Published in Cell on May 01, 2009
Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases. J Biol Chem (2011) 1.42
Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. J Proteome Res (2012) 1.41
The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxid Redox Signal (2011) 1.24
Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties. J Biol Chem (2011) 1.12
Computational modeling of mitochondrial energy transduction. Crit Rev Biomed Eng (2011) 0.78
Metabolic manipulators: a well founded strategy to combat mitochondrial dysfunction. J Inherit Metab Dis (2010) 0.76
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell (2006) 11.38
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A (2006) 7.00
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A (2008) 6.53
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell (2009) 3.91
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. J Mol Biol (2008) 3.27
Mechanisms and molecular probes of sirtuins. Chem Biol (2008) 1.90
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A (2006) 7.00
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell (2002) 6.36
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell (2010) 5.73
2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken) (2012) 5.22
Mechanism of human SIRT1 activation by resveratrol. J Biol Chem (2005) 4.86
Histone H3-K56 acetylation is catalyzed by histone chaperone-dependent complexes. Mol Cell (2007) 3.38
2012 American College of Rheumatology guidelines for management of gout. Part 2: therapy and antiinflammatory prophylaxis of acute gouty arthritis. Arthritis Care Res (Hoboken) (2012) 2.83
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol Cell (2012) 2.54
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science (2013) 2.49
G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J Cell Biol (2007) 2.34
Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes. Mol Cell (2002) 2.33
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol Cell (2011) 2.29
Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases. Biochemistry (2004) 2.11
Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins. J Biol Chem (2013) 2.03
Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells. Arthritis Rheum (2012) 2.03
The Sirtuin family: therapeutic targets to treat diseases of aging. Curr Opin Chem Biol (2008) 2.00
Mechanisms and molecular probes of sirtuins. Chem Biol (2008) 1.90
Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases. J Biol Chem (2002) 1.88
Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases. J Biol Chem (2003) 1.87
Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75. Nat Struct Mol Biol (2008) 1.78
SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. J Biol Chem (2012) 1.77
Chemical mechanisms of histone lysine and arginine modifications. Biochim Biophys Acta (2008) 1.69
Structure and biochemical functions of SIRT6. J Biol Chem (2011) 1.67
Assays for mechanistic investigations of protein/histone acetyltransferases. Methods (2005) 1.65
Catalysis and substrate selection by histone/protein lysine acetyltransferases. Curr Opin Struct Biol (2008) 1.64
Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases. J Biol Chem (2002) 1.62
Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications. Biochem J (2009) 1.59
Catalytic mechanism of a MYST family histone acetyltransferase. Biochemistry (2007) 1.57
Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J (2004) 1.56
Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9. J Biol Chem (2011) 1.55
Metabolite of SIR2 reaction modulates TRPM2 ion channel. J Biol Chem (2006) 1.55
A continuous microplate assay for sirtuins and nicotinamide-producing enzymes. Anal Biochem (2009) 1.54
Small molecule regulation of Sir2 protein deacetylases. FEBS J (2005) 1.54
Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine. Biochemistry (2006) 1.49
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide. Biochemistry (2007) 1.44
Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation. J Biol Chem (2004) 1.43
Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases. J Biol Chem (2011) 1.42
Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome. J Pediatr (2003) 1.42
Acetyl-lysine analog peptides as mechanistic probes of protein deacetylases. J Biol Chem (2007) 1.41
Combinatorial profiling of chromatin binding modules reveals multisite discrimination. Nat Chem Biol (2010) 1.39
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Mol Cell (2012) 1.39
Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression. Proc Natl Acad Sci U S A (2012) 1.37
Sirtuin catalysis and regulation. J Biol Chem (2012) 1.35
Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome. Arthritis Res Ther (2004) 1.33
KAT(ching) metabolism by the tail: insight into the links between lysine acetyltransferases and metabolism. Chembiochem (2010) 1.32
Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation. J Immunol (2003) 1.31
Where in the cell is SIRT3?--functional localization of an NAD+-dependent protein deacetylase. Biochem J (2008) 1.31
Probing the function of conserved residues in the serine/threonine phosphatase PP2Calpha. Biochemistry (2003) 1.28
Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose. Biochim Biophys Acta (2010) 1.25
Quantitative assays for characterization of the Sir2 family of NAD(+)-dependent deacetylases. Methods Enzymol (2004) 1.23
Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation. J Biol Chem (2013) 1.20
Phase Ib dose-escalation study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma. Clin Cancer Res (2013) 1.19
SIRT3 substrate specificity determined by peptide arrays and machine learning. ACS Chem Biol (2010) 1.17
Sir2 deacetylases exhibit nucleophilic participation of acetyl-lysine in NAD+ cleavage. J Am Chem Soc (2007) 1.14
Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase. Biochemistry (2002) 1.14
Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. J Clin Invest (2013) 1.14
Nucleosome recognition by the Piccolo NuA4 histone acetyltransferase complex. Biochemistry (2007) 1.14
Hydrolase regulates NAD+ metabolites and modulates cellular redox. J Biol Chem (2009) 1.13
Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties. J Biol Chem (2011) 1.12
SIRT1 top 40 hits: use of one-bead, one-compound acetyl-peptide libraries and quantum dots to probe deacetylase specificity. Biochemistry (2006) 1.11
Identification and characterization of small molecule inhibitors of a plant homeodomain finger. Biochemistry (2012) 1.11
Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation. J Biol Chem (2011) 1.09
Autoacetylation of the histone acetyltransferase Rtt109. J Biol Chem (2011) 1.08
The acetyltransferase activity of CBP is required for wingless activation and H4 acetylation in Drosophila melanogaster. Mol Cell Biol (2002) 1.08
Modulating acetyl-CoA binding in the GCN5 family of histone acetyltransferases. J Biol Chem (2002) 1.08
End of life care--the importance of advance care planning. Aust Fam Physician (2010) 1.06
Acetylation-dependent ADP-ribosylation by Trypanosoma brucei Sir2. J Biol Chem (2007) 1.06
Dynamic interplay between histone H3 modifications and protein interpreters: emerging evidence for a "histone language". Chembiochem (2010) 1.06
Kinetic mechanism of the Rtt109-Vps75 histone acetyltransferase-chaperone complex. Biochemistry (2010) 1.06
Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells. J Cell Biol (2007) 1.04
Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3). J Biol Chem (2011) 1.04
Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone. Proc Natl Acad Sci U S A (2010) 1.03
A phase I/II study of carfilzomib 2-10-min infusion in patients with advanced solid tumors. Cancer Chemother Pharmacol (2013) 1.00
Analysis of O-acetyl-ADP-ribose as a target for Nudix ADP-ribose hydrolases. J Biol Chem (2002) 1.00
A combinatorial H4 tail library for exploring the histone code. Biochemistry (2008) 0.99
Site-specific reactivity of nonenzymatic lysine acetylation. ACS Chem Biol (2015) 0.99
Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain. J Comp Neurol (2010) 0.98
Multivalent recognition of histone tails by the PHD fingers of CHD5. Biochemistry (2012) 0.97
Feasibility of interactive text message response (ITR) as a novel, real-time measure of adherence to antiretroviral therapy for HIV+ youth. AIDS Behav (2013) 0.96
Synthesis and biochemical evaluation of O-acetyl-ADP-ribose and N-acetyl analogs. Org Biomol Chem (2007) 0.92
Regulation of Dictyostelium morphogenesis by RapGAP3. Dev Biol (2009) 0.92
Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease. J Inherit Metab Dis (2010) 0.92
Quantification of endogenous sirtuin metabolite O-acetyl-ADP-ribose. Anal Biochem (2008) 0.91
Dual-specificity protein tyrosine phosphatase VHR down-regulates c-Jun N-terminal kinase (JNK). Oncogene (2002) 0.91
Quantification of SAHA-Dependent Changes in Histone Modifications Using Data-Independent Acquisition Mass Spectrometry. J Proteome Res (2015) 0.91
Dictyostelium Dock180-related RacGEFs regulate the actin cytoskeleton during cell motility. Mol Biol Cell (2008) 0.90
Linking SIRT2 to Parkinson's disease. ACS Chem Biol (2007) 0.90
Understandings of death and dying for people of Chinese origin. Death Stud (2009) 0.89