Published in J Exp Med on October 01, 1984
The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique. Proc Natl Acad Sci U S A (1987) 2.77
HLA class II allelic variation and susceptibility to pemphigus vulgaris. Proc Natl Acad Sci U S A (1988) 2.72
Molecular diversity of HLA-DR4 haplotypes. Proc Natl Acad Sci U S A (1986) 2.40
Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J Exp Med (1994) 2.23
EBI2 mediates B cell segregation between the outer and centre follicle. Nature (2009) 2.20
Sequence analysis and structure-function correlations of murine q, k, u, s, and f haplotype I-A beta cDNA clones. Proc Natl Acad Sci U S A (1986) 1.39
Molecular genetic analysis of 178 I-Abm12-reactive T cells. J Exp Med (1989) 1.36
Cotransfer of the Ed alpha and Ad beta genes into L cells results in the surface expression of a functional mixed-isotype Ia molecule. Proc Natl Acad Sci U S A (1986) 1.17
Shared T cell recognition sites on human histocompatibility leukocyte antigen class II molecules of patients with seropositive rheumatoid arthritis. J Clin Invest (1986) 1.14
Molecular analysis of antigen recognition by insulin-specific T-cell hybridomas from B6 wild-type and bm12 mutant mice. Mol Cell Biol (1987) 1.11
Genetic control of T cell responsiveness to the Friend murine leukemia virus envelope antigen. Identification of class II loci of the H-2 as immune response genes. J Exp Med (1988) 1.11
Structural requirements for recognition of the HLA-Dw14 class II epitope: a key HLA determinant associated with rheumatoid arthritis. Proc Natl Acad Sci U S A (1990) 1.03
HLA-DR2 subtypes form an additional supertypic family of DR beta alleles. Proc Natl Acad Sci U S A (1987) 1.03
A molecular basis for the Ia.2 and Ia.19 antigenic determinants. Proc Natl Acad Sci U S A (1985) 0.99
Polymorphic DQ alpha and DQ beta interactions dictate HLA class II determinants of allo-recognition. J Exp Med (1990) 0.97
A determination of the frequency of gene conversion in unmanipulated mouse sperm. Proc Natl Acad Sci U S A (1994) 0.91
The contribution of mutant amino acids to alloantigenicity. J Exp Med (1989) 0.90
Sequence and evolution of HLA-DR7- and -DRw53-associated beta-chain genes. Proc Natl Acad Sci U S A (1987) 0.89
Peripheral deletion of rheumatoid factor B cells after abortive activation by IgG. Proc Natl Acad Sci U S A (1997) 0.86
Regulation of immune responses by I-J gene products. VI. Recognition of I-E molecules by I-J-bearing suppressor factors. J Exp Med (1986) 0.86
Predicted protein sequence of the murine I-E-beta S-polypeptide chain from cDNA and genomic clones. Proc Natl Acad Sci U S A (1985) 0.85
The murine bm12 gene conversion provides evidence that T cells recognize predominantly Ia conformation. Proc Natl Acad Sci U S A (1985) 0.82
CCR5 is required for regulation of alloreactive T-cell responses to single class II MHC-mismatched murine cardiac grafts. Am J Transplant (2009) 0.81
Intergenic exchange maintains identity between two human lambda light chain immunoglobulin gene intron sequences. Nucleic Acids Res (1988) 0.80
Pathogenesis of rheumatoid arthritis: its relevance to therapy in the '90s. Trans Am Clin Climatol Assoc (1991) 0.78
Lessons and limits of mouse models. Cold Spring Harb Perspect Med (2013) 0.78
Novel CD8 T cell alloreactivities in CCR5-deficient recipients of class II MHC disparate kidney grafts. J Immunol (2014) 0.77
Role of a Novel Human Leukocyte Antigen-DQA1*01:02;DRB1*15:01 Mixed Isotype Heterodimer in the Pathogenesis of "Humanized" Multiple Sclerosis-like Disease. J Biol Chem (2015) 0.75
Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08
Screening lambdagt recombinant clones by hybridization to single plaques in situ. Science (1977) 83.82
Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing. J Mol Biol (1980) 61.16
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv Immunol (1979) 15.58
Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes. Cell (1980) 14.88
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region. Cell (1981) 9.54
Gene conversion: some implications for immunoglobulin genes. Cell (1981) 6.70
Genetic recombination: strand transfer and mismatch repair. Annu Rev Biochem (1978) 5.79
Two-gene control of the expression of a murine Ia antigen. J Exp Med (1978) 4.79
Antigen-reactive T cell clones. I. Transcomplementing hybrid I-A-region gene products function effectively in antigen presentation. J Exp Med (1980) 4.47
Determinant selection and macrophage function in genetic control of the immune response. Immunol Rev (1978) 4.24
Interaction between antigen-presenting cells and primed T lymphocytes: an assessment of Ir gene expression in the antigen-presenting cell. Immunol Rev (1978) 3.67
The traditional and a new version of the mouse H-2 complex. Nature (1981) 3.12
Complete primary structures of the E beta chain and gene of the mouse major histocompatibility complex. Proc Natl Acad Sci U S A (1983) 3.09
The murine E alpha immune response gene. Cell (1983) 2.86
Regions of allelic hypervariability in the murine A alpha immune response gene. Cell (1983) 2.53
Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon. Cell (1983) 2.42
B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse. J Exp Med (1979) 2.28
Clonal analysis of B- and T-cell responses to Ia antigens. I. Topology of epitope regions on I-Ak and I-Ek molecules analyzed with 35 monoclonal alloantibodies. Immunogenetics (1981) 2.27
A potential donor gene for the bm1 gene conversion event in the C57BL mouse. Nature (1984) 2.18
Nucleotide sequence of mutant I-A beta bm12 gene is evidence for genetic exchange between mouse immune response genes. Nature (1984) 2.09
Murine I-A beta chain polymorphism: nucleotide sequences of three allelic I-A beta genes. Science (1983) 2.04
Isolation and characterization of a cDNA clone for the murine I-E beta polypeptide chain. Proc Natl Acad Sci U S A (1983) 1.54
Ir gene function in an I-A subregion mutant B6.C-H-2bm12. J Exp Med (1981) 1.51
Selective loss of antigen-specific Ir gene function in IA mutant B6.C-H-2bm12 is an antigen presenting cell defect. Proc Natl Acad Sci U S A (1981) 1.40
Clones of alloreactive T cells. I. A. unique homozygous MLR-stimulating determinant present on B6 stimulators. Immunogenetics (1980) 1.36
Reconstitution of Ir genes, Ia antigens, and mixed lymphocyte reaction determinants by gene complementation. Proc Natl Acad Sci U S A (1981) 1.35
The I-Ab mutant B6.C-H-2bm12 allows definition of multiple T cell epitopes on I-A molecules. J Exp Med (1983) 1.28
Functional expression of a transfected murine class II MHC gene. Nature (1984) 1.22
The role of H-2 I region genes in regulation of the immune response. J Immunogenet (1981) 1.17
Tryptic peptide comparison of Ia antigen alpha and beta polypeptides from the I-A mutant B6.C-H-2bm12 and its congenic parental strain B6. Immunogenetics (1981) 1.08
Detection of an altered I-A beta polypeptide in the murine Ir mutant, B6.C-h-2bm12. J Immunol (1982) 1.00
Evidence for mutation in an I-A gene. Nature (1980) 1.00
Molecular analysis of human class II transplantation antigens and their genes. Hum Immunol (1983) 0.90
Genetic control of the immune response to haemoglobin. III. Variant A beta (bm12) but not Ae (D2.GD) Ia polypeptides alter immune responsiveness towards the alpha -subunit of human haemoglobin. J Immunogenet (1981) 0.85
A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell (2000) 17.61
Histocompatibility-linked immune response genes. Science (1972) 16.79
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature (1987) 10.70
Genetic control of specific immune responses. Adv Immunol (1969) 8.81
Genetic control of the antibody response. I. Demonstration of determinant-specific differences in response to synthetic polypeptide antigens in two strains of inbred mice. J Exp Med (1965) 7.27
Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A (1997) 6.99
Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol (1996) 6.44
A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes. J Exp Med (1976) 6.11
Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell (1988) 5.73
HL-A, immune-response genes, and disease. Lancet (1974) 5.67
Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells. J Exp Med (1989) 5.65
Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today (1995) 5.32
Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature (1993) 5.10
Two-gene control of the expression of a murine Ia antigen. J Exp Med (1978) 4.79
Genetic control of the antibody response: relationship between immune response and histocompatibility (H-2) type. Science (1969) 4.53
Antigen-reactive T cell clones. I. Transcomplementing hybrid I-A-region gene products function effectively in antigen presentation. J Exp Med (1980) 4.47
Genetic control of the immune response. Mapping of the Ir-1 locus. J Exp Med (1972) 3.96
Genetic control of the antibody response in inbred mice. Transfer of response by spleen cells and linkage to the major histocompatibility (H-2) locus. J Exp Med (1968) 3.52
Tumour necrosis factor-alpha in murine autoimmune 'lupus' nephritis. Nature (1988) 3.46
Polyarginine enters cells more efficiently than other polycationic homopolymers. J Pept Res (2000) 3.41
A sensitive radioimmunoassay for detecting products translated from cloned DNA fragments. Cell (1978) 3.30
The localization of antigen in relation to specific antibody-producing cells. I. Use of a synthetic polypeptide [(T,G)-A--L] labelled with iodine-125. Immunology (1966) 3.09
Analysis of HLA-D region-associated molecules with monoclonal antibody. Proc Natl Acad Sci U S A (1979) 3.06
Genetic control of the immune response. The effect of thymectomy on the primary and secondary antibody response of mice to poly-L(tyr, glu)-poly-D, L-ala--poly-L-lys. J Exp Med (1972) 3.06
CD8(+) T cell-mediated spontaneous diabetes in neonatal mice. J Immunol (1996) 3.02
Selective expression of H-2 (i-region) loci controlling determinants on helper and suppressor T lymphocytes. J Exp Med (1976) 2.94
In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon. J Exp Med (1987) 2.93
Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus. Proc Natl Acad Sci U S A (1990) 2.88
The murine E alpha immune response gene. Cell (1983) 2.86
Detection of a common polypeptide chain in I--A and I--E sub-region immunoprecipitates. Mol Immunol (1979) 2.86
Endotoxin-induced uveitis in rats as a model for human disease. Nature (1980) 2.85
Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes. Proc Natl Acad Sci U S A (1983) 2.84
Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. Cell (1989) 2.77
The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique. Proc Natl Acad Sci U S A (1987) 2.77
Histocompatibility (HL-A) antigens associated with systemic lupus erythematosus. A possible genetic predisposition to disease. N Engl J Med (1971) 2.69
Correlation of grain counts with radioactivity (125I and tritium) in autoradiography. Exp Cell Res (1966) 2.62
Protein clinical manifestations of primary tumors of the heart. Am J Med (1972) 2.61
Regions of allelic hypervariability in the murine A alpha immune response gene. Cell (1983) 2.53
Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes. Science (1988) 2.46
Genetic control of the antibody response. II. Further analysis of the specificity of determinant-specific control, and genetic analysis of the response to (H,G)-A--L in CBA and C57 mice. J Exp Med (1967) 2.41
Histocompatibility-linked genetic control of disease susceptibility. Murine lymphocytic choriomeningitis virus infection. J Exp Med (1973) 2.39
Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J Exp Med (1994) 2.33
The presumptive CDR3 regions of both T cell receptor alpha and beta chains determine T cell specificity for myoglobin peptides. J Exp Med (1990) 2.32
Abnormal migration of T lymphocyte clones. J Immunol (1982) 2.30
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature (1996) 2.30
A sequential model for peptide binding and transport by the transporters associated with antigen processing. Immunity (1994) 2.26
Autoimmune diseases: the failure of self tolerance. Science (1990) 2.24
Clones of alloreactive T cells. Nature (1978) 2.21
Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study. Proc Natl Acad Sci U S A (1988) 2.19
Genetic and functional analysis of the Ia antigens: their possible role in regulating the immune response. Transplant Rev (1976) 2.15
Definition of T cell idiotypes using anti-idiotypic antisera produced by immunization with T cell clones. J Exp Med (1982) 2.14
Genetic control of the antibody response to poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys in C3H--CWB tetraparental mice. J Exp Med (1974) 2.14
Variable synthesis and expression of E alpha and Ae (E beta) Ia polypeptide chains in mice of different H-2 haplotypes. Immunogenetics (1981) 2.13
Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1. Proc Natl Acad Sci U S A (1990) 2.13
A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity (1994) 2.09
The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity (1996) 2.05
Thymus cell maturation. II. Differentiation of three "mature" subclasses in vivo. Cell Immunol (1975) 2.04
T cell recognition as the target for immune intervention in autoimmune disease. Cell (1989) 2.04
Correlation of T cell receptor V beta gene family with MHC restriction. J Exp Med (1987) 2.04
In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis. Proc Natl Acad Sci U S A (1981) 2.00
The structure of T-cell epitopes. Annu Rev Immunol (1987) 1.99
Increased frequency of HLA-Cw3 and HLA-Dw4 in rheumatoid arthritis. Arthritis Rheum (1977) 1.95
Genetic control of the antibody response. 3. Qualitative and quantitative characterization of the antibody response to (T,G)-A--L in CBA and C57 mice. J Immunol (1968) 1.94
Insulin-dependent diabetes mellitus: the initial lesion. N Engl J Med (1981) 1.93
Allelic variation in the DR subregion of the human major histocompatibility complex. Proc Natl Acad Sci U S A (1987) 1.92
Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling. J Exp Med (1997) 1.92
In vitro secondary mixed leukocyte reaction (MLR). II. Interaction MLR determinants expressed by F1 cells. Eur J Immunol (1977) 1.90
Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis. J Exp Med (1988) 1.89
Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis. Proc Natl Acad Sci U S A (1996) 1.85
Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumours. EMBO J (1989) 1.81
Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies. J Exp Med (1983) 1.79
CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice. J Immunol (1997) 1.79
T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages. J Exp Med (1990) 1.79
H-2 gene complementation in cytotoxic T cell responses of female against male cells. Eur J Immunol (1977) 1.75
The nature of the antigenic determinant in a genetic control of the antibody response. J Exp Med (1969) 1.74
Characterization of HLA-D-region antigens by two-dimensional gel electrophoresis. Molecular-genotyping. J Exp Med (1980) 1.73
CD4+ but not CD8+ cells are essential for allorejection. J Exp Med (1996) 1.72
Disrupted splenic architecture, but normal lymph node development in mice expressing a soluble lymphotoxin-beta receptor-IgG1 fusion protein. Proc Natl Acad Sci U S A (1996) 1.71
The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology. Proc Natl Acad Sci U S A (1983) 1.69
Ia alloantigen(s) detected on thymocytes by use of a fluorescence-activated cell sorter. J Immunol (1975) 1.65
Mapping of the class II region of the human major histocompatibility complex by pulsed-field gel electrophoresis. Nature (1986) 1.64
Modulation of CD4 by antigenic activation. J Immunol (1987) 1.63
Evidence for a role of Ir-associated alloantigens in mixed lymphocyte culture stimulation. J Exp Med (1974) 1.62
Major histocompatibility complex-restricted antigen presentation to antigen-reactive T cells by B lymphocyte tumor cells. J Exp Med (1981) 1.60
Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen. Nature (1993) 1.60
The genetic control of antibody specificity. J Exp Med (1969) 1.58
Structure of murine Ia antigens: partial NH2-terminal amino acid sequences of products of the I-E or I-C subregion. Proc Natl Acad Sci U S A (1977) 1.56
Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation. J Exp Med (1986) 1.56
Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science (1992) 1.56
Genetic control of the immune response. Frequency and characteristics of antigen-binding cells in high and low responder mice. J Exp Med (1973) 1.55
Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis. J Exp Med (1997) 1.55
Isolation and characterization of a cDNA clone for the murine I-E beta polypeptide chain. Proc Natl Acad Sci U S A (1983) 1.54
Genetic control of radiation leukemia virus-induced tumorigenesis. I. Role of the major murine histocompatibility complex, H-2. J Exp Med (1977) 1.54
Increased synthesis and expression of H-2 antigens on thymocytes as a result of radiation leukemia virus infection: a possible mechanism for H-2 linked control of virus-induced neoplasia. J Exp Med (1978) 1.53
In vivo therapy with monoclonal anti-I-A antibody suppresses immune responses to acetylcholine receptor. Proc Natl Acad Sci U S A (1983) 1.52
Regulation of the immune response by the major histocompatibility system. N Engl J Med (1980) 1.52
Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein. Proc Natl Acad Sci U S A (1988) 1.51
Genetic control of the immune response: in vitro stimulation of lymphocytes by (T,G)-A--L, (H,G)-A--L, and (Phe,G)-A--L. J Exp Med (1974) 1.50