Published in Mol Cell on December 25, 2009
Alternative ways to think about cellular internal ribosome entry. J Biol Chem (2010) 1.57
DEAD-box proteins as RNA helicases and chaperones. Wiley Interdiscip Rev RNA (2011) 1.37
Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits. Proc Natl Acad Sci U S A (2011) 1.32
RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage. Nucleic Acids Res (2011) 1.27
A functional genomic screen in planarians identifies novel regulators of germ cell development. Genes Dev (2010) 1.24
Subcellular communication through RNA transport and localized protein synthesis. Traffic (2010) 1.22
Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1. J Cell Biol (2013) 1.14
A cellular response linking eIF4AI activity to eIF4AII transcription. RNA (2012) 1.13
Cytoplasmic RNA-binding proteins and the control of complex brain function. Cold Spring Harb Perspect Biol (2012) 1.12
A HuD-ZBP1 ribonucleoprotein complex localizes GAP-43 mRNA into axons through its 3' untranslated region AU-rich regulatory element. J Neurochem (2013) 1.10
Molecular determinants of the axonal mRNA transcriptome. Dev Neurobiol (2013) 1.04
AU-rich-element-dependent translation repression requires the cooperation of tristetraprolin and RCK/P54. Mol Cell Biol (2011) 1.03
A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI. PLoS One (2010) 0.93
HuD regulates coding and noncoding RNA to induce APP→Aβ processing. Cell Rep (2014) 0.92
BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA. Dev Biol (2010) 0.91
Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction. RNA (2013) 0.90
HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens. Mol Vis (2010) 0.88
Prenatal deletion of the RNA-binding protein HuD disrupts postnatal cortical circuit maturation and behavior. J Neurosci (2014) 0.87
Mechanisms of translational regulation by a human eIF5-mimic protein. Nucleic Acids Res (2011) 0.86
Post-transcriptional regulatory elements and spatiotemporal specification of neocortical stem cells and projection neurons. Neuroscience (2013) 0.86
Competing Interactions of RNA-Binding Proteins, MicroRNAs, and Their Targets Control Neuronal Development and Function. Biomolecules (2015) 0.86
Serine-threonine kinase receptor-associated protein (STRAP) regulates translation of type I collagen mRNAs. Mol Cell Biol (2013) 0.85
HuD promotes BDNF expression in brain neurons via selective stabilization of the BDNF long 3'UTR mRNA. PLoS One (2013) 0.84
eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease. PLoS One (2010) 0.83
Trans-acting factors governing acetylcholinesterase mRNA metabolism in neurons. Front Mol Neurosci (2012) 0.83
RNA-binding proteins, neural development and the addictions. Genes Brain Behav (2016) 0.81
The molecular mechanism of translational control via the communication between the microRNA pathway and RNA-binding proteins. RNA Biol (2015) 0.79
Functional and direct interaction between the RNA binding protein HuD and active Akt1. Nucleic Acids Res (2011) 0.78
HuR function and translational state analysis following global brain ischemia and reperfusion. Transl Stroke Res (2013) 0.77
HuD stimulates translation via eIF4A. Mol Cell (2009) 0.77
RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions. Biomolecules (2015) 0.76
The DPYSL2 gene connects mTOR and schizophrenia. Transl Psychiatry (2016) 0.75
Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish. Dev Biol (2017) 0.75
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet (2008) 32.08
Upstream and downstream of mTOR. Genes Dev (2004) 21.61
Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science (2006) 18.14
Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem (2010) 12.06
Translational control in stress and apoptosis. Nat Rev Mol Cell Biol (2005) 8.91
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res (2006) 6.99
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity (2004) 6.72
Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature (2005) 6.69
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res (2007) 5.45
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science (2010) 4.81
Translational control of long-lasting synaptic plasticity and memory. Neuron (2009) 4.77
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem (2007) 4.45
MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science (2007) 4.33
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc Natl Acad Sci U S A (2001) 4.16
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Mol Cell Biol (2002) 4.11
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell (2010) 4.01
Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms. Genes Dev (2005) 3.92
The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol Cell Biol (2003) 3.90
eIF4E--from translation to transformation. Oncogene (2004) 3.78
Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature (2010) 3.77
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem (2005) 3.74
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J (2006) 3.57
Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430. Curr Biol (2006) 3.51
eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell (2007) 3.46
A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG. EMBO J (2003) 3.44
The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nat Struct Mol Biol (2012) 3.42
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. EMBO J (2004) 3.29
Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature (2012) 3.13
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc Natl Acad Sci U S A (2010) 3.13
The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell (2008) 3.10
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol (2004) 3.00
14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature (2007) 2.98
Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell (2004) 2.91
Dissecting the role of mTOR: lessons from mTOR inhibitors. Biochim Biophys Acta (2009) 2.89
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J Clin Invest (2007) 2.86
Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat Cell Biol (2005) 2.80
A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cell (2005) 2.80
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature (2005) 2.67
miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nat Struct Mol Biol (2011) 2.61
Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell (2009) 2.60
Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. J Mol Biol (2002) 2.53
A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. J Cell Biol (2005) 2.51
A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in Cap/Poly(A)-dependent translation. J Biol Chem (2002) 2.43
mRNA helicases: the tacticians of translational control. Nat Rev Mol Cell Biol (2011) 2.41
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J (2006) 2.41
A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Mol Cell Biol (2004) 2.38
Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut (2011) 2.38
eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Nat Struct Mol Biol (2004) 2.38
Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation. PLoS One (2007) 2.35
The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. J Neurosci (2005) 2.33
Translational control of the innate immune response through IRF-7. Nature (2008) 2.30
Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science (2002) 2.28
Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J (2007) 2.27
The dynamics of mammalian P body transport, assembly, and disassembly in vivo. Mol Biol Cell (2008) 2.25
The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase. Cancer Prev Res (Phila) (2008) 2.23
Translational homeostasis via the mRNA cap-binding protein, eIF4E. Mol Cell (2012) 2.19
The Akt of translational control. Oncogene (2005) 2.15
Cap and cap-binding proteins in the control of gene expression. Wiley Interdiscip Rev RNA (2010) 2.11
Reconstitution reveals the functional core of mammalian eIF3. EMBO J (2007) 2.06
Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression. J Neurosci (2006) 2.04
Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide. Cancer Res (2003) 2.04
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest (2010) 2.04
Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol (2002) 2.02
Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection. Cell Host Microbe (2011) 2.01
Translation initiator EIF4G1 mutations in familial Parkinson disease. Am J Hum Genet (2011) 2.00
Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proc Natl Acad Sci U S A (2005) 2.00
Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1. Structure (2006) 1.99
Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation. Mol Cell Biol (2005) 1.99
A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proc Natl Acad Sci U S A (2004) 1.97
A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Mol Cell Proteomics (2005) 1.95
Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species. Mol Cell Biol (2006) 1.93
Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth. Mol Cell Biol (2002) 1.92
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab (2013) 1.91
La autoantigen is necessary for optimal function of the poliovirus and hepatitis C virus internal ribosome entry site in vivo and in vitro. Mol Cell Biol (2004) 1.87
Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal. Cancer Sci (2003) 1.86
Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife (2013) 1.85
Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes Dev (2005) 1.84
Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses. EMBO J (2006) 1.79
S6K1 plays a critical role in early adipocyte differentiation. Dev Cell (2010) 1.74
The leader of human immunodeficiency virus type 1 genomic RNA harbors an internal ribosome entry segment that is active during the G2/M phase of the cell cycle. J Virol (2003) 1.71
Signaling control of mRNA translation in cancer pathogenesis. Oncogene (2004) 1.71
Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease. J Hepatol (2012) 1.70
Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. RNA (2008) 1.69
Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation. Nat Struct Mol Biol (2010) 1.66
Dendritic BC1 RNA: functional role in regulation of translation initiation. J Neurosci (2002) 1.64
Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. EMBO J (2006) 1.64
ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress. Cell Metab (2008) 1.62
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies. Cancer Res (2012) 1.62
HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA. Nucleic Acids Res (2012) 1.58
Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP. J Cell Biol (2008) 1.56
Pervasive and cooperative deadenylation of 3'UTRs by embryonic microRNA families. Mol Cell (2010) 1.55
Paip1 interacts with poly(A) binding protein through two independent binding motifs. Mol Cell Biol (2002) 1.55