PubRank

Thierry Levade

Author PubWeight™ 82.75‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem 2006 2.96
2 Recommendations on the diagnosis and management of Niemann-Pick disease type C. Mol Genet Metab 2009 2.78
3 Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem 2008 2.31
4 Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision? Autophagy 2007 1.28
5 Sphingomyelin hydrolysis during apoptosis. Biochim Biophys Acta 2002 1.27
6 Incidence and natural history of mucopolysaccharidosis type III in France and comparison with United Kingdom and Greece. Am J Med Genet A 2011 1.26
7 The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing. FASEB J 2007 1.25
8 Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis. Proc Natl Acad Sci U S A 2002 1.23
9 Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression. Blood 2005 1.20
10 Danon's disease (X-linked vacuolar cardiomyopathy and myopathy): a case with a novel Lamp-2 gene mutation. Neuromuscul Disord 2002 1.13
11 Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1. Am J Hum Genet 2012 1.11
12 Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways. Arterioscler Thromb Vasc Biol 2002 1.11
13 Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation. Cancer Res 2009 1.11
14 Ceramide-induced autophagy: to junk or to protect cells? Autophagy 2009 1.09
15 Striking phenotypic variability in two familial cases of myosin storage myopathy with a MYH7 Leu1793pro mutation. Neuromuscul Disord 2009 1.07
16 Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes 2011 1.05
17 Lysosomes and lysosomal proteins in cancer cell death (new players of an old struggle). Biochim Biophys Acta 2005 1.04
18 Glutathione peroxidase-1 protects from CD95-induced apoptosis. J Biol Chem 2002 1.03
19 Functions of sphingolipid metabolism in mammals--lessons from genetic defects. Biochim Biophys Acta 2008 1.03
20 IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. PLoS One 2009 1.01
21 Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis. J Biol Chem 2005 1.00
22 Sphingolipids as modulators of cancer cell death: potential therapeutic targets. Biochim Biophys Acta 2006 0.98
23 N-acetylcysteine prevents the deleterious effect of tumor necrosis factor-(alpha) on calcium transients and contraction in adult rat cardiomyocytes. Circulation 2004 0.98
24 Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues. Chem Phys Lipids 2006 0.96
25 FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response. J Immunol 2009 0.96
26 Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases. Chembiochem 2007 0.96
27 Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23. PLoS One 2012 0.95
28 On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem 2014 0.94
29 Systemic ceramide accumulation leads to severe and varied pathological consequences. EMBO Mol Med 2013 0.94
30 A simple fluorogenic method for determination of acid ceramidase activity and diagnosis of Farber disease. J Lipid Res 2010 0.94
31 Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage. Hum Mol Genet 2008 0.93
32 Potential roles of membrane fluidity and ceramide in hyperthermia and alcohol stimulation of TRAIL apoptosis. Apoptosis 2007 0.93
33 The natural marine anhydrophytosphingosine, Jaspine B, induces apoptosis in melanoma cells by interfering with ceramide metabolism. Biochem Pharmacol 2009 0.93
34 Neutral sphingomyelinase inhibition participates to the benefits of N-acetylcysteine treatment in post-myocardial infarction failing heart rats. J Mol Cell Cardiol 2007 0.93
35 Ceramide production associated with retinal apoptosis after retinal detachment. Graefes Arch Clin Exp Ophthalmol 2008 0.92
36 A MANBA mutation resulting in residual beta-mannosidase activity associated with severe leukoencephalopathy: a possible pseudodeficiency variant. BMC Med Genet 2009 0.91
37 Regulation of autophagy by sphingolipids. Anticancer Agents Med Chem 2011 0.91
38 Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine. J Biol Chem 2011 0.91
39 Sphingolipids in macroautophagy. Methods Mol Biol 2008 0.90
40 Role of FAN in tumor necrosis factor-alpha and lipopolysaccharide-induced interleukin-6 secretion and lethality in D-galactosamine-sensitized mice. J Biol Chem 2004 0.89
41 The French Gaucher's disease registry: clinical characteristics, complications and treatment of 562 patients. Orphanet J Rare Dis 2012 0.89
42 Synthesis of cytotoxic aza analogues of jaspine B. J Org Chem 2010 0.89
43 CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation. Proc Natl Acad Sci U S A 2011 0.88
44 Beta-mannosidosis: a new cause of spinocerebellar ataxia. Clin Neurol Neurosurg 2008 0.88
45 Autologous transplantation of lentivector/acid ceramidase-transduced hematopoietic cells in nonhuman primates. Hum Gene Ther 2011 0.88
46 Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss. PLoS Genet 2010 0.87
47 The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells. FASEB J 2012 0.87
48 Abnormal iron metabolism in fibroblasts from a patient with the neurodegenerative disease hereditary ferritinopathy. Mol Neurodegener 2010 0.87
49 The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior. Psychopharmacology (Berl) 2008 0.87
50 Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk. PLoS One 2010 0.85
51 FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling. J Leukoc Biol 2010 0.84
52 Palmitoyl protein thioesterase 1 modulates tumor necrosis factor alpha-induced apoptosis. Biochim Biophys Acta 2009 0.84
53 Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer. Pharmacol Res 2003 0.83
54 Ara-C- and daunorubicin-induced recruitment of Lyn in sphingomyelinase-enriched membrane rafts. FASEB J 2002 0.83
55 Lysosomal storage diseases: is impaired apoptosis a pathogenic mechanism? Neurochem Res 2004 0.83
56 Lethal toxin from Clostridium sordellii induces apoptotic cell death by disruption of mitochondrial homeostasis in HL-60 cells. Cell Microbiol 2003 0.83
57 Sphingolipid signalling: molecular basis and role in TNF-alpha-induced cell death. Expert Rev Mol Med 2002 0.83
58 In vivo delivery of human acid ceramidase via cord blood transplantation and direct injection of lentivirus as novel treatment approaches for Farber disease. Mol Genet Metab 2008 0.83
59 The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs. FASEB J 2003 0.82
60 Expression of p27(Kip1) in bladder cancers: immunohistochemical study and prognostic value in a series of 95 cases. Cancer Lett 2002 0.82
61 Regulation of cell death by sphingosine 1-phosphate lyase. Autophagy 2010 0.82
62 Danon disease: further clinical and molecular heterogeneity. Muscle Nerve 2009 0.81
63 Human genetic disorders of sphingolipid biosynthesis. J Inherit Metab Dis 2014 0.81
64 Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1. Toxicol Appl Pharmacol 2004 0.81
65 Enhanced skeletal muscle lipid oxidative efficiency in insulin-resistant vs insulin-sensitive nondiabetic, nonobese humans. J Clin Endocrinol Metab 2013 0.80
66 Ceramide in regulation of apoptosis. Implication in multitoxicant resistance. Subcell Biochem 2002 0.80
67 Mannose 6-phosphorylated proteins are required for tumor necrosis factor-induced apoptosis: defective response in I-cell disease fibroblasts. J Biol Chem 2004 0.80
68 Phosphatidylcholine-derived phosphatidic acid and diacylglycerol are involved in the signaling pathways activated by docetaxel. J Exp Ther Oncol 2003 0.80
69 Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner. J Biol Chem 2009 0.80
70 Detection of an intragenic deletion expands the spectrum of CTSC mutations in Papillon-Lefèvre syndrome. J Invest Dermatol 2007 0.79
71 Production of multiple brain-like ganglioside species is dispensable for fas-induced apoptosis of lymphoid cells. PLoS One 2011 0.79
72 [Sphingolipid-mediated apoptotic signaling pathways]. J Soc Biol 2003 0.79
73 Apolipoprotein E-deficient mice develop an anti-Chlamydophila pneumoniae T helper 2 response and resist vascular infection. J Infect Dis 2010 0.78
74 Refsum's disease may mimic familial Guillain Barre syndrome. Neuromuscul Disord 2006 0.78
75 Accumulation of ordered ceramide-cholesterol domains in farber disease fibroblasts. JIMD Rep 2013 0.78
76 C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors. Org Biomol Chem 2006 0.78
77 Hypoketotic hypoglycemia with myolysis and hypoparathyroidism: an unusual association in medium chain acyl-CoA desydrogenase deficiency (MCADD). J Pediatr Endocrinol Metab 2009 0.77
78 Morniga G: a plant lectin as an endocytic ligand for photosensitizer molecule targeting toward tumor-associated T/Tn antigens. Photochem Photobiol 2010 0.77
79 Molecular basis of acid ceramidase deficiency in a neonatal form of Farber disease: identification of the first large deletion in ASAH1 gene. Mol Genet Metab 2013 0.76
80 The pro-inflammatory action of tumour necrosis factor-α in non-alcoholic steatohepatitis is independent of the NSMAF gene product. Dig Liver Dis 2012 0.76
81 Is active acid sphingomyelinase required for the antiproliferative response to rituximab? Blood 2011 0.76
82 Alteration of ceramide 1-O-functionalization as a promising approach for cancer therapy. Anticancer Agents Med Chem 2012 0.76
83 Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis. Biochim Biophys Acta 2012 0.76
84 New insights into the organ-specific adverse effects of fumonisin B1: comparison between lung and liver. Arch Toxicol 2014 0.75
85 Refsum Disease Presenting with a Late-Onset Leukodystrophy. JIMD Rep 2015 0.75
86 The tricyclodecan-9-yl-xanthogenate D609 triggers ceramide increase and enhances FasL-induced caspase-dependent and -independent cell death in T lymphocytes. Int J Mol Sci 2012 0.75
87 Targeting of T/Tn antigens with a plant lectin to kill human leukemia cells by photochemotherapy. PLoS One 2011 0.75
88 Extensive Mongolian spots in 4p16.3 deletion (Wolf-Hirschhorn syndrome). Clin Dysmorphol 2014 0.75
89 Genetic disorders of simple sphingolipid metabolism. Handb Exp Pharmacol 2013 0.75
90 [Current management of Fabry disease]. Nephrol Ther 2006 0.75
91 Identification of novel CERT ligands as potential ceramide trafficking inhibitors. Chembiochem 2014 0.75
92 Farber lipogranulomatosis with predominant joint involvement mimicking juvenile idiopathic arthritis. J Inherit Metab Dis 2013 0.75
93 Danon disease: intrafamilial phenotypic variability related to a novel LAMP-2 mutation. J Inherit Metab Dis 2010 0.75