Published in Virchows Arch on October 21, 2009
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Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am J Hum Genet (2011) 5.18
450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect (2012) 4.89
Personalized epigenomic signatures that are stable over time and covary with body mass index. Sci Transl Med (2010) 3.81
Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment. PLoS Med (2010) 2.20
Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease. Int J Epidemiol (2012) 2.12
Epigenetic regulation of gene expression in keratinocytes. J Invest Dermatol (2012) 1.32
Measuring the methylome in clinical samples: improved processing of the Infinium Human Methylation450 BeadChip Array. Epigenetics (2012) 1.30
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The Janus face of DNA methylation in aging. Aging (Albany NY) (2010) 1.17
MethHC: a database of DNA methylation and gene expression in human cancer. Nucleic Acids Res (2014) 1.17
Maternal genome-wide DNA methylation patterns and congenital heart defects. PLoS One (2011) 1.16
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Genetics and epigenetics of obesity. Maturitas (2011) 1.14
Stress and the epigenetic landscape: a link to the pathobiology of human diseases? Nat Rev Genet (2010) 1.13
Cadmium exposure and clinical cardiovascular disease: a systematic review. Curr Atheroscler Rep (2013) 1.05
Novel region discovery method for Infinium 450K DNA methylation data reveals changes associated with aging in muscle and neuronal pathways. Aging Cell (2013) 1.05
Methylomic analysis identifies frequent DNA methylation of zinc finger protein 582 (ZNF582) in cervical neoplasms. PLoS One (2012) 0.99
Epigenetics and autoimmune diseases. Autoimmune Dis (2012) 0.97
Genomic imprinting in diabetes. Genome Med (2010) 0.97
The epigenomic interface between genome and environment in common complex diseases. Brief Funct Genomics (2010) 0.96
Association of global DNA methylation and global DNA hydroxymethylation with metals and other exposures in human blood DNA samples. Environ Health Perspect (2014) 0.96
Epigenetics and psychoneuroimmunology: mechanisms and models. Brain Behav Immun (2010) 0.95
Disease specific characteristics of fetal epigenetic markers for non-invasive prenatal testing of trisomy 21. BMC Med Genomics (2014) 0.87
Expanding epigenomics to archived FFPE tissues: an evaluation of DNA repair methodologies. Cancer Epidemiol Biomarkers Prev (2014) 0.87
Associations between dietary intake of choline and betaine and lung cancer risk. PLoS One (2013) 0.86
Linking genome to epigenome. Wiley Interdiscip Rev Syst Biol Med (2012) 0.85
Pharmacogenetics of analgesic drugs. Br J Pain (2013) 0.83
The Epigenetic Regulation of Wound Healing. Adv Wound Care (New Rochelle) (2014) 0.82
Normal early pregnancy: a transient state of epigenetic change favoring hypomethylation. Epigenetics (2012) 0.81
Rare mutations of CACNB2 found in autism spectrum disease-affected families alter calcium channel function. PLoS One (2014) 0.80
Searching for blood DNA methylation markers of breast cancer risk and early detection. J Natl Cancer Inst (2013) 0.80
Cancer control and prevention by nutrition and epigenetic approaches. Antioxid Redox Signal (2012) 0.79
Epigenetic research in cancer epidemiology: trends, opportunities, and challenges. Cancer Epidemiol Biomarkers Prev (2013) 0.78
Human complex trait genetics: lifting the lid of the genomics toolbox - from pathways to prediction. Curr Genomics (2012) 0.78
New perspectives on rodent models of advanced paternal age: relevance to autism. Front Behav Neurosci (2011) 0.77
Nuclear DNA methylation and chromatin condensation phenotypes are distinct between normally proliferating/aging, rapidly growing/immortal, and senescent cells. Oncotarget (2013) 0.77
Variable selection in semi-parametric models. Stat Methods Med Res (2013) 0.77
DNA methylation levels are highly correlated between pooled samples and averaged values when analysed using the Infinium HumanMethylation450 BeadChip array. Clin Epigenetics (2015) 0.77
Predisposing Factors to Abnormal First Trimester Placentation and the Impact on Fetal Outcomes. Semin Reprod Med (2015) 0.75
Long-range autocorrelations of CpG islands in the human genome. PLoS One (2012) 0.75
On chromatin remodeling in mammary gland differentiation and breast tumorigenesis. Cold Spring Harb Perspect Biol (2012) 0.75
DNA methylation signatures in peripheral blood strongly predict all-cause mortality. Nat Commun (2017) 0.75
Optimization of techniques for multiple platform testing in small, precious samples such as human chorionic villus sampling. Prenat Diagn (2016) 0.75
Genome sequencing in microfabricated high-density picolitre reactors. Nature (2005) 150.21
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
CpG-rich islands and the function of DNA methylation. Nature (1986) 24.90
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet (1999) 22.84
Epigenetic programming by maternal behavior. Nat Neurosci (2004) 20.92
Accurate multiplex polony sequencing of an evolved bacterial genome. Science (2005) 20.91
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet (2009) 18.90
A HapMap harvest of insights into the genetics of common disease. J Clin Invest (2008) 18.31
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
High sensitivity mapping of methylated cytosines. Nucleic Acids Res (1994) 16.62
Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet (2005) 15.37
The history of cancer epigenetics. Nat Rev Cancer (2004) 14.38
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature (2000) 12.97
The DNA methyltransferases of mammals. Hum Mol Genet (2000) 10.66
Phenotypic plasticity and the epigenetics of human disease. Nature (2007) 10.37
Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet (2007) 9.88
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res (2005) 8.69
Comprehensive high-throughput arrays for relative methylation (CHARM). Genome Res (2008) 8.62
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci (2006) 8.24
High-throughput DNA methylation profiling using universal bead arrays. Genome Res (2006) 8.05
Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci (2006) 8.00
A novel CpG island set identifies tissue-specific methylation at developmental gene loci. PLoS Biol (2008) 7.95
Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. Am J Hum Genet (2008) 7.13
Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. Am J Epidemiol (2007) 7.06
Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science (2003) 6.85
Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17
Comparative isoschizomer profiling of cytosine methylation: the HELP assay. Genome Res (2006) 5.99
Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Am J Hum Genet (2008) 5.44
Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2. N Engl J Med (2006) 5.28
A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism. Am J Hum Genet (2008) 5.28
An integrated epigenetic and genetic approach to common human disease. Trends Genet (2004) 4.89
Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression. Proc Natl Acad Sci U S A (2005) 4.59
CpG islands--'a rough guide'. FEBS Lett (2009) 4.55
DNA methylation represses FMR-1 transcription in fragile X syndrome. Hum Mol Genet (1992) 4.22
A gene expression bar code for microarray data. Nat Methods (2007) 4.20
The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. Proc Natl Acad Sci U S A (1999) 4.13
Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. Am J Hum Genet (2002) 3.93
Mutational and selective effects on copy-number variants in the human genome. Nat Genet (2007) 3.82
X-chromosome inactivation and cell memory. Trends Genet (1992) 3.76
A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. Genome Res (2002) 3.50
The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. PLoS One (2009) 3.41
Evidence from Turner's syndrome of an imprinted X-linked locus affecting cognitive function. Nature (1997) 3.27
Epigenomics: beyond CpG islands. Nat Rev Genet (2004) 3.21
Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr (2000) 2.80
DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J Neurosci (2001) 2.75
Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science (2005) 2.72
A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 21q. Genome Res (2004) 2.56
Epigenetic marks by DNA methylation specific to stem, germ and somatic cells in mice. Genes Cells (2002) 2.52
Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets. Carcinogenesis (2006) 2.45
Hypomethylation of ras oncogenes in primary human cancers. Biochem Biophys Res Commun (1983) 2.41
Epigenetics and assisted reproductive technology: a call for investigation. Am J Hum Genet (2004) 2.41
Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr (1998) 2.36
Age-associated activation of epigenetically repressed genes in the mouse. Genetics (2003) 2.24
In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene. Am J Hum Genet (2003) 2.21
Restriction landmark genome scanning. Methods (2002) 2.20
Disruption of contactin 4 in three subjects with autism spectrum disorder. J Med Genet (2008) 2.19
Activity-dependent suppression of miniature neurotransmission through the regulation of DNA methylation. J Neurosci (2008) 2.18
GoldenGate assay for DNA methylation profiling. Methods Mol Biol (2009) 2.15
Inheritance of allelic blueprints for methylation patterns. Cell (1988) 2.00
Age related reactivation of an X-linked gene. Nature (1987) 1.92
High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers. Nucleic Acids Res (2009) 1.80
Genetic effects of methylation diets. Annu Rev Nutr (2002) 1.70
Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site. Cancer Res (2001) 1.69
Patterns of maternal transmission in bipolar affective disorder. Am J Hum Genet (1995) 1.60
Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats. Cancer Res (1995) 1.60
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Methylation meets genomics. Nat Genet (2001) 1.46
Methyl groups in carcinogenesis: effects on DNA methylation and gene expression. Cancer Res (1992) 1.36
Engineering a high-affinity methyl-CpG-binding protein. Nucleic Acids Res (2006) 1.36
From epigenesis to epigenetics: the case of C. H. Waddington. Ann N Y Acad Sci (2002) 1.30
Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat. Cancer Lett (1997) 1.29
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A (2007) 1.15
Impact of extracellular folate levels on global gene expression. Mol Pharmacol (2001) 1.10
A longitudinal study of X-inactivation ratio in human females. Hum Genet (2004) 1.05
Haloperidol treatment induces tissue- and sex-specific changes in DNA methylation: a control study using rats. Behav Brain Funct (2006) 1.01
Hypomethylation in cervical tissue: is there a correlation with folate status? Cancer Epidemiol Biomarkers Prev (1998) 1.00
Genomic imprinting and imprinting defects in humans. Adv Genet (2008) 1.00
The new field of epigenomics: implications for cancer and other common disease research. Cold Spring Harb Symp Quant Biol (2004) 0.98
The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: an introduction. J Nutr (2002) 0.93
Psychiatric epigenetics: a new focus for the new century. Mol Psychiatry (2000) 0.84
Age-related reactivation of an X-linked gene close to the inactivation centre in the mouse. Genet Res (1988) 0.82