Published in J Biol Chem on January 13, 2010
Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene (2011) 2.36
Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation. Cell Stem Cell (2015) 1.65
ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4. Nat Struct Mol Biol (2012) 1.30
Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4. Oncogene (2012) 1.18
A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context. Mol Cell Biol (2011) 1.13
Determination of protein interactome of transcription factor Sox2 in embryonic stem cells engineered for inducible expression of four reprogramming factors. J Biol Chem (2012) 1.10
Wnt activation promotes neuronal differentiation of glioblastoma. Cell Death Dis (2013) 1.08
"Go with the flow": how Krüppel-like factor 2 regulates the vasoprotective effects of shear stress. Antioxid Redox Signal (2011) 1.07
Isolation and characterization of neural crest-derived stem cells from dental pulp of neonatal mice. PLoS One (2011) 1.07
Expression of the tumor suppressor Krüppel-like factor 4 as a prognostic predictor for colon cancer. Cancer Epidemiol Biomarkers Prev (2010) 1.06
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miR-145 and miR-143 regulate odontoblast differentiation through targeting Klf4 and Osx genes in a feedback loop. J Biol Chem (2013) 0.94
Role of Kruppel-like factor 4 in neurogenesis and radial neuronal migration in the developing cerebral cortex. Mol Cell Biol (2012) 0.92
Phosphorylation of Nanog is essential to regulate Bmi1 and promote tumorigenesis. Oncogene (2013) 0.91
Krüppel-like factors in cancer progression: three fingers on the steering wheel. Oncotarget (2014) 0.90
Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics. PLoS One (2012) 0.89
Induction of cancerous stem cells during embryonic stem cell differentiation. J Biol Chem (2012) 0.88
Expression of Kruppel-like factor KLF4 in mouse hair follicle stem cells contributes to cutaneous wound healing. PLoS One (2012) 0.88
Regulation of induced pluripotent stem (iPS) cell induction by Wnt/β-catenin signaling. J Biol Chem (2014) 0.88
A model-based analysis of culture-dependent phenotypes of mESCs. PLoS One (2014) 0.85
MicroRNAs regulate bone development and regeneration. Int J Mol Sci (2015) 0.84
miR-10a restores human mesenchymal stem cell differentiation by repressing KLF4. J Cell Physiol (2013) 0.82
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Micheliolide overcomes KLF4-mediated cisplatin resistance in breast cancer cells by downregulating glutathione. Onco Targets Ther (2015) 0.80
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Pluripotency Factors on Their Lineage Move. Stem Cells Int (2015) 0.75
Transcriptional repression of FOXO1 by KLF4 contributes to glioma progression. Oncotarget (2016) 0.75
Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy. Oncotarget (2016) 0.75
Describing the Stem Cell Potency: The Various Methods of Functional Assessment and In silico Diagnostics. Front Cell Dev Biol (2016) 0.75
Inhibition of KLF4 by Statins Reverses Adriamycin-Induced Metastasis and Cancer Stemness in Osteosarcoma Cells. Stem Cell Reports (2017) 0.75
Candidate gene expression patterns in rabbit preimplantation embryos developed in vivo and in vitro. J Assist Reprod Genet (2014) 0.75
Roles of Klf5 Acetylation in the Self-Renewal and the Differentiation of Mouse Embryonic Stem Cells. PLoS One (2015) 0.75
Krüppel-like factors in mammalian stem cells and development. Development (2017) 0.75
Effects of Klf4 and c-Myc Knockdown on Pluripotency Maintenance in Porcine Induced Pluripotent Stem Cell. Cell J (2017) 0.75
Sp5 induces the expression of Nanog to maintain mouse embryonic stem cell self-renewal. PLoS One (2017) 0.75
The transcription factor Gbx2 induces expression of Kruppel-like factor 4 to maintain and induce naive pluripotency of embryonic stem cells. J Biol Chem (2017) 0.75
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The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol (2005) 4.29
KLF4, p21 and context-dependent opposing forces in cancer. Nat Rev Cancer (2006) 4.14
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Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal. Cell Stem Cell (2009) 3.27
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Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle. J Biol Chem (2001) 2.71
Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Mol Cell Biol (2006) 2.59
Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells. PLoS One (2008) 2.51
Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem Cell (2008) 1.94
Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog. Stem Cells (2009) 1.90
Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells (2009) 1.79
Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-freeBMP4 culture. BMC Genomics (2007) 1.34
Chipping away at the embryonic stem cell network. Cell (2005) 1.19
Containing pandemic influenza with antiviral agents. Am J Epidemiol (2004) 12.82
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Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells. Blood (2002) 5.47
A polymer tandem solar cell with 10.6% power conversion efficiency. Nat Commun (2013) 4.48
A mechanism for Wnt coreceptor activation. Mol Cell (2004) 4.31
Do birth cohorts matter? Age-period-cohort analyses of the obesity epidemic in the United States. Soc Sci Med (2009) 3.87
Antiviral effects on influenza viral transmission and pathogenicity: observations from household-based trials. Am J Epidemiol (2006) 3.48
Neuronal basis of age-related working memory decline. Nature (2011) 3.15
Two physically, functionally, and developmentally distinct peritoneal macrophage subsets. Proc Natl Acad Sci U S A (2010) 2.94
High-throughput solution processing of large-scale graphene. Nat Nanotechnol (2008) 2.93
Patterning organic single-crystal transistor arrays. Nature (2006) 2.80
The Na(V)1.7 sodium channel: from molecule to man. Nat Rev Neurosci (2012) 2.71
A practical comparison of de novo genome assembly software tools for next-generation sequencing technologies. PLoS One (2011) 2.55
NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex. Neuron (2013) 2.46
Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity (2010) 2.44
Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system. Pain (2012) 2.34
Engaging in an auditory task suppresses responses in auditory cortex. Nat Neurosci (2009) 2.34
Exploratory analyses of efficacy data from major depressive disorder trials submitted to the US Food and Drug Administration in support of new drug applications. J Clin Psychiatry (2011) 2.33
Murine B7-H3 is a negative regulator of T cells. J Immunol (2004) 2.33
Planar heterojunction perovskite solar cells via vapor-assisted solution process. J Am Chem Soc (2013) 2.32
Containing a large bioterrorist smallpox attack: a computer simulation approach. Int J Infect Dis (2006) 2.29
Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane. Proc Natl Acad Sci U S A (2008) 2.18
Association of the beta2-adrenergic receptor gene with essential hypertension in the non-Han Chinese Yi minority human population. J Hypertens (2006) 2.16
Hand, foot, and mouth disease in China: patterns of spread and transmissibility. Epidemiology (2011) 2.13
Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. Dev Cell (2008) 2.13
Prostaglandin E2 Stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer. J Biol Chem (2005) 2.09
Klf4 organizes long-range chromosomal interactions with the oct4 locus in reprogramming and pluripotency. Cell Stem Cell (2013) 2.04
Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. Mol Cell Biol (2006) 1.96
Mechanical Deformation Behavior of Nonpolar GaN Thick Films by Berkovich Nanoindentation. Nanoscale Res Lett (2009) 1.95
Expression of esophageal cancer related gene 4 (ECRG4), a novel tumor suppressor gene, in esophageal cancer and its inhibitory effect on the tumor growth in vitro and in vivo. Int J Cancer (2009) 1.92
Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton. J Neurosci (2006) 1.90
Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells. J Biol Chem (2006) 1.86
Practical chemical sensors from chemically derived graphene. ACS Nano (2009) 1.85
Development of effective quantum mechanical/molecular mechanical (QM/MM) methods for complex biological processes. J Phys Chem B (2006) 1.83
Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation. Transplantation (2005) 1.82
High heparanase activity in multiple myeloma is associated with elevated microvessel density. Cancer Res (2003) 1.81
Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells (2009) 1.79
Digital memory device based on tobacco mosaic virus conjugated with nanoparticles. Nat Nanotechnol (2006) 1.79
Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. J Biol Chem (2007) 1.78
Roles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cells. Acta Biochim Biophys Sin (Shanghai) (2008) 1.76
Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis. Matrix Biol (2004) 1.75
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma. J Biol Chem (2008) 1.74
Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung. ACS Nano (2011) 1.74
Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor. J Control Release (2011) 1.72
Plasmonic polymer tandem solar cell. ACS Nano (2011) 1.68
HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. J Biol Chem (2005) 1.66
Polyaniline nanofiber/gold nanoparticle nonvolatile memory. Nano Lett (2005) 1.64
Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies. J Cell Biochem (2005) 1.64
Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge. Proc Natl Acad Sci U S A (2009) 1.61
Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells. Med Oncol (2009) 1.60
LncRNAs expression signatures of renal clear cell carcinoma revealed by microarray. PLoS One (2012) 1.59
Plant DNA barcoding: from gene to genome. Biol Rev Camb Philos Soc (2014) 1.56
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The presence of a membrane-bound progesterone receptor sensitizes the estradiol-induced effect on the proliferation of human breast cancer cells. Menopause (2011) 1.52
Low-temperature solution processing of graphene-carbon nanotube hybrid materials for high-performance transparent conductors. Nano Lett (2009) 1.50
Triggering of toll-like receptor-4 in human multiple myeloma cells promotes proliferation and alters cell responses to immune and chemotherapy drug attack. Cancer Biol Ther (2011) 1.50
Oncomodulin links inflammation to optic nerve regeneration. Proc Natl Acad Sci U S A (2009) 1.50
Long-term in vivo biodistribution imaging and toxicity of polyacrylic acid-coated upconversion nanophosphors. Biomaterials (2010) 1.50
The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA. J Biol Chem (2005) 1.49
Surgical management and evaluation of prognostic factors influencing postoperative visual outcome of suprasellar meningiomas. World Neurosurg (2011) 1.49
Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. Mol Cell Biol (2008) 1.48
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Dynamic Network Connectivity: A new form of neuroplasticity. Trends Cogn Sci (2010) 1.48
Surface charge and cellular processing of covalently functionalized multiwall carbon nanotubes determine pulmonary toxicity. ACS Nano (2013) 1.47
Single-crystal linear polymers through visible light-triggered topochemical quantitative polymerization. Science (2014) 1.45
Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP. Clin Sci (Lond) (2013) 1.45
Macrolide resistance and molecular types of Treponema pallidum causing primary syphilis in Shanghai, China. Clin Infect Dis (2009) 1.44
KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin. Mol Cell Biol (2009) 1.44
Long-term renal changes in the liver-specific glucokinase knockout mouse: implications for renal disease in maturity-onset diabetes of the young 2. Transl Res (2010) 1.44
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MiRNA-451 plays a role as tumor suppressor in human glioma cells. Brain Res (2010) 1.43
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Pluronic F108 coating decreases the lung fibrosis potential of multiwall carbon nanotubes by reducing lysosomal injury. Nano Lett (2012) 1.40
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SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis. Clin Cancer Res (2011) 1.40
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Mapping spread and risk of avian influenza A (H7N9) in China. Sci Rep (2013) 1.38
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An efficient triple-junction polymer solar cell having a power conversion efficiency exceeding 11%. Adv Mater (2014) 1.35
Low-temperature solution-processed perovskite solar cells with high efficiency and flexibility. ACS Nano (2014) 1.35
New forecasting methodology indicates more disease and earlier mortality ahead for today's younger Americans. Health Aff (Millwood) (2011) 1.34
KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol (2008) 1.33
Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells. Leuk Res (2006) 1.33
A scoring model based on neutrophil to lymphocyte ratio predicts recurrence of HBV-associated hepatocellular carcinoma after liver transplantation. PLoS One (2011) 1.32
Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice. Hepatology (2009) 1.31
DNA gridiron nanostructures based on four-arm junctions. Science (2013) 1.31
Social Change and Socioeconomic Disparities in Health over the Life Course in China: A Cohort Analysis. Am Sociol Rev (2010) 1.31
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Transcriptional regulator Id2 controls survival of hepatic NKT cells. Proc Natl Acad Sci U S A (2009) 1.30
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Syndecan-1: a dynamic regulator of the myeloma microenvironment. Clin Exp Metastasis (2007) 1.27
Dual plasmonic nanostructures for high performance inverted organic solar cells. Adv Mater (2012) 1.25
Distinct progenitors for B-1 and B-2 cells are present in adult mouse spleen. Proc Natl Acad Sci U S A (2011) 1.25
Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population. BMC Med Genet (2010) 1.24