Published in Science on February 24, 2005
A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer (2011) 11.33
High-throughput DNA methylation profiling using universal bead arrays. Genome Res (2006) 8.05
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature (2008) 7.64
Epigenetics in cancer. Carcinogenesis (2009) 7.49
Epigenetics and colorectal cancer. Nat Rev Gastroenterol Hepatol (2011) 3.15
Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nat Rev Cancer (2013) 2.41
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev (2007) 2.34
Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc Natl Acad Sci U S A (2005) 2.11
Genome-scale approaches to the epigenetics of common human disease. Virchows Arch (2009) 2.02
The H19 locus acts in vivo as a tumor suppressor. Proc Natl Acad Sci U S A (2008) 1.98
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Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development. Genes Dev (2009) 1.68
The proliferating role of insulin and insulin-like growth factors in cancer. Trends Endocrinol Metab (2010) 1.67
Growth hormone, the insulin-like growth factor axis, insulin and cancer risk. Nat Rev Endocrinol (2010) 1.61
Lsh is involved in de novo methylation of DNA. EMBO J (2006) 1.57
Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. Proc Natl Acad Sci U S A (2007) 1.54
Musashi1 modulates mammary progenitor cell expansion through proliferin-mediated activation of the Wnt and Notch pathways. Mol Cell Biol (2008) 1.47
Suppression of intestinal neoplasia by deletion of Dnmt3b. Mol Cell Biol (2006) 1.35
Animal models of colitis-associated carcinogenesis. J Biomed Biotechnol (2011) 1.33
The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling. Gastroenterology (2009) 1.30
Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate. Cancer Res (2008) 1.30
APC and its modifiers in colon cancer. Adv Exp Med Biol (2009) 1.28
Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine. Am J Pathol (2007) 1.28
Biological functions of DNA methyltransferase 1 require its methyltransferase activity. Mol Cell Biol (2007) 1.27
Histone modifications as markers of cancer prognosis: a cellular view. Br J Cancer (2007) 1.26
Toward a genetics of cancer resistance. Proc Natl Acad Sci U S A (2009) 1.25
Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin. Am J Pathol (2012) 1.23
Hypoxic tumor microenvironment and cancer cell differentiation. Curr Mol Med (2009) 1.19
Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming. EMBO J (2006) 1.19
Epigenetics: the link between nature and nurture. Mol Aspects Med (2012) 1.18
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A (2007) 1.15
Evidence for transgenerational transmission of epigenetic tumor susceptibility in Drosophila. PLoS Genet (2007) 1.12
Insulin-like growth factor-2 (IGF2) loss of imprinting marks a field defect within human prostates containing cancer. Prostate (2011) 1.12
Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach. J Med Chem (2009) 1.10
Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis. Antioxid Redox Signal (2013) 1.09
Musashi1: a stem cell marker no longer in search of a function. Cell Cycle (2008) 1.09
Promoter hypermethylation of tumour suppressor genes as potential biomarkers in colorectal cancer. Int J Mol Sci (2015) 1.09
Epigenetic modulators, modifiers and mediators in cancer aetiology and progression. Nat Rev Genet (2016) 1.07
Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor. EMBO J (2008) 1.07
IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype. J Biol Chem (2009) 1.05
Hypomethylation of the IGF2 DMR in colorectal tumors, detected by bisulfite pyrosequencing, is associated with poor prognosis. Gastroenterology (2010) 1.01
Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts. Br J Cancer (2007) 1.01
A role for VICKZ proteins in the progression of colorectal carcinomas: regulating lamellipodia formation. J Pathol (2008) 1.01
Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9. Endocrinology (2007) 0.99
Loss of IGF2 imprinting is associated with abrogation of long-range intrachromosomal interactions in human cancer cells. Hum Mol Genet (2009) 0.99
Effect of insulin-like growth factor gene polymorphisms alone or in interaction with diabetes on the risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev (2008) 0.97
Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions. Nucleic Acids Res (2011) 0.95
Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications. Carcinogenesis (2010) 0.95
Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse models. PLoS One (2012) 0.93
DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development. Epigenetics (2008) 0.92
Temporal stability and age-related prevalence of loss of imprinting of the insulin-like growth factor-2 gene. Epigenetics (2009) 0.91
DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus. World J Gastroenterol (2014) 0.91
Igf2 ligand dependency of Pten(+/-) developmental and tumour phenotypes in the mouse. Oncogene (2011) 0.90
Accumulation of aberrant DNA methylation during colorectal cancer development. World J Gastroenterol (2014) 0.90
Methylation profiling defines an extensive field defect in histologically normal prostate tissues associated with prostate cancer. Neoplasia (2013) 0.90
Chromatin insulators and cohesins. EMBO Rep (2008) 0.89
A novel locus for maternally inherited human gingival fibromatosis at chromosome 11p15. Hum Genet (2006) 0.88
Helicobacter pylori infection induces candidate stem cell marker Musashi-1 in the human gastric epithelium. Dig Dis Sci (2007) 0.88
Expression of RNA-binding protein Musashi in hair follicle development and hair cycle progression. Am J Pathol (2006) 0.88
Common features of chromatin in aging and cancer: cause or coincidence? Trends Cell Biol (2014) 0.86
Stability of genomic imprinting in human induced pluripotent stem cells. BMC Genet (2013) 0.85
Environmental Epigenetics: Crossroad between Public Health, Lifestyle, and Cancer Prevention. Biomed Res Int (2015) 0.84
Specific gene hypomethylation and cancer: new insights into coding region feature trends. Bioinformation (2009) 0.83
Loss of imprinting of IGF2 and the epigenetic progenitor model of cancer. Am J Stem Cells (2011) 0.82
Identification of a novel intronic enhancer responsible for the transcriptional regulation of musashi1 in neural stem/progenitor cells. Mol Brain (2011) 0.81
Loss of imprinting of insulin-like growth factor 2 is associated with increased risk of lymph node metastasis and gastric corpus cancer. J Exp Clin Cancer Res (2009) 0.81
IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions. World J Gastroenterol (2014) 0.80
New insights into the molecular pathogenesis of colorectal cancer. Drug Discov Today Dis Mech (2006) 0.80
IGF-II promoter specific methylation and expression in epithelial ovarian cancer and their associations with disease characteristics. Oncol Rep (2011) 0.79
Essential role of insulin-like growth factor 2 in resistance to histone deacetylase inhibitors. Oncogene (2016) 0.79
TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome. J Clin Invest (2016) 0.78
Essential role of DNA methyltransferase 1-mediated transcription of insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors. Clin Cancer Res (2016) 0.78
Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications. J Gastroenterol (2016) 0.78
Effects of somatic mutations in the C-terminus of insulin-like growth factor 1 receptor on activity and signaling. J Signal Transduct (2012) 0.78
CRISPR Cas9-guided chromatin immunoprecipitation identifies miR483 as an epigenetic modulator of IGF2 imprinting in tumors. Oncotarget (2017) 0.78
Loss of insulin-like growth factor II imprinting is a hallmark associated with enhanced chemo/radiotherapy resistance in cancer stem cells. Oncotarget (2016) 0.77
Genetic variation in insulin pathway genes and distal colorectal adenoma risk. Int J Colorectal Dis (2012) 0.76
How an imprint can lead to cancer. CMAJ (2005) 0.76
The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development. Curr Colorectal Cancer Rep (2012) 0.76
Analyzing the gene expression profile of anaplastic histology Wilms' tumor with real-time polymerase chain reaction arrays. Cancer Cell Int (2015) 0.75
DNA methylation-based variation between human populations. Mol Genet Genomics (2016) 0.75
Stromal-derived IGF2 promotes colon cancer progression via paracrine and autocrine mechanisms. Oncogene (2017) 0.75
Precision medicine based on epigenomics: the paradigm of carcinoma of unknown primary. Nat Rev Clin Oncol (2017) 0.75
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med (2002) 24.07
Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature (2010) 17.38
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54
The epigenetic progenitor origin of human cancer. Nat Rev Genet (2006) 9.65
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature (2002) 9.40
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res (2004) 9.18
Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Nat Genet (2006) 8.99
Increased methylation variation in epigenetic domains across cancer types. Nat Genet (2011) 8.92
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet (2010) 8.74
Comprehensive high-throughput arrays for relative methylation (CHARM). Genome Res (2008) 8.62
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature (2008) 7.64
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science (2009) 7.39
Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science (2003) 6.85
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol (2007) 6.69
Variation in the safety of induced pluripotent stem cell lines. Nat Biotechnol (2009) 6.39
Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17
Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature (2010) 6.06
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics (2014) 5.93
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol (2013) 5.89
Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell (2002) 5.69
Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. Nat Genet (2009) 5.52
Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell (2003) 5.36
Data Sharing. N Engl J Med (2016) 5.12
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 5.00
Dynamics of global gene expression changes during mouse preimplantation development. Dev Cell (2004) 4.97
An integrated epigenetic and genetic approach to common human disease. Trends Genet (2004) 4.89
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci U S A (2002) 4.27
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat Med (2006) 4.18
The origins of age-related proinflammatory state. Blood (2004) 4.15
Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA (2011) 4.09
Generation of transgenic non-human primates with germline transmission. Nature (2009) 4.06
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med (2009) 4.03
An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Science (2007) 4.00
New neurons follow the flow of cerebrospinal fluid in the adult brain. Science (2006) 3.98
Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. Am J Hum Genet (2002) 3.93
Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med (2009) 3.71
Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. Hum Mutat (2011) 3.63
Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies. Int J Epidemiol (2012) 3.62
Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Nat Genet (2004) 3.56
A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. Genome Res (2002) 3.50
DNA methylation signatures within the human brain. Am J Hum Genet (2007) 3.50
A web-based tool for principal component and significance analysis of microarray data. Bioinformatics (2005) 3.42
Identification of a putative intestinal stem cell and early lineage marker; musashi-1. Differentiation (2003) 3.41
Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies. Cell (2012) 3.39
Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. Immunity (2004) 3.35
Database for mRNA half-life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells. DNA Res (2008) 3.29
Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy. Cancer Biol Ther (2005) 3.28
A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord. Nat Med (2006) 3.28
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat Biotechnol (2011) 3.25
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature (2012) 3.23
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res (2002) 3.21
A putative human breast stem cell population is enriched for steroid receptor-positive cells. Dev Biol (2005) 3.19
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat Struct Mol Biol (2011) 3.00
Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma. Neuron (2013) 2.90
Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci (2006) 2.85
Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis. Clin Cancer Res (2004) 2.84
CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator. EMBO Rep (2005) 2.80
RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Proc Natl Acad Sci U S A (2002) 2.79
Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum. J Neurosci (2006) 2.79
The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide. Genome Res (2004) 2.78
Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects. Am J Hum Genet (2002) 2.73
Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. Cancer Cell (2004) 2.73
Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction. Blood (2004) 2.72
Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science (2011) 2.69
High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res (2006) 2.69
Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad. Cell Stem Cell (2008) 2.69
Precision medicine--personalized, problematic, and promising. N Engl J Med (2015) 2.67
The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. Semin Cancer Biol (2002) 2.66
Tumor heterogeneity and personalized medicine. N Engl J Med (2012) 2.63
BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A (2002) 2.62
Distinct DNA methylation changes highly correlated with chronological age in the human brain. Hum Mol Genet (2011) 2.62
Drug-Induced Megaloblastic Anemia. N Engl J Med (2015) 2.62
Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Mol Cell Biol (2006) 2.59
Insights into thymic aging and regeneration. Immunol Rev (2005) 2.55
Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. Proc Natl Acad Sci U S A (2010) 2.52
Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity. Cancer Res (2002) 2.52
Dissecting Oct3/4-regulated gene networks in embryonic stem cells by expression profiling. PLoS One (2006) 2.46
Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature (2010) 2.46
Reversible switching between epigenetic states in honeybee behavioral subcastes. Nat Neurosci (2012) 2.44
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res (2009) 2.44
Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nat Rev Cancer (2013) 2.41
Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes. Am J Pathol (2011) 2.41
Epigenetics and assisted reproductive technology: a call for investigation. Am J Hum Genet (2004) 2.41
Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. PLoS Biol (2010) 2.38
New therapies for castration-resistant prostate cancer. N Engl J Med (2010) 2.37
Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice. Hepatology (2007) 2.34
Talking with patients about dying. N Engl J Med (2012) 2.34
Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells. Nat Biotechnol (2005) 2.34
Red cell distribution width and mortality in older adults: a meta-analysis. J Gerontol A Biol Sci Med Sci (2009) 2.32
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell (2009) 2.32