Published in Nature on May 12, 2005
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol (2009) 4.36
Type 1 diabetes. Lancet (2013) 3.45
Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest (2006) 2.73
Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci U S A (2005) 2.70
Recent advances in the genetics of autoimmune disease. Annu Rev Immunol (2009) 2.41
Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol (2007) 2.28
Melanocyte antigen triggers autoimmunity in human psoriasis. J Exp Med (2015) 2.11
Effects of exenatide alone and in combination with daclizumab on beta-cell function in long-standing type 1 diabetes. Diabetes Care (2009) 2.02
Immunotherapy of type 1 diabetes: where are we and where should we be going? Immunity (2010) 1.98
Insulin as an autoantigen in NOD/human diabetes. Curr Opin Immunol (2008) 1.95
Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes. Immunity (2015) 1.91
Translational mini-review series on type 1 diabetes: Immune-based therapeutic approaches for type 1 diabetes. Clin Exp Immunol (2007) 1.86
Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes. Sci Transl Med (2013) 1.84
Genetics of type 1 diabetes: what's next? Diabetes (2010) 1.80
HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease. J Clin Invest (2006) 1.66
Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft. Diabetologia (2009) 1.65
Understanding type 1 diabetes through genetics: advances and prospects. Nat Rev Genet (2011) 1.64
Insulitis in human type 1 diabetes: The quest for an elusive lesion. Islets (2011) 1.61
Beta cell function during rapamycin monotherapy in long-term type 1 diabetes. Diabetologia (2010) 1.60
The insulin A-chain epitope recognized by human T cells is posttranslationally modified. J Exp Med (2005) 1.55
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation. J Biol Chem (2010) 1.49
Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves' disease. J Immunol (2008) 1.45
Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity. J Clin Invest (2007) 1.44
Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes. Diabetes (2011) 1.39
Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells. Diabetes (2009) 1.39
Islet inflammation and CXCL10 in recent-onset type 1 diabetes. Clin Exp Immunol (2010) 1.38
EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2. J Exp Med (2008) 1.33
Type 1 diabetes: pathogenesis and prevention. CMAJ (2006) 1.30
TCR recognition of peptide/MHC class II complexes and superantigens. Semin Immunol (2007) 1.30
Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy. Immunol Rev (2009) 1.19
Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes. Proc Natl Acad Sci U S A (2006) 1.17
Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy. J Autoimmun (2010) 1.10
Conserved T cell receptor alpha-chain induces insulin autoantibodies. Proc Natl Acad Sci U S A (2008) 1.10
TGF-beta signaling is required for the function of insulin-reactive T regulatory cells. J Clin Invest (2006) 1.09
CD4 T cells and their antigens in the pathogenesis of autoimmune diabetes. Curr Opin Immunol (2011) 1.08
Recognition of self-peptide-MHC complexes by autoimmune T-cell receptors. Trends Biochem Sci (2007) 1.07
Gene expression profiles for the human pancreas and purified islets in type 1 diabetes: new findings at clinical onset and in long-standing diabetes. Clin Exp Immunol (2009) 1.07
DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype. Proc Natl Acad Sci U S A (2006) 1.04
Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNgamma. Diabetologia (2010) 1.02
Rituximab induces sustained reduction of pathogenic B cells in patients with peripheral nervous system autoimmunity. J Clin Invest (2012) 1.00
Disruption of the homeostatic balance between autoaggressive (CD4+CD40+) and regulatory (CD4+CD25+FoxP3+) T cells promotes diabetes. J Leukoc Biol (2008) 1.00
The anti-insulin trimolecular complex in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes (2010) 1.00
B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases. Adv Immunol (2008) 0.98
Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects. Proc Natl Acad Sci U S A (2015) 0.96
Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes. Mol Ther (2009) 0.95
Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains. J Autoimmun (2009) 0.94
Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire. J Biol Chem (2011) 0.94
Vaccine against autoimmune disease: antigen-specific immunotherapy. Curr Opin Immunol (2013) 0.94
The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes. Clin Exp Immunol (2009) 0.93
A clonotype nomenclature for T cell receptors. Immunogenetics (2009) 0.93
Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases? Cold Spring Harb Perspect Med (2012) 0.92
The U1-snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases. Immunol Rev (2010) 0.92
Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes. Proc Natl Acad Sci U S A (2014) 0.92
ZnT8-Specific CD4+ T cells display distinct cytokine expression profiles between type 1 diabetes patients and healthy adults. PLoS One (2013) 0.91
CD4⁺ CD45RA⁻ FoxP3high activated regulatory T cells are functionally impaired and related to residual insulin-secreting capacity in patients with type 1 diabetes. Clin Exp Immunol (2013) 0.90
Targeting the B7 family of co-stimulatory molecules: successes and challenges. BioDrugs (2013) 0.89
T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives. Clin Dev Immunol (2011) 0.89
T cell responses: naive to memory and everything in between. Adv Physiol Educ (2013) 0.89
Stable, soluble, high-affinity, engineered T cell receptors: novel antibody-like proteins for specific targeting of peptide antigens. Clin Exp Immunol (2005) 0.88
Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats. Genes Immun (2011) 0.88
An immunologic homunculus for type 1 diabetes. J Clin Invest (2006) 0.87
p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells. J Biol Chem (2008) 0.86
CD4 T cell differentiation in type 1 diabetes. Clin Exp Immunol (2015) 0.86
Insulitis in human type 1 diabetes: a comparison between patients and animal models. Semin Immunopathol (2014) 0.85
TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential. J Immunol (2014) 0.84
The immunotherapeutic potential of dendritic cells in type 1 diabetes. Clin Exp Immunol (2010) 0.84
Growth hormone prevents the development of autoimmune diabetes. Proc Natl Acad Sci U S A (2013) 0.84
Mechanistic basis of immunotherapies for type 1 diabetes mellitus. Transl Res (2013) 0.84
Autoantigens plus interleukin-10 suppress diabetes autoimmunity. Diabetes Technol Ther (2010) 0.83
Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes. Diabetes (2010) 0.82
Suppression of dendritic cell activation by diabetes autoantigens linked to the cholera toxin B subunit. Immunobiology (2010) 0.82
Immunology: insulin trigger for diabetes. Nature (2005) 0.81
Proinsulin is encoded by an RNA splice variant in human blood myeloid cells. Proc Natl Acad Sci U S A (2006) 0.81
Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention. Pediatr Diabetes (2015) 0.81
Class II MHC self-antigen presentation in human B and T lymphocytes. PLoS One (2012) 0.81
Primer: immunity and autoimmunity. Diabetes (2008) 0.80
Defining a new biomarker for the autoimmune component of Multiple Sclerosis: Th40 cells. J Neuroimmunol (2014) 0.80
Therapeutic Targets for Management of Periodontitis and Diabetes. Curr Pharm Des (2016) 0.79
Etiopathogenesis of insulin autoimmunity. Anat Res Int (2012) 0.79
Immunology: Insulin auto-antigenicity in type 1 diabetes. Nature (2005) 0.79
Multimerized T cell epitopes protect from experimental autoimmune diabetes by inducing dominant tolerance. Proc Natl Acad Sci U S A (2007) 0.79
High frequency of cytolytic 21-hydroxylase-specific CD8+ T cells in autoimmune Addison's disease patients. J Immunol (2014) 0.79
How Does Thymus Infection by Coxsackievirus Contribute to the Pathogenesis of Type 1 Diabetes? Front Immunol (2015) 0.79
Novel biomarkers in type 1 diabetes. Rev Diabet Stud (2012) 0.78
Advances in the cellular immunological pathogenesis of type 1 diabetes. J Cell Mol Med (2014) 0.78
Molecular Interactions Governing Autoantigen Presentation in Type 1 Diabetes. Curr Diab Rep (2015) 0.78
Cellular therapies for type 1 diabetes. Horm Metab Res (2008) 0.77
Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes. Diabetologia (2017) 0.76
CD40-mediated Signaling Influences Trafficking, TCR Expression, and T cell Pathogenesis, in the NOD Model of Type 1 Diabetes. Immunology (2017) 0.76
Impact of T-cell-specific Smad4 deficiency on the development of autoimmune diabetes in NOD mice. Immunol Cell Biol (2016) 0.76
Genetics and pathogenesis of type 1 diabetes: prospects for prevention and intervention. J Diabetes Investig (2011) 0.75
Prevention of Type 1 Diabetes Mellitus using a Novel Vaccine. Ther Adv Endocrinol Metab (2011) 0.75
Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry. J Phys Chem B (2010) 0.75
Self-glycolipids modulate dendritic cells changing the cytokine profiles of committed autoreactive T cells. PLoS One (2012) 0.75
The case for an autoimmune aetiology of type 1 diabetes. Clin Exp Immunol (2015) 0.75
Regeneration and DNA demethylation do not trigger PDX-1 expression in rat hepatocytes. World J Biol Chem (2010) 0.75
From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era. Rev Diabet Stud (2012) 0.75
A molecule's right to choose: how diabetogenic class II MHC products bind peptides. J Clin Invest (2005) 0.75
Novel epitope begets a novel pathway in type 1 diabetes progression. J Clin Invest (2008) 0.75
Thymic self-antigen expression for the design of a negative/tolerogenic self-vaccine against type 1 diabetes. Clin Dev Immunol (2011) 0.75
Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
International trial of the Edmonton protocol for islet transplantation. N Engl J Med (2006) 13.43
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Methods for high-density admixture mapping of disease genes. Am J Hum Genet (2004) 12.02
A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet (2004) 10.87
Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med (2004) 8.98
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet (2007) 8.74
FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol (2010) 8.73
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16
IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature (2008) 7.00
The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci U S A (2006) 5.41
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet (2005) 5.02
Automated high-dimensional flow cytometric data analysis. Proc Natl Acad Sci U S A (2009) 4.91
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature (2013) 4.57
Induction and molecular signature of pathogenic TH17 cells. Nat Immunol (2012) 4.43
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
MHC class II expression identifies functionally distinct human regulatory T cells. J Immunol (2006) 4.06
Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature (2007) 3.92
De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nat Genet (2009) 3.86
Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science (2007) 3.70
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell (2005) 3.52
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol (2011) 3.52
Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care (2012) 3.20
Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis. Sci Transl Med (2011) 3.19
Human CD4+CD25+ regulatory T cells. Semin Immunol (2004) 3.13
Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience. Am J Transplant (2005) 3.07
Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain (2009) 3.04
IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood (2009) 3.04
Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol (2009) 2.95
Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial. JAMA (2012) 2.85
2008 Update from the Collaborative Islet Transplant Registry. Transplantation (2008) 2.84
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science (2014) 2.77
A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations. Am J Transplant (2005) 2.74
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med (2007) 2.64
Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science (2014) 2.63
Inhibition of human CD4(+)CD25(+high) regulatory T cell function. J Immunol (2002) 2.61
Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells. Clin Immunol (2005) 2.60
Human regulatory T cells and their role in autoimmune disease. Immunol Rev (2006) 2.56
Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody. Am J Transplant (2004) 2.55
A high-density screen for linkage in multiple sclerosis. Am J Hum Genet (2005) 2.50
Innervation patterns of autonomic axons in the human endocrine pancreas. Cell Metab (2011) 2.48
Dysregulated T cell expression of TIM3 in multiple sclerosis. J Exp Med (2006) 2.43
Noninvasive in vivo imaging of pancreatic islet cell biology. Nat Med (2008) 2.41
Multiple sclerosis. J Clin Invest (2012) 2.41
Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Ann Neurol (2009) 2.41
The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A (2009) 2.38
Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells. Diabetes (2010) 2.36
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A (2009) 2.31
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet (2009) 2.30
Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease. Nat Med (2011) 2.14
Rescue purification maximizes the use of human islet preparations for transplantation. Am J Transplant (2005) 2.04
Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol (2008) 2.03
Glutamate is a positive autocrine signal for glucagon release. Cell Metab (2008) 2.01
Polyfunctional responses by human T cells result from sequential release of cytokines. Proc Natl Acad Sci U S A (2011) 2.00
TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol (2009) 2.00
An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity (2004) 2.00
A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol (2007) 1.99
Capsule synthesis by Bacillus anthracis is required for dissemination in murine inhalation anthrax. EMBO J (2004) 1.98
Transplant options for patients undergoing total pancreatectomy for chronic pancreatitis. J Am Coll Surg (2004) 1.98
Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab Chip (2010) 1.97
GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J Clin Invest (2002) 1.95
Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets. Hepatology (2011) 1.94
Reversal of diabetes in non-immunosuppressed rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejection. Xenotransplantation (2004) 1.94
Quality of life improves for pediatric patients after total pancreatectomy and islet autotransplant for chronic pancreatitis. Clin Gastroenterol Hepatol (2011) 1.93
Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. J Clin Invest (2006) 1.91
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. Am J Hum Genet (2010) 1.89
Fingolimod for multiple sclerosis. N Engl J Med (2012) 1.85
Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol (2009) 1.83
The use of exenatide in islet transplant recipients with chronic allograft dysfunction: safety, efficacy, and metabolic effects. Transplantation (2008) 1.83
Islet autotransplant outcomes after total pancreatectomy: a contrast to islet allograft outcomes. Transplantation (2008) 1.80
Role of "Western diet" in inflammatory autoimmune diseases. Curr Allergy Asthma Rep (2014) 1.79
PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. Cell Immunol (2004) 1.78
Stopping type 1 diabetes: attempts to prevent or cure type 1 diabetes in man. Diabetes (2011) 1.77
Specific peripheral B cell tolerance defects in patients with multiple sclerosis. J Clin Invest (2013) 1.76
Suppressor T cells in human diseases. J Exp Med (2004) 1.73
Long-term insulin independence and improvement in insulin secretion after supplemental islet infusion under exenatide and etanercept. Transplantation (2008) 1.66
Current advances and travails in islet transplantation. Diabetes (2009) 1.63
The role of total pancreatectomy and islet autotransplantation for chronic pancreatitis. Surg Clin North Am (2007) 1.63
Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans. Nat Med (2011) 1.62
Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis. Brain (2011) 1.61
TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol (2008) 1.58
Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS Genet (2013) 1.55
Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure. Diabetes (2004) 1.55
Effect of short-term culture on functional and stress-related parameters in isolated human islets. Transpl Int (2008) 1.55
Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. J Immunol (2009) 1.55
Human regulatory T cells and autoimmunity. Eur J Immunol (2008) 1.54
Quantitative differential expression analysis reveals miR-7 as major islet microRNA. Biochem Biophys Res Commun (2007) 1.54
Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol (2009) 1.50
Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus. Neurology (2013) 1.46
Lack of TIM-3 immunoregulation in multiple sclerosis. J Immunol (2008) 1.45
Edmonton's islet success has indeed been replicated elsewhere. Lancet (2003) 1.45
Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. J Clin Invest (2015) 1.43
Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J Immunol (2005) 1.43
The TIGIT/CD226 axis regulates human T cell function. J Immunol (2012) 1.43