Published in Mol Cell Biol on April 11, 2011
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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol (2010) 5.59
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A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Mol Cell (2007) 3.23
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S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood (2002) 4.27
Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Nat Med (2003) 4.04
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Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev (2010) 3.33
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A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Mol Cell (2007) 3.23
Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol Cell Biol (2004) 3.20
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Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol Cell (2011) 2.61
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Mol Cell (2006) 2.51
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Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nat Med (2011) 2.35
Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell (2012) 2.26
The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. Hum Mol Genet (2005) 2.23
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Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. Mol Cell Biol (2006) 2.02
Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells. EMBO J (2006) 1.97
Interaction of FANCD2 and NBS1 in the DNA damage response. Nat Cell Biol (2002) 1.96
XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Mol Cell (2003) 1.94
Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde. Cancer Res (2007) 1.92
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature (2002) 1.89
Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J (2004) 1.89
Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway. Mol Cancer Ther (2006) 1.88
Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines. Nat Biotechnol (2002) 1.87
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proc Natl Acad Sci U S A (2011) 1.86
REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo. Mol Cell (2006) 1.85
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Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest (2007) 1.80
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage. Mol Cell (2006) 1.79
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Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway. Mol Cell Biol (2007) 1.77
Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase. Mol Cell Biol (2007) 1.75
The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly. DNA Repair (Amst) (2008) 1.74
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Regulation of Rev1 by the Fanconi anemia core complex. Nat Struct Mol Biol (2012) 1.72
RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors. Cancer Res (2007) 1.68
Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair. PLoS Genet (2010) 1.66
Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Mol Cell Biol (2006) 1.65
An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells. J Cell Biol (2007) 1.65
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A novel diagnostic screen for defects in the Fanconi anemia pathway. Blood (2002) 1.54
PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA. J Cell Biol (2008) 1.53
Multiple roles of vertebrate REV genes in DNA repair and recombination. Mol Cell Biol (2005) 1.52
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DNA polymerase POLN participates in cross-link repair and homologous recombination. Mol Cell Biol (2009) 1.47
Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks. DNA Repair (Amst) (2006) 1.46
Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. J Biol Chem (2010) 1.43
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RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. Mol Cell Biol (2007) 1.41
Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. J Biol Chem (2010) 1.40
Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Dev Cell (2003) 1.38
Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells. J Clin Invest (2010) 1.38
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Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2. Mol Cell (2003) 1.33
Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination. Mol Cell Biol (2005) 1.33
Direct DNA binding activity of the Fanconi anemia D2 protein. J Biol Chem (2005) 1.33
DNA damage responses and their many interactions with the replication fork. Carcinogenesis (2006) 1.32