Published in Clin Epigenetics on March 25, 2015
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Epigenetic Signatures of Cigarette Smoking. Circ Cardiovasc Genet (2016) 0.88
Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes. Clin Epigenetics (2015) 0.88
Nutrition and Inflammation in Older Individuals: Focus on Vitamin D, n-3 Polyunsaturated Fatty Acids and Whey Proteins. Nutrients (2016) 0.83
Dietary Flaxseed Mitigates Impaired Skeletal Muscle Regeneration: in Vivo, in Vitro and in Silico Studies. Int J Med Sci (2016) 0.83
Epigenetics of Aging. Curr Genomics (2015) 0.79
Epigenetic Mechanisms in Bone Biology and Osteoporosis: Can They Drive Therapeutic Choices? Int J Mol Sci (2016) 0.78
Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation. Curr Opin Pharmacol (2015) 0.78
Nutritional Genomics and the Mediterranean Diet's Effects on Human Cardiovascular Health. Nutrients (2016) 0.77
Inflammatory Markers Change with Age, but do not Fall Beyond Reported Normal Ranges. Arch Immunol Ther Exp (Warsz) (2015) 0.76
Age-related epigenetic drift and phenotypic plasticity loss: implications in prevention of age-related human diseases. Epigenomics (2016) 0.76
The Immunomodulatory Effects of Plant Extracts and Plant Secondary Metabolites on Chronic Neuroinflammation and Cognitive Aging: A Mechanistic and Empirical Review. Front Pharmacol (2017) 0.75
Bariatric Surgery: Bad to the Bone, Part 2. Integr Med (Encinitas) (2016) 0.75
The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer's disease: an overview of pre-clinical studies and translational perspectives in clinical practice. Infect Agent Cancer (2017) 0.75
DNA methylation of oxidative stress genes and cancer risk in the Normative Aging Study. Am J Cancer Res (2016) 0.75
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Developmental Origins of Cardiometabolic Diseases: Role of the Maternal Diet. Front Physiol (2016) 0.75
Combined Effects of Phytochemicals and Exercise on Fatty Acid Oxidation. J Exerc Nutrition Biochem (2017) 0.75
Vitamin C, Aging and Alzheimer's Disease. Nutrients (2017) 0.75
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An integrated encyclopedia of DNA elements in the human genome. Nature (2012) 64.73
DNA methylation patterns and epigenetic memory. Genes Dev (2002) 33.83
Mapping and analysis of chromatin state dynamics in nine human cell types. Nature (2011) 24.37
Personal genomes: The case of the missing heritability. Nature (2008) 19.56
Epigenetics in cancer. N Engl J Med (2008) 17.36
Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat Rev Genet (2010) 15.70
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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell (2010) 15.20
Effect of in utero and early-life conditions on adult health and disease. N Engl J Med (2008) 14.46
The hallmarks of aging. Cell (2013) 14.29
Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov (2006) 11.77
Environmental epigenomics and disease susceptibility. Nat Rev Genet (2007) 11.02
Integrative analysis of 111 reference human epigenomes. Nature (2015) 10.32
Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science (2005) 10.02
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell (2012) 9.88
Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet (2007) 9.88
Caloric restriction delays disease onset and mortality in rhesus monkeys. Science (2009) 9.84
Discovery and characterization of chromatin states for systematic annotation of the human genome. Nat Biotechnol (2010) 9.84
ATP-citrate lyase links cellular metabolism to histone acetylation. Science (2009) 8.82
Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer (2003) 8.06
Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic Acids Res (2004) 7.50
Polyphenols: food sources and bioavailability. Am J Clin Nutr (2004) 7.46
Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet (2009) 7.07
Epigenetic protein families: a new frontier for drug discovery. Nat Rev Drug Discov (2012) 6.70
Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell (2012) 6.50
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer (2010) 6.27
The IKK NF-kappa B system: a treasure trove for drug development. Nat Rev Drug Discov (2004) 6.21
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell (2007) 6.07
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Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res (2011) 6.02
DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet (2009) 5.99
Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol (2002) 5.91
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol (2013) 5.89
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nat Commun (2011) 5.66
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev (2006) 5.61
DNA methylation and body-mass index: a genome-wide analysis. Lancet (2014) 5.49
Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution. Nat Genet (2002) 5.37
Nutritional control of reproductive status in honeybees via DNA methylation. Science (2008) 5.13
Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res (2007) 5.13
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep (2011) 4.89
Chromatin dynamics during epigenetic reprogramming in the mouse germ line. Nature (2008) 4.69
Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr (2005) 4.57
Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol (2006) 4.55
Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect (2006) 4.46
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature (2011) 4.41
Polycomb group proteins: navigators of lineage pathways led astray in cancer. Nat Rev Cancer (2009) 4.40
Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period. Eur J Hum Genet (2002) 4.33
ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell (2011) 4.26
Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med (2008) 4.25
Rethinking how DNA methylation patterns are maintained. Nat Rev Genet (2009) 4.03
Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell (2013) 3.83
Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell (2012) 3.65
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Epigenetics and aging: the targets and the marks. Trends Genet (2007) 3.44
Cancer is a preventable disease that requires major lifestyle changes. Pharm Res (2008) 3.28
Transgenerational epigenetic effects. Annu Rev Genomics Hum Genet (2008) 3.16
DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science (2008) 3.09
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders. Nat Rev Drug Discov (2014) 3.09
Function and information content of DNA methylation. Nature (2015) 3.09
Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition (2004) 3.08
In utero effects. In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism. Science (2014) 3.07
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci (2010) 3.05
The rise of regulatory RNA. Nat Rev Genet (2014) 3.02
Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle (2010) 3.00
Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res (2010) 2.99
Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity. Circulation (2013) 2.95
A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element. Nat Genet (2014) 2.94
Royalactin induces queen differentiation in honeybees. Nature (2011) 2.91
Individualized medicine from prewomb to tomb. Cell (2014) 2.76
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature (2013) 2.76
Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metab (2009) 2.76
Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life. BJOG (2008) 2.74
Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr (2009) 2.71
Developmental origins of non-communicable disease: implications for research and public health. Environ Health (2012) 2.65
The Dutch famine and its long-term consequences for adult health. Early Hum Dev (2006) 2.64
Influence of metabolism on epigenetics and disease. Cell (2013) 2.64
Chromatin proteins and modifications as drug targets. Nature (2013) 2.60
Metabolic regulation of epigenetics. Cell Metab (2012) 2.55
Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood. Hum Mol Genet (2011) 2.48
Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations. Br J Nutr (2007) 2.48
Moving AHEAD with an international human epigenome project. Nature (2008) 2.38
The maternal and fetal origins of cardiovascular disease. J Epidemiol Community Health (1992) 2.38
Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci (2014) 2.37
Inflammation and oncogenesis: a vicious connection. Curr Opin Genet Dev (2009) 2.35
Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature (2009) 2.35
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. Diabetes (2009) 2.34
Environmental epigenetics and asthma: current concepts and call for studies. Am J Respir Crit Care Med (2008) 2.26
Obesity related methylation changes in DNA of peripheral blood leukocytes. BMC Med (2010) 2.24
Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab (2011) 2.22
Methyl donor supplementation prevents transgenerational amplification of obesity. Int J Obes (Lond) (2008) 2.19
Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan. Cell Metab (2014) 2.11
Epigenetic transgenerational actions of endocrine disruptors. Endocrinology (2006) 2.08
Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice. PLoS Genet (2006) 2.07
Environmental epigenomics in human health and disease. Environ Mol Mutagen (2008) 2.06
Histone methyl transferases and demethylases; can they link metabolism and transcription? Cell Metab (2010) 2.04
DNA methylation as a biomarker for cardiovascular disease risk. PLoS One (2010) 2.04
Nutrition, epigenetics, and developmental plasticity: implications for understanding human disease. Annu Rev Nutr (2010) 1.97
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun (2014) 1.96