Published in JAMA on November 03, 2004
PRecisiOn MEdicine to Target Frailty of Endocrine-metabolic Origin (PROMETEO) | NCT04856683
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet (2008) 7.05
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32
Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest (2005) 5.19
The Rotterdam Study: 2010 objectives and design update. Eur J Epidemiol (2009) 3.44
The Rotterdam Study: 2012 objectives and design update. Eur J Epidemiol (2011) 3.26
Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med (2009) 2.80
Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. Am J Hum Genet (2010) 2.57
Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. JAMA (2008) 2.52
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet (2010) 2.43
Genome-wide association with bone mass and geometry in the Framingham Heart Study. BMC Med Genet (2007) 2.32
Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. Am J Hum Genet (2009) 2.14
Common variants in the region around Osterix are associated with bone mineral density and growth in childhood. Hum Mol Genet (2009) 1.99
Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study. PLoS Med (2006) 1.68
Association of ESR1 gene tagging SNPs with breast cancer risk. Hum Mol Genet (2009) 1.58
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genet (2012) 1.55
Molecular genetic studies of gene identification for osteoporosis: a 2004 update. J Bone Miner Res (2006) 1.52
Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis. PLoS Genet (2010) 1.41
Bone mineral density in children and adolescents with neurofibromatosis type 1. J Pediatr (2007) 1.17
Genetics of osteoporosis: accelerating pace in gene identification and validation. Hum Genet (2009) 1.14
Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures. Calcif Tissue Int (2008) 1.08
Vitamin D binding protein genotype and osteoporosis. Calcif Tissue Int (2009) 1.07
COL1A1, ESR1, VDR and TGFB1 polymorphisms and haplotypes in relation to BMD in Spanish postmenopausal women. Osteoporos Int (2006) 1.04
Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC study. Neurobiol Aging (2007) 1.00
Genetic epidemiology of age-related osteoporosis and its clinical applications. Nat Rev Rheumatol (2010) 0.99
Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men. Osteoporos Int (2008) 0.97
Polymorphism in vitamin D receptor is associated with bone mineral density in patients with adolescent idiopathic scoliosis. Eur Spine J (2010) 0.95
Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia. Haematologica (2009) 0.94
A review of estrogen receptor alpha gene (ESR1) polymorphisms, mood, and cognition. Menopause (2010) 0.94
IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study. J Bone Miner Res (2010) 0.92
Sex steroid-related candidate genes in psychiatric disorders. J Psychiatry Neurosci (2008) 0.88
VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey. PLoS One (2010) 0.88
Lack of association between oestrogen receptor polymorphisms and change in bone mineral density with tamoxifen therapy. Br J Cancer (2009) 0.88
Assessment of linkage and association of 13 genetic loci with bone mineral density. J Bone Miner Metab (2006) 0.88
Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. J Bone Miner Res (2010) 0.87
Genetic studies in osteoporosis--the end of the beginning. Arthritis Res Ther (2008) 0.86
Association of estrogen receptor alpha gene polymorphisms with bone mineral density in Chinese women: a meta-analysis. Osteoporos Int (2006) 0.85
Association analysis of the polymorphisms of the VDR gene with bone mineral density and the occurrence of fractures. J Bone Miner Metab (2007) 0.85
Vertebral body integrity: a review of various anatomical factors involved in the lumbar region. Osteoporos Int (2007) 0.85
The relation of the XbaI and PvuII polymorphisms of the estrogen receptor gene and the CAG repeat polymorphism of the androgen receptor gene to peak bone mass and bone turnover rate among young healthy men. Osteoporos Int (2005) 0.85
How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging. Age (Dordr) (2010) 0.84
The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: a pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort. Osteoporos Int (2009) 0.84
Effect of hormone therapy and calcitriol on serum lipid profile in postmenopausal older women: association with estrogen receptor-α genotypes. Menopause (2011) 0.83
Genetic determinants of osteoporosis: common bases to cardiovascular diseases? Int J Hypertens (2010) 0.83
Age-specific effects of estrogen receptors' polymorphisms on the bone traits in healthy fertile women: the BONTURNO study. Reprod Biol Endocrinol (2009) 0.83
Polymorphisms of caffeine metabolism and estrogen receptor genes and risk of Parkinson's disease in men and women. Parkinsonism Relat Disord (2010) 0.83
The genetics of bone mass and susceptibility to bone diseases. Nat Rev Rheumatol (2016) 0.82
ALDH2 polymorphisms and bone mineral density in an elderly Japanese population. Osteoporos Int (2006) 0.82
Association of estrogen and aromatase gene polymorphisms with systemic lupus erythematosus. Lupus (2010) 0.81
Confirmation of linkage to chromosome 1q for spine bone mineral density in southern Chinese. Hum Genet (2006) 0.81
Calcitonin and calcitonin receptors. Clin Cases Miner Bone Metab (2007) 0.81
Association of aromatase and estrogen receptor gene polymorphisms with hip fractures. Osteoporos Int (2008) 0.81
Association between estrogen receptor α gene (ESR1) PvuII (C/T) and XbaI (A/G) polymorphisms and hip fracture risk: evidence from a meta-analysis. PLoS One (2013) 0.80
The ESR1 (6q25) locus is associated with calcaneal ultrasound parameters and radial volumetric bone mineral density in European men. PLoS One (2011) 0.80
Associations between OPG and RANKL polymorphisms, vertebral fractures, and abdominal aortic calcification in community-dwelling older subjects: the Sao Paulo Ageing & Health Study (SPAH). Osteoporos Int (2016) 0.80
Association between Estrogen Receptor-α Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility: A Meta-Analysis. Dis Markers (2015) 0.80
Bisphosphonate treatment in ochronotic osteoporotic patients. Clin Rheumatol (2006) 0.79
Relationship of volumetric bone mineral density and structural parameters with ERalpha gene polymorphisms. Calcif Tissue Int (2007) 0.79
Developmental origins of genotype-phenotype correlations in chronic diseases of old age. Aging Dis (2012) 0.78
Estrogen receptor α variants affect age at onset of Alzheimer's disease in a multiethnic female cohort. Dement Geriatr Cogn Disord (2014) 0.78
Searching for genes underlying susceptibility to osteoporotic fracture: current progress and future prospect. Osteoporos Int (2007) 0.78
Identification of candidate gene regions in the rat by co-localization of QTLs for bone density, size, structure and strength. PLoS One (2011) 0.78
A Follow-up Association Study of Genetic Variants for Bone Mineral Density in a Korean Population. Genomics Inform (2014) 0.77
Genetics of osteoporosis. Wien Med Wochenschr (2006) 0.77
Post-genomic update on a classical candidate gene for coronary artery disease: ESR1. Circ Cardiovasc Genet (2011) 0.77
Meta-analysis of haplotype-association studies: comparison of methods and empirical evaluation of the literature. BMC Genet (2011) 0.77
Haplotypes of intron 4 of the estrogen receptor alpha gene and hip fractures: a replication study in Caucasians. BMC Med Genet (2010) 0.77
Evaluation of the effects of vitamin D receptor and estrogen receptor 1 gene polymorphisms on bone mineral density in postmenopausal women. Clin Rheumatol (2010) 0.77
Influence of estrogen receptor α polymorphisms on bone density in response to habitual exercise in Japanese postmenopausal women. ScientificWorldJournal (2014) 0.77
Bone mass pharmacogenetics and ethnic health implications. Clin Cases Miner Bone Metab (2007) 0.76
Estrogen receptor alpha CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women. Osteoporos Int (2007) 0.76
Association between estrogen receptora gene (ESR1) PvuII (T/C) and XbaI (A/G) polymorphisms and premature ovarian failure risk: evidence from a meta-analysis. J Assist Reprod Genet (2014) 0.76
Quantitative ultrasound variables of the heel in Finnish men aged 18-20 yr: predictors, relationship to bone mineral content, and changes during military service. Osteoporos Int (2006) 0.76
The genetics of response to estrogen treatment. Clin Cases Miner Bone Metab (2009) 0.75
Risk factors for symptomatic osteonecrosis in childhood ALL: A retrospective study of a Slovenian pediatric ALL population between 1970 and 2004. Exp Ther Med (2016) 0.75
Structural maintenance of chromosome complexes and bone development: the beginning of a wonderful relationship? Bonekey Rep (2013) 0.75
CYP19 and ESR1 gene polymorphisms: response of the bone mineral density in post-menopausal women to hormonal replacement therapy. Clin Cases Miner Bone Metab (2014) 0.75
Polymorphisms of estrogen metabolism-related genes ESR1, UGT2B17, and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women. Prz Menopauzalny (2015) 0.75
Pharmacogenomics in osteoporosis: Steps toward personalized medicine. Pharmgenomics Pers Med (2009) 0.75
The role of osteoprotegerin (OPG) and estrogen receptor (ER-α) gene polymorphisms in rheumatoid arthritis. Clin Cases Miner Bone Metab (2007) 0.75
The latest news from the GENOMOS study. Clin Cases Miner Bone Metab (2009) 0.75
Impact of CYP19A1 and ESR1 variants on early-onset side effects during combined endocrine therapy in the TEXT trial. Breast Cancer Res (2016) 0.75
Association study of estrogen receptor alpha gene polymorphisms with bone mass assessed by quantitative ultrasound in young adults. Rheumatol Int (2017) 0.75
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med (2009) 10.06
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet (2009) 8.42
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases. Am J Epidemiol (2006) 7.66
Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet (2010) 7.62
Host polymorphisms in interleukin 4, complement factor H, and C-reactive protein associated with nasal carriage of Staphylococcus aureus and occurrence of boils. J Infect Dis (2008) 7.45
A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet (2007) 7.35
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Rheumatoid arthritis association at 6q23. Nat Genet (2007) 6.71
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet (2001) 6.56
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet (2008) 5.93
Intravenous zoledronic acid in postmenopausal women with low bone mineral density. N Engl J Med (2002) 5.83
Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst (2008) 5.82
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
The Rotterdam Study: objectives and design update. Eur J Epidemiol (2007) 5.78
Heterogeneity in meta-analyses of genome-wide association investigations. PLoS One (2007) 5.77
Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial. BMJ (2012) 5.63
Lasofoxifene in postmenopausal women with osteoporosis. N Engl J Med (2010) 5.60
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet (2013) 5.58
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32
Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet (2009) 5.20
Correlation between genetic and geographic structure in Europe. Curr Biol (2008) 5.02
Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet (2009) 4.78
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Genetics and biology of vitamin D receptor polymorphisms. Gene (2004) 4.60
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. PLoS Genet (2009) 4.24
Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet (2009) 3.80
Genome-wide association study of PR interval. Nat Genet (2010) 3.73
Association studies for finding cancer-susceptibility genetic variants. Nat Rev Cancer (2004) 3.64
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55
Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. Diabetes (2008) 3.54
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet (2009) 3.52
Fracture risk and zoledronic acid therapy in men with osteoporosis. N Engl J Med (2012) 3.51
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet (2012) 3.48
The Rotterdam Study: 2010 objectives and design update. Eur J Epidemiol (2009) 3.44
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med (2004) 3.32
The Rotterdam Study: 2012 objectives and design update. Eur J Epidemiol (2011) 3.26
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet (2012) 3.20
Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nat Genet (2008) 3.18
NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet (2009) 3.18
Identification of genetic loci associated with Helicobacter pylori serologic status. JAMA (2013) 3.15
Presentation of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop. J Clin Endocrinol Metab (2009) 3.11
A common 8q24 variant in prostate and breast cancer from a large nested case-control study. Cancer Res (2007) 3.08
Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study. Lancet Oncol (2011) 3.04
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet (2004) 2.98
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature (2011) 2.96
Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction. JAMA (2004) 2.93
A meta-analysis of prior corticosteroid use and fracture risk. J Bone Miner Res (2004) 2.92
Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. J Natl Cancer Inst (2009) 2.88
Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1). J Clin Endocrinol Metab (2012) 2.87