Published in Nature on August 31, 2011
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Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet (2012) 4.08
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Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
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HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease. Nucleic Acids Res (2015) 1.36
Metabolomics and cardiovascular biomarker discovery. Clin Chem (2011) 1.36
Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease. Mol Cell Proteomics (2012) 1.36
Metabolomics in nutritional epidemiology: identifying metabolites associated with diet and quantifying their potential to uncover diet-disease relations in populations. Am J Clin Nutr (2014) 1.35
A genome-wide association study of the human metabolome in a community-based cohort. Cell Metab (2013) 1.33
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OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A (2014) 1.24
Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits. Hum Mol Genet (2013) 1.23
Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. JAMA (2013) 1.22
Role of plasma kallikrein in diabetes and metabolism. Thromb Haemost (2013) 1.22
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Targeted metabolomics profiles are strongly correlated with nutritional patterns in women. Metabolomics (2012) 1.13
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Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. Cell Metab (2015) 1.11
GLiMMPS: robust statistical model for regulatory variation of alternative splicing using RNA-seq data. Genome Biol (2013) 1.11
Genetic and epigenetic regulation of gene expression in fetal and adult human livers. BMC Genomics (2014) 1.09
Analytical methods in untargeted metabolomics: state of the art in 2015. Front Bioeng Biotechnol (2015) 1.08
Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem. Front Genet (2013) 1.07
An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins. Nat Commun (2014) 1.06
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes (2013) 1.06
Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis. Front Genet (2014) 1.06
Genetic analysis of the metabolome exemplified using a rice population. Proc Natl Acad Sci U S A (2013) 1.04
Diving through the "-omics": the case for deep phenotyping and systems epidemiology. OMICS (2012) 1.03
Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery. Drug Discov Today (2013) 1.03
Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes. J Clin Invest (2011) 1.03
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Translational regulation shapes the molecular landscape of complex disease phenotypes. Nat Commun (2015) 1.02
Toward new biomarkers of cardiometabolic diseases. Cell Metab (2013) 1.02
Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism. Eur J Epidemiol (2014) 1.01
Pleiotropic genes for metabolic syndrome and inflammation. Mol Genet Metab (2014) 1.01
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Network medicine approaches to the genetics of complex diseases. Discov Med (2012) 1.00
Addressing human variability in next-generation human health risk assessments of environmental chemicals. Environ Health Perspect (2012) 1.00
Statistical methods for the analysis of high-throughput metabolomics data. Comput Struct Biotechnol J (2013) 1.00
Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster. Aging Cell (2014) 0.99
Personalized genomic disease risk of volunteers. Proc Natl Acad Sci U S A (2013) 0.99
On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies. BMC Bioinformatics (2012) 0.99
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Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study. PLoS One (2012) 0.98
GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence. Diabetologia (2014) 0.97
Cellular genomics for complex traits. Nat Rev Genet (2012) 0.97
Large-scale metabolomic profiling identifies novel biomarkers for incident coronary heart disease. PLoS Genet (2014) 0.97
Liver enzymes, metabolomics and genome-wide association studies: from systems biology to the personalized medicine. World J Gastroenterol (2015) 0.96
Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease. Transl Psychiatry (2015) 0.96
Genetic regulation of mouse liver metabolite levels. Mol Syst Biol (2014) 0.95
The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression. Mol Psychiatry (2013) 0.95
Genetic determinants influencing human serum metabolome among African Americans. PLoS Genet (2014) 0.95
Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses. PLoS Genet (2015) 0.94
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Development and validation of a robust automated analysis of plasma phospholipid fatty acids for metabolic phenotyping of large epidemiological studies. Genome Med (2013) 0.93
Metabolomic analysis of key regulatory metabolites in hepatitis C virus-infected tree shrews. Mol Cell Proteomics (2012) 0.92
Metabolomics in pneumonia and sepsis: an analysis of the GenIMS cohort study. Intensive Care Med (2013) 0.91
Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links. PLoS Genet (2014) 0.91
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. J Clin Invest (2015) 0.90
Analyzing and mapping sweat metabolomics by high-resolution NMR spectroscopy. PLoS One (2011) 0.89
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. Genet Epidemiol (2013) 0.89
Neuroinflammation and comorbidities are frequently ignored factors in CNS pathology. Neural Regen Res (2015) 0.89
Acylcarnitines--old actors auditioning for new roles in metabolic physiology. Nat Rev Endocrinol (2015) 0.89
Serum biomarkers of habitual coffee consumption may provide insight into the mechanism underlying the association between coffee consumption and colorectal cancer. Am J Clin Nutr (2015) 0.88
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat Commun (2016) 0.88
Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma. Genome Med (2013) 0.88
Genetics of human metabolism: an update. Hum Mol Genet (2015) 0.87
Association between gout and polymorphisms in GCKR in male Han Chinese. Hum Genet (2012) 0.86
A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study. Prostaglandins Leukot Essent Fatty Acids (2014) 0.86
Differences in metabolomic and transcriptomic profiles between responders and non-responders to an n-3 polyunsaturated fatty acids (PUFAs) supplementation. Genes Nutr (2012) 0.86
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A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet (2009) 30.09
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature (2009) 12.58
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
SLCO1B1 variants and statin-induced myopathy--a genomewide study. N Engl J Med (2008) 11.31
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet (2009) 8.39
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KORA-gen--resource for population genetics, controls and a broad spectrum of disease phenotypes. Gesundheitswesen (2005) 7.93
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet (2008) 7.05
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base. Pharmacogenomics J (2001) 5.94
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet (2008) 5.23
A genome-wide perspective of genetic variation in human metabolism. Nat Genet (2009) 5.00
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet (2008) 4.69
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Nat Genet (2008) 4.67
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Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. PLoS Genet (2009) 4.24
Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75
Analysis of the adult human plasma metabolome. Pharmacogenomics (2008) 3.74
SLC2A9 is a high-capacity urate transporter in humans. PLoS Med (2008) 2.87
Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS One (2010) 2.84
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Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. Blood (2009) 2.64
Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats. Toxicol Pathol (2009) 2.16
Genome-wide association meta-analysis for total serum bilirubin levels. Hum Mol Genet (2009) 1.96
The SLC22 drug transporter family. Pflugers Arch (2003) 1.95
Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. Hum Mol Genet (2009) 1.87
Bioinformatics analysis of targeted metabolomics--uncovering old and new tales of diabetic mice under medication. Endocrinology (2008) 1.75
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Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genet (2011) 1.30
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Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. Cancer Epidemiol Biomarkers Prev (2008) 1.10
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Getting biological about the genetics of diabetes. Nat Med (2010) 1.05
AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. Cancer Res (2009) 1.04
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Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes. Diabetes (2015) 0.85
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Gender-specific pathway differences in the human serum metabolome. Metabolomics (2015) 0.83
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Lipoprotein(a): there's life in the old dog yet. Circulation (2014) 0.82
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A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes (2017) 0.75
A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population. PLoS One (2017) 0.75
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Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: a cross-sectional analysis in population-based data. Int J Epidemiol (2016) 0.75
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Automated pathway and reaction prediction facilitates in silico identification of unknown metabolites in human cohort studies. J Chromatogr B Analyt Technol Biomed Life Sci (2017) 0.75
Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes. Diabetologia (2016) 0.75
Comprehensive metabolic characterization of serum osteocalcin action in a large non-diabetic sample. PLoS One (2017) 0.75
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