Published in Cancer Gene Ther on April 10, 2009
Absence of systemic immune response to adenovectors after intraocular administration to children with retinoblastoma. Mol Ther (2010) 1.23
A phase I clinical trial of Ad5.SSTR/TK.RGD, a novel infectivity-enhanced bicistronic adenovirus, in patients with recurrent gynecologic cancer. Clin Cancer Res (2012) 1.04
Oncolytic viruses: From bench to bedside with a focus on safety. Hum Vaccin Immunother (2015) 1.01
Improving the safety of cell therapy with the TK-suicide gene. Front Pharmacol (2015) 0.96
Improving the safety of cell therapy products by suicide gene transfer. Front Pharmacol (2014) 0.94
Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity. Cancer Gene Ther (2014) 0.90
Gene therapy for ocular diseases. Br J Ophthalmol (2010) 0.90
Suicide Gene Therapy for Cancer - Current Strategies. J Genet Syndr Gene Ther (2013) 0.87
Hypoxia/hepatoma dual specific suicide gene expression plasmid delivery using bio-reducible polymer for hepatocellular carcinoma therapy. J Control Release (2013) 0.83
Progress and problems with the use of suicide genes for targeted cancer therapy. Adv Drug Deliv Rev (2015) 0.81
Drug discovery in advanced prostate cancer: translating biology into therapy. Nat Rev Drug Discov (2016) 0.78
Adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of recurrent high-grade glioma. Oncotarget (2016) 0.78
Republished review: Gene therapy for ocular diseases. Postgrad Med J (2011) 0.77
Gene-directed enzyme prodrug therapy. AAPS J (2014) 0.77
A double suicide gene system driven by vascular endothelial growth factor promoter selectively kills human hepatocellular carcinoma cells. Oncol Lett (2016) 0.75
New Variants of Tomato Thymidine Kinase 1 Selected for Increased Sensitivity of E. coli KY895 towards Azidothymidine. Cancers (Basel) (2015) 0.75
Safety and efficacy of suicide gene therapy with adenosine deaminase 5-fluorocytosine silmutaneously in in vitro cultures of melanoma and retinal cell lines. J Cancer (2014) 0.75
Serial analysis of gene expression. Science (1995) 60.15
Electric field effect in atomically thin carbon films. Science (2004) 45.10
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (1999) 36.25
Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature (1999) 16.97
Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med (1999) 14.30
IntAct--open source resource for molecular interaction data. Nucleic Acids Res (2006) 13.82
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science (2000) 13.62
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol (2000) 11.62
Characterization of the yeast transcriptome. Cell (1997) 11.33
Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med (2000) 11.12
Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell (2000) 11.09
The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med (1996) 10.62
Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol (2001) 10.20
Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus. Nat Med (1996) 8.94
A public database for gene expression in human cancers. Cancer Res (1999) 8.81
Smoking in China: findings of the 1996 National Prevalence Survey. JAMA (1999) 8.67
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell (2001) 8.60
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med (1995) 8.51
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest (1999) 8.38
Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med (1995) 8.23
Mammalian sweet taste receptors. Cell (2001) 8.04
PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95
Disruption of IRS-2 causes type 2 diabetes in mice. Nature (1998) 7.94
The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health (1994) 7.38
Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong. Virology (1999) 7.32
A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer. N Engl J Med (1994) 7.25
14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell (1997) 7.20
HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci U S A (1997) 6.92
Rapid modification of bacterial artificial chromosomes by ET-recombination. Nucleic Acids Res (1999) 6.85
Significant acidification in major Chinese croplands. Science (2010) 6.68
Assembly and analysis of conical models for the HIV-1 core. Science (1999) 6.35
TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. Biochem Biophys Res Commun (1999) 6.33
Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med (1999) 6.27
Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet (2001) 6.23
Analysis of human transcriptomes. Nat Genet (1999) 6.14
Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest (1999) 6.13
Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J (1998) 5.96
The evolution of H5N1 influenza viruses in ducks in southern China. Proc Natl Acad Sci U S A (2004) 5.87
An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum (1998) 5.72
MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet (1999) 5.61
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell (1998) 5.52
Smads: transcriptional activators of TGF-beta responses. Cell (1998) 5.33
Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science (2001) 5.25
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity (1997) 5.23
E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res (1995) 5.11
Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation (2000) 5.09
Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med (1992) 5.05
Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol Cell (2001) 5.04
Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit. Mol Cell Biol (1998) 5.01
Ligand binding to integrins. J Biol Chem (2000) 4.94
Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology. Proc Natl Acad Sci U S A (2000) 4.79
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science (1996) 4.59
Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. J Am Chem Soc (2001) 4.46
Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly. EMBO J (1998) 4.46
VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest (2000) 4.36
Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet (1999) 4.36
Myogenin gene disruption results in perinatal lethality because of severe muscle defect. Nature (1993) 4.33
Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci U S A (1997) 4.29
Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurement. J Clin Virol (2004) 4.28
PCR amplification and restriction endonuclease analysis of a 65-kilodalton heat shock protein gene sequence for taxonomic separation of rapidly growing mycobacteria. J Clin Microbiol (1995) 4.27
Orientation selectivity and the arrangement of horizontal connections in tree shrew striate cortex. J Neurosci (1997) 4.26
Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem (2001) 4.23
Delay or probability discounting in a model of impulsive behavior: effect of alcohol. J Exp Anal Behav (1999) 4.23
Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3. EMBO J (2001) 4.23
Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res (2001) 4.22
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med (2001) 4.22
A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab Invest (1992) 4.21
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci U S A (1994) 4.21
Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue. J Virol (1998) 4.17
Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs. Science (2013) 4.17
Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet (2000) 4.17
Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem (1997) 4.12
The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nat Med (2000) 4.08
Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum (1997) 4.08
Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria. Science (1997) 4.07
The effect of postmenopausal estrogen therapy on bone density in elderly women. N Engl J Med (1993) 4.04
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature (1999) 3.99
From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor. Proc Natl Acad Sci U S A (1998) 3.99
Multiattribute utility function for a comprehensive health status classification system. Health Utilities Index Mark 2. Med Care (1996) 3.96
The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum (1995) 3.93
A quantum dot single-photon turnstile device. Science (2000) 3.89
Visual acuity and quality of life in patients with cataract in Doumen County, China. Ophthalmology (1999) 3.82
Molecular dynamics simulations of a lipid bilayer and of hexadecane: an investigation of membrane fluidity. Science (1993) 3.81
DNA supercoiling promotes formation of a bent repression loop in lac DNA. J Mol Biol (1987) 3.81
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. J Biol Chem (1997) 3.80
High-level semi-synthetic production of the potent antimalarial artemisinin. Nature (2013) 3.80
Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis. Antimicrob Agents Chemother (1997) 3.75
Characterization of a virtually full-length human immunodeficiency virus type 1 genome of a prevalent intersubtype (C/B') recombinant strain in China. J Virol (2000) 3.70
The genome reconstruction manager: a software environment for supporting high-throughput DNA sequencing. Genomics (1994) 3.69
Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J Am Chem Soc (1997) 3.69
Cognitive impairment in hemodialysis patients is common. Neurology (2006) 3.68
Extent and distribution of linkage disequilibrium in three genomic regions. Am J Hum Genet (2000) 3.68
Translocation (8;21) in oligoblastic leukemia: is this a true myelodysplastic syndrome? Leuk Res (1994) 3.66
DNA large restriction fragment patterns of sporadic and epidemic nosocomial strains of Mycobacterium chelonae and Mycobacterium abscessus. J Clin Microbiol (1993) 3.65