quantitative proteomics identify novel miR-155 target proteins. PLoS One (2011) 0.96

Stem cells as a therapeutic target for diabetes. Front Biosci (Landmark Ed) (2010) 0.96

Use of microRNA Let-7 to control the replication specificity of oncolytic adenovirus in hepatocellular carcinoma cells. PLoS One (2011) 0.95

Evidence demonstrating role of microRNAs in the etiopathology of major depression. J Chem Neuroanat (2011) 0.94

miR-708 promotes the development of bladder carcinoma via direct repression of Caspase-2. J Cancer Res Clin Oncol (2013) 0.92

MicroRNA: potential targets for the development of novel drugs? Drugs R D (2010) 0.92

Inhibition of BCR/ABL protein expression by miR-203 sensitizes for imatinib mesylate. PLoS One (2013) 0.91

MicroRNA-320a inhibits proliferation and invasion of breast cancer cells by targeting RAB11A. Am J Cancer Res (2015) 0.91

MicroRNAs in Ewing Sarcoma. Front Oncol (2013) 0.90

MicroRNAs in Breastmilk and the Lactating Breast: Potential Immunoprotectors and Developmental Regulators for the Infant and the Mother. Int J Environ Res Public Health (2015) 0.88

Control of MicroRNA-21 expression in colorectal cancer cells by oncogenic epidermal growth factor/Ras signaling and Ets transcription factors. DNA Cell Biol (2012) 0.87

MicroRNA in carcinogenesis & cancer diagnostics: a new paradigm. Indian J Med Res (2013) 0.86

Clock genes: their role in colorectal cancer. World J Gastroenterol (2014) 0.86

The emerging role of microRNAs in drug responses. Curr Opin Mol Ther (2010) 0.85

MmPalateMiRNA, an R package compendium illustrating analysis of miRNA microarray data. Source Code Biol Med (2013) 0.84

ECM-based materials in cardiovascular applications: Inherent healing potential and augmentation of native regenerative processes. Int J Mol Sci (2009) 0.84

MicroRNA signatures as biomarkers and therapeutic target for CNS embryonal tumors: the pros and the cons. Int J Mol Sci (2014) 0.81

Sulforaphane-induced transcription of thioredoxin reductase in lens: possible significance against cataract formation. Clin Ophthalmol (2013) 0.79

Utility of micro-ribonucleic acid profile for predicting recurrence of rectal cancer. J Surg Res (2012) 0.79

MicroRNA-34c Suppresses Breast Cancer Migration and Invasion by Targeting GIT1. J Cancer (2016) 0.79

Noncoding RNAs: emerging players in muscular dystrophies. Biomed Res Int (2014) 0.79

MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells. Sci Rep (2016) 0.78

miR-139-5p Inhibits the Epithelial-Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2. Sci Rep (2016) 0.78

Phytoalexins, miRNAs and breast cancer: a review of phytochemical-mediated miRNA regulation in breast cancer. J Health Care Poor Underserved (2013) 0.77

Gossypol acetate induced apoptosis of pituitary tumor cells by targeting the BCL-2 via the upregulated microRNA miR-15a. Int J Clin Exp Med (2015) 0.77

Identification of Cellular Targets of MicroRNA-181a in HepG2 Cells: A New Approach for Functional Analysis of MicroRNAs. PLoS One (2015) 0.77

Prospects of miRNA-based therapy for pancreatic cancer. Curr Drug Targets (2013) 0.76

Future of the Genetic Code. Life (Basel) (2017) 0.75

MiR-139-5p reverses CD44+/CD133+-associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells. Oncotarget (2016) 0.75

miR-23a/b promote tumor growth and suppress apoptosis by targeting PDCD4 in gastric cancer. Cell Death Dis (2017) 0.75

Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med (2011) 13.18

Assemblathon 1: a competitive assessment of de novo short read assembly methods. Genome Res (2011) 8.38

Predicting overweight and obesity in adulthood from body mass index values in childhood and adolescence. Am J Clin Nutr (2002) 6.19

Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature (2002) 5.61

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature (2007) 5.54

Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature (2005) 4.88

Maize inbreds exhibit high levels of copy number variation (CNV) and presence/absence variation (PAV) in genome content. PLoS Genet (2009) 3.88

The Forkhead transcription factor Hcm1 regulates chromosome segregation genes and fills the S-phase gap in the transcriptional circuitry of the cell cycle. Genes Dev (2006) 3.58

Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop of resource-poor farmers. Nat Biotechnol (2011) 3.51

Control and characterization of individual grains and grain boundaries in graphene grown by chemical vapour deposition. Nat Mater (2011) 3.23

Treatment of pressure ulcers: a systematic review. JAMA (2008) 2.96

A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet (2011) 2.85

R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell (2004) 2.73

Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris. Genome Res (2005) 2.65

Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nat Nanotechnol (2007) 2.57

A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains. Cell (2007) 2.50

The effect of computerized physician order entry with clinical decision support on the rates of adverse drug events: a systematic review. J Gen Intern Med (2008) 2.46

Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev (2005) 2.44

From neural development to cognition: unexpected roles for chromatin. Nat Rev Genet (2013) 2.42

TOS9 regulates white-opaque switching in Candida albicans. Eukaryot Cell (2006) 2.42

Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell (2006) 2.40

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol (2010) 2.37

NONCODEv4: exploring the world of long non-coding RNA genes. Nucleic Acids Res (2013) 2.37

Memristor-CMOS hybrid integrated circuits for reconfigurable logic. Nano Lett (2009) 2.35

Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers. J Pathol (2011) 2.27

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26

Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells. Nano Lett (2006) 2.24

MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling. Hum Mol Genet (2004) 2.10

Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy. Diabetes (2011) 2.03

Levels of prenatal mercury exposure and their relationships to neonatal anthropometry in Wujiang City, China. Environ Pollut (2013) 2.01

The nature of the fourth bond in the ground state of C2: the quadruple bond conundrum. Chemistry (2014) 1.97

Gibberellin mobilizes distinct DELLA-dependent transcriptomes to regulate seed germination and floral development in Arabidopsis. Plant Physiol (2006) 1.91

Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Nat Biotechnol (2011) 1.91

Oral drug therapy for multiple neglected tropical diseases: a systematic review. JAMA (2007) 1.88

Expression of lymphocytes and lymphocyte subsets in patients with severe acute respiratory syndrome. Clin Infect Dis (2003) 1.84

Systematic review of HIV transmission between heterosexual serodiscordant couples where the HIV-positive partner is fully suppressed on antiretroviral therapy. PLoS One (2013) 1.79

MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A (2011) 1.77

Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer. J Biol Chem (2011) 1.73

Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model. Proc Natl Acad Sci U S A (2012) 1.71

Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis. Clin Dev Immunol (2012) 1.70

Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways. Am J Respir Crit Care Med (2014) 1.69

A new look at state-space models for neural data. J Comput Neurosci (2009) 1.69

Dscam2 mediates axonal tiling in the Drosophila visual system. Nature (2007) 1.66

DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. Hum Mol Genet (2007) 1.65

Quadruple bonding in C2 and analogous eight-valence electron species. Nat Chem (2012) 1.62

Characterization of a sub-family of Arabidopsis genes with the SPX domain reveals their diverse functions in plant tolerance to phosphorus starvation. Plant J (2008) 1.60

The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development (2008) 1.59

PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients. Mol Immunol (2007) 1.58

Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues. J Exp Clin Cancer Res (2012) 1.55

Vapor-phase self-assembled monolayer for improved mold release in nanoimprint lithography. Langmuir (2005) 1.55

An efficient algorithm for energy gradients and orbital optimization in valence bond theory. J Comput Chem (2009) 1.52

Circuit fabrication at 17 nm half-pitch by nanoimprint lithography. Nano Lett (2006) 1.51

Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. Nat Genet (2012) 1.49

The Min oscillator uses MinD-dependent conformational changes in MinE to spatially regulate cytokinesis. Cell (2011) 1.49

Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol (2013) 1.49

A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms. Cell (2008) 1.48

Surgical safety checklist: implementation in an ambulatory surgical facility. Can J Anaesth (2013) 1.48

Safety and viability of microencapsulated human islets transplanted into diabetic humans. Diabetes Care (2009) 1.48

Levels of vasoactive intestinal peptide, cholecystokinin and calcitonin gene-related peptide in plasma and jejunum of rats following traumatic brain injury and underlying significance in gastrointestinal dysfunction. World J Gastroenterol (2004) 1.48

Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int (2005) 1.47

Allicin, a major component of garlic, inhibits apoptosis in vital organs in rats with trauma/hemorrhagic shock. Crit Care Med (2008) 1.47

Sarcophaga (Hoa)flexuosa Ho (Diptera: Sarcophagidae): association of sexes using morphological and molecular approaches, and a redefinition of Hoa Rohdendorf. Zootaxa (2013) 1.46

Development of the personalized criteria for microscopic review following four different series of hematology analyzer in a Chinese large scale hospital. Chin Med J (Engl) (2010) 1.45

Genome-wide discovery and characterization of maize long non-coding RNAs. Genome Biol (2014) 1.45

Plaque volume compression ratio, a novel biomechanical index, is independently associated with ischemic cerebrovascular events. J Hypertens (2009) 1.41

MiR-223 suppresses cell proliferation by targeting IGF-1R. PLoS One (2011) 1.41

Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. PLoS One (2008) 1.41

Parkinson's disease associated with myasthenia gravis and rheumatoid arthritis. Neurol Sci (2014) 1.41

The negative prognostic impact of derivative 9 deletions in patients who received hydroxyurea treatment for chronic myelogenous leukemia in the chronic phase. Onkologie (2008) 1.39

Improvements of cardiac electrophysiologic stability and ventricular fibrillation threshold in rats with myocardial infarction treated with cardiac stem cells. Crit Care Med (2011) 1.39

Association between occult hepatitis B infection and the risk of hepatocellular carcinoma: a meta-analysis. Liver Int (2011) 1.39

Solitary large hepatocellular carcinoma: a specific subtype of hepatocellular carcinoma with good outcome after hepatic resection. Ann Surg (2009) 1.37

Rapid, repeated, and clustered loss of duplicate genes in allopolyploid plant populations of independent origin. Curr Biol (2012) 1.37

miR-133b regulates the MET proto-oncogene and inhibits the growth of colorectal cancer cells in vitro and in vivo. Cancer Biol Ther (2010) 1.37

Characterization of duplicate gene evolution in the recent natural allopolyploid Tragopogon miscellus by next-generation sequencing and Sequenom iPLEX MassARRAY genotyping. Mol Ecol (2010) 1.37

GTP-independent rapid and slow endocytosis at a central synapse. Nat Neurosci (2007) 1.36

MiR-27 as a prognostic marker for breast cancer progression and patient survival. PLoS One (2012) 1.35

Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection. Immunology (2007) 1.35

Undertreatment of cardiovascular risk factors among persons with diabetes in the United States. Diabetes Res Clin Pract (2006) 1.31

Repeat subtraction-mediated sequence capture from a complex genome. Plant J (2010) 1.31

Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression. Arterioscler Thromb Vasc Biol (2009) 1.30

Molecular evidence for natural hybridization in the mangrove fern genus Acrostichum. BMC Plant Biol (2013) 1.29

Hybrid nanoimprint-soft lithography with sub-15 nm resolution. Nano Lett (2009) 1.28

Frequency recognition based on canonical correlation analysis for SSVEP-based BCIs. IEEE Trans Biomed Eng (2007) 1.27

[Isolation, identification and characterization of SFTS bunyavirus from ticks collected on the surface of domestic animals]. Bing Du Xue Bao (2012) 1.26

Genic and nongenic contributions to natural variation of quantitative traits in maize. Genome Res (2012) 1.26

Double functionalization of carbon nanotubes for multimodal drug delivery. Chem Commun (Camb) (2006) 1.25

Ultrasmooth silver thin films deposited with a germanium nucleation layer. Nano Lett (2009) 1.25

The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA. Mol Biol Cell (2005) 1.25

Financial Conflicts of Interest Checklist 2010 for clinical research studies. Open Med (2010) 1.19

Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation. Sci Transl Med (2012) 1.19

Light-induced reversible formation of polymeric micelles. Angew Chem Int Ed Engl (2007) 1.19

miR-150 promotes human breast cancer growth and malignant behavior by targeting the pro-apoptotic purinergic P2X7 receptor. PLoS One (2013) 1.18

Heterodyne detected nonlinear optical imaging in a lock-in free manner. J Biophotonics (2012) 1.18

XMVB: a program for ab initio nonorthogonal valence bond computations. J Comput Chem (2005) 1.18

Gaucher disease: alendronate disodium improves bone mineral density in adults receiving enzyme therapy. Blood (2004) 1.17

Enhanced bioavailability of the poorly water-soluble drug fenofibrate by using liposomes containing a bile salt. Int J Pharm (2009) 1.16

Logos: a modular bayesian model for de novo motif detection. J Bioinform Comput Biol (2004) 1.16

Functional and morphological changes of the gut barrier during the restitution process after hemorrhagic shock. World J Gastroenterol (2005) 1.16

Room-temperature ferroelectricity in supramolecular networks of charge-transfer complexes. Nature (2012) 1.16