Published in Br J Cancer on December 01, 2009
A SNP in steroid receptor coactivator-1 disrupts a GSK3β phosphorylation site and is associated with altered tamoxifen response in bone. Mol Endocrinol (2011) 1.45
Pharmacogenomics of breast cancer therapy: an update. Pharmacol Ther (2013) 1.01
Novel modeling of combinatorial miRNA targeting identifies SNP with potential role in bone density. PLoS Comput Biol (2012) 0.97
Markers of endocrine sensitivity. Breast Cancer Res (2008) 0.90
ESR1 and ESR2 polymorphisms in the BIG 1-98 trial comparing adjuvant letrozole versus tamoxifen or their sequence for early breast cancer. Breast Cancer Res Treat (2015) 0.78
Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet (2001) 22.07
UK and USA breast cancer deaths down 25% in year 2000 at ages 20-69 years. Lancet (2000) 7.19
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet (2008) 7.05
Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol (2005) 6.90
Multiple genetic loci for bone mineral density and fractures. N Engl J Med (2008) 6.35
CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst (2005) 5.92
Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment. Clin Pharmacol Ther (2006) 4.81
Tamoxifen in the treatment of breast cancer. N Engl J Med (1998) 4.75
Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. N Engl J Med (2002) 3.68
Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer. N Engl J Med (1992) 3.54
Incidence, time course, and determinants of menstrual bleeding after breast cancer treatment: a prospective study. J Clin Oncol (2006) 3.53
Bone mineral density changes during the menopause transition in a multiethnic cohort of women. J Clin Endocrinol Metab (2007) 3.05
Effect of tamoxifen on bone mineral density measured by dual-energy x-ray absorptiometry in healthy premenopausal and postmenopausal women. J Clin Oncol (1996) 2.76
Effect of letrozole versus placebo on bone mineral density in women with primary breast cancer completing 5 or more years of adjuvant tamoxifen: a companion study to NCIC CTG MA.17. J Clin Oncol (2006) 2.74
Ovarian failure after adjuvant chemotherapy is associated with rapid bone loss in women with early-stage breast cancer. J Clin Oncol (2001) 2.29
Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes. JAMA (2004) 2.20
Effect of anastrozole on bone mineral density: 5-year results from the anastrozole, tamoxifen, alone or in combination trial 18233230. J Clin Oncol (2008) 1.99
Estrogen receptor genotypes influence hot flash prevalence and composite score before and after tamoxifen therapy. J Clin Oncol (2008) 1.91
Chemical castration induced by adjuvant cyclophosphamide, methotrexate, and fluorouracil chemotherapy causes rapid bone loss that is reduced by clodronate: a randomized study in premenopausal breast cancer patients. J Clin Oncol (1997) 1.80
Germline pharmacogenetics of tamoxifen response: have we learned enough? J Clin Oncol (2007) 1.76
Sex steroids, bone mass, and bone loss. A prospective study of pre-, peri-, and postmenopausal women. J Clin Invest (1996) 1.59
Estrogen receptor genotypes and haplotypes associated with breast cancer risk. Cancer Res (2004) 1.52
Aromatase inhibitors and bone health in women with breast cancer. J Clin Oncol (2006) 1.51
Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort. Breast Cancer Res Treat (2009) 1.20
Sex steroids and bone density in premenopausal and perimenopausal women. J Clin Endocrinol Metab (1989) 1.11
Tamoxifen treatment after adjuvant chemotherapy has opposite effects on bone mineral density in premenopausal patients depending on menstrual status. J Clin Oncol (2006) 1.10
Breast cancer treatment and ovarian failure: risk factors and emerging genetic determinants. Nat Rev Cancer (2006) 1.08
Pamidronate in the prevention of chemotherapy-induced bone loss in premenopausal women with breast cancer: a randomized controlled trial. J Clin Endocrinol Metab (2005) 1.07
Tamoxifen and bone metabolism in postmenopausal low-risk breast cancer patients: a randomized study. J Clin Oncol (1994) 1.06
Effects of raloxifene, a selective estrogen receptor modulator, on bone turnover markers and serum sex steroid and lipid levels in elderly men. J Bone Miner Res (2001) 1.04
Bone mineral density and its change in white women: estrogen and vitamin D receptor genotypes and their interaction. J Bone Miner Res (1998) 1.03
Polymorphisms in ER-alpha gene interact with estrogen receptor status in breast cancer survival. Clin Cancer Res (2005) 0.99
Bone mineral density among premenopausal women with early breast cancer in a randomized trial of adjuvant endocrine therapy. J Clin Oncol (2004) 0.98
Selective estrogen receptor modulators for postmenopausal osteoporosis: current state of development. Drugs Aging (2007) 0.97
Raloxifene treatment is associated with increased serum estradiol and decreased bone remodeling in healthy middle-aged men with low sex hormone levels. J Bone Miner Res (2004) 0.91
Estrogen receptor genotypes and their association with the 10-year changes in bone mineral density and osteocalcin concentrations. J Clin Endocrinol Metab (2004) 0.91
The causes and treatment of bone loss associated with carcinoma of the breast. Cancer Treat Rev (2005) 0.88
Estrogen receptor (ER) gene polymorphism may predict the bone mineral density response to raloxifene in postmenopausal women on chronic hemodialysis. Ren Fail (2005) 0.82
Influence of adjuvant tamoxifen treatment on bone mineral density and bone turnover markers in postmenopausal breast cancer patients in Japan. Cancer Lett (2002) 0.78
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol (1997) 29.02
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90
Construction and properties of an integrable plasmid for Bacillus subtilis. J Bacteriol (1983) 7.12
Role of LXRs in control of lipogenesis. Genes Dev (2000) 6.98
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science (2000) 6.52
Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science (1999) 5.22
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell (2001) 5.19
Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ Res (2001) 5.08
The GA5 locus of Arabidopsis thaliana encodes a multifunctional gibberellin 20-oxidase: molecular cloning and functional expression. Proc Natl Acad Sci U S A (1995) 4.80
Prognostic factors in breast cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med (2000) 4.67
Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs. Science (2013) 4.17
The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake. Cell (1994) 4.12
Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A (2000) 4.08
A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer. Ann Oncol (1996) 4.07
From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor. Proc Natl Acad Sci U S A (1998) 3.99
Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation (2001) 3.98
Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67. Am J Pathol (1991) 3.82
Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment. J Virol (2001) 3.40
Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation. Neuron (2001) 3.37
2000 update of recommendations for the use of tumor markers in breast and colorectal cancer: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol (2001) 3.25
Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases. Proc Natl Acad Sci U S A (2000) 3.24
Determinants of car travel on daily journeys to school: cross sectional survey of primary school children. BMJ (1998) 3.11
'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737. Oncogene (2006) 3.10
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. Clin Pharmacol Ther (2011) 3.09
Activity of neurons in anterior inferior temporal cortex during a short-term memory task. J Neurosci (1993) 3.04
Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects. Clin Pharmacol Ther (2009) 2.98
Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus. Clin Pharmacol Ther (2009) 2.96
New tricks for modelers from the crystallography toolkit: the particle mesh Ewald algorithm and its use in nucleic acid simulations. Structure (1999) 2.92
A neural mechanism for working and recognition memory in inferior temporal cortex. Science (1991) 2.86
Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83
The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH. Cell (1995) 2.78
Global gene expression profiles of Bacillus subtilis grown under anaerobic conditions. J Bacteriol (2000) 2.77
Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer. J Clin Oncol (1994) 2.77
Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature (2001) 2.76
Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect. Nature (1998) 2.74
The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer. N Engl J Med (1996) 2.74
From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci U S A (2001) 2.66
Multiple novel astrovirus species in human stool. J Gen Virol (2009) 2.63
Ultrastructural evidence for hair cell regeneration in the mammalian inner ear. Science (1993) 2.62
Cellular and molecular pharmacology of antiestrogen action and resistance. Pharmacol Rev (2001) 2.54
Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers. J Natl Cancer Inst (1994) 2.50
Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets. Carcinogenesis (2006) 2.45
Analysis of trends in deaths from accidental drug poisoning in teenagers, 1985-95. BMJ (1997) 2.44
Fluorescence and photobleaching dynamics of single light-harvesting complexes. Proc Natl Acad Sci U S A (1997) 2.42
Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation (1999) 2.40
Implications of a new dietary measurement error model for estimation of relative risk: application to four calibration studies. Am J Epidemiol (1999) 2.40
Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants. Clin Pharmacol Ther (2013) 2.38
Influence of changing travel patterns on child death rates from injury: trend analysis. BMJ (1997) 2.37
Molecular cloning and photoperiod-regulated expression of gibberellin 20-oxidase from the long-day plant spinach. Plant Physiol (1996) 2.36
Studies on the properties and mode of action of the purified regulatory subunit of bovine heart adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem (1978) 2.32
Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure. J Biol Chem (2001) 2.32
Phylogeny of the Simbu serogroup of the genus Bunyavirus. J Gen Virol (2001) 2.30
A role for destabilizing amino acid replacements in light-chain amyloidosis. Proc Natl Acad Sci U S A (1994) 2.27
Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I. Nat Cell Biol (1999) 2.25
Overview of the MHC fine mapping data. Diabetes Obes Metab (2009) 2.24
Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat Genet (2000) 2.24
Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment. J Virol (2000) 2.24
The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev (1998) 2.23
Disturbed sleep: effects of sociocultural factors and illness. Arch Dis Child (1998) 2.23
Regulatory mechanisms in the control of protein kinases. CRC Crit Rev Biochem (1982) 2.20
The looming epidemic of diabetes-associated tuberculosis: learning lessons from HIV-associated tuberculosis. Int J Tuberc Lung Dis (2011) 2.19
Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nat Genet (1996) 2.18
Ginsenoside-Rd improves outcome of acute ischaemic stroke - a randomized, double-blind, placebo-controlled, multicenter trial. Eur J Neurol (2012) 2.18
The pharmacogenetics research network: from SNP discovery to clinical drug response. Clin Pharmacol Ther (2007) 2.18
Coniferyl aldehyde 5-hydroxylation and methylation direct syringyl lignin biosynthesis in angiosperms. Proc Natl Acad Sci U S A (1999) 2.17
Human albumin solution for resuscitation and volume expansion in critically ill patients. Cochrane Database Syst Rev (2002) 2.15
A genetic linkage map of the bovine genome. Nat Genet (1994) 2.15
Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy. Circulation (1998) 2.14
The measurement and therapeutic implications of circulating tumour cells in breast cancer. Br J Cancer (2006) 2.14
Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes (2007) 2.13
Cancer and comorbidity: redefining chronic diseases. Cancer (2000) 2.12
Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development. Proc Natl Acad Sci U S A (1997) 2.12
KATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore-forming subunit. Proc Natl Acad Sci U S A (1998) 2.07
Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: new perspectives 2006. Ann Oncol (2007) 2.05
Peroral endoscopic remyotomy for failed Heller myotomy: a prospective single-center study. Endoscopy (2013) 2.04
A systematic review of therapeutic interventions to reduce acute and chronic post-surgical pain after amputation, thoracotomy or mastectomy. Eur J Pain (2014) 2.03
A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia (1994) 2.03
Prognostic factors in breast cancer: current and new predictors of metastasis. J Mammary Gland Biol Neoplasia (2001) 2.02
Laparoscopic versus open total mesorectal excision with anal sphincter preservation for low rectal cancer. Surg Endosc (2004) 2.01
Field evaluation of the Computer Science and Applications, Inc. physical activity monitor. Med Sci Sports Exerc (2000) 1.99
Hip strengthening reduces symptoms but not knee load in people with medial knee osteoarthritis and varus malalignment: a randomised controlled trial. Osteoarthritis Cartilage (2010) 1.99
Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells. Nat Med (1998) 1.98
Attributable causes of cancer in China. Ann Oncol (2012) 1.98
Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg (2009) 1.98
Comparison of circulating CA15-3 and carcinoembryonic antigen levels in patients with breast cancer. J Clin Oncol (1986) 1.94
Shanxi Province Cervical Cancer Screening Study: a cross-sectional comparative trial of multiple techniques to detect cervical neoplasia. Gynecol Oncol (2001) 1.93
Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. J Biol Chem (2000) 1.91
Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation (2001) 1.90
Psychiatric illness and irritable bowel syndrome: a comparison with inflammatory bowel disease. Am J Psychiatry (1990) 1.87
Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells. Toxicol Sci (2000) 1.87
ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. J Biol Chem (1998) 1.87
Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity. Kidney Int (2008) 1.86
Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2. Cancer Res (2000) 1.85
Pleiotropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation. Hum Mol Genet (2000) 1.85
Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat Struct Biol (2000) 1.85
A medium-density genetic linkage map of the bovine genome. Mamm Genome (1997) 1.85
Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature (1995) 1.81
The use of propranolol in the treatment of infantile haemangiomas: an update on potential mechanisms of action. Br J Dermatol (2014) 1.80