B and T cells are not required for the viable motheaten phenotype.

PubWeight™: 1.14‹?› | Rank: Top 10%

🔗 View Article (PMC 2192436)

Published in J Exp Med on February 01, 1996

Authors

C C Yu1, H W Tsui, B Y Ngan, M J Shulman, G E Wu, F W Tsui

Author Affiliations

1: Department of Immunology, University of Toronto, Ontario, Canada.

Articles citing this

Interactions between the microbiota and the immune system. Science (2012) 10.45

Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice. Immunity (2013) 1.80

Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U S A (2008) 1.74

Shp1 regulates T cell homeostasis by limiting IL-4 signals. J Exp Med (2013) 1.64

Influence of microbial environment on autoimmunity. Nat Immunol (2009) 1.59

Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev (2009) 1.25

B cell inhibitory receptors and autoimmunity. Immunology (2003) 1.19

A critical role of SHP-1 in regulation of type 2 inflammation in the lung. Am J Respir Cell Mol Biol (2008) 1.01

Innate receptors and microbes in induction of autoimmunity. Curr Opin Immunol (2009) 1.00

Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response. J Exp Med (2002) 0.99

Alteration in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6/SHP1) may contribute to neutrophilic dermatoses. Am J Pathol (2011) 0.95

Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans. Am J Pathol (2011) 0.91

Antigen receptor signaling in the rheumatic diseases. Arthritis Res Ther (2009) 0.91

SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lung. J Immunol (2009) 0.90

Involvement of a tissue-specific autoantibody in skin disorders of murine systemic lupus erythematosus and autoinflammatory diseases. Proc Natl Acad Sci U S A (2006) 0.82

Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation. Immunol Res (2010) 0.81

LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane. J Biol Chem (2012) 0.80

Shp1 function in myeloid cells. J Leukoc Biol (2017) 0.75

Articles cited by this

RAG-1-deficient mice have no mature B and T lymphocytes. Cell (1992) 20.97

Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol (1979) 10.51

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell (1993) 4.06

The scid mutation in mice causes a general defect in DNA repair. Nature (1990) 3.85

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat Genet (1993) 3.11

Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells. J Immunol (1981) 2.94

A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. Nature (1991) 2.80

The CBA/N mouse strain: an experimental model illustrating the influence of the X-chromosome on immunity. Adv Immunol (1982) 2.79

The lymphoid tissues in mice with congenital aplasia of the thymus. Clin Exp Immunol (1969) 2.77

A link between double-strand break-related repair and V(D)J recombination: the scid mutation. Proc Natl Acad Sci U S A (1991) 2.68

Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences. Mol Cell Biol (1992) 2.48

Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13. Mol Cell Biol (1992) 2.41

"Viable motheaten," a new allele at the motheaten locus. I. Pathology. Am J Pathol (1984) 2.26

Production of immunoglobulin isotypes by Ly-1+ B cells in viable motheaten and normal mice. Science (1986) 2.24

Isolation of a src homology 2-containing tyrosine phosphatase. Proc Natl Acad Sci U S A (1992) 2.22

Genetically determined murine models of immunodeficiency. Annu Rev Immunol (1987) 1.98

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med (1993) 1.95

Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology. J Hered (1976) 1.94

X-linked immune deficiency (xid) of CBA/N mice. Curr Top Microbiol Immunol (1986) 1.68

Nude mice in immunology. Prog Allergy (1979) 1.61

Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins. J Immunol (1976) 1.43

Pleiotropic effects of deleterious alleles at the "motheaten" locus. Curr Top Microbiol Immunol (1988) 1.11

Suppressive effects of monocytic cells and transforming growth factor-beta on natural killer cell differentiation in autoimmune viable motheaten mutant mice. J Immunol (1991) 0.96

The interaction of the xid and me genes. J Immunol (1987) 0.95

Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6). Genomics (1992) 0.90

Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6. Genomics (1992) 0.88

Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice. J Immunol (1993) 0.88

Articles by these authors

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J (1996) 5.17

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat Genet (1993) 3.11

The coding function of nucleotide sequences can be discerned by statistical analysis. J Theor Biol (1981) 2.61

Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nat Immunol (2000) 2.59

Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences. Proc Natl Acad Sci U S A (1982) 2.44

Deletions in immunoglobulin mu chains. EMBO J (1982) 2.35

Production of functional chimaeric mouse/human antibody. Nature (1985) 2.35

Isolated chloroma: the effect of early antileukemic therapy. Ann Intern Med (1995) 2.29

Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells. Proc Natl Acad Sci U S A (1983) 2.03

Properties of recombination-deficient mutants of bacteriophage lambda. J Mol Biol (1970) 1.80

VH gene family utilization in colonies derived from B and pre-B cells detected by the RNA colony blot assay. EMBO J (1986) 1.77

Homologous recombination can restore normal immunoglobulin production in a mutant hybridoma cell line. Proc Natl Acad Sci U S A (1988) 1.70

Mutations affecting the structure and function of immunoglobulin M. Mol Cell Biol (1982) 1.58

Conservation of sequence in recombination signal sequence spacers. Nucleic Acids Res (1994) 1.58

Secretion of a lambda 2 immunoglobulin chain is prevented by a single amino acid substitution in its variable region. Cell (1983) 1.57

Immunoglobulin production by lymphocyte hybridomas. Eur J Immunol (1978) 1.56

Transposition of two different intracisternal A particle elements into an immunoglobulin kappa-chain gene. Mol Cell Biol (1984) 1.55

RNA splicing mutation in an aberrantly rearranged immunoglobulin lambda I gene. Proc Natl Acad Sci U S A (1981) 1.55

Gene replacement with one-sided homologous recombination. Mol Cell Biol (1992) 1.51

Transfer of a cloned immunoglobulin light-chain gene to mutant hybridoma cells restores specific antibody production. Nature (1983) 1.51

Hypothesis: genes which function in a stochastic lineage commitment process are subject to monoallelic expression. Semin Immunol (1999) 1.42

Isolation, structure and expression of mammalian genes for histidyl-tRNA synthetase. Nucleic Acids Res (1987) 1.40

IgM--molecular requirements for its assembly and function. Immunol Today (1989) 1.38

Enumeration and characterization of DJH structures in mouse fetal liver. EMBO J (1992) 1.37

Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain. Proc Natl Acad Sci U S A (1991) 1.36

Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression. J Immunol (1998) 1.31

Tufting enteropathy: a newly recognized clinicopathological entity associated with refractory diarrhea in infants. J Pediatr Gastroenterol Nutr (1994) 1.25

New att mutants of phage lambda. Virology (1976) 1.20

Hematopoietic transforming potential of activated ras in chimeric mice. Oncogene (1995) 1.18

Nucleotide sequence of a chromosomal rearranged lambda 2 immunoglobulin gene of mouse. Nucleic Acids Res (1982) 1.17

On the linkage between RNA processing and RNA translatability. J Biol Chem (1994) 1.14

Frequency of VH81x usage during B cell development: initial decline in usage is independent of Ig heavy chain cell surface expression. J Immunol (1996) 1.13

On the structure of polymeric IgM. Eur J Immunol (1988) 1.11

Complement activation is required for IgM-mediated enhancement of the antibody response. J Exp Med (1988) 1.08

Prevalence of RAS oncogene mutation in head and neck carcinomas. J Otolaryngol (1992) 1.08

Kappa light chain rearrangement in mouse fetal liver. J Immunol (1994) 1.07

Intermolecular disulfide bonding in IgM: effects of replacing cysteine residues in the mu heavy chain. EMBO J (1989) 1.07

Analysis of hybridoma mutants defective in synthesis of immunoglobulin M. Somat Cell Mol Genet (1986) 1.06

Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function. J Immunol (1999) 1.05

High frequency of normal DJH joints in B cell progenitors in severe combined immunodeficiency mice. J Exp Med (1993) 1.04

A linkage map of the mouse immunoglobulin lambda light chain locus. Immunogenetics (1989) 1.04

Nucleotide sequences of immunoglobulin mu heavy chain deletion mutants. Nucleic Acids Res (1983) 1.03

Variegated expression of the endogenous immunoglobulin heavy-chain gene in the absence of the intronic locus control region. Mol Cell Biol (1999) 1.03

Cellular and molecular restrictions of the lymphocyte fusion. Curr Top Microbiol Immunol (1978) 1.02

A hit-and-run system for introducing mutations into the Ig H chain locus of hybridoma cells by homologous recombination. J Immunol (1993) 1.02

Homologous recombination between transferred and chromosomal immunoglobulin kappa genes. Mol Cell Biol (1988) 1.01

Immunoglobulin mu and gamma heavy chain classes are not determined by class-specific RNA-splicing enzymes. Nature (1978) 1.00

The origins of V(D)J recombination. Cell (1997) 1.00

Molecular basis of the motheaten phenotype. Immunol Rev (1994) 1.00

Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathway. J Exp Med (1995) 1.00

Expression of the (recombinant) endogenous immunoglobulin heavy-chain locus requires the intronic matrix attachment regions. Mol Cell Biol (1997) 0.99

Development of the immunoglobulin repertoire. Clin Immunol Immunopathol (1996) 0.98

H-ras oncogene mutation and human papillomavirus infection in oral carcinomas. Arch Otolaryngol Head Neck Surg (1994) 0.98

Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of lambda light chains. EMBO J (1987) 0.98

Alterations of the p53 tumor suppressor gene in diffuse large cell lymphomas with translocations of the c-MYC and BCL-2 proto-oncogenes. Blood (1994) 0.97

The old and the restless. J Exp Med (2000) 0.97

Model for wandering restriction enzymes. Nature (1974) 0.97

Infrequent translation of a nonsense codon is sufficient to decrease mRNA level. Mol Biol Cell (1999) 0.96

Amplification of the gene for histidyl-tRNA synthetase in histidinol-resistant Chinese hamster ovary cells. Mol Cell Biol (1985) 0.95

Domain-switched mouse IgM/IgG2b hybrids indicate individual roles for C mu 2, C mu 3, and C mu 4 domains in the regulation of the interaction of IgM with complement C1q. J Immunol (1997) 0.95

Activation of complement by immunoglobulin M is impaired by the substitution serine-406----asparagine in the immunoglobulin mu heavy chain. Proc Natl Acad Sci U S A (1986) 0.95

Assembly of IgM. Role of disulfide bonding and noncovalent interactions. J Immunol (1995) 0.93

Detection of RNA transcripts in normal lymphoid and myeloid colonies. J Immunol Methods (1986) 0.92

Complement activation by IgM: evidence for the importance of the third constant domain of the mu heavy chain. Eur J Immunol (1987) 0.92

C1 binding by mouse IgM. The effect of abnormal glycosylation at position 402 resulting from a serine to asparagine exchange at residue 406 of the mu-chain. J Biol Chem (1990) 0.92

Epitope mapping of the cloned human autoantigen, histidyl-tRNA synthetase. Analysis of the myositis-associated anti-Jo-1 autoimmune response. J Immunol (1989) 0.91

A simple one-step hemolytic assay for C2 with C2-deficient human serum. J Immunol (1977) 0.91

Ig gene rearrangements on individual alleles of Abelson murine leukemia cell lines from (C57BL/6 x BALB/c) F1 fetal livers. J Immunol (1991) 0.91

Role of the intronic elements in the endogenous immunoglobulin heavy chain locus. Either the matrix attachment regions or the core enhancer is sufficient to maintain expression. J Biol Chem (1999) 0.91

Epitope studies indicate that histidyl-tRNA synthetase is a stimulating antigen in idiopathic myositis. FASEB J (1995) 0.91

V(H) gene replacement occurs in the spleen and bone marrow of non-autoimmune quasi-monoclonal mice. Eur J Immunol (1998) 0.90

Rapid vertical tube rotor gradient assay for binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the Ah receptor. Can J Physiol Pharmacol (1981) 0.90

Effects of vector cutting on its recombination with the chromosomal immunoglobulin gene in hybridoma cells. Somat Cell Mol Genet (1991) 0.89

Inversions produced during V(D)J rearrangement at IgH, the immunoglobulin heavy-chain locus. Mol Cell Biol (1995) 0.89

Molecular mechanisms involved in receptor editing at the Ig heavy chain locus. Int Immunol (1998) 0.89

C1 binding by murine IgM. The effect of a Pro-to-Ser exchange at residue 436 of the mu-chain. J Biol Chem (1988) 0.88

Production of mouse V/human C chimeric kappa genes by homologous recombination in hybridoma cells. Analysis of vector design and recombinant gene expression. J Immunol (1994) 0.88

Overexpression of the protein tyrosine phosphatase, nonreceptor type 6 (PTPN6), in human epithelial ovarian cancer. Gynecol Oncol (1995) 0.88

Association of Ig L chain-like protein lambda 5 with a 16-kilodalton protein in mouse pre-B cell lines is not dependent on the presence of Ig H chain protein. J Immunol (1990) 0.88

Mouse VH7183 recombination signal sequences mediate recombination more frequently than those of VHJ558. J Immunol (1995) 0.87

Differential glycosylation of polymeric and monomeric IgM. Mol Immunol (1989) 0.87

Mouse RSS spacer sequences affect the rate of V(D)J recombination. Immunogenetics (1996) 0.87

B cell developmental defects in X-linked immunodeficiency. Int Immunol (1993) 0.87

Effects of mutation position on frequency of marker rescue by homologous recombination. Mol Cell Biol (1992) 0.87

An improved system of somatic cell molecular genetics for analyzing the requirements of Ig synthesis and function. Int Immunol (1994) 0.86

The B cell repertoire. FASEB J (1989) 0.86

Analysis of a hot spot for DNA insertion suggests a mechanism for Ig switch recombination. J Immunol (1996) 0.86

Evolution of gonadotropin structure and function. Recent Prog Horm Res (1976) 0.86

Detection of occult lymphoma in the peripheral blood and bone marrow of patients with untreated early-stage and advanced-stage follicular lymphoma. J Clin Oncol (1993) 0.86

Development of B lymphocytes from lymphoid committed and uncommitted progenitors. Immunol Rev (1994) 0.86

A region of the immunoglobulin-mu heavy chain necessary for forming pentameric IgM. J Immunol (1986) 0.85

Progenitor cell hyperplasia with rare development of myeloid leukemia in interleukin 11 bone marrow chimeras. J Exp Med (1993) 0.85

Isolation of new nonsense and frameshift mutants in the immunoglobulin mu heavy-chain gene of hybridoma cells. Somat Cell Mol Genet (1993) 0.85

An element in the endogenous IgH locus stimulates gene targeting in hybridoma cells. Nucleic Acids Res (1996) 0.84

A V region mutation in a phosphocholine-binding monoclonal antibody results in loss of antigen binding. J Immunol (1991) 0.84

Interplay of J chain and disulfide bonding in assembly of polymeric IgM. Int Immunol (1997) 0.84

Mapping of amino acid residues in the C mu 3 domain of mouse IgM important in macromolecular assembly and complement-dependent cytolysis. J Immunol (1994) 0.84