HuD regulates coding and noncoding RNA to induce APP→Aβ processing.

PubWeight™: 0.92‹?›

🔗 View Article (PMC 4074355)

Published in Cell Rep on May 22, 2014

Authors

Min-Ju Kang1, Kotb Abdelmohsen1, Emmette R Hutchison2, Sarah J Mitchell3, Ioannis Grammatikakis1, Rong Guo1, Ji Heon Noh1, Jennifer L Martindale1, Xiaoling Yang1, Eun Kyung Lee1, Mohammad A Faghihi4, Claes Wahlestedt4, Juan C Troncoso5, Olga Pletnikova5, Nora Perrone-Bizzozero6, Susan M Resnick7, Rafael de Cabo3, Mark P Mattson2, Myriam Gorospe8

Author Affiliations

1: Laboratory of Genetics, National Institute on Aging-Intramural Research Program, NIH, Baltimore, MD 21224, USA.
2: Laboratory of Neurosciences, National Institute on Aging-Intramural Research Program, NIH, Baltimore, MD 21224, USA.
3: Translational Gerontology Branch, National Institute on Aging-Intramural Research Program, NIH, Baltimore, MD 21224, USA.
4: Center for Therapeutic Innovation, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
5: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
6: Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
7: Laboratory of Behavioral Neuroscience, National Institute on Aging-Intramural Research Program, NIH, Baltimore, MD 21224, USA.
8: Laboratory of Genetics, National Institute on Aging-Intramural Research Program, NIH, Baltimore, MD 21224, USA. Electronic address: myriam-gorospe@nih.gov.

Articles cited by this

Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem (2010) 12.06

From birth to death: the complex lives of eukaryotic mRNAs. Science (2005) 8.75

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat Med (2008) 5.62

RNA-binding proteins and post-transcriptional gene regulation. FEBS Lett (2008) 5.00

Eukaryotic mRNPs may represent posttranscriptional operons. Mol Cell (2002) 4.39

Diverse molecular functions of Hu proteins. Cell Mol Life Sci (2008) 4.09

ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR. Genes Dev (2002) 3.71

A conserved family of elav-like genes in vertebrates. Proc Natl Acad Sci U S A (1995) 3.43

Posttranscriptional gene regulation by long noncoding RNA. J Mol Biol (2012) 1.87

The RNA-binding protein HuD regulates neuronal cell identity and maturation. Proc Natl Acad Sci U S A (2005) 1.66

hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol (2010) 1.61

Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memory. Proc Natl Acad Sci U S A (2004) 1.47

Systematic analysis of posttranscriptional gene expression. Wiley Interdiscip Rev Syst Biol Med (2010) 1.44

miR-375 inhibits differentiation of neurites by lowering HuD levels. Mol Cell Biol (2010) 1.43

Cytoplasmic localization is required for the mammalian ELAV-like protein HuD to induce neuronal differentiation. Genes Cells (1999) 1.37

The RNA-binding protein HuD: a regulator of neuronal differentiation, maintenance and plasticity. Bioessays (2006) 1.33

The ELAV protein HuD stimulates cap-dependent translation in a Poly(A)- and eIF4A-dependent manner. Mol Cell (2009) 1.27

Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets. Nucleic Acids Res (2009) 1.26

RNA-binding protein HuD controls insulin translation. Mol Cell (2012) 1.25

Overexpression of HuD accelerates neurite outgrowth and increases GAP-43 mRNA expression in cortical neurons and retinoic acid-induced embryonic stem cells in vitro. Exp Neurol (2001) 1.25

Defining a neuron: neuronal ELAV proteins. Cell Mol Life Sci (2008) 1.22

Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques. Acta Neuropathol (2012) 1.09

Increased expression of axogenesis-related genes and mossy fibre length in dentate granule cells from adult HuD overexpressor mice. ASN Neuro (2011) 0.89