Published in N Engl J Med on March 02, 2010
Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med (2010) 6.19
The potential of biologics for the treatment of asthma. Nat Rev Drug Discov (2012) 1.11
Biologics in asthma--the next step toward personalized treatment. J Allergy Clin Immunol Pract (2015) 0.88
Predictors of asthma control and lung function responsiveness to step 3 therapy in children with uncontrolled asthma. J Allergy Clin Immunol (2013) 0.86
Prescribing patterns of asthma controller therapy for children in UK primary care: a cross-sectional observational study. BMC Pulm Med (2010) 0.85
Severe asthma in children. J Allergy Clin Immunol Pract (2014) 0.80
Step-up therapy for children with uncontrolled asthma. N Engl J Med (2010) 0.76
A systematic review with attempted network meta-analysis of asthma therapy recommended for five to eighteen year olds in GINA steps three and four. BMC Pulm Med (2012) 0.75
Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med (2010) 6.51
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. N Engl J Med (2004) 14.78
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. JAMA (2004) 14.17
Statistics in medicine--reporting of subgroup analyses in clinical trials. N Engl J Med (2007) 12.55
Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med (2002) 9.14
Letting the genome out of the bottle--will we get our wish? N Engl J Med (2008) 9.10
The asthma epidemic. N Engl J Med (2006) 8.60
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. CMAJ (2004) 8.52
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Lancet (2004) 7.18
Exposure to environmental microorganisms and childhood asthma. N Engl J Med (2011) 6.38
Data Sharing. N Engl J Med (2016) 5.12
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Ann Intern Med (2004) 5.06
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
Financial associations of authors. N Engl J Med (2002) 4.85
Expression of concern: Bombardier et al., "Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis," N Engl J Med 2000;343:1520-8. N Engl J Med (2005) 4.48
Variants of DENND1B associated with asthma in children. N Engl J Med (2009) 4.18
Clinical trial registration--looking back and moving ahead. N Engl J Med (2007) 4.07
Sharing Clinical Trial Data: A Proposal From the International Committee of Medical Journal Editors. Ann Intern Med (2016) 3.95
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science (2002) 3.91
Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol (2002) 3.66
Registry research and medical privacy. N Engl J Med (2004) 3.49
Is this clinical trial fully registered?--A statement from the International Committee of Medical Journal Editors. N Engl J Med (2005) 3.44
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2002. A 28-year-old woman with ocular inflammation, fever, and headache. N Engl J Med (2002) 3.31
Physicians and execution. N Engl J Med (2008) 3.30
SARS, the Internet, and the Journal. N Engl J Med (2003) 3.16
Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol (2010) 3.12
Sharing Clinical Trial Data--A Proposal from the International Committee of Medical Journal Editors. N Engl J Med (2016) 3.06
Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Nat Med (2002) 2.94
Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet (2006) 2.81
The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol Rev (2006) 2.80
A sad day for science at the FDA. N Engl J Med (2005) 2.77
Prescriptions, privacy, and the First Amendment. N Engl J Med (2011) 2.75
Data Sharing and the Journal. N Engl J Med (2016) 2.74
Inappropriate advertising of dietary supplements. N Engl J Med (2003) 2.73
A patient with asthma seeks medical advice in 1828, 1928, and 2012. N Engl J Med (2012) 2.72
Controlling research trials. N Engl J Med (2003) 2.70
A pivotal medical-device case. N Engl J Med (2008) 2.69
The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol (2004) 2.69
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med (2004) 2.62
The FDA, politics, and plan B. N Engl J Med (2004) 2.53
Mechanotransduction through growth-factor shedding into the extracellular space. Nature (2004) 2.48
Uniform format for disclosure of competing interests in ICMJE journals. N Engl J Med (2009) 2.46
Is eczema really on the increase worldwide? J Allergy Clin Immunol (2007) 2.46
Allergic disease and sensitization in Steiner school children. J Allergy Clin Immunol (2005) 2.44
Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med (2003) 2.39
Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. PLoS Genet (2008) 2.29
Early identification of atopy in the prediction of persistent asthma in children. Lancet (2008) 2.27
Sharing clinical trial data: a proposal from the International Committee of Medical Journal Editors. Lancet (2016) 2.25
Systemic effect comparisons of six inhaled corticosteroid preparations. Am J Respir Crit Care Med (2002) 2.24
Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet (2002) 2.23
Atopic sensitization and the international variation of asthma symptom prevalence in children. Am J Respir Crit Care Med (2007) 2.21
Believe the data. N Engl J Med (2012) 2.20
Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet (2003) 2.16
Awake and informed. N Engl J Med (2004) 2.16
Filaggrin mutations, atopic eczema, hay fever, and asthma in children. J Allergy Clin Immunol (2008) 2.16
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. Lancet (2005) 2.15
Public access to biomedical research. N Engl J Med (2004) 2.12
Toll-like receptor 2 as a major gene for asthma in children of European farmers. J Allergy Clin Immunol (2004) 2.10
Sharing individual patient data from clinical trials. N Engl J Med (2015) 2.09
Legislative myopia on stem cells. N Engl J Med (2003) 2.03
COX-2 inhibitors--a lesson in unexpected problems. N Engl J Med (2005) 2.01
Expression of concern reaffirmed. N Engl J Med (2006) 1.97
Clinical trial registration. BMJ (2007) 1.95
The many faces of the hygiene hypothesis. J Allergy Clin Immunol (2006) 1.94
Trial registration report card. N Engl J Med (2005) 1.89
Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. J Allergy Clin Immunol (2009) 1.89
Risks of long-acting beta-agonists in achieving asthma control. N Engl J Med (2009) 1.89
Clinical trial registration: looking back and moving ahead. Croat Med J (2007) 1.89
G-Protein-coupled receptor polymorphisms are associated with asthma in a large German population. Am J Respir Crit Care Med (2005) 1.88
Endothelial nitric oxide synthase variants in cystic fibrosis lung disease. Am J Respir Crit Care Med (2002) 1.87
Clinical and epidemiologic phenotypes of childhood asthma. Am J Respir Crit Care Med (2014) 1.87
Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children. J Allergy Clin Immunol (2006) 1.84
Contact with farm animals in early life and juvenile inflammatory bowel disease: a case-control study. Pediatrics (2007) 1.82
IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma. J Allergy Clin Immunol (2006) 1.82
The Medical Device Safety Act of 2009. N Engl J Med (2009) 1.81
Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner. Am J Respir Cell Mol Biol (2005) 1.79
Revisiting the commercial-academic interface. N Engl J Med (2015) 1.79
Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78. J Exp Med (2009) 1.79
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. CMAJ (2005) 1.78
Impairment of T-regulatory cells in cord blood of atopic mothers. J Allergy Clin Immunol (2008) 1.76
Exhaled nitric oxide as a diagnostic test for asthma: online versus offline techniques and effect of flow rate. Am J Respir Crit Care Med (2002) 1.76
Modeling annual benzene, toluene, NO2, and soot concentrations on the basis of road traffic characteristics. Environ Res (2002) 1.72
Clinical trial registration: looking back and moving ahead. Ann Intern Med (2007) 1.71
Cord blood allergen-specific IgE is associated with reduced IFN-gamma production by cord blood cells: the Protection against Allergy-Study in Rural Environments (PASTURE) Study. J Allergy Clin Immunol (2008) 1.68
NOD1 variation, immunoglobulin E and asthma. Hum Mol Genet (2005) 1.66
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. JAMA (2005) 1.65
Salvation by registration. N Engl J Med (2007) 1.63
Don't mess with the DSMB. N Engl J Med (2010) 1.60
Informed consent and SUPPORT. N Engl J Med (2013) 1.59
Toward more uniform conflict disclosures--the updated ICMJE conflict of interest reporting form. N Engl J Med (2010) 1.52
Decisions at the end of life. N Engl J Med (2003) 1.51
Opposite effects of CD 14/-260 on serum IgE levels in children raised in different environments. J Allergy Clin Immunol (2005) 1.43
Physicians and the First Amendment. N Engl J Med (2008) 1.43
Sharing clinical trial data. BMJ (2016) 1.43
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. Ann Intern Med (2005) 1.42
The growth of hospitalists and the changing face of primary care. N Engl J Med (2009) 1.42
Peer review in the balance. N Engl J Med (2008) 1.42
The FDA and tobacco regulation. N Engl J Med (2008) 1.42
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Arch Dermatol (2005) 1.41