Published in Angew Chem Int Ed Engl on January 01, 2009
Enantiospecific total synthesis of the important biogenetic intermediates along the ajmaline pathway, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epivellosimine and macusine A. J Org Chem (2010) 0.91
Emergent decarboxylase activity and attenuation of α/β-hydrolase activity during the evolution of methylketone biosynthesis in tomato. Plant Cell (2012) 0.85
A Metabolic Gene Cluster in the Wheat W1 and the Barley Cer-cqu Loci Determines β-Diketone Biosynthesis and Glaucousness. Plant Cell (2016) 0.84
Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding. J Biol Chem (2012) 0.76
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J Biol Chem (2005) 1.87
On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths. Acta Crystallogr D Biol Crystallogr (2007) 1.78
Strictosidine synthase: mechanism of a Pictet-Spengler catalyzing enzyme. J Am Chem Soc (2008) 1.50
Structure-based engineering of strictosidine synthase: auxiliary for alkaloid libraries. Chem Biol (2007) 1.46
Automated technologies and novel techniques to accelerate protein crystallography for structural genomics. Proteomics (2008) 1.43
Optimal fine φ-slicing for single-photon-counting pixel detectors. Acta Crystallogr D Biol Crystallogr (2011) 1.36
The structural basis of signal transduction for the response regulator PrrA from Mycobacterium tuberculosis. J Biol Chem (2006) 1.34
The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed beta-propeller fold in plant proteins. Plant Cell (2006) 1.32
On the routine use of soft X-rays in macromolecular crystallography. Part III. The optimal data-collection wavelength. Acta Crystallogr D Biol Crystallogr (2005) 1.30
C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain. J Mol Biol (2008) 1.28
Crystal structure of vinorine synthase, the first representative of the BAHD superfamily. J Biol Chem (2005) 1.26
Crystal structure of human enterovirus 71 3C protease. J Mol Biol (2011) 1.20
Preparation of two sets of 5,6,7-trioxygenated dihydroflavonol derivatives as free radical scavengers and neuronal cell protectors to oxidative damage. Bioorg Med Chem (2009) 1.16
Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues. J Virol (2011) 1.12
X-ray structure of Cerulean GFP: a tryptophan-based chromophore useful for fluorescence lifetime imaging. Biochemistry (2007) 1.08
Heterologous expression of a Rauvolfia cDNA encoding strictosidine glucosidase, a biosynthetic key to over 2000 monoterpenoid indole alkaloids. Eur J Biochem (2002) 1.08
On the influence of the incident photon energy on the radiation damage in crystalline biological samples. J Synchrotron Radiat (2005) 1.07
Structural insights into the mechanism of protein O-fucosylation. PLoS One (2011) 1.06
Structure of the motor subunit of type I restriction-modification complex EcoR124I. Nat Struct Mol Biol (2008) 1.06
Cyanuric acid hydrolase: evolutionary innovation by structural concatenation. Mol Microbiol (2013) 1.06
Molecular architecture of strictosidine glucosidase: the gateway to the biosynthesis of the monoterpenoid indole alkaloid family. Plant Cell (2007) 1.05
Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum. Structure (2008) 1.05
Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition. J Mol Biol (2006) 1.05
Structure of spinach nitrite reductase: implications for multi-electron reactions by the iron-sulfur:siroheme cofactor. Biochemistry (2005) 1.04
3D-Structure and function of strictosidine synthase--the key enzyme of monoterpenoid indole alkaloid biosynthesis. Plant Physiol Biochem (2008) 1.02
Structural and functional aspects of the sensor histidine kinase PrrB from Mycobacterium tuberculosis. Structure (2006) 1.02
The crystal structure of the herpes simplex virus 1 ssDNA-binding protein suggests the structural basis for flexible, cooperative single-stranded DNA binding. J Biol Chem (2004) 1.00
The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device. Nature (2013) 1.00
New alkaloids of the sarpagine group from Rauvolfia serpentina hairy root culture. J Nat Prod (2002) 1.00
Acetyltransfer in natural product biosynthesis--functional cloning and molecular analysis of vinorine synthase. Bioorg Med Chem (2004) 0.99
Nonprocessive [2 + 2]e- off-loading reductase domains from mycobacterial nonribosomal peptide synthetases. Proc Natl Acad Sci U S A (2012) 0.98
Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide. J Biol Chem (2012) 0.97
Crystallization and preliminary X-ray crystallographic analysis of strictosidine synthase from Rauvolfia: the first member of a novel enzyme family. Biochim Biophys Acta (2004) 0.97
The three-dimensional structure of the extracellular adhesion domain of the sialic acid-binding adhesin SabA from Helicobacter pylori. J Biol Chem (2013) 0.96
Crystallization of the c14-rotor of the chloroplast ATP synthase reveals that it contains pigments. Biochim Biophys Acta (2008) 0.96
Crystal structures of a poplar thioredoxin peroxidase that exhibits the structure of glutathione peroxidases: insights into redox-driven conformational changes. J Mol Biol (2007) 0.96
A facile chemoenzymatic approach: one-step syntheses of monoterpenoid indole alkaloids. Chem Asian J (2010) 0.96
Radiation damage in room-temperature data acquisition with the PILATUS 6M pixel detector. J Synchrotron Radiat (2011) 0.96
Crystal structure of CBD2 from the Drosophila Na(+)/Ca(2+) exchanger: diversity of Ca(2+) regulation and its alternative splicing modification. J Mol Biol (2009) 0.96
Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex. EMBO J (2011) 0.96
Structures of Mycobacterium tuberculosispyridoxine 5'-phosphate oxidase and its complexes with flavin mononucleotide and pyridoxal 5'-phosphate. Acta Crystallogr D Biol Crystallogr (2005) 0.95
Arbutin synthase, a novel member of the NRD1beta glycosyltransferase family, is a unique multifunctional enzyme converting various natural products and xenobiotics. Bioorg Med Chem (2002) 0.93
Expression, purification, crystallization and preliminary X-ray analysis of strictosidine glucosidase, an enzyme initiating biosynthetic pathways to a unique diversity of indole alkaloid skeletons. Biochim Biophys Acta (2004) 0.92
YoeB-ribosome structure: a canonical RNase that requires the ribosome for its specific activity. Nucleic Acids Res (2013) 0.91
Structural basis for the oxidation of protein-bound sulfur by the sulfur cycle molybdohemo-enzyme sulfane dehydrogenase SoxCD. J Biol Chem (2010) 0.91
Crystal structure of Ca2+/H+ antiporter protein YfkE reveals the mechanisms of Ca2+ efflux and its pH regulation. Proc Natl Acad Sci U S A (2013) 0.91
Crystal structure and Raman studies of dsFP483, a cyan fluorescent protein from Discosoma striata. J Mol Biol (2008) 0.91
The crystal structure of the CRISPR-associated protein Csn2 from Streptococcus agalactiae. J Struct Biol (2012) 0.90
Structure of phenoxazinone synthase from Streptomyces antibioticus reveals a new type 2 copper center. Biochemistry (2006) 0.90
Crystallization and preliminary X-ray analysis of strictosidine synthase and its complex with the substrate tryptamine. Acta Crystallogr D Biol Crystallogr (2005) 0.89
Chloroplasts assemble the major subunit FaeG of Escherichia coli F4 (K88) fimbriae to strand-swapped dimers. J Mol Biol (2007) 0.89
Crystal structure of Pseudomonas aeruginosa Tsi2 reveals a stably folded superhelical antitoxin. J Mol Biol (2012) 0.89
Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system. Planta (2005) 0.88
The structure of a full-length response regulator from Mycobacterium tuberculosis in a stabilized three-dimensional domain-swapped, activated state. J Biol Chem (2007) 0.88
Crystallization and structural analysis of GADPH from Spinacia oleracea in a new form. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.88
High-resolution structure of NodZ fucosyltransferase involved in the biosynthesis of the nodulation factor. Acta Biochim Pol (2007) 0.88
Trends for diverse production strategies of plant medicinal alkaloids. Nat Prod Rep (2010) 0.88
The M-T hook structure is critical for design of HIV-1 fusion inhibitors. J Biol Chem (2012) 0.87
Crystal structures of progressive Ca2+ binding states of the Ca2+ sensor Ca2+ binding domain 1 (CBD1) from the CALX Na+/Ca2+ exchanger reveal incremental conformational transitions. J Biol Chem (2009) 0.87
Discovery of critical residues for viral entry and inhibition through structural Insight of HIV-1 fusion inhibitor CP621-652. J Biol Chem (2012) 0.87
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapB (Rv2773c) from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.86
Structure of lambda CII: implications for recognition of direct-repeat DNA by an unusual tetrameric organization. Proc Natl Acad Sci U S A (2005) 0.85
High-resolution structure of Bombyx mori lipoprotein 7: crystallographic determination of the identity of the protein and its potential role in detoxification. Acta Crystallogr D Biol Crystallogr (2012) 0.85
Metal binding to porcine pancreatic elastase: calcium or not calcium. Acta Crystallogr D Biol Crystallogr (2002) 0.85
Purification, crystallization and preliminary X-ray diffraction analysis of aspartate semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.85
On the routine use of soft X-rays in macromolecular crystallography. Part II. Data-collection wavelength and scaling models. Acta Crystallogr D Biol Crystallogr (2003) 0.85
Structural characterization of the multidomain regulatory protein Rv1364c from Mycobacterium tuberculosis. Structure (2011) 0.84
Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX. Acta Crystallogr D Biol Crystallogr (2013) 0.84
Crystal structure of archaemetzincin AmzA from Methanopyrus kandleri at 1.5 A resolution. Proteins (2010) 0.83
Additional phase information from UV damage of selenomethionine labelled proteins. J Synchrotron Radiat (2011) 0.83
Crystal structure of NAD+-dependent Peptoniphilus asaccharolyticus glutamate dehydrogenase reveals determinants of cofactor specificity. J Struct Biol (2011) 0.83
Preparation of C-23 esterified silybin derivatives and evaluation of their lipid peroxidation inhibitory and DNA protective properties. Bioorg Med Chem (2009) 0.83
On the routine use of soft X-rays in macromolecular crystallography. Part V. Molecular replacement and anomalous scattering. Acta Crystallogr D Biol Crystallogr (2011) 0.83
Short-peptide fusion inhibitors with high potency against wild-type and enfuvirtide-resistant HIV-1. FASEB J (2012) 0.83
Purification, cloning, functional expression and characterization of perakine reductase: the first example from the AKR enzyme family, extending the alkaloidal network of the plant Rauvolfia. Plant Mol Biol (2008) 0.83
Crystal structures of Cg1458 reveal a catalytic lid domain and a common catalytic mechanism for the FAH family. Biochem J (2013) 0.82
A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis. J Biol Chem (2006) 0.82
Scaffold tailoring by a newly detected Pictet-Spenglerase activity of strictosidine synthase: from the common tryptoline skeleton to the rare piperazino-indole framework. J Am Chem Soc (2012) 0.81
Structural analysis reveals DNA binding properties of Rv2827c, a hypothetical protein from Mycobacterium tuberculosis. J Struct Funct Genomics (2009) 0.81
Nonspecific base recognition mediated by water bridges and hydrophobic stacking in ribonuclease I from Escherichia coli. Protein Sci (2008) 0.81
Purification, crystallization and preliminary X-ray analysis of the HsdR subunit of the EcoR124I endonuclease from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.81
Structures of alkaloid biosynthetic glucosidases decode substrate specificity. ACS Chem Biol (2011) 0.81
Structural insight in histo-blood group binding by the F18 fimbrial adhesin FedF. Mol Microbiol (2012) 0.81
Expression, purification, crystallization and preliminary X-ray analysis of perakine reductase, a new member of the aldo-keto reductase enzyme superfamily from higher plants. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.81
Vinorine synthase from Rauvolfia: the first example of crystallization and preliminary X-ray diffraction analysis of an enzyme of the BAHD superfamily. Biochim Biophys Acta (2004) 0.81
Advanced Crystallographic Data Collection Protocols for Experimental Phasing. Methods Mol Biol (2016) 0.80
Structural basis of potent and broad HIV-1 fusion inhibitor CP32M. J Biol Chem (2012) 0.79
Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives. Bioorg Med Chem (2005) 0.79
Heterologous expression, purification, crystallization and preliminary X-ray analysis of raucaffricine glucosidase, a plant enzyme specifically involved in Rauvolfia alkaloid biosynthesis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.79
The X-ray structure of the N-terminal domain of PILB from Neisseria meningitidis reveals a thioredoxin-fold. J Mol Biol (2006) 0.79