Published in J Neurodev Disord on September 01, 2009
Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation. Nat Biotechnol (2012) 3.07
Experimental models of Rett syndrome based on Mecp2 dysfunction. Exp Biol Med (Maywood) (2011) 1.27
Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons. Mol Psychiatry (2014) 1.09
BDNF deregulation in Rett syndrome. Neuropharmacology (2013) 1.02
Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model. Mol Brain (2011) 0.98
Dendritic spine dysgenesis in Rett syndrome. Front Neuroanat (2014) 0.97
Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders. Neurotoxicol Teratol (2012) 0.95
Altered balance of proteolytic isoforms of pro-brain-derived neurotrophic factor in autism. J Neuropathol Exp Neurol (2012) 0.92
Positive feedback regulation between gamma-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons. J Biol Chem (2011) 0.91
DIA1R is an X-linked gene related to Deleted In Autism-1. PLoS One (2011) 0.90
Hippocampal CA1 pyramidal neurons of Mecp2 mutant mice show a dendritic spine phenotype only in the presymptomatic stage. Neural Plast (2012) 0.90
Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity. EMBO J (2013) 0.89
Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation. Mol Cell Neurosci (2013) 0.86
Dendritic spine dysgenesis in autism related disorders. Neurosci Lett (2015) 0.85
Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes. Front Cell Neurosci (2015) 0.84
DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? Environ Epigenet (2016) 0.84
Lighting a path: genetic studies pinpoint neurodevelopmental mechanisms in autism and related disorders. Dialogues Clin Neurosci (2012) 0.84
Development of social skills in children: neural and behavioral evidence for the elaboration of cognitive models. Front Neurosci (2015) 0.84
Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway. PLoS Pathog (2015) 0.84
Loss of function of KIAA2022 causes mild to severe intellectual disability with an autism spectrum disorder and impairs neurite outgrowth. Hum Mol Genet (2013) 0.83
An introduction to model-independent diffusion magnetic resonance imaging. Top Magn Reson Imaging (2010) 0.81
Microtubule-Actin Crosslinking Factor 1 Is Required for Dendritic Arborization and Axon Outgrowth in the Developing Brain. Mol Neurobiol (2015) 0.81
Characterization of the deleted in autism 1 protein family: implications for studying cognitive disorders. PLoS One (2011) 0.80
Multiple approaches to investigate the transport and activity-dependent release of BDNF and their application in neurogenetic disorders. Neural Plast (2012) 0.79
Changes in the serum levels of brain-derived neurotrophic factor in adults with attention deficit hyperactivity disorder after treatment with atomoxetine. Psychopharmacology (Berl) (2013) 0.78
Recent advances in understanding synaptic abnormalities in Rett syndrome. F1000Res (2015) 0.78
Corpus callosum measurements correlate with developmental delay in Smith-Lemli-Opitz syndrome. Pediatr Neurol (2013) 0.78
Sera from children with autism induce autistic features which can be rescued with a CNTF small peptide mimetic in rats. PLoS One (2015) 0.76
Dysfunctional mTORC1 Signaling: A Convergent Mechanism between Syndromic and Nonsyndromic Forms of Autism Spectrum Disorder? Int J Mol Sci (2017) 0.75
Endosomal system genetics and autism spectrum disorders: A literature review. Neurosci Biobehav Rev (2016) 0.75
Pilot Study and Review: Physiological Differences in BDNF, a Potential Biomarker in Males and Females with Autistic Disorder. Int Neuropsychiatr Dis J (2014) 0.75
Comparative insights using the molecular homology model of BDNF (Brain derived neurotrophic factor) of Varanus komodoensis and the known NGF (Nerve growth factor) structure of Naja atra. Bioinformation (2013) 0.75
Dysregulation of TrkB phosphorylation and proBDNF protein in adenylyl cyclase 1 and 8 knockout mice in a model of fetal alcohol spectrum disorder. Alcohol (2016) 0.75
Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer's-like memory deficits in the Ts65Dn mouse model of Down syndrome. Sci Rep (2017) 0.75
Reversal Learning Deficits Associated with Increased Frontal Cortical Brain-Derived Neurotrophic Factor Tyrosine Kinase B Signaling in a Prenatal Cocaine Exposure Mouse Model. Dev Neurosci (2016) 0.75
The BDNF val-66-met Polymorphism Affects Neuronal Morphology and Synaptic Transmission in Cultured Hippocampal Neurons from Rett Syndrome Mice. Front Cell Neurosci (2017) 0.75
Strong association of de novo copy number mutations with autism. Science (2007) 27.84
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet (1999) 22.84
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet (1998) 13.27
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell (2003) 12.50
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature (2002) 11.85
MeCP2, a key contributor to neurological disease, activates and represses transcription. Science (2008) 10.11
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet (2001) 9.82
DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science (2003) 8.81
Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet (2001) 8.64
Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons. Nat Neurosci (2001) 8.55
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (2003) 8.48
The story of Rett syndrome: from clinic to neurobiology. Neuron (2007) 8.08
The mechanisms of vesicle budding and fusion. Cell (2004) 7.96
Long-term dendritic spine stability in the adult cortex. Nature (2002) 7.47
Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci (2006) 7.18
Reversal of neurological defects in a mouse model of Rett syndrome. Science (2007) 7.09
Neurotrophins as synaptic modulators. Nat Rev Neurosci (2001) 7.08
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron (2006) 6.50
MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell (1997) 6.45
Morphological changes in dendritic spines associated with long-term synaptic plasticity. Annu Rev Neurosci (2001) 6.36
Transient and persistent dendritic spines in the neocortex in vivo. Neuron (2005) 6.30
Structure and function of dendritic spines. Annu Rev Physiol (2002) 6.17
Pten regulates neuronal arborization and social interaction in mice. Neuron (2006) 6.11
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science (2006) 5.89
Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron (2002) 5.71
Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron (1998) 5.05
Physiology of the neurotrophins. Annu Rev Neurosci (1996) 4.82
Evidence for a role of dendritic filopodia in synaptogenesis and spine formation. Neuron (1996) 4.75
The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron (2006) 4.74
Rapid actin-based plasticity in dendritic spines. Neuron (1998) 4.70
Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines. Science (2008) 4.55
Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A (2005) 4.52
The yin and yang of neurotrophin action. Nat Rev Neurosci (2005) 4.45
Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. Hum Mol Genet (2004) 4.45
BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol (2005) 4.34
Dendritic spine pathology: cause or consequence of neurological disorders? Brain Res Brain Res Rev (2002) 4.31
Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes. Neuron (2006) 4.27
MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number. Neuron (2007) 4.15
A novel class of clathrin-coated vesicles budding from endosomes. J Cell Biol (1996) 4.05
Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Nat Neurosci (2007) 3.81
Miniature synaptic events maintain dendritic spines via AMPA receptor activation. Nat Neurosci (1999) 3.80
Dendritic anomalies in disorders associated with mental retardation. Cereb Cortex (2000) 3.69
Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. J Neurosci (2006) 3.69
Do thin spines learn to be mushroom spines that remember? Curr Opin Neurobiol (2007) 3.63
Spine growth precedes synapse formation in the adult neocortex in vivo. Nat Neurosci (2006) 3.57
A genetic variant that disrupts MET transcription is associated with autism. Proc Natl Acad Sci U S A (2006) 3.55
A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival. J Neurosci (2007) 3.51
MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions. Mol Cell Neurosci (2004) 3.48
Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci (2004) 3.47
Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology. Nat Neurosci (2009) 3.42
Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice. Proc Natl Acad Sci U S A (2009) 3.23
The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines. Am J Anat (1970) 3.08
DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG. Mol Cell (2005) 3.01
Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci (1996) 2.98
Spine-neck geometry determines NMDA receptor-dependent Ca2+ signaling in dendrites. Neuron (2005) 2.96
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog Neurobiol (2001) 2.88
Dendritic spines and long-term plasticity. Nat Rev Neurosci (2005) 2.83
From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learn Mem (2002) 2.79
Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis. Neuron (2005) 2.77
Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nat Neurosci (2005) 2.59
Molecular mechanisms of dendritic spine development and remodeling. Prog Neurobiol (2005) 2.54
Developmental regulation of spine motility in the mammalian central nervous system. Proc Natl Acad Sci U S A (1999) 2.53
BDNF enhances quantal neurotransmitter release and increases the number of docked vesicles at the active zones of hippocampal excitatory synapses. J Neurosci (2001) 2.51
Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. J Clin Invest (2007) 2.45
Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome. Neurobiol Dis (2005) 2.44
Dendritic spine "dysgenesis" and mental retardation. Science (1974) 2.44
Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized. Nat Rev Genet (2006) 2.42
Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF. Nat Neurosci (2008) 2.38
Neuronal release of proBDNF. Nat Neurosci (2009) 2.36
Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions. J Neurosci (2009) 2.35
Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons. J Neurosci (2002) 2.33
Spine-type-specific recruitment of newly synthesized AMPA receptors with learning. Science (2008) 2.29
MeCP2-dependent transcriptional repression regulates excitatory neurotransmission. Curr Biol (2006) 2.25
Rho GTPases, dendritic structure, and mental retardation. J Neurobiol (2005) 2.19
Selective dendritic alterations in the cortex of Rett syndrome. J Neuropathol Exp Neurol (1995) 2.15
Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging. J Neurosci (2003) 2.15
Lateral organization of endocytic machinery in dendritic spines. Nat Neurosci (2004) 2.04
Epigenetics of autism spectrum disorders. Hum Mol Genet (2006) 2.03
ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons. Learn Mem (2004) 1.99
Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiol Dis (2007) 1.90
Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation. Ann Neurol (2001) 1.87
Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Hum Mol Genet (2005) 1.87
The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons. J Neurosci (2005) 1.86
Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome. J Neurosci (2007) 1.85
Neuropathology of Rett syndrome. J Child Neurol (2005) 1.83
Reversing neurodevelopmental disorders in adults. Neuron (2008) 1.80
Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor. Proc Natl Acad Sci U S A (2004) 1.76
Miniature synaptic transmission and BDNF modulate dendritic spine growth and form in rat CA1 neurones. J Physiol (2003) 1.67
Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations. Neurobiol Dis (2009) 1.66
Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism susceptibility gene. Am J Med Genet B Neuropsychiatr Genet (2005) 1.64
Control of extracellular cleavage of ProBDNF by high frequency neuronal activity. Proc Natl Acad Sci U S A (2009) 1.64
High-resolution in vivo imaging of hippocampal dendrites and spines. J Neurosci (2004) 1.63
Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci (2000) 1.58
Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks. J Comp Neurol (2009) 1.57
TRPC3 channels are necessary for brain-derived neurotrophic factor to activate a nonselective cationic current and to induce dendritic spine formation. J Neurosci (2007) 1.56
The AP-1 adaptor complex binds to immature secretory granules from PC12 cells, and is regulated by ADP-ribosylation factor. J Cell Biol (1996) 1.55
Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy. Biol Psychiatry (2005) 1.53
Neurotrophin secretion from hippocampal neurons evoked by long-term-potentiation-inducing electrical stimulation patterns. Proc Natl Acad Sci U S A (2002) 1.53
Delayed maturation of neuronal architecture and synaptogenesis in cerebral cortex of Mecp2-deficient mice. J Neuropathol Exp Neurol (2005) 1.52
Rett syndrome: 3-D confocal microscopy of cortical pyramidal dendrites and afferents. Neuroreport (1994) 1.49
ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons. Learn Mem (2004) 1.99
Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway. J Neurosci (2005) 1.68
Miniature synaptic transmission and BDNF modulate dendritic spine growth and form in rat CA1 neurones. J Physiol (2003) 1.67
Preclinical research in Rett syndrome: setting the foundation for translational success. Dis Model Mech (2012) 1.66
Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations. Neurobiol Dis (2009) 1.66
TRPC3 channels are necessary for brain-derived neurotrophic factor to activate a nonselective cationic current and to induce dendritic spine formation. J Neurosci (2007) 1.56
Network hyperexcitability in hippocampal slices from Mecp2 mutant mice revealed by voltage-sensitive dye imaging. J Neurophysiol (2011) 1.33
Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations. Neurobiol Dis (2009) 1.31
Kainate modulates presynaptic GABA release from two vesicle pools. J Neurosci (2008) 1.29
Experimental models of Rett syndrome based on Mecp2 dysfunction. Exp Biol Med (Maywood) (2011) 1.27
BDNF increases release probability and the size of a rapidly recycling vesicle pool within rat hippocampal excitatory synapses. J Physiol (2006) 1.26
Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function. Hum Mol Genet (2013) 1.15
BDNF induces calcium elevations associated with IBDNF, a nonselective cationic current mediated by TRPC channels. J Neurophysiol (2007) 1.08
The actions of BDNF on dendritic spine density and morphology in organotypic slice cultures depend on the presence of serum in culture media. J Neurosci Methods (2007) 1.06
Activity-dependent release of endogenous BDNF from mossy fibers evokes a TRPC3 current and Ca2+ elevations in CA3 pyramidal neurons. J Neurophysiol (2010) 1.06
Transient receptor potential channels as novel effectors of brain-derived neurotrophic factor signaling: potential implications for Rett syndrome. Pharmacol Ther (2006) 1.03
Excitation/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 of Mecp2 knockout mice. Hippocampus (2014) 1.02
BDNF deregulation in Rett syndrome. Neuropharmacology (2013) 1.02
Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses. Nat Neurosci (2007) 0.99
Intracellular Ca2+ stores and Ca2+ influx are both required for BDNF to rapidly increase quantal vesicular transmitter release. Neural Plast (2012) 0.96
Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+) -permeable TRPC6 channels. Hippocampus (2012) 0.93
Activity-dependent BDNF release and TRPC signaling is impaired in hippocampal neurons of Mecp2 mutant mice. Proc Natl Acad Sci U S A (2012) 0.93
Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels. Free Radic Biol Med (2010) 0.91
Regulation of inositol phospholipid binding and signaling through syndecan-4. J Biol Chem (2002) 0.91
Hippocampal CA1 pyramidal neurons of Mecp2 mutant mice show a dendritic spine phenotype only in the presymptomatic stage. Neural Plast (2012) 0.90
MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons. PLoS One (2013) 0.87
Divergent roles of p75NTR and Trk receptors in BDNF's effects on dendritic spine density and morphology. Neural Plast (2012) 0.87
The neuronal Arf GAP centaurin alpha1 modulates dendritic differentiation. J Cell Sci (2007) 0.87
GABA vesicles at synapses: are there 2 distinct pools? Neuroscientist (2009) 0.86
HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons. Hippocampus (2011) 0.83
The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton. Eur J Cell Biol (2004) 0.83
Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue Mice. Autism Open Access (2012) 0.81
A novel DNA-binding feature of MeCP2 contributes to Rett syndrome. Front Cell Neurosci (2013) 0.80
Evaluation of current pharmacological treatment options in the management of Rett syndrome: from the present to future therapeutic alternatives. Curr Clin Pharmacol (2013) 0.80
The dynamics of excitatory synapse formation on dendritic spines. Cellscience (2009) 0.79
Multiple approaches to investigate the transport and activity-dependent release of BDNF and their application in neurogenetic disorders. Neural Plast (2012) 0.79
The effect of Rho-associated kinase inhibition on the ocular penetration of timolol maleate. Invest Ophthalmol Vis Sci (2013) 0.77