Published in Cancer Sci on April 22, 2009
TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer (2010) 5.27
Tumors as organs: complex tissues that interface with the entire organism. Dev Cell (2010) 3.98
Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol (2010) 2.79
Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant. Br J Cancer (2010) 1.85
Targeting the osteosarcoma cancer stem cell. J Orthop Surg Res (2010) 1.52
Causes and consequences of cysteine S-glutathionylation. J Biol Chem (2013) 1.43
Glutathione S-transferase P influences redox and migration pathways in bone marrow. PLoS One (2014) 1.38
Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104. PLoS One (2011) 1.23
The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer. Free Radic Biol Med (2011) 1.22
Advances in understanding the leukaemia microenvironment. Br J Haematol (2014) 1.19
Tumor-initiating and -propagating cells: cells that we would like to identify and control. Neoplasia (2010) 1.11
Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection. J Clin Invest (2011) 1.05
Carbohydrate engineered cells for regenerative medicine. Adv Drug Deliv Rev (2010) 1.04
Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation. Proc Natl Acad Sci U S A (2011) 1.00
Aging of the microenvironment influences clonality in hematopoiesis. PLoS One (2012) 1.00
A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs. Oncotarget (2010) 0.97
The bone marrow microenvironment as a sanctuary for minimal residual disease in CML. Biochem Pharmacol (2010) 0.96
Oxidative stress, redox regulation and diseases of cellular differentiation. Biochim Biophys Acta (2014) 0.94
Bone marrow homing and engraftment of human hematopoietic stem and progenitor cells is mediated by a polarized membrane domain. Blood (2012) 0.93
Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles. Int J Nanomedicine (2013) 0.92
The three-layer concentric model of glioblastoma: cancer stem cells, microenvironmental regulation, and therapeutic implications. ScientificWorldJournal (2011) 0.91
A c-Met inhibitor increases the chemosensitivity of cancer stem cells to the irinotecan in gastric carcinoma. Br J Cancer (2013) 0.91
Molecular targeted therapy for hepatocellular carcinoma in the current and potential next strategies. J Gastroenterol (2011) 0.90
The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies. Pharmacol Ther (2010) 0.90
Redox platforms in cancer drug discovery and development. Curr Opin Chem Biol (2010) 0.89
The implications of cancer stem cells for cancer therapy. Int J Mol Sci (2012) 0.87
The invasion and metastasis promotion role of CD97 small isoform in gastric carcinoma. PLoS One (2012) 0.86
Not all quiet on the noise front. Nat Chem Biol (2009) 0.85
The Bone Niche of Chondrosarcoma: A Sanctuary for Drug Resistance, Tumour Growth and also a Source of New Therapeutic Targets. Sarcoma (2011) 0.85
The hemopoietic stem cell niche versus the microenvironment of the multiple myeloma-tumor initiating cell. Cancer Microenviron (2010) 0.85
Cancer stem cells accountability in progression of head and neck squamous cell carcinoma: the most recent trends! Mol Biol Int (2014) 0.84
Endothelial cells promote stem-like phenotype of glioma cells through activating the Hedgehog pathway. J Pathol (2014) 0.83
Functional diversity of fibroblast growth factors in bone formation. Int J Endocrinol (2015) 0.81
The Role of Stroma in Tumor Development. Cancer J (2015) 0.81
Relationship of tumor marker CA125 and ovarian tumor stem cells: preliminary identification. J Ovarian Res (2015) 0.81
Are metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma. PLoS One (2012) 0.80
Overexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer. Histopathology (2012) 0.79
Bone Tumor Environment as a Potential Therapeutic Target in Ewing Sarcoma. Front Oncol (2015) 0.78
Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations. Adv Drug Deliv Rev (2014) 0.76
Role of ADAM17 in invasion and migration of CD133-expressing liver cancer stem cells after irradiation. Oncotarget (2016) 0.76
Human Stromal Cells in the Peripheral Zone of the Prostate Promote Tumorigenesis of Prostatic Cancer Stem Cells through Up-regulation of C-Kit Expression. J Cancer (2015) 0.75
Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133. Sci Rep (2017) 0.75
Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness. Int J Mol Sci (2016) 0.75
A possible explanation for the variable frequencies of cancer stem cells in tumors. PLoS One (2013) 0.75
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell (2004) 12.67
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med (2006) 7.62
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature (2004) 7.21
Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell (2007) 5.94
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell (2010) 4.90
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab (2006) 4.33
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell (2007) 4.31
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med (2009) 4.03
DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J Exp Med (2005) 4.02
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat Med (2006) 3.78
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med (2012) 3.33
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad. Cell Stem Cell (2008) 2.69
Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med (2009) 2.66
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem (2003) 2.59
p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70. Cell Stem Cell (2011) 2.58
Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell (2013) 2.58
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature (2010) 2.47
Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell (2012) 2.36
M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med (2009) 2.29
Identification and characterization of stem cells in prepubertal spermatogenesis in mice. Dev Biol (2003) 2.24
Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ Res (2007) 2.22
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev (2005) 2.18
Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest. Cell Stem Cell (2008) 2.14
Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab (2009) 2.13
Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. Dev Biol (2004) 2.13
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev (2008) 2.12
The first round of mouse spermatogenesis is a distinctive program that lacks the self-renewing spermatogonia stage. Development (2006) 2.07
VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment. Arterioscler Thromb Vasc Biol (2008) 1.90
Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med (2011) 1.79
Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells. Blood (2010) 1.78
Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Ann N Y Acad Sci (2007) 1.78
Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4. Cancer Res (2003) 1.78
Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. EMBO J (2005) 1.77
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood (2005) 1.75
Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. Blood (2005) 1.71
Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction. Biochem Biophys Res Commun (2007) 1.66
Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation. J Exp Med (2002) 1.63
Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes. J Immunol (2007) 1.62
Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med (2005) 1.61
The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. J Exp Med (2010) 1.59
Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche. Biochem Biophys Res Commun (2007) 1.45
Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades. Mol Biol Cell (2007) 1.44
Hematopoietic cells regulate the angiogenic switch during tumorigenesis. Blood (2004) 1.44
Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo. Circ Res (2004) 1.40
Angiopoietin-like proteins: potential new targets for metabolic syndrome therapy. Trends Mol Med (2005) 1.40
Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. J Biol Chem (2009) 1.39
Angiopoietin-related/angiopoietin-like proteins regulate angiogenesis. Int J Hematol (2004) 1.37
CD24 is expressed specifically in the nucleus pulposus of intervertebral discs. Biochem Biophys Res Commun (2005) 1.32
Regulation of reactive oxygen species in stem cells and cancer stem cells. J Cell Physiol (2012) 1.30
Induction of DC-STAMP by alternative activation and downstream signaling mechanisms. J Bone Miner Res (2007) 1.30
Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells. J Bone Miner Metab (2006) 1.29
Pathological neoangiogenesis depends on oxidative stress regulation by ATM. Nat Med (2012) 1.26
Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells. Blood (2010) 1.25
Cooperative interaction of Angiopoietin-like proteins 1 and 2 in zebrafish vascular development. Proc Natl Acad Sci U S A (2005) 1.20
Differentiation and function of osteoclasts. Keio J Med (2003) 1.20
Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice. J Clin Invest (2008) 1.18
Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor. Invest Ophthalmol Vis Sci (2005) 1.18
Angiopoietins and angiopoietin-like proteins in angiogenesis. Endothelium (2006) 1.18
Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin. Proc Natl Acad Sci U S A (2009) 1.17
Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification. J Exp Med (2007) 1.16
Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. Proc Natl Acad Sci U S A (2003) 1.15
Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow. Cell Stem Cell (2010) 1.14
Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell (2013) 1.14
Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos. Dev Biol (2008) 1.14
Derivation and morphological characterization of mouse spermatogonial stem cell lines. Arch Histol Cytol (2004) 1.14
Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells. Blood (2002) 1.12
Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization. Arterioscler Thromb Vasc Biol (2006) 1.12
FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging. Blood (2008) 1.12
A germ cell-specific gene, Prmt5, works in somatic cell reprogramming. J Biol Chem (2011) 1.08
Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis. Biochem Biophys Res Commun (2008) 1.07
Ephrin-B2 induces migration of endothelial cells through the phosphatidylinositol-3 kinase pathway and promotes angiogenesis in adult vasculature. Arterioscler Thromb Vasc Biol (2003) 1.07
Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing. Blood (2011) 1.06
Regulation of hematopoietic stem cells by the niche. Trends Cardiovasc Med (2005) 1.06
Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. Blood (2012) 1.06
Craniofacial malformation in R-spondin2 knockout mice. Biochem Biophys Res Commun (2009) 1.05
Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver. Blood (2010) 1.05
Cell fusion in osteoclasts plays a critical role in controlling bone mass and osteoblastic activity. Biochem Biophys Res Commun (2008) 1.04
Vascular endothelial growth factor-A is a survival factor for nucleus pulposus cells in the intervertebral disc. Biochem Biophys Res Commun (2008) 1.04
Defective smooth muscle development in qkI-deficient mice. Dev Growth Differ (2004) 1.03
Spatial analysis of germ stem cell development in Oct-4/EGFP transgenic mice. Arch Histol Cytol (2004) 1.03
Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression. Arterioscler Thromb Vasc Biol (2014) 1.03
A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis. Biochem Biophys Res Commun (2002) 1.02
Niche regulation of hematopoietic stem cells in the endosteum. Ann N Y Acad Sci (2009) 1.02
DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4. Circ Res (2010) 1.02
Angiopoietin-1 guides directional angiogenesis through integrin αvβ5 signaling for recovery of ischemic retinopathy. Sci Transl Med (2013) 1.02
MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner. Biochem Biophys Res Commun (2009) 1.01
Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells. Biochem Biophys Res Commun (2011) 1.01
Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor kappaB ligand on adult T-cell leukemia cells. Blood (2002) 1.01
The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function. Int Immunol (2008) 1.00
Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism. Blood (2011) 1.00
Angiopoietin-related growth factor (AGF) promotes angiogenesis. Blood (2004) 1.00
Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity. Stem Cells (2008) 0.99
von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina. Development (2010) 0.99
A quantitative matrigel assay for assessing repopulating capacity of prostate stem cells. Biochem Biophys Res Commun (2005) 0.98
Regulation of hematopoiesis and its interaction with stem cell niches. Int J Hematol (2005) 0.97
TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool. Blood (2010) 0.97
Dimer formation of receptor activator of nuclear factor kappaB induces incomplete osteoclast formation. Biochem Biophys Res Commun (2004) 0.96
Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model. Arterioscler Thromb Vasc Biol (2008) 0.96
The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells. Blood (2014) 0.96