Published in Diabetes Care on December 15, 2009
Fasting plasma triglycerides predict the glycaemic response to treatment of type 2 diabetes by gastric electrical stimulation. A novel lipotoxicity paradigm. Diabet Med (2013) 0.96
The co-transplantation of bone marrow derived mesenchymal stem cells reduced inflammation in intramuscular islet transplantation. PLoS One (2015) 0.81
Striated muscle as implantation site for transplanted pancreatic islets. J Transplant (2011) 0.79
Molecular mediators of hepatic steatosis and liver injury. J Clin Invest (2004) 9.40
Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A (1994) 4.01
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Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci U S A (1997) 3.07
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci (2008) 2.99
Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest (1994) 2.76
Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets. Proc Natl Acad Sci U S A (2000) 2.11
Diabetes and apoptosis: lipotoxicity. Apoptosis (2009) 1.75
Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB. Diabetes (2009) 1.50
Prevalence of hepatic steatosis after islet transplantation and its relation to graft function. Diabetes (2004) 1.46
Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. J Biol Chem (1998) 1.39
Magnetic resonance-defined periportal steatosis following intraportal islet transplantation: a functional footprint of islet graft survival? Diabetes (2003) 1.27
Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin. Diabetes (2007) 1.26
Apolipoprotein CIII promotes Ca2+-dependent beta cell death in type 1 diabetes. Proc Natl Acad Sci U S A (2004) 1.23
Type 2 diabetes mellitus phenotype and graft survival after islet transplantation. Transplantation (2009) 0.79
International trial of the Edmonton protocol for islet transplantation. N Engl J Med (2006) 13.43
The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci U S A (2006) 5.41
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature (2005) 3.62
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell (2005) 3.52
Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care (2012) 3.20
Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis. Sci Transl Med (2011) 3.19
Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience. Am J Transplant (2005) 3.07
Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial. JAMA (2012) 2.85
A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations. Am J Transplant (2005) 2.74
Innervation patterns of autonomic axons in the human endocrine pancreas. Cell Metab (2011) 2.48
Noninvasive in vivo imaging of pancreatic islet cell biology. Nat Med (2008) 2.41
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells. Science (2007) 2.36
Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells. Diabetes (2010) 2.36
Rescue purification maximizes the use of human islet preparations for transplantation. Am J Transplant (2005) 2.04
Glutamate is a positive autocrine signal for glucagon release. Cell Metab (2008) 2.01
Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets. Hepatology (2011) 1.94
Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J Biol Chem (2002) 1.85
The use of exenatide in islet transplant recipients with chronic allograft dysfunction: safety, efficacy, and metabolic effects. Transplantation (2008) 1.83
Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye. Nat Protoc (2008) 1.77
Stopping type 1 diabetes: attempts to prevent or cure type 1 diabetes in man. Diabetes (2011) 1.77
Donor islet endothelial cells participate in formation of functional vessels within pancreatic islet grafts. Diabetes (2005) 1.74
Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell (2003) 1.71
SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells. J Gen Physiol (2003) 1.68
ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells. Diabetes (2004) 1.66
Long-term insulin independence and improvement in insulin secretion after supplemental islet infusion under exenatide and etanercept. Transplantation (2008) 1.66
Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans. Nat Med (2011) 1.62
The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology. Endocr Rev (2006) 1.59
Quantitative differential expression analysis reveals miR-7 as major islet microRNA. Biochem Biophys Res Commun (2007) 1.54
Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab (2010) 1.49
Edmonton's islet success has indeed been replicated elsewhere. Lancet (2003) 1.45
Retinol-binding protein 4 is not associated with insulin resistance in pregnancy. Metabolism (2011) 1.44
Regulation of alloimmune responses (GvH reactions) in vitro by autologous donor bone marrow cell preparation used in clinical organ transplantation. Transplantation (2002) 1.42
ATP inhibits the generation and function of regulatory T cells through the activation of purinergic P2X receptors. Sci Signal (2011) 1.38
Reversal of diabetes by pancreatic islet transplantation into a subcutaneous, neovascularized device. Transplantation (2006) 1.37
ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cell. Proc Natl Acad Sci U S A (2010) 1.35
Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth. Diabetes (2006) 1.33
Improved human islet isolation outcome from marginal donors following addition of oxygenated perfluorocarbon to the cold-storage solution. Transplantation (2003) 1.31
Insulin signaling in the pancreatic beta-cell. Annu Rev Nutr (2008) 1.29
Toward maximizing the success rates of human islet isolation: influence of donor and isolation factors. Cell Transplant (2007) 1.26
Endocrine cell clustering during human pancreas development. J Histochem Cytochem (2009) 1.26
Rapamycin impairs in vivo proliferation of islet beta-cells. Transplantation (2007) 1.26
Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells. PLoS One (2008) 1.24
Insulin feedback action on pancreatic beta-cell function. FEBS Lett (2002) 1.24
Enhanced oxygenation promotes beta-cell differentiation in vitro. Stem Cells (2007) 1.24
MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas. Gene Expr Patterns (2008) 1.24
Apolipoprotein CIII promotes Ca2+-dependent beta cell death in type 1 diabetes. Proc Natl Acad Sci U S A (2004) 1.23
Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials. Proc Natl Acad Sci U S A (2012) 1.23
High-resolution, noninvasive longitudinal live imaging of immune responses. Proc Natl Acad Sci U S A (2011) 1.22
Transthyretin constitutes a functional component in pancreatic beta-cell stimulus-secretion coupling. Proc Natl Acad Sci U S A (2005) 1.22
Cholinergic augmentation of insulin release requires ankyrin-B. Sci Signal (2010) 1.21
Inositol pyrophosphates: structure, enzymology and function. Cell Mol Life Sci (2009) 1.21
Sirt1: a metabolic master switch that modulates lifespan. Nat Med (2006) 1.20
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells. Proc Natl Acad Sci U S A (2003) 1.20
Point: steady progress and current challenges in clinical islet transplantation. Diabetes Care (2009) 1.20
Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion. FASEB J (2010) 1.19
Short telomeres compromise β-cell signaling and survival. PLoS One (2011) 1.17
Combined treatment of intrapancreatic autologous bone marrow stem cells and hyperbaric oxygen in type 2 diabetes mellitus. Cell Transplant (2008) 1.17
Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis. Diabetes (2006) 1.17
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function. Proc Natl Acad Sci U S A (2008) 1.16
Beta-cell CaV channel regulation in physiology and pathophysiology. Am J Physiol Endocrinol Metab (2005) 1.16
Inositol hexakisphosphate promotes dynamin I- mediated endocytosis. Proc Natl Acad Sci U S A (2002) 1.14
The use of the BD oxygen biosensor system to assess isolated human islets of langerhans: oxygen consumption as a potential measure of islet potency. Cell Transplant (2006) 1.13
Regional differences in islet distribution in the human pancreas--preferential beta-cell loss in the head region in patients with type 2 diabetes. PLoS One (2013) 1.13
Allosensitization of islet allograft recipients. Transplantation (2007) 1.13
Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model. Transplantation (2007) 1.13
Assessment of cytotoxic lymphocyte gene expression in the peripheral blood of human islet allograft recipients: elevation precedes clinical evidence of rejection. Diabetes (2004) 1.13
R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion. Nat Cell Biol (2007) 1.12
Tyrosine 537 within the Na+,K+-ATPase alpha-subunit is essential for AP-2 binding and clathrin-dependent endocytosis. J Biol Chem (2002) 1.12
Implantation site-dependent dysfunction of transplanted pancreatic islets. Diabetes (2007) 1.12
Effect of living-related donor bone marrow infusion on chimerism and in vitro immunoregulatory activity in kidney transplant recipients. Transplantation (2002) 1.11
Requirements for success in clinical islet transplantation. Transplantation (2005) 1.11
Transplantation: current developments and future directions; the future of clinical islet transplantation as a cure for diabetes. Front Biosci (2008) 1.11
Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets. Diabetes (2008) 1.09
Prediction of clinical outcome in islet allotransplantation. Diabetes Care (2007) 1.08
Human, nonhuman primate, and rat pancreatic islets express erythropoietin receptors. Transplantation (2003) 1.08