Published in Dev Cell on October 01, 2004
Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A (2011) 4.52
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature (2012) 3.44
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc Natl Acad Sci U S A (2007) 3.24
The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol (2012) 3.16
A Wnt survival guide: from flies to human disease. J Invest Dermatol (2009) 2.91
LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling. EMBO Rep (2011) 2.77
Coat variation in the domestic dog is governed by variants in three genes. Science (2009) 2.70
R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell (2008) 2.37
Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers. Gastroenterology (2011) 2.33
Wnt signal transduction pathways. Organogenesis (2008) 2.14
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The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength. Genes Dev (2014) 1.68
Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins. EMBO J (2012) 1.63
R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/beta-catenin pathway. Proc Natl Acad Sci U S A (2009) 1.63
The R-spondin protein family. Genome Biol (2012) 1.62
Lrp4 modulates extracellular integration of cell signaling pathways in development. PLoS One (2008) 1.60
Molecular regulation of kidney development: is the answer blowing in the Wnt? Pediatr Nephrol (2007) 1.52
A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype. PLoS One (2013) 1.51
Man's best friend becomes biology's best in show: genome analyses in the domestic dog. Annu Rev Genet (2010) 1.51
LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling. Mol Cell Biol (2012) 1.48
R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5. PLoS One (2012) 1.44
The way Wnt works: components and mechanism. Growth Factors (2012) 1.37
Wnt signaling and injury repair. Cold Spring Harb Perspect Biol (2012) 1.30
Mutations in the gene encoding the Wnt-signaling component R-spondin 4 (RSPO4) cause autosomal recessive anonychia. Am J Hum Genet (2006) 1.30
Cellular signaling and biological functions of R-spondins. Cell Signal (2011) 1.25
Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian development. BMC Dev Biol (2008) 1.24
Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb. Dev Biol (2007) 1.23
LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. PLoS One (2012) 1.22
Wnt signaling, stem cells, and cancer of the gastrointestinal tract. Cold Spring Harb Perspect Biol (2012) 1.19
Wnt4 inhibits beta-catenin/TCF signalling by redirecting beta-catenin to the cell membrane. Biol Cell (2008) 1.17
A WNT/beta-catenin signaling activator, R-spondin, plays positive regulatory roles during skeletal myogenesis. J Biol Chem (2011) 1.16
Structural basis for R-spondin recognition by LGR4/5/6 receptors. Genes Dev (2013) 1.13
Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy. Nat Biotechnol (2015) 1.13
The structural basis of R-spondin recognition by LGR5 and RNF43. Genes Dev (2013) 1.11
Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3. Development (2011) 1.11
The R-spondin family of proteins: emerging regulators of WNT signaling. Int J Biochem Cell Biol (2012) 1.09
To beta or not to beta: canonical beta-catenin signaling pathway and ovarian development. Dev Dyn (2008) 1.09
Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish. FASEB J (2008) 1.07
RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary. PLoS One (2011) 1.02
Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. Nat Commun (2013) 1.01
Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J Biol Chem (2009) 1.01
Genomic insights into WNT/β-catenin signaling. Trends Pharmacol Sci (2013) 1.00
The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction. Dev Biol (2011) 1.00
Human RSPO1/R-spondin1 is expressed during early ovary development and augments β-catenin signaling. PLoS One (2011) 0.99
Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells. Biochemistry (2010) 0.98
New methods for finding common insertion sites and co-occurring common insertion sites in transposon- and virus-based genetic screens. Nucleic Acids Res (2012) 0.98
Crystal structures of Lgr4 and its complex with R-spondin1. Structure (2013) 0.97
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis (2016) 0.97
AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration. Biochem Pharmacol (2008) 0.96
R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation. BMC Dev Biol (2008) 0.95
Wnt signaling in cancer. Oncogene (2016) 0.95
Wnt and the Wnt signaling pathway in bone development and disease. Front Biosci (Landmark Ed) (2014) 0.94
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin. EMBO Rep (2013) 0.93
Runx2 promotes both osteoblastogenesis and novel osteoclastogenic signals in ST2 mesenchymal progenitor cells. Osteoporos Int (2011) 0.92
Human SRY inhibits beta-catenin-mediated transcription. Int J Biochem Cell Biol (2008) 0.92
The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies. Lab Invest (2015) 0.91
Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation. Mol Cell Biol (2011) 0.91
Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function. Cell Signal (2009) 0.90
Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target. Future Oncol (2009) 0.87
Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells. PLoS One (2012) 0.86
The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells. PLoS One (2013) 0.85
R-spondins are involved in the ovarian differentiation in a teleost, medaka (Oryzias latipes). BMC Dev Biol (2012) 0.84
Secreted factor R-Spondin 2 is involved in refinement of patterning of the mammalian cochlea. Dev Dyn (2013) 0.84
Keeping Wnt signalosome in check by vesicular traffic. J Cell Physiol (2015) 0.84
Wnt signaling: the good and the bad. Acta Biochim Biophys Sin (Shanghai) (2008) 0.84
Fusion genes in solid tumors: an emerging target for cancer diagnosis and treatment. Chin J Cancer (2013) 0.84
Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli. Biochemistry (2013) 0.84
Position-dependent plasticity of distinct progenitor types in the primitive streak. Elife (2016) 0.83
Spondin-2 (SPON2), a more prostate-cancer-specific diagnostic biomarker. PLoS One (2012) 0.83
LGR4 and Its Role in Intestinal Protection and Energy Metabolism. Front Endocrinol (Lausanne) (2015) 0.83
A finger on the pulse of Wnt receptor signaling. Cell Res (2012) 0.83
Novel missense mutation in the RSPO4 gene in congenital hyponychia and evidence for a polymorphic initiation codon (p.M1I). BMC Med Genet (2012) 0.83
Loss of SFRP1 promotes ductal branching in the murine mammary gland. BMC Dev Biol (2012) 0.83
Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis. Mol Cell Biol (2013) 0.82
Structure and function of LGR5: an enigmatic G-protein coupled receptor marking stem cells. Protein Sci (2014) 0.82
Novel insights into Notum and glypicans regulation in colorectal cancer. Oncotarget (2015) 0.82
Planar cell polarity signaling in craniofacial development. Organogenesis (2011) 0.82
Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3. J Struct Biol (2015) 0.82
Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development (2014) 0.81
β-catenin/Tcf-signaling appears to establish the murine ovarian surface epithelium (OSE) and remains active in selected postnatal OSE cells. BMC Dev Biol (2012) 0.81
Distinct transcriptional networks in quiescent myoblasts: a role for Wnt signaling in reversible vs. irreversible arrest. PLoS One (2013) 0.81
Primary small cell carcinoma of the esophagus: clinicopathological study of 44 cases. BMC Cancer (2014) 0.80
Engineering high-potency R-spondin adult stem cell growth factors. Mol Pharmacol (2014) 0.79
Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/B-catenin signaling activator R-spondin 2. PLoS One (2013) 0.79
Prognostic significance of RSPO1, WNT1, P16, WT1, and SDC1 expressions in invasive ductal carcinoma of the breast. World J Surg Oncol (2013) 0.79
Inhibitory effects of cigarette smoke extract on neural crest migration occur through suppression of R-spondin1 expression via aryl hydrocarbon receptor. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.78
R-spondin 3 regulates dorsoventral and anteroposterior patterning by antagonizing Wnt/β-catenin signaling in zebrafish embryos. PLoS One (2014) 0.78
Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells. Mol Biol Cell (2016) 0.78
Wnt pathway regulation of intestinal stem cells. J Physiol (2016) 0.78
Identification, visualization and clonal analysis of intestinal stem cells in fish. Development (2016) 0.77
Crystal structure of LGR4-Rspo1 complex: insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs). J Biol Chem (2014) 0.77
Identification and Functional Characterization of RSPO2 as a Susceptibility Gene for Ossification of the Posterior Longitudinal Ligament of the Spine. Am J Hum Genet (2016) 0.77
CD34+ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury. Proc Natl Acad Sci U S A (2017) 0.76
R-spondin2 activates hepatic stellate cells and promotes liver fibrosis. Dig Dis Sci (2014) 0.76
Computational biophysical, biochemical, and evolutionary signature of human R-spondin family proteins, the member of canonical Wnt/β-catenin signaling pathway. Biomed Res Int (2014) 0.76
Microarray-assisted fine mapping of quantitative trait loci on chromosome 15 for susceptibility to seizure-induced cell death in mice. Eur J Neurosci (2013) 0.76
N-Glycosylation of Human R-Spondin 1 Is Required for Efficient Secretion and Stability but Not for Its Heparin Binding Ability. Int J Mol Sci (2016) 0.76
R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5. Sci Rep (2016) 0.75
Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med (2011) 13.18
Assemblathon 1: a competitive assessment of de novo short read assembly methods. Genome Res (2011) 8.38
Predicting overweight and obesity in adulthood from body mass index values in childhood and adolescence. Am J Clin Nutr (2002) 6.19
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature (2002) 5.61
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature (2007) 5.54
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science (2007) 5.45
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature (2005) 4.88
Maize inbreds exhibit high levels of copy number variation (CNV) and presence/absence variation (PAV) in genome content. PLoS Genet (2009) 3.88
The Forkhead transcription factor Hcm1 regulates chromosome segregation genes and fills the S-phase gap in the transcriptional circuitry of the cell cycle. Genes Dev (2006) 3.58
Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop of resource-poor farmers. Nat Biotechnol (2011) 3.51
Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res (2006) 3.44
Control and characterization of individual grains and grain boundaries in graphene grown by chemical vapour deposition. Nat Mater (2011) 3.23
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science (2010) 3.04
Fibroblast growth factor signaling during early vertebrate development. Endocr Rev (2005) 2.99
Treatment of pressure ulcers: a systematic review. JAMA (2008) 2.96
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet (2011) 2.85
LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling. EMBO Rep (2011) 2.77
Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris. Genome Res (2005) 2.65
Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nat Nanotechnol (2007) 2.57
Cell cycle control of wnt receptor activation. Dev Cell (2009) 2.52
A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains. Cell (2007) 2.50
The effect of computerized physician order entry with clinical decision support on the rates of adverse drug events: a systematic review. J Gen Intern Med (2008) 2.46
Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev (2005) 2.44
From neural development to cognition: unexpected roles for chromatin. Nat Rev Genet (2013) 2.42
TOS9 regulates white-opaque switching in Candida albicans. Eukaryot Cell (2006) 2.42
Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell (2006) 2.40
Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol (2010) 2.37
NONCODEv4: exploring the world of long non-coding RNA genes. Nucleic Acids Res (2013) 2.37
Memristor-CMOS hybrid integrated circuits for reconfigurable logic. Nano Lett (2009) 2.35
RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling. Science (2013) 2.27
Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers. J Pathol (2011) 2.27
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26
Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells. Nano Lett (2006) 2.24
MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling. Hum Mol Genet (2004) 2.10
Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy. Diabetes (2011) 2.03
Levels of prenatal mercury exposure and their relationships to neonatal anthropometry in Wujiang City, China. Environ Pollut (2013) 2.01
Secreted and transmembrane wnt inhibitors and activators. Cold Spring Harb Perspect Biol (2013) 2.01
Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. Gene (2003) 1.99
The nature of the fourth bond in the ground state of C2: the quadruple bond conundrum. Chemistry (2014) 1.97
Gibberellin mobilizes distinct DELLA-dependent transcriptomes to regulate seed germination and floral development in Arabidopsis. Plant Physiol (2006) 1.91
Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Nat Biotechnol (2011) 1.91
Oral drug therapy for multiple neglected tropical diseases: a systematic review. JAMA (2007) 1.88
Expression of lymphocytes and lymphocyte subsets in patients with severe acute respiratory syndrome. Clin Infect Dis (2003) 1.84
Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis. Dev Cell (2011) 1.83
Systematic review of HIV transmission between heterosexual serodiscordant couples where the HIV-positive partner is fully suppressed on antiretroviral therapy. PLoS One (2013) 1.79
MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A (2011) 1.77
Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer. J Biol Chem (2011) 1.73
Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model. Proc Natl Acad Sci U S A (2012) 1.71
Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis. Clin Dev Immunol (2012) 1.70
Nuclear reprogramming of human somatic cells by xenopus egg extract requires BRG1. Curr Biol (2004) 1.70
Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways. Am J Respir Crit Care Med (2014) 1.69
A new look at state-space models for neural data. J Comput Neurosci (2009) 1.69
Dscam2 mediates axonal tiling in the Drosophila visual system. Nature (2007) 1.66
DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. Hum Mol Genet (2007) 1.65
Quadruple bonding in C2 and analogous eight-valence electron species. Nat Chem (2012) 1.62
Characterization of a sub-family of Arabidopsis genes with the SPX domain reveals their diverse functions in plant tolerance to phosphorus starvation. Plant J (2008) 1.60
Transcriptional regulation of BMP4 synexpression in transgenic Xenopus. EMBO J (2004) 1.60
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development (2008) 1.59
PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients. Mol Immunol (2007) 1.58
Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues. J Exp Clin Cancer Res (2012) 1.55
Vapor-phase self-assembled monolayer for improved mold release in nanoimprint lithography. Langmuir (2005) 1.55
Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline. Cell Stem Cell (2013) 1.53
The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling. Nat Cell Biol (2003) 1.53
An efficient algorithm for energy gradients and orbital optimization in valence bond theory. J Comput Chem (2009) 1.52
Circuit fabrication at 17 nm half-pitch by nanoimprint lithography. Nano Lett (2006) 1.51
Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. Nat Genet (2012) 1.49
The Min oscillator uses MinD-dependent conformational changes in MinE to spatially regulate cytokinesis. Cell (2011) 1.49
Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol (2013) 1.49
A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms. Cell (2008) 1.48
Surgical safety checklist: implementation in an ambulatory surgical facility. Can J Anaesth (2013) 1.48
Safety and viability of microencapsulated human islets transplanted into diabetic humans. Diabetes Care (2009) 1.48
Levels of vasoactive intestinal peptide, cholecystokinin and calcitonin gene-related peptide in plasma and jejunum of rats following traumatic brain injury and underlying significance in gastrointestinal dysfunction. World J Gastroenterol (2004) 1.48
Allicin, a major component of garlic, inhibits apoptosis in vital organs in rats with trauma/hemorrhagic shock. Crit Care Med (2008) 1.47
Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int (2005) 1.47
Sarcophaga (Hoa)flexuosa Ho (Diptera: Sarcophagidae): association of sexes using morphological and molecular approaches, and a redefinition of Hoa Rohdendorf. Zootaxa (2013) 1.46
Development of the personalized criteria for microscopic review following four different series of hematology analyzer in a Chinese large scale hospital. Chin Med J (Engl) (2010) 1.45
Genome-wide discovery and characterization of maize long non-coding RNAs. Genome Biol (2014) 1.45
MicroRNA-based therapeutics for cancer. BioDrugs (2009) 1.45
MiR-223 suppresses cell proliferation by targeting IGF-1R. PLoS One (2011) 1.41
Plaque volume compression ratio, a novel biomechanical index, is independently associated with ischemic cerebrovascular events. J Hypertens (2009) 1.41
Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol (2008) 1.41
Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. PLoS One (2008) 1.41
Parkinson's disease associated with myasthenia gravis and rheumatoid arthritis. Neurol Sci (2014) 1.41
The negative prognostic impact of derivative 9 deletions in patients who received hydroxyurea treatment for chronic myelogenous leukemia in the chronic phase. Onkologie (2008) 1.39
Improvements of cardiac electrophysiologic stability and ventricular fibrillation threshold in rats with myocardial infarction treated with cardiac stem cells. Crit Care Med (2011) 1.39
Association between occult hepatitis B infection and the risk of hepatocellular carcinoma: a meta-analysis. Liver Int (2011) 1.39
Solitary large hepatocellular carcinoma: a specific subtype of hepatocellular carcinoma with good outcome after hepatic resection. Ann Surg (2009) 1.37
Rapid, repeated, and clustered loss of duplicate genes in allopolyploid plant populations of independent origin. Curr Biol (2012) 1.37
miR-133b regulates the MET proto-oncogene and inhibits the growth of colorectal cancer cells in vitro and in vivo. Cancer Biol Ther (2010) 1.37
Characterization of duplicate gene evolution in the recent natural allopolyploid Tragopogon miscellus by next-generation sequencing and Sequenom iPLEX MassARRAY genotyping. Mol Ecol (2010) 1.37