Published in Nature on November 22, 2006
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev (2008) 4.85
Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer (2009) 4.06
TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell (2009) 3.15
p53--a Jack of all trades but master of none. Nat Rev Cancer (2009) 2.96
Fertility preservation in women with cancer. Lancet (2014) 2.21
p63 and p73, the ancestors of p53. Cold Spring Harb Perspect Biol (2010) 2.16
TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol (2009) 2.15
The p53 family: guardians of maternal reproduction. Nat Rev Mol Cell Biol (2011) 2.13
Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. Nat Med (2009) 2.03
ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development (2012) 1.97
p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ (2011) 1.94
The origins and evolution of the p53 family of genes. Cold Spring Harb Perspect Biol (2009) 1.90
A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages. Development (2010) 1.83
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci U S A (2009) 1.79
TAp63 is a master transcriptional regulator of lipid and glucose metabolism. Cell Metab (2012) 1.77
An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate. PLoS One (2009) 1.69
Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis. PLoS Genet (2007) 1.68
The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex. PLoS One (2010) 1.63
p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia. Proc Natl Acad Sci U S A (2013) 1.57
p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome. Genes Cancer (2011) 1.54
Geography of Follicle Formation in the Embryonic Mouse Ovary Impacts Activation Pattern During the First Wave of Folliculogenesis. Biol Reprod (2015) 1.49
Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proc Natl Acad Sci U S A (2009) 1.46
p53 Isoforms: An Intracellular Microprocessor? Genes Cancer (2011) 1.37
p53 ancestry: gazing through an evolutionary lens. Nat Rev Cancer (2009) 1.37
DeltaNp73 regulates neuronal survival in vivo. Proc Natl Acad Sci U S A (2009) 1.35
p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis. Nat Rev Cancer (2013) 1.34
p53 Family and Cellular Stress Responses in Cancer. Front Oncol (2014) 1.33
The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development. PLoS Genet (2009) 1.29
Meiotic recombination provokes functional activation of the p53 regulatory network. Science (2010) 1.27
DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa. Mol Cell (2012) 1.27
DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer. Cell (2011) 1.25
The p53 circuit board. Biochim Biophys Acta (2012) 1.24
Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway. Science (2014) 1.21
Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise. Aging (Albany NY) (2011) 1.21
TAp63 suppress metastasis via miR-133b in colon cancer cells. Br J Cancer (2014) 1.21
Phylogeny and function of the invertebrate p53 superfamily. Cold Spring Harb Perspect Biol (2010) 1.19
Rescue of platinum-damaged oocytes from programmed cell death through inactivation of the p53 family signaling network. Cell Death Differ (2013) 1.16
Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells. Stem Cells (2008) 1.15
The p53 tumor suppressor-like protein nvp63 mediates selective germ cell death in the sea anemone Nematostella vectensis. PLoS One (2007) 1.15
RNPC1, an RNA-binding protein and a target of the p53 family, regulates p63 expression through mRNA stability. Proc Natl Acad Sci U S A (2010) 1.14
DeltaNp63 regulates stem cell dynamics in the mammalian olfactory epithelium. J Neurosci (2011) 1.12
Cancer susceptibility and reproductive trade-offs: a model of the evolution of cancer defences. Philos Trans R Soc Lond B Biol Sci (2015) 1.11
Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family. BMC Genomics (2008) 1.11
FANCD2 activates transcription of TAp63 and suppresses tumorigenesis. Mol Cell (2013) 1.11
p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells. Cell Death Differ (2014) 1.11
A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. Proc Natl Acad Sci U S A (2010) 1.11
Transcriptional network of p63 in human keratinocytes. PLoS One (2009) 1.10
Regulation of female reproduction by p53 and its family members. FASEB J (2011) 1.08
One billion years of p53/p63/p73 evolution. Proc Natl Acad Sci U S A (2009) 1.08
The C-terminus of p63 contains multiple regulatory elements with different functions. Cell Death Dis (2010) 1.07
The Sum1/Ndt80 transcriptional switch and commitment to meiosis in Saccharomyces cerevisiae. Microbiol Mol Biol Rev (2012) 1.07
Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries. PLoS One (2011) 1.07
The meiotic checkpoint network: step-by-step through meiotic prophase. Cold Spring Harb Perspect Biol (2014) 1.04
Toward precision medicine for preserving fertility in cancer patients: existing and emerging fertility preservation options for women. J Gynecol Oncol (2016) 1.04
Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes. Proc Natl Acad Sci U S A (2011) 1.03
The role of p53 gene family in reproduction. Cold Spring Harb Perspect Biol (2009) 1.03
ΔNp63α represses anti-proliferative genes via H2A.Z deposition. Genes Dev (2012) 1.02
Regulation of skin aging and heart development by TAp63. Cell Death Differ (2011) 1.02
Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling. PLoS Genet (2011) 1.00
DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes. PLoS One (2012) 1.00
Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia. Mol Cell Biol (2008) 1.00
Tumour suppressor genes in chemotherapeutic drug response. Biosci Rep (2012) 0.99
Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo. PLoS One (2010) 0.98
p63 the guardian of human reproduction. Cell Cycle (2012) 0.98
Gene discovery in the threatened elkhorn coral: 454 sequencing of the Acropora palmata transcriptome. PLoS One (2011) 0.98
Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases. Chem Rev (2014) 0.98
Reply to: Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib. Nat Med (2012) 0.97
The Regulation of Aging and Longevity: A New and Complex Role of p53. Genes Cancer (2011) 0.97
Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15. J Clin Invest (2012) 0.96
Different fates of oocytes with DNA double-strand breaks in vitro and in vivo. Cell Cycle (2014) 0.96
TAp73 is required for spermatogenesis and the maintenance of male fertility. Proc Natl Acad Sci U S A (2014) 0.95
Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib. Nat Med (2012) 0.95
Analysis of the oligomeric state and transactivation potential of TAp73α. Cell Death Differ (2013) 0.94
DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint. Nat Commun (2015) 0.94
Caspase-1 is a novel target of p63 in tumor suppression. Cell Death Dis (2013) 0.93
p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish. PLoS Genet (2014) 0.93
DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age. Nat Commun (2015) 0.93
Oogenesis and cell death in human prenatal ovaries: what are the criteria for oocyte selection? Mol Hum Reprod (2009) 0.92
Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis. Proc Natl Acad Sci U S A (2007) 0.92
Role of p63 in Development, Tumorigenesis and Cancer Progression. Cancer Microenviron (2012) 0.91
Preserving fertility during cancer treatment. Nat Med (2009) 0.91
Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. Mol Cell Biol (2009) 0.90
Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level. Elife (2016) 0.90
c-Abl phosphorylation of ΔNp63α is critical for cell viability. Cell Death Dis (2010) 0.90
The DNA damage response in mammalian oocytes. Front Genet (2013) 0.89
Phosphorylation and stabilization of TAp63gamma by IkappaB kinase-beta. J Biol Chem (2008) 0.89
Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. Cell Cycle (2012) 0.89
Embryonic stem cells shed new light on the developmental roles of p53. Cell Biosci (2013) 0.88
Role of p63 and the Notch pathway in cochlea development and sensorineural deafness. Proc Natl Acad Sci U S A (2013) 0.88
Tumor suppressors: enhancers or suppressors of regeneration? Development (2013) 0.87
The p53-like Protein CEP-1 Is Required for Meiotic Fidelity in C. elegans. Curr Biol (2016) 0.87
Poly (C)-binding protein 1 regulates p63 expression through mRNA stability. PLoS One (2013) 0.87
ΔNp63α activates CD82 metastasis suppressor to inhibit cancer cell invasion. Cell Death Dis (2014) 0.87
DNA repair and aging: the impact of the p53 family. Aging (Albany NY) (2015) 0.87
ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis. Oncogene (2012) 0.86
Characterization of specific p63 and p63-N-terminal isoform antibodies and their application for immunohistochemistry. Virchows Arch (2013) 0.86
TAp73 is essential for germ cell adhesion and maturation in testis. J Cell Biol (2014) 0.86
Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis. Endocr Rev (2013) 0.85
Pathway Regulation of p63, a Director of Epithelial Cell Fate. Front Endocrinol (Lausanne) (2015) 0.85
p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis. J Exp Med (2013) 0.85
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17
Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell (2005) 15.06
Assessing computational tools for the discovery of transcription factor binding sites. Nat Biotechnol (2005) 14.29
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell (2004) 8.48
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell (2004) 8.16
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
LKB1 modulates lung cancer differentiation and metastasis. Nature (2007) 7.80
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature (2005) 6.86
p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell (2007) 6.50
Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship. Am J Surg Pathol (2007) 5.68
Cyclin E ablation in the mouse. Cell (2003) 5.58
Regulation of inflammatory responses by IL-17F. J Exp Med (2008) 5.56
Millisecond-timescale optical control of neural dynamics in the nonhuman primate brain. Neuron (2009) 5.50
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell (2006) 5.34
Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha. Proc Natl Acad Sci U S A (2004) 5.15
Mosaic analysis with double markers reveals tumor cell of origin in glioma. Cell (2011) 4.78
Mouse development and cell proliferation in the absence of D-cyclins. Cell (2004) 4.69
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med (2002) 4.65
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature (2002) 4.56
Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol Cell (2006) 4.51
Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell (2005) 4.14
Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res (2008) 4.08
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proc Natl Acad Sci U S A (2009) 4.02
Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biol (2004) 3.99
The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome. Am J Surg Pathol (2006) 3.96
A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med (2007) 3.96
Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction. J Clin Oncol (2007) 3.94
Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med (2007) 3.91
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature (2003) 3.77
On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet (2002) 3.57
Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat Med (2004) 3.55
Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity. J Virol (2005) 3.54
Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Res (2004) 3.43
Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. Cancer Res (2005) 3.41
Residual embryonic cells as precursors of a Barrett's-like metaplasia. Cell (2011) 3.36
The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature (2002) 3.30
REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell (2002) 3.29
Suppression of lung adenocarcinoma progression by Nkx2-1. Nature (2011) 3.27
Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature (2011) 3.19
Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity (2003) 3.17
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat Med (2010) 3.09
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res (2006) 3.06
Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell (2011) 3.00
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature (2005) 2.87
New Alström syndrome phenotypes based on the evaluation of 182 cases. Arch Intern Med (2005) 2.74
Unique recurrence patterns of cervical intraepithelial neoplasia after excision of the squamocolumnar junction. Int J Cancer (2014) 2.74
Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci (2003) 2.67
New insights into the pathogenesis of asthma. J Clin Invest (2003) 2.66
A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations. Gynecol Oncol (2008) 2.65
Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med (2006) 2.63
Perp is a p63-regulated gene essential for epithelial integrity. Cell (2005) 2.58
Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc Natl Acad Sci U S A (2002) 2.54
Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest (2002) 2.52
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood (2007) 2.51
Serous tubal intraepithelial carcinoma: its potential role in primary peritoneal serous carcinoma and serous cancer prevention. J Clin Oncol (2008) 2.50
mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci U S A (2008) 2.50
Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell (2002) 2.48
Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models. Cancer Res (2007) 2.45
Development of mice expressing a single D-type cyclin. Genes Dev (2002) 2.43
Serous carcinogenesis in the fallopian tube: a descriptive classification. Int J Gynecol Pathol (2008) 2.42
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nat Med (2011) 2.35
Disruption of muscle membrane and phenotype divergence in two novel mouse models of dysferlin deficiency. Hum Mol Genet (2004) 2.32
Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nat Genet (2002) 2.30
Nuclear factor I/B is an oncogene in small cell lung cancer. Genes Dev (2011) 2.29
Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28
Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment. Proc Natl Acad Sci U S A (2010) 2.20
Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proc Natl Acad Sci U S A (2007) 2.18
Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors. Proc Natl Acad Sci U S A (2006) 2.17
The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nat Immunol (2003) 2.17
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell (2011) 2.17
Endocervical adenocarcinoma in situ with ovarian metastases: a unique variant with potential for long-term survival. Int J Gynecol Pathol (2010) 2.16
An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells. Cancer Cell (2011) 2.14
Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development (2004) 2.14
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci U S A (2004) 2.12
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc Natl Acad Sci U S A (2009) 2.11
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science (2009) 2.11
Regulation of pulmonary fibrosis by chemokine receptor CXCR3. J Clin Invest (2004) 2.10
Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo. Am J Obstet Gynecol (2002) 2.02
Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron (2007) 2.01
Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal. Proc Natl Acad Sci U S A (2002) 1.99
T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol (2009) 1.99
Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev (2002) 1.97
Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes Dev (2010) 1.95
Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. J Clin Invest (2003) 1.90
APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci U S A (2002) 1.89
NAD(P)H and collagen as in vivo quantitative fluorescent biomarkers of epithelial precancerous changes. Cancer Res (2002) 1.88
Loss of p63 expression is associated with tumor progression in bladder cancer. Am J Pathol (2002) 1.88
Precursors to pelvic serous carcinoma and their clinical implications. Gynecol Oncol (2009) 1.87