Published in J Biol Chem on October 01, 2007
Mammalian Krüppel-like factors in health and diseases. Physiol Rev (2010) 4.09
Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest (2011) 3.08
KLF8 recruits the p300 and PCAF co-activators to its amino terminal activation domain to activate transcription. Cell Cycle (2010) 2.69
Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression. J Biol Chem (2010) 1.79
Roles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cells. Acta Biochim Biophys Sin (Shanghai) (2008) 1.76
Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res (2008) 1.64
KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin. Mol Cell Biol (2009) 1.44
Krüppel-like factors in cancer. Nat Rev Cancer (2013) 1.32
Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4). J Biol Chem (2010) 1.25
Regulation of the potential marker for intestinal cells, Bmi1, by β-catenin and the zinc finger protein KLF4: implications for colon cancer. J Biol Chem (2011) 1.23
Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression. EMBO J (2009) 1.22
Stochasticity and the molecular mechanisms of induced pluripotency. PLoS One (2008) 1.20
SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization mechanism that blocks let-7 biogenesis in human ESCs. Cell Stem Cell (2014) 1.20
NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors. Genome Res (2013) 1.15
Krüppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation. J Neuroinflammation (2010) 1.15
Protein post-translational modifications and regulation of pluripotency in human stem cells. Cell Res (2013) 1.12
Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF). Proc Natl Acad Sci U S A (2011) 1.06
Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network. PLoS One (2011) 1.06
The emerging role of Krüppel-like factors in endocrine-responsive cancers of female reproductive tissues. J Endocrinol (2009) 1.03
Transforming growth factor-beta1 up-regulation of human alpha(1)(I) collagen is mediated by Sp1 and Smad2 transacting factors. DNA Cell Biol (2009) 1.02
Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis. Curr Genomics (2009) 1.01
Tuning the orchestra: transcriptional pathways controlling axon regeneration. Front Mol Neurosci (2012) 1.00
ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. Genes Dev (2014) 0.98
Residual expression of reprogramming factors affects the transcriptional program and epigenetic signatures of induced pluripotent stem cells. PLoS One (2012) 0.98
Regulation of Krüppel-like factor 4 by the anaphase promoting complex pathway is involved in TGF-beta signaling. J Biol Chem (2010) 0.96
Krüppel-like factors: three fingers in control. Hum Genomics (2010) 0.95
1,25-dihydroxyvitamin D3 and its nuclear receptor repress human α1 (I) collagen expression and type I collagen formation. Liver Int (2013) 0.94
Krüppel-like transcription factors in the nervous system: novel players in neurite outgrowth and axon regeneration. Mol Cell Neurosci (2011) 0.94
Role of Kruppel-like factor 4 in neurogenesis and radial neuronal migration in the developing cerebral cortex. Mol Cell Biol (2012) 0.92
Suppression of neurotensin receptor type 1 expression and function by histone deacetylase inhibitors in human colorectal cancers. Mol Cancer Ther (2010) 0.91
MicroRNAs 206 and 21 cooperate to promote RAS-extracellular signal-regulated kinase signaling by suppressing the translation of RASA1 and SPRED1. Mol Cell Biol (2014) 0.90
Krüppel-like factor 4 interacts with p300 to activate mitofusin 2 gene expression induced by all-trans retinoic acid in VSMCs. Acta Pharmacol Sin (2010) 0.90
Tolerance to ischemia - an increasingly complex biology. Transl Stroke Res (2013) 0.89
Epigenetic regulation of axon and dendrite growth. Front Mol Neurosci (2012) 0.89
Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer. J Biol Chem (2014) 0.89
KLF4 modulates expression of IL-6 in dendritic cells via both promoter activation and epigenetic modification. J Biol Chem (2013) 0.87
Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells. PLoS Pathog (2015) 0.87
Epigenetic landscape of pluripotent stem cells. Antioxid Redox Signal (2012) 0.86
12-O-tetradecanoylphorbol-13-acetate promotes breast cancer cell motility by increasing S100A14 level in a Kruppel-like transcription factor 4 (KLF4)-dependent manner. J Biol Chem (2014) 0.86
Novel insight into KLF4 proteolytic regulation in estrogen receptor signaling and breast carcinogenesis. J Biol Chem (2012) 0.86
The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression. Nucleic Acids Res (2011) 0.84
Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells. Br J Haematol (2011) 0.84
Inner cell mass localization of NANOG precedes OCT3/4 in rhesus monkey blastocysts. Stem Cells Dev (2009) 0.83
Zebrafish krüppel-like factor 4a represses intestinal cell proliferation and promotes differentiation of intestinal cell lineages. PLoS One (2011) 0.83
Transcriptional profiling of fetal hypothalamic TRH neurons. BMC Genomics (2011) 0.83
KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer. Cell Death Differ (2015) 0.83
Loss of epigenetic Kruppel-like factor 4 histone deacetylase (KLF-4-HDAC)-mediated transcriptional suppression is crucial in increasing vascular endothelial growth factor (VEGF) expression in breast cancer. J Biol Chem (2013) 0.81
Nitric oxide and KLF4 protein epigenetically modify class II transactivator to repress major histocompatibility complex II expression during Mycobacterium bovis bacillus Calmette-Guerin infection. J Biol Chem (2013) 0.81
Differential roles of KLF4 in the development and differentiation of CD8+ T cells. Immunol Lett (2013) 0.81
A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4. Toxicol Appl Pharmacol (2012) 0.80
KLF4 deletion alters gastric cell lineage and induces MUC2 expression. Cell Death Dis (2016) 0.80
F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression. Oncotarget (2015) 0.79
Post-Transcriptional Regulation of KLF4 by High-Risk Human Papillomaviruses Is Necessary for the Differentiation-Dependent Viral Life Cycle. PLoS Pathog (2016) 0.79
Deregulated KLF4 Expression in Myeloid Leukemias Alters Cell Proliferation and Differentiation through MicroRNA and Gene Targets. Mol Cell Biol (2015) 0.79
Krüppel-like factors 4 and 5: unity in diversity. Curr Genomics (2009) 0.78
Role of histone deacetylase 2 and its posttranslational modifications in cardiac hypertrophy. BMB Rep (2015) 0.78
Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome. BMC Syst Biol (2015) 0.78
Tinkering with transcription factors uncovers plasticity of somatic cells. Genes Cancer (2010) 0.77
Identification of HDA15-PIF1 as a key repression module directing the transcriptional network of seed germination in the dark. Nucleic Acids Res (2017) 0.76
The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis. Nat Commun (2016) 0.76
Kruppel-Like Factor 4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development. PLoS One (2015) 0.76
PHD finger protein 2 (PHF2) represses ribosomal RNA gene transcription by antagonizing PHF finger protein 8 (PHF8) and recruiting methyltransferase SUV39H1. J Biol Chem (2014) 0.76
Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis. Cancer Med (2014) 0.75
Cell culture density affects the stemness gene expression of adipose tissue-derived mesenchymal stem cells. Biomed Rep (2017) 0.75
The EP300, KDM5A, KDM6A and KDM6B chromatin regulators cooperate with KLF4 in the transcriptional activation of POU5F1. PLoS One (2012) 0.75
Krüppel-like factors in mammalian stem cells and development. Development (2017) 0.75
TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development. Mol Cell Endocrinol (2014) 0.75
Regulation of vascular smooth muscle phenotype by cross-regulation of krüppel-like factors. Korean J Physiol Pharmacol (2016) 0.75
Krüppel-like factor 4 (KLF4): What we currently know. Gene (2017) 0.75
Kruppel-like factor4 regulates PRDM1 expression through binding to an autoimmune risk allele. JCI Insight (2017) 0.75
Krüppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions. Oncotarget (2017) 0.75
DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol (2003) 84.79
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication. Proc Natl Acad Sci U S A (2002) 17.22
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest (2011) 14.22
Structures of the bacterial ribosome at 3.5 A resolution. Science (2005) 12.63
Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol (2003) 9.08
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01
The first metal-organic framework (MOF) of Imazethapyr and its SHG, piezoelectric and ferroelectric properties. Dalton Trans (2008) 8.86
Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell (2008) 7.93
Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform. Mol Cell (2004) 7.32
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell (2002) 6.95
Hydrogen-bonded ferroelectrics based on metal-organic coordination. J Am Chem Soc (2009) 6.69
Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol (2010) 5.92
Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med (2008) 5.89
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev (2007) 5.79
Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell (2010) 5.77
The medaka draft genome and insights into vertebrate genome evolution. Nature (2007) 5.77
Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest (2005) 5.51
Exploration of essential gene functions via titratable promoter alleles. Cell (2004) 5.21
Probing microRNAs with microarrays: tissue specificity and functional inference. RNA (2004) 4.91
Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. Immunity (2013) 4.82
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science (2004) 4.81
Supramolecular bola-like ferroelectric: 4-methoxyanilinium tetrafluoroborate-18-crown-6. J Am Chem Soc (2011) 4.73
Experimental observation of the quantum anomalous Hall effect in a magnetic topological insulator. Science (2013) 4.69
Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genome. Nat Genet (2005) 4.66
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell (2010) 4.62
Expression profile matrix of Arabidopsis transcription factor genes suggests their putative functions in response to environmental stresses. Plant Cell (2002) 4.58
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol (2010) 4.56
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res (2011) 4.55
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol (2005) 4.54
A mechanism for Wnt coreceptor activation. Mol Cell (2004) 4.31
Diisopropylammonium chloride: a ferroelectric organic salt with a high phase transition temperature and practical utilization level of spontaneous polarization. Adv Mater (2011) 4.30
High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell (2004) 4.18
Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors. J Virol (2011) 4.06
Evolution of the mammalian transcription factor binding repertoire via transposable elements. Genome Res (2008) 3.76
Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell (2011) 3.53
Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals. Proc Natl Acad Sci U S A (2003) 3.47
Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem (2006) 3.24
Improved virological outcomes in British Columbia concomitant with decreasing incidence of HIV type 1 drug resistance detection. Clin Infect Dis (2010) 3.12
A panoramic view of yeast noncoding RNA processing. Cell (2003) 3.11
Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol (2004) 2.96
The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R. Nat Cell Biol (2005) 2.94
Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease. FASEB J (2005) 2.91
Proportion of different subtypes of stroke in China. Stroke (2003) 2.90
Extracting biological meaning from large gene lists with DAVID. Curr Protoc Bioinformatics (2009) 2.88
A multiferroic perdeutero metal-organic framework. Angew Chem Int Ed Engl (2011) 2.88
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell (2010) 2.87
Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Cancer Res (2010) 2.85
Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis. Nat Med (2013) 2.85
A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis. Eur J Cancer (2010) 2.84
The cerebrospinal fluid provides a proliferative niche for neural progenitor cells. Neuron (2011) 2.83
Attention training in individuals with generalized social phobia: A randomized controlled trial. J Consult Clin Psychol (2009) 2.76
High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies. J Virol Methods (2009) 2.75
Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family. J Virol (2012) 2.74
Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG. Proc Natl Acad Sci U S A (2013) 2.69
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat Immunol (2010) 2.68
Net primary production of Chinese croplands from 1950 to 1999. Ecol Appl (2007) 2.61
Network model of survival signaling in large granular lymphocyte leukemia. Proc Natl Acad Sci U S A (2008) 2.60
The membrane-anchored BOTRYTIS-INDUCED KINASE1 plays distinct roles in Arabidopsis resistance to necrotrophic and biotrophic pathogens. Plant Cell (2005) 2.57
Structural basis for mRNA and tRNA positioning on the ribosome. Proc Natl Acad Sci U S A (2006) 2.55
Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat Struct Mol Biol (2007) 2.54
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. Nat Cell Biol (2012) 2.48
Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF. J Clin Invest (2008) 2.43
Serum microRNA expression profile as a biomarker in the diagnosis and prognosis of pancreatic cancer. Clin Chem (2011) 2.42
RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings. Cell Res (2012) 2.41
Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron (2008) 2.40
The BOTRYTIS SUSCEPTIBLE1 gene encodes an R2R3MYB transcription factor protein that is required for biotic and abiotic stress responses in Arabidopsis. Plant Cell (2003) 2.39
Hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells. Stem Cells (2005) 2.37
Electronic origin of high-temperature superconductivity in single-layer FeSe superconductor. Nat Commun (2012) 2.37
Syphilis among female sex workers in southwestern China: potential for HIV transmission. Sex Transm Dis (2006) 2.34
Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma. Clin Chem (2010) 2.34
Phase diagram and electronic indication of high-temperature superconductivity at 65 K in single-layer FeSe films. Nat Mater (2013) 2.34
Alternative splicing of conserved exons is frequently species-specific in human and mouse. Trends Genet (2005) 2.26
Two essential but distinct functions of the mammalian abasic endonuclease. Proc Natl Acad Sci U S A (2005) 2.26
A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries. J Am Chem Soc (2005) 2.22
A graphene platform for sensing biomolecules. Angew Chem Int Ed Engl (2009) 2.19
Genetic control of rice plant architecture under domestication. Nat Genet (2008) 2.17
Electrical transport along bacterial nanowires from Shewanella oneidensis MR-1. Proc Natl Acad Sci U S A (2010) 2.17
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet (2012) 2.17
Recognizing falls from silhouettes. Conf Proc IEEE Eng Med Biol Soc (2006) 2.16
Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs. Nat Genet (2005) 2.15
Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice. J Hepatol (2013) 2.14
Hand, foot, and mouth disease in China: patterns of spread and transmissibility. Epidemiology (2011) 2.13
Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature (2008) 2.11
Use of mobile phones in an emergency reporting system for infectious disease surveillance after the Sichuan earthquake in China. Bull World Health Organ (2009) 2.11
Genome-wide identification of Francisella tularensis virulence determinants. Infect Immun (2007) 2.09
Prostaglandin E2 Stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer. J Biol Chem (2005) 2.09
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. EMBO J (2004) 2.08
High prevalence of aeroallergen sensitization among infants of atopic parents. J Pediatr (2006) 2.08
Attractor landscape analysis reveals feedback loops in the p53 network that control the cellular response to DNA damage. Sci Signal (2012) 2.07
Effectiveness of a combination therapy using calcineurin inhibitor and mTOR inhibitor in preventing allograft rejection and post-transplantation renal cancer progression. Cancer Lett (2012) 2.05
Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs. J Clin Invest (2006) 2.02
H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination. PLoS One (2011) 2.02
Magnetoelectric switching of exchange bias. Phys Rev Lett (2005) 2.00
RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia. Invest Ophthalmol Vis Sci (2003) 2.00
Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting. PLoS One (2011) 1.99
Experimental demonstration of topological surface states protected by time-reversal symmetry. Phys Rev Lett (2009) 1.99
Extended applications of vascularized preauricular and helical rim flaps in reconstruction of nasal defects. Plast Reconstr Surg (2008) 1.98