Published in DNA Res on June 26, 2013
Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect (2014) 1.03
The evidence for functional non-CpG methylation in mammalian cells. Epigenetics (2014) 1.02
Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: An ENVIRONAGE birth cohort study. Epigenetics (2015) 0.99
MethPat: a tool for the analysis and visualisation of complex methylation patterns obtained by massively parallel sequencing. BMC Bioinformatics (2016) 0.91
Environmental exposure and mitochondrial epigenetics: study design and analytical challenges. Hum Genet (2014) 0.89
Epigenetic Modification of Mitochondrial DNA in the Development of Diabetic Retinopathy. Invest Ophthalmol Vis Sci (2015) 0.87
Mitochondrial DNA variants can mediate methylation status of inflammation, angiogenesis and signaling genes. Hum Mol Genet (2015) 0.85
Expanded genetic codes in next generation sequencing enable decontamination and mitochondrial enrichment. PLoS One (2014) 0.84
Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease: The Role of DNA Hydroxymethylation and TET Proteins. Medicine (Baltimore) (2015) 0.83
The mitochondrial epigenome: a role in Alzheimer's disease? Epigenomics (2014) 0.83
Insulin resistance is associated with epigenetic and genetic regulation of mitochondrial DNA in obese humans. Clin Epigenetics (2015) 0.82
Nuclear and mitochondrial DNA alterations in newborns with prenatal exposure to cigarette smoke. Int J Environ Res Public Health (2015) 0.81
Redox-based epigenetic status in drug addiction: a potential contributor to gene priming and a mechanistic rationale for metabolic intervention. Front Neurosci (2015) 0.80
CpG methylation patterns of human mitochondrial DNA. Sci Rep (2016) 0.80
Epigenomics and bolting tolerance in sugar beet genotypes. J Exp Bot (2015) 0.79
Mitochondrial mutations in subjects with psychiatric disorders. PLoS One (2015) 0.78
DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated? Front Genet (2015) 0.78
Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries. Sci Rep (2016) 0.78
Integrating mitochondriomics in children's environmental health. J Appl Toxicol (2015) 0.77
Quantification of global mitochondrial DNA methylation levels and inverse correlation with age at two CpG sites. Aging (Albany NY) (2016) 0.76
Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation. Age (Dordr) (2016) 0.76
Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases. Br J Pharmacol (2016) 0.76
Energizing Genetics and Epi-genetics: Role in the Regulation of Mitochondrial Function. Curr Genomics (2014) 0.75
Experimental mitochondria-targeted DNA methylation identifies GpC methylation, not CpG methylation, as potential regulator of mitochondrial gene expression. Sci Rep (2017) 0.75
Review: can diet influence the selective advantage of mitochondrial DNA haplotypes? Biosci Rep (2015) 0.75
Mitochondrial DNA in innate immune responses and inflammatory pathology. Nat Rev Immunol (2017) 0.75
Opening up the DNA methylome of dementia. Mol Psychiatry (2017) 0.75
Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids. PLoS One (2016) 0.75
Synonymous codon usage bias in plant mitochondrial genes is associated with intron number and mirrors species evolution. PLoS One (2015) 0.75
Occupational exposure to particles and mitochondrial DNA - relevance for blood pressure. Environ Health (2017) 0.75
Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome. Semin Cancer Biol (2017) 0.75
Maternal smoking during pregnancy is associated with mitochondrial DNA methylation. Environ Epigenet (2016) 0.75
SMRT Sequencing Revealed Mitogenome Characteristics and Mitogenome-Wide DNA Modification Pattern in Ophiocordyceps sinensis. Front Microbiol (2017) 0.75
Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP. Stem Cells Int (2017) 0.75
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science (2009) 18.82
Eukaryotic cytosine methyltransferases. Annu Rev Biochem (2005) 15.45
Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci (2006) 13.32
A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Proc Natl Acad Sci U S A (2006) 10.63
CpG islands and the regulation of transcription. Genes Dev (2011) 9.50
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell (2011) 9.16
Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc Natl Acad Sci U S A (2000) 8.12
Mitochondrial pseudogenes: evolution's misplaced witnesses. Trends Ecol Evol (2001) 7.83
Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates. PLoS One (2010) 6.38
Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes Cells (2006) 5.68
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev (2011) 4.09
Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome. Cell (2012) 4.00
Genomic patterns of DNA methylation: targets and function of an epigenetic mark. Curr Opin Cell Biol (2007) 3.54
Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks. PLoS Genet (2012) 2.89
Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metab (2009) 2.76
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation. Nucleic Acids Res (2012) 2.55
Regulation and function of DNA methylation in plants and animals. Cell Res (2011) 2.41
RNA-directed DNA methylation. Plant Mol Biol (2000) 2.38
Pervasive CpG suppression in animal mitochondrial genomes. Proc Natl Acad Sci U S A (1994) 2.35
Cytosine-5-methyltransferases add aldehydes to DNA. Nat Chem Biol (2009) 2.31
Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development (2012) 2.24
DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. Proc Natl Acad Sci U S A (2011) 2.21
Asymmetrical distribution of CpG in an 'average' mammalian gene. Nucleic Acids Res (1982) 2.04
Mammalian mitochondrial D-loop region structural analysis: identification of new conserved sequences and their functional and evolutionary implications. Gene (1997) 1.83
Tissue-specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genomes. J Biol Chem (2011) 1.80
Early demethylation of non-CpG, CpC-rich, elements in the myogenin 5'-flanking region: a priming effect on the spreading of active demethylation. Cell Cycle (2010) 1.72
Methylated bases in DNA from Paramecium aurelia. Biochim Biophys Acta (1974) 1.57
Methylation pattern of mouse mitochondrial DNA. Nucleic Acids Res (1984) 1.54
Transcription and replication of mitochondrial DNA. Hum Reprod (2000) 1.52
Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells. In vivo and in vitro methylation. J Mol Biol (1973) 1.41
Mitochondrial DNA in mortal and immortal human cells. Genome number, integrity, and methylation. J Biol Chem (1983) 1.41
Mitochondrial DNA from various organisms does not contain internally methylated cytosine in -CCGG- sequences. Biochim Biophys Acta (1979) 1.34
5-methylcytidylic acid: absence from mitochondrial DNA of frogs and HeLa cells. Science (1974) 1.27
DNA methylation in higher plants: past, present and future. Biochim Biophys Acta (2011) 1.24
Methylation of mitochondrial DNA is not a useful marker for cancer detection. Clin Chem (2004) 1.16
Effect of aging on 5-hydroxymethylcytosine in brain mitochondria. Neurobiol Aging (2012) 1.15
In vivo methylation of mtDNA reveals the dynamics of protein-mtDNA interactions. Nucleic Acids Res (2009) 1.10
Inheritance of an epigenetic mark: the CpG DNA methyltransferase 1 is required for de novo establishment of a complex pattern of non-CpG methylation. PLoS One (2007) 1.07
Regulation of expression and activity of DNA (cytosine-5) methyltransferases in mammalian cells. Prog Mol Biol Transl Sci (2011) 1.07
Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency. Neurobiol Aging (2009) 1.05
Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development. Nucleic Acids Res (2012) 1.05
Conservation and divergence in eukaryotic DNA methylation. Proc Natl Acad Sci U S A (2010) 1.02
What are the determinants of gene expression levels and breadths in the human genome? Hum Mol Genet (2011) 0.96
Mitochondrial DNA: A Blind Spot in Neuroepigenetics. Biomol Concepts (2012) 0.95
Non-CpG methylation occurs in the regulatory region of the Sry gene. J Reprod Dev (2011) 0.84
The role of selection in the evolution of human mitochondrial genomes. Genetics (2005) 4.56
In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions. Mol Cell (2011) 3.67
Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome. Nat Genet (2004) 3.32
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics (2005) 3.19
Molecular subtypes and phenotypic expression of Beckwith-Wiedemann syndrome. Eur J Hum Genet (2005) 2.62
The H19 locus acts in vivo as a tumor suppressor. Proc Natl Acad Sci U S A (2008) 1.98
Hypomethylation at multiple maternally methylated imprinted regions including PLAGL1 and GNAS loci in Beckwith-Wiedemann syndrome. Eur J Hum Genet (2008) 1.59
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. Proc Natl Acad Sci U S A (2003) 1.56
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell (2013) 1.56
Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer. PLoS One (2008) 1.56
Mechanisms causing imprinting defects in familial Beckwith-Wiedemann syndrome with Wilms' tumour. Hum Mol Genet (2006) 1.38
DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma. Oncotarget (2012) 1.33
Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Aging Cell (2013) 1.33
Association of the mitochondrial DNA haplogroup J with longevity is population specific. Eur J Hum Genet (2004) 1.32
Management of hilar biliary strictures. Am J Gastroenterol (2007) 1.27
Handgrip strength among nonagenarians and centenarians in three European regions. J Gerontol A Biol Sci Med Sci (2006) 1.25
Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome. Hum Mol Genet (2011) 1.22
The KCNQ1OT1 imprinting control region and non-coding RNA: new properties derived from the study of Beckwith-Wiedemann syndrome and Silver-Russell syndrome cases. Hum Mol Genet (2011) 1.17
The molecular function and clinical phenotype of partial deletions of the IGF2/H19 imprinting control region depends on the spatial arrangement of the remaining CTCF-binding sites. Hum Mol Genet (2012) 1.16
Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumour. Hum Mol Genet (2008) 1.13
Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: in vitro and in vivo anti-tumor activity. Oncotarget (2014) 1.07
Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease. PLoS One (2010) 1.06
miR-29b induces SOCS-1 expression by promoter demethylation and negatively regulates migration of multiple myeloma and endothelial cells. Cell Cycle (2013) 1.06
Global DNA methylation in old subjects is correlated with frailty. Age (Dordr) (2011) 1.05
The Arabidopsis SUPERMAN protein is able to specifically bind DNA through its single Cys2-His2 zinc finger motif. Nucleic Acids Res (2002) 1.03
The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster. Hum Mol Genet (2005) 1.02
Human longevity and 11p15.5: a study in 1321 centenarians. Eur J Hum Genet (2009) 1.00
Radial neck fractures in children: results when open reduction is indicated. J Pediatr Orthop (2014) 0.99
Acute hemorrhagic cyst of the ligamentum flavum. J Spinal Disord Tech (2007) 0.98
MS-MLPA is a specific and sensitive technique for detecting all chromosome 11p15.5 imprinting defects of BWS and SRS in a single-tube experiment. Eur J Hum Genet (2008) 0.98
Mitochondrial DNA involvement in human longevity. Biochim Biophys Acta (2006) 0.98
Frailty phenotypes in the elderly based on cluster analysis: a longitudinal study of two Danish cohorts. Evidence for a genetic influence on frailty. Age (Dordr) (2011) 0.97
The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect. Biogerontology (2009) 0.97
High frequency of loss of heterozygosity at 11p15 and IGF2 overexpression are not related to clinical outcome in childhood adrenocortical tumors positive for the R337H TP53 mutation. Cancer Genet Cytogenet (2008) 0.96
The impact of mitochondrial DNA on human lifespan: a view from studies on centenarians. Biotechnol J (2008) 0.96
A case of Beckwith-Wiedemann syndrome caused by a cryptic 11p15 deletion encompassing the centromeric imprinted domain of the BWS locus. J Med Genet (2009) 0.95
Epigenetics and aging. Maturitas (2012) 0.95
APOE polymorphism affects episodic memory among non demented elderly subjects. Exp Gerontol (2008) 0.94
Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes. Aging (Albany NY) (2013) 0.94
The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring. BMC Genomics (2007) 0.93
Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity. Exp Gerontol (2011) 0.93
Global DNA methylation levels are modulated by mitochondrial DNA variants. Epigenomics (2012) 0.93
Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity. PLoS One (2011) 0.93
Prognostic significance of the short physical performance battery in older patients discharged from acute care hospitals. Rejuvenation Res (2011) 0.93
Heat shock response by EBV-immortalized B-lymphocytes from centenarians and control subjects: a model to study the relevance of stress response in longevity. Exp Gerontol (2004) 0.92
Gain of function in CDKN1C. Nat Genet (2012) 0.92
Surgical therapy of goiter plunged in the mediastinum. Considerations regarding our experience with 165 patients. Chir Ital (2008) 0.91
The genetic component of human longevity: analysis of the survival advantage of parents and siblings of Italian nonagenarians. Eur J Hum Genet (2011) 0.91
SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress. Gene (2012) 0.91
External lymphatic fistula after intra-abdominal lymphadenectomy for cancer. Treatment with total parenteral nutrition and somatostatin. Nutrition (2008) 0.91
Human longevity within an evolutionary perspective: the peculiar paradigm of a post-reproductive genetics. Exp Gerontol (2007) 0.91
Hemostatic matrix sealant in neurosurgery: a clinical and imaging study. Acta Neurochir (Wien) (2010) 0.90
Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines. Genes Cells (2006) 0.90
TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells. Aging (Albany NY) (2012) 0.90
Slipped capital femoral epiphysis: an ultrastructural study before and after osteosynthesis. Acta Orthop (2010) 0.90
Targeting inflammation to slow or delay functional decline: where are we? Biogerontology (2010) 0.89
Exploring the role of genetic variability and lifestyle in oxidative stress response for healthy aging and longevity. Int J Mol Sci (2013) 0.89
A novel, population-specific approach to define frailty. Age (Dordr) (2010) 0.89
A novel microdeletion in the IGF2/H19 imprinting centre region defines a recurrent mutation mechanism in familial Beckwith-Wiedemann syndrome. Eur J Med Genet (2011) 0.88
Genetic and epigenetic mutations affect the DNA binding capability of human ZFP57 in transient neonatal diabetes type 1. FEBS Lett (2013) 0.88
Silver-Russell syndrome and Beckwith-Wiedemann syndrome phenotypes associated with 11p duplication in a single family. Pediatr Dev Pathol (2010) 0.88
Reappraisal of surgical indications and approach for liver hemangioma: single-center experience on 74 patients. Am J Surg (2010) 0.88
Resistance of mtDNA-depleted cells to apoptosis. Cytometry A (2008) 0.87
Nephrological findings and genotype-phenotype correlation in Beckwith-Wiedemann syndrome. Pediatr Nephrol (2011) 0.86
Mitochondrial DNA haplogroups and highly active antiretroviral therapy-related lipodystrophy. Clin Infect Dis (2008) 0.86
A common polymorphism in the UCP3 promoter influences hand grip strength in elderly people. Biogerontology (2011) 0.86
Paternal imprints can be established on the maternal Igf2-H19 locus without altering replication timing of DNA. Hum Mol Genet (2003) 0.86
A novel sampling design to explore gene-longevity associations: the ECHA study. Eur J Hum Genet (2007) 0.86
Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study. PLoS One (2010) 0.86
Relationship between renal function and physical performance in elderly hospitalized patients. Rejuvenation Res (2012) 0.85
Developmentally regulated functions of the H19 differentially methylated domain. Hum Mol Genet (2003) 0.85
Imprinting at the PLAGL1 domain is contained within a 70-kb CTCF/cohesin-mediated non-allelic chromatin loop. Nucleic Acids Res (2013) 0.84
Paternal deletion of the 11p15.5 centromeric-imprinting control region is associated with alteration of imprinted gene expression and recurrent severe intrauterine growth restriction. J Med Genet (2012) 0.84
Silver-Russell syndrome following in vitro fertilization. Pediatr Dev Pathol (2008) 0.84
CORRELATION BETWEEN HUMP DIMENSIONS AND CURVE SEVERITY IN IDIOPATHIC SCOLIOSIS BEFORE AND AFTER CONSERVATIVE TREATMENT. Spine (Phila Pa 1976) (2011) 0.84
The PEG13-DMR and brain-specific enhancers dictate imprinted expression within the 8q24 intellectual disability risk locus. Epigenetics Chromatin (2014) 0.83
TP53*P72 allele influences negatively female life expectancy in a population of central Italy: cross-sectional study and genetic-demographic approach analysis. J Gerontol A Biol Sci Med Sci (2012) 0.83
[Thoracotomy enucleation of a giant leiomyoma of the upper oesophagus. Case report and review of the literature]. Chir Ital (2007) 0.83
Galeazzi's modified technique for recurrent patella dislocation in skeletally immature patients. J Orthop Sci (2012) 0.83
Surgery for isolated liver metastases from pancreatic cancer. Updates Surg (2015) 0.83
Transparent equine collagen biomatrix as dural repair. A prospective clinical study. Acta Neurochir (Wien) (2009) 0.83
Genetic polymorphism of the major regulatory element HS-40 upstream of the human alpha-globin gene cluster. Br J Haematol (2002) 0.83
An iterative method for tomographic x-ray perfusion estimation in a decomposition model-based approach. Med Phys (2010) 0.83
Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans. Biogerontology (2013) 0.82
To grow old in southern Italy: a comprehensive description of the old and oldest old in Calabria. Gerontology (2010) 0.82
Giant breast tumors in a patient with Beckwith-Wiedemann syndrome. Am J Med Genet A (2013) 0.82
Wilms tumor and constitutional epigenetic defects. Nat Genet (2008) 0.82
Prevalence of Beckwith-Wiedemann syndrome in North West of Italy. Am J Med Genet A (2013) 0.82
UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts. Mech Ageing Dev (2012) 0.81
Handgrip strength: indications of paternal inheritance in three European regions. J Gerontol A Biol Sci Med Sci (2010) 0.81