Published in Science on January 12, 2007
On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum Mol Genet (2008) 3.24
The genetic contribution to non-syndromic human obesity. Nat Rev Genet (2009) 2.70
Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS One (2008) 2.67
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35
The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Obesity (Silver Spring) (2009) 2.34
Association of the FTO gene with BMI. Obesity (Silver Spring) (2008) 1.79
From monogenic to polygenic obesity: recent advances. Eur Child Adolesc Psychiatry (2010) 1.49
Multilocus lod scores in large pedigrees: combination of exact and approximate calculations. Hum Hered (2007) 1.46
Recent progress in the genetics of common obesity. Br J Clin Pharmacol (2009) 1.40
Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program. Diabetologia (2008) 1.27
Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort. Diabetes (2008) 1.26
The genetics of human obesity. Ann N Y Acad Sci (2013) 1.22
Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry. Obesity (Silver Spring) (2009) 1.19
Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet (2009) 1.18
Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes. PLoS One (2008) 1.17
Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing. Pharmacogenomics (2007) 1.12
Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity. Diabetes (2009) 1.11
Genomics and genome-wide association studies: an integrative approach to expression QTL mapping. Genomics (2008) 1.04
The imprinted gene neuronatin is regulated by metabolic status and associated with obesity. Obesity (Silver Spring) (2009) 1.02
Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample. BMC Med Genet (2007) 0.98
The challenges for molecular nutrition research 1: linking genotype to healthy nutrition. Genes Nutr (2008) 0.96
Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children. BMC Med Genet (2013) 0.96
Contribution of common genetic variants to obesity and obesity-related traits in mexican children and adults. PLoS One (2013) 0.96
Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS). BMC Med Genet (2010) 0.96
INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men. BMC Med Genet (2008) 0.94
Functional genomic architecture of predisposition to voluntary exercise in mice: expression QTL in the brain. Genetics (2012) 0.93
INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study. Obesity (Silver Spring) (2009) 0.89
The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts. BMC Med Genet (2009) 0.87
Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry. BMC Med Genet (2009) 0.86
Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age. Metabolism (2009) 0.84
A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans. BMC Med Genet (2009) 0.83
Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R. Eur J Hum Genet (2014) 0.82
Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations. BMC Med Genet (2009) 0.80
The Genetics of Pediatric Obesity. Trends Endocrinol Metab (2015) 0.78
Quantitative genomics of voluntary exercise in mice: transcriptional analysis and mapping of expression QTL in muscle. Physiol Genomics (2014) 0.77
Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity. Hum Genet (2015) 0.77
Genetic association study with metabolic syndrome and metabolic-related traits in a cross-sectional sample and a 10-year longitudinal sample of chinese elderly population. PLoS One (2014) 0.77
Obesity: interactions of genome and nutrients intake. Prev Nutr Food Sci (2015) 0.77
Ethnicity, body mass, and genome-wide data. Biodemography Soc Biol (2010) 0.77
Association of INSIG2 polymorphism with overweight and LDL in children. PLoS One (2015) 0.76
INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months. Clin Med Pediatr (2009) 0.75
The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. BMC Cancer (2010) 0.75
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med (2008) 38.76
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (2003) 9.79
Severe hypoglycemia and risks of vascular events and death. N Engl J Med (2010) 8.54
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet (2009) 6.39
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity. Nat Genet (2007) 5.93
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med (2007) 5.89
Use of HbA1c in predicting progression to diabetes in French men and women: data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Diabetes Care (2006) 5.56
Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet (2008) 5.55
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet (2008) 5.49
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet (2009) 5.43
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA (2009) 5.32
Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. N Engl J Med (2006) 4.88
Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem (2002) 4.79
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet (2005) 4.44
Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes. J Am Soc Nephrol (2009) 4.43
A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science (2008) 4.38
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem (2002) 4.16
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem (2003) 4.08
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases. Hum Mol Genet (2007) 4.07
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women. Arch Intern Med (2004) 3.68
Downward trends in the prevalence of childhood overweight in the setting of 12-year school- and community-based programmes. Public Health Nutr (2008) 3.53
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet (2011) 3.46
Intensive glucose control improves kidney outcomes in patients with type 2 diabetes. Kidney Int (2013) 3.42
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature (2012) 3.41
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. Am J Hum Genet (2007) 3.31
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum Mol Genet (2008) 3.24
Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet (2008) 3.24