Autoimmune diseases: the failure of self tolerance.

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Published in Science on June 15, 1990

Authors

A A Sinha1, M T Lopez, H O McDevitt

Author Affiliations

1: Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305.

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Interaction between I region loci influences the expression of a cell surface Ia antigen. Proc Natl Acad Sci U S A (1980) 1.20