Published in N Engl J Med on July 22, 1971
Predominance of histocompatibility antigen HL-A8 in patients with gluten-sensitive enteropathy. J Clin Invest (1972) 3.09
Host genetic control of recovery from Friend leukemia virus-induced splenomegaly: mapping of a gene within the major histocompatability complex. J Exp Med (1974) 2.89
Coeliac disease and immunological disorders. Br Med J (1978) 2.07
Unraveling the genetics of systemic lupus erythematosus. Springer Semin Immunopathol (2006) 1.64
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Hepatitis B antigen (HBAg) infection in a hemodialysis unit. I. HL-A8 and immune response to HBAg. Can Med Assoc J (1975) 1.45
The association of HLA-B8 with visceral disease in systemic sclerosis. Clin Exp Immunol (1978) 1.45
Histocompatibility antigens in active chronic hepatitis and primary biliary cirrhosis. Br Med J (1974) 1.45
Oral ulceration and Behçet's syndrome. Gut (1977) 1.31
Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus. J Clin Invest (1975) 1.28
Steroid-responsive nephrotic syndrome and allergy: immunological studies. Arch Dis Child (1981) 1.24
Ethnic difference in the prevalence of systemic lupus erythematosus. Ann Rheum Dis (1983) 1.20
Clinical and laboratory aspects of raised virus antibody titres in systemic lupus erythematosus. Ann Rheum Dis (1973) 1.19
HLA-A, B antigens and alpha 1-antitrypsin phenotypes in nodal generalised osteoarthritis and erosive osteoarthritis. Ann Rheum Dis (1989) 1.18
Genetic associations between myasthenia gravis and the HL-A system. J Neurol Neurosurg Psychiatry (1976) 1.08
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Anti-Ro(SSA) autoantibodies are associated with T cell receptor beta genes in systemic lupus erythematosus patients. J Clin Invest (1990) 0.96
Neonatal lupus erythematosus: five new cases with HLA typing. Can Med Assoc J (1983) 0.95
The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity. J Clin Invest (2010) 0.93
HLA antigen frequency of Northern Ireland blood donors. Ulster Med J (1978) 0.91
Increased incidence of HL-A 1 and 8 in patients showing IgG or complement coating on their red cells. J Clin Pathol (1974) 0.90
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Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations. Am J Hum Genet (2012) 0.87
HL--A typing in Northern Ireland 1971-74. Ulster Med J (1975) 0.86
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Recognition of self and altered self by T cells in autoimmunity and allergy. Protein Cell (2013) 0.85
HLA antigens in systemic lupus erythematosus. Ann Rheum Dis (1977) 0.84
Iridocyclitis in black Americans: association with HLA B8 suggests an autoimmune aetiology. Br J Ophthalmol (1981) 0.83
Role of MHC-linked susceptibility genes in the pathogenesis of human and murine lupus. Clin Dev Immunol (2012) 0.83
Human leukocyte antigen (HLA) in Korean patients with autoimmune thyroid diseases. Korean J Intern Med (1986) 0.81
HLA-antigens in systemic lupus erythematosus (SLE). Arch Dermatol Res (1979) 0.81
Diseases associated with specific HL-A antigens. Can Med Assoc J (1975) 0.79
Leucocyte migration-inhibition in systemic lupus erythematosus. Ann Rheum Dis (1974) 0.78
HLA-A and B antigen frequencies and mesothelioma in relation to asbestos exposure. Br J Cancer (1983) 0.78
Hürthle cells predict hypothyroidism in interferon-γ transgenic mice of different genetic backgrounds. Endocrinology (2012) 0.78
Human histocompatibility antigen associations in subacute cutaneous lupus erythematosus. J Clin Invest (1981) 0.78
The genetics of acute lung injury: looking back and pointing the way forward. Crit Care (2009) 0.75
The MHC locus and genetic susceptibility to autoimmune and infectious diseases. Genome Biol (2017) 0.75
Commentary. EB virus, infectious mononucleosis, and cancer: the closing of the web. Yale J Biol Med (1974) 0.75
Recent advances in the immunopathogenesis of systemic lupus erythematosus. West J Med (1975) 0.75
Dermatitis herpetiformis and leiomyomas with HLA-B8, a marker of immune diseases. Can Med Assoc J (1976) 0.75
Histocompatibility-linked immune response genes. Science (1972) 16.79
Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis. Cell (1978) 14.82
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature (1987) 10.70
Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature (1987) 10.21
Genetic control of specific immune responses. Adv Immunol (1969) 8.81
The number of balanced polymorphisms that can be maintained in a natural population. Genetics (1967) 8.80
Genetic control of the antibody response. I. Demonstration of determinant-specific differences in response to synthetic polypeptide antigens in two strains of inbred mice. J Exp Med (1965) 7.27
Linkage and selection: theoretical analysis of the deterministic two locus random mating model. Genetics (1967) 7.12
Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A (1997) 6.99
Monoclonal antibodies for analysis of the HLA system. Immunol Rev (1979) 6.63
A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes. J Exp Med (1976) 6.11
Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell (1988) 5.73
HL-A, immune-response genes, and disease. Lancet (1974) 5.67
p53 mutations in colorectal cancer. Proc Natl Acad Sci U S A (1990) 5.43
Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today (1995) 5.32
Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature (1993) 5.10
Use of a monoclonal antibody (W6/32) in structural studies of HLA-A,B,C, antigens. J Immunol (1979) 5.06
Two-gene control of the expression of a murine Ia antigen. J Exp Med (1978) 4.79
Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects. Blood (2001) 4.65
A migration matrix model for the study of random genetic drift. Genetics (1968) 4.59
Genetic control of the antibody response: relationship between immune response and histocompatibility (H-2) type. Science (1969) 4.53
Chromosome 5 allele loss in human colorectal carcinomas. Nature (1987) 4.46
HL-A antigens and disease. Statistical and genetical considerations. Tissue Antigens (1974) 4.41
Monoclonal antibody to cytokeratin for use in routine histopathology. J Clin Pathol (1984) 4.36
Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci U S A (1999) 4.35
The ABC of APC. Hum Mol Genet (2001) 4.16
Evolutionary significance of the HL-A system. Nature (1972) 4.06
Genetic control of the immune response. Mapping of the Ir-1 locus. J Exp Med (1972) 3.96
Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture. Int J Cancer (1981) 3.90
Beta-catenin mutations in cell lines established from human colorectal cancers. Proc Natl Acad Sci U S A (1997) 3.79
Activation of human T lymphocyte subsets: helper and suppressor/cytotoxic T cells recognize and respond to distinct histocompatibility antigens. J Immunol (1981) 3.69
Genetic control of the antibody response in inbred mice. Transfer of response by spleen cells and linkage to the major histocompatibility (H-2) locus. J Exp Med (1968) 3.52
Tumour necrosis factor-alpha in murine autoimmune 'lupus' nephritis. Nature (1988) 3.46
Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas. Lancet (1992) 3.44
Prevention of transfusion-acquired cytomegalovirus infections in newborn infants. J Pediatr (1981) 3.42
IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens (2000) 3.41
APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits". Proc Natl Acad Sci U S A (2000) 3.41
The Eurasian heartland: a continental perspective on Y-chromosome diversity. Proc Natl Acad Sci U S A (2001) 3.38
A sensitive radioimmunoassay for detecting products translated from cloned DNA fragments. Cell (1978) 3.30
Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens. Eur J Immunol (1979) 3.27
Nomenclature for factors of the HLA system, 2010. Tissue Antigens (2010) 3.22
Recombination and integration in Bacillus subtilis transformation: involvement of DNA synthesis. J Mol Biol (1965) 3.21
Familial testicular cancer: a report of the UK family register, estimation of risk and an HLA class 1 sib-pair analysis. Br J Cancer (1992) 3.10
The localization of antigen in relation to specific antibody-producing cells. I. Use of a synthetic polypeptide [(T,G)-A--L] labelled with iodine-125. Immunology (1966) 3.09
Evolution of sickle variant gene. Lancet (1979) 3.09
Familial patterns of narcolepsy. Lancet (1989) 3.07
Analysis of HLA-D region-associated molecules with monoclonal antibody. Proc Natl Acad Sci U S A (1979) 3.06
Genetic control of the immune response. The effect of thymectomy on the primary and secondary antibody response of mice to poly-L(tyr, glu)-poly-D, L-ala--poly-L-lys. J Exp Med (1972) 3.06
CD8(+) T cell-mediated spontaneous diabetes in neonatal mice. J Immunol (1996) 3.02
Selective expression of H-2 (i-region) loci controlling determinants on helper and suppressor T lymphocytes. J Exp Med (1976) 2.94
In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon. J Exp Med (1987) 2.93
Monoclonal antibody to a human histocompatibility alloantigen, HLA-A2. Nature (1978) 2.93
Evolution and function of the HLA system. Br Med Bull (1978) 2.91
Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus. Proc Natl Acad Sci U S A (1990) 2.88
The murine E alpha immune response gene. Cell (1983) 2.86
Detection of a common polypeptide chain in I--A and I--E sub-region immunoprecipitates. Mol Immunol (1979) 2.86
Endotoxin-induced uveitis in rats as a model for human disease. Nature (1980) 2.85
Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes. Proc Natl Acad Sci U S A (1983) 2.84
Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. Cell (1989) 2.77
The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique. Proc Natl Acad Sci U S A (1987) 2.77
The mutation rate and cancer. Proc Natl Acad Sci U S A (1996) 2.73
CpG island clones from a deletion encompassing the gene for adenomatous polyposis coli. Proc Natl Acad Sci U S A (1989) 2.66
Correlation of grain counts with radioactivity (125I and tritium) in autoradiography. Exp Cell Res (1966) 2.62
Protein clinical manifestations of primary tumors of the heart. Am J Med (1972) 2.61
Genetic control of the immune response. A selective defect in immunologic (IgG) memory in nonresponder mice. J Exp Med (1972) 2.60
HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients. Sleep (1997) 2.59
Human genetics: the molecular challenge. Cold Spring Harb Symp Quant Biol (1986) 2.54
Regions of allelic hypervariability in the murine A alpha immune response gene. Cell (1983) 2.53
cDNA clones coding for the heavy chain of human HLA-DR antigen. Proc Natl Acad Sci U S A (1982) 2.51
Targeting of iodine-123-labelled tumour-associated monoclonal antibodies to ovarian, breast, and gastrointestinal tumours. Lancet (1982) 2.51
Genetic control of the antibody response. II. Further analysis of the specificity of determinant-specific control, and genetic analysis of the response to (H,G)-A--L in CBA and C57 mice. J Exp Med (1967) 2.41
The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin. Tissue Antigens (1978) 2.40
Histocompatibility-linked genetic control of disease susceptibility. Murine lymphocytic choriomeningitis virus infection. J Exp Med (1973) 2.39
Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J Exp Med (1994) 2.33
Integration of deoxyribonuclease-treated DNA in bacillus subtilis transformation. J Gen Physiol (1966) 2.32
The beta2-microglobulin gene is on chromosome 15 and not in the HL-A region. Nature (1975) 2.29
The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. Proc Natl Acad Sci U S A (1998) 2.27
Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours. Nat Genet (2000) 2.26
A sequential model for peptide binding and transport by the transporters associated with antigen processing. Immunity (1994) 2.26
Autoimmune diseases: the failure of self tolerance. Science (1990) 2.24
Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. Science (1996) 2.22
Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study. Proc Natl Acad Sci U S A (1988) 2.19
Sequence of an HLA-DR alpha-chain cDNA clone and intron-exon organization of the corresponding gene. Nature (1982) 2.18
IMGT/HLA Database--a sequence database for the human major histocompatibility complex. Nucleic Acids Res (2001) 2.17
Genetic and functional analysis of the Ia antigens: their possible role in regulating the immune response. Transplant Rev (1976) 2.15
Genetic control of the antibody response to poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys in C3H--CWB tetraparental mice. J Exp Med (1974) 2.14
Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1. Proc Natl Acad Sci U S A (1990) 2.13
Variable synthesis and expression of E alpha and Ae (E beta) Ia polypeptide chains in mice of different H-2 haplotypes. Immunogenetics (1981) 2.13
A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity (1994) 2.09
DQ (rather than DR) gene marks susceptibility to narcolepsy. Lancet (1992) 2.08
The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity (1996) 2.05
Cellular distrubtion, purification, and molecular nature of human Ia antigens. Scand J Immunol (1977) 2.04
T cell recognition as the target for immune intervention in autoimmune disease. Cell (1989) 2.04
Chromosomal localisation of the human homologues to the oncogenes erbA and B. EMBO J (1984) 2.02
A monoclonal antibody that detects HLA-D region antigen in routinely fixed, wax embedded sections of normal and neoplastic lymphoid tissues. J Clin Pathol (1985) 2.00
In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis. Proc Natl Acad Sci U S A (1981) 2.00