Published in J Virol on October 13, 2010
Expanding roles for CD4⁺ T cells in immunity to viruses. Nat Rev Immunol (2012) 2.94
Regulating the adaptive immune response to respiratory virus infection. Nat Rev Immunol (2012) 1.87
Viral infection of the lung: host response and sequelae. J Allergy Clin Immunol (2013) 1.01
T cell responses during influenza infection: getting and keeping control. Trends Immunol (2011) 1.00
T cell-mediated host immune defenses in the lung. Annu Rev Immunol (2013) 1.00
Late engagement of CD86 after influenza virus clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner. PLoS Pathog (2014) 0.95
Partial depletion of natural CD4⁺CD25⁺ regulatory T cells with anti-CD25 antibody does not alter the course of acute influenza A virus infection. PLoS One (2011) 0.90
Prevention of Influenza Virus-Induced Immunopathology by TGF-β Produced during Allergic Asthma. PLoS Pathog (2015) 0.88
CD4(+)CD62L(+) central memory T cells can be converted to Foxp3(+) T cells. PLoS One (2013) 0.85
An analysis of regulatory T-cell and Th-17 cell dynamics during cytomegalovirus replication in solid organ transplant recipients. PLoS One (2012) 0.83
Recent insights into pulmonary repair following virus-induced inflammation of the respiratory tract. Curr Opin Virol (2012) 0.82
Recovery of an antiviral antibody response following attrition caused by unrelated infection. PLoS Pathog (2014) 0.81
CD8+ Treg cells suppress CD8+ T cell-responses by IL-10-dependent mechanism during H5N1 influenza virus infection. Eur J Immunol (2013) 0.79
New insights into the aryl hydrocarbon receptor as a modulator of host responses to infection. Semin Immunopathol (2013) 0.78
A novel DNA vaccine expressing the Ag85A-HA2 fusion protein provides protection against influenza A virus and Staphylococcus aureus. Virol J (2013) 0.77
Activation of the aryl hydrocarbon receptor during development enhances the pulmonary CD4+ T-cell response to viral infection. Am J Physiol Lung Cell Mol Physiol (2015) 0.77
The Immune Fulcrum: Regulatory T Cells Tip the Balance Between Pro- and Anti-inflammatory Outcomes upon Infection. Prog Mol Biol Transl Sci (2015) 0.75
Molecular adjuvant Ag85A enhances protection against influenza A virus in mice following DNA vaccination. Viruses (2012) 0.75
Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice. PLoS One (2013) 0.75
RAG-1-deficient mice have no mature B and T lymphocytes. Cell (1992) 20.97
Regulatory T cells and immune tolerance. Cell (2008) 18.77
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med (2006) 14.21
CTLA-4 control over Foxp3+ regulatory T cell function. Science (2008) 12.67
How regulatory T cells work. Nat Rev Immunol (2008) 11.66
Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature (2007) 10.40
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity (2008) 9.82
Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity (2009) 9.28
Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol (2009) 8.67
Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res (2009) 7.83
The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature (2007) 7.82
Monocyte-mediated defense against microbial pathogens. Annu Rev Immunol (2008) 7.21
Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature (2006) 6.46
CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med (2003) 6.00
Th17 and regulatory T cells in mediating and restraining inflammation. Cell (2010) 5.89
The pathology of influenza virus infections. Annu Rev Pathol (2008) 5.37
Coordination of early protective immunity to viral infection by regulatory T cells. Science (2008) 5.33
Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity. Nat Med (2004) 5.22
H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathog (2008) 4.79
Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurement. J Clin Virol (2004) 4.28
Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci U S A (2009) 4.25
Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nat Med (2009) 4.22
Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci U S A (2009) 4.12
CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol (2001) 4.07
Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol (2006) 3.84
Regulatory T cells in the control of host-microorganism interactions (*). Annu Rev Immunol (2009) 3.82
TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc Natl Acad Sci U S A (2009) 3.70
CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality. J Immunol (2008) 3.60
Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J Exp Med (2005) 3.48
Adaptive immune cells temper initial innate responses. Nat Med (2007) 3.37
IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol (2001) 3.22
Influenza A H5N1 replication sites in humans. Emerg Infect Dis (2005) 3.21
Functional impairment of CD8(+) T cells by regulatory T cells during persistent retroviral infection. Immunity (2004) 3.10
Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol (1996) 2.96
Plasticity of CD4(+) FoxP3(+) T cells. Curr Opin Immunol (2009) 2.93
The role of interferon in influenza virus tissue tropism. J Virol (1998) 2.88
IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge. J Immunol (2009) 2.74
Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation. J Exp Med (2005) 2.59
Regulatory T cells in virus infections. Immunol Rev (2006) 2.54
Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes. PLoS Pathog (2009) 2.44
Pathogenesis of emerging avian influenza viruses in mammals and the host innate immune response. Immunol Rev (2008) 2.41
Outcome of influenza infection: effect of site of initial infection and heterotypic immunity. Infect Immun (1980) 2.35
Contribution of virus-specific CD8+ cytotoxic T cells to virus clearance or pathologic manifestations of influenza virus infection in a T cell receptor transgenic mouse model. J Exp Med (1998) 2.31
Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions. Eur J Immunol (2009) 2.21
Tregs control the development of symptomatic West Nile virus infection in humans and mice. J Clin Invest (2009) 2.18
Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection. Proc Natl Acad Sci U S A (2001) 2.04
Innate immune responses to influenza A H5N1: friend or foe? Trends Immunol (2009) 1.89
The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity. Immunol Rev (2003) 1.79
Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1. J Leukoc Biol (1996) 1.75
The acquired immune system: a vantage from beneath. Immunity (2004) 1.64
Naturally occurring lung CD4(+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta. J Immunol (2007) 1.63
Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities. J Immunol (2005) 1.54
Regulatory T cells promote early influx of CD8+ T cells in the lungs of respiratory syncytial virus-infected mice and diminish immunodominance disparities. J Virol (2009) 1.51
In vivo sites and cellular mechanisms of T reg cell-mediated suppression. J Exp Med (2006) 1.37
Expression of monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 by human airway smooth-muscle cells. Modulation by corticosteroids and T-helper 2 cytokines. Am J Respir Cell Mol Biol (1999) 1.28
No apoptotic deaths and different levels of inductions of inflammatory cytokines in alveolar macrophages infected with influenza viruses. Virology (2004) 1.26
Homeostasis and T cell regulation. Curr Opin Immunol (2004) 1.26
Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus. PLoS Pathog (2009) 1.26
Human immunopathogenesis of severe acute respiratory syndrome (SARS). Virus Res (2007) 1.24
Interleukin-6 is crucial for recall of influenza-specific memory CD4 T cells. PLoS Pathog (2008) 1.21
Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathology. Immunity (2008) 1.20
Multiorgan distribution of human influenza A virus strains observed in a mouse model. Arch Virol (2009) 1.16
In vitro-generated antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells control the severity of herpes simplex virus-induced ocular immunoinflammatory lesions. J Virol (2008) 1.16
Synergistic induction of MCP-1 and -2 by IL-1beta and interferons in fibroblasts and epithelial cells. J Leukoc Biol (1998) 1.09
Immunopathology during coxsackievirus infection. Springer Semin Immunopathol (2002) 0.98
Inhibition of pathogenic effect of effector T cells by specific suppressor T cells during influenza virus infection in mice. Nature (1983) 0.98
Functional specialization of memory Th cells revealed by expression of integrin CD49b. J Immunol (2006) 0.96
Receptors, signal transduction, and spectrum of action of monocyte chemotactic protein-1 and related chemokines. J Leukoc Biol (1995) 0.94
Human cytomegalovirus and immunopathology. Springer Semin Immunopathol (2002) 0.94
Efficient generation and expansion of antigen-specific CD4+ T cells by recombinant influenza viruses. Eur J Immunol (2003) 0.92
Onset and progression in inherited ALS determined by motor neurons and microglia. Science (2006) 9.42
T cell regulation as a side effect of homeostasis and competition. J Exp Med (2003) 2.15
CD4+ memory T cells: functional differentiation and homeostasis. Immunol Rev (2006) 1.84
Resurrection of endogenous retroviruses in antibody-deficient mice. Nature (2012) 1.81
Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis. J Immunol (2005) 1.34
Homeostasis and T cell regulation. Curr Opin Immunol (2004) 1.26
Generalized immune activation as a direct result of activated CD4+ T cell killing. J Biol (2009) 1.22
Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathology. Immunity (2008) 1.20
A major role for memory CD4 T cells in the control of lymphopenia-induced proliferation of naive CD4 T cells. J Immunol (2005) 1.17
Emv2, the only endogenous ecotropic murine leukemia virus of C57BL/6J mice. Retrovirology (2012) 1.15
B lymphocyte activation by coinfection prevents immune control of friend virus infection. J Immunol (2008) 1.06
Race between retroviral spread and CD4+ T-cell response determines the outcome of acute Friend virus infection. J Virol (2009) 1.05
CD4 T-cell memory. Semin Immunol (2004) 1.01
Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis. Bioessays (2013) 0.98
Noncognate interaction with MHC class II molecules is essential for maintenance of T cell metabolism to establish optimal memory CD4 T cell function. J Immunol (2007) 0.95
Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection. PLoS Pathog (2012) 0.95
The concept of space and competition in immune regulation. Immunology (2004) 0.95
Mechanisms of control of acute Friend virus infection by CD4+ T helper cells and their functional impairment by regulatory T cells. J Gen Virol (2009) 0.91
Tumor necrosis factor-alpha regulation of insulin-like growth factor-I, type 1 IGF receptor, and IGF binding protein expression in cerebellum of transgenic mice. J Neurosci Res (2003) 0.91
B cells and TCR avidity determine distinct functions of CD4+ T cells in retroviral infection. J Immunol (2011) 0.90
Distinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model. Retrovirology (2011) 0.89
IL-2-independent and TNF-α-dependent expansion of Vβ5+ natural regulatory T cells during retrovirus infection. J Immunol (2013) 0.86
Negative impact of IFN-γ on early host immune responses to retroviral infection. J Immunol (2012) 0.85
The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized 'anti-TNF' therapies. Curr Dir Autoimmun (2002) 0.85
Counterpoise between the microbiome, host immune activation and pathology. Curr Opin Immunol (2013) 0.83