Published in BMC Bioinformatics on January 14, 2010
Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software. Bioinformatics (2011) 12.98
Pattern recognition software and techniques for biological image analysis. PLoS Comput Biol (2010) 2.22
MATtrack: A MATLAB-Based Quantitative Image Analysis Platform for Investigating Real-Time Photo-Converted Fluorescent Signals in Live Cells. PLoS One (2015) 1.42
Increasing the Content of High-Content Screening: An Overview. J Biomol Screen (2014) 1.36
RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. Mol Syst Biol (2011) 1.27
Near surface swimming of Salmonella Typhimurium explains target-site selection and cooperative invasion. PLoS Pathog (2012) 1.10
Workflow and metrics for image quality control in large-scale high-content screens. J Biomol Screen (2011) 1.08
Morphology-based prediction of osteogenic differentiation potential of human mesenchymal stem cells. PLoS One (2013) 1.04
Salmonella enterica serovar Typhimurium binds to HeLa cells via Fim-mediated reversible adhesion and irreversible type three secretion system 1-mediated docking. Infect Immun (2010) 0.96
Functional genomic and high-content screening for target discovery and deconvolution. Expert Opin Drug Discov (2012) 0.87
A new age in functional genomics using CRISPR/Cas9 in arrayed library screening. Front Genet (2015) 0.83
Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects. PLoS One (2015) 0.82
Label-free morphology-based prediction of multiple differentiation potentials of human mesenchymal stem cells for early evaluation of intact cells. PLoS One (2014) 0.80
HCS-Neurons: identifying phenotypic changes in multi-neuron images upon drug treatments of high-content screening. BMC Bioinformatics (2013) 0.80
Quantitative analysis of F-actin redistribution in astrocytoma cells treated with candidate pharmaceuticals. Cytometry A (2014) 0.79
A comparative study of cell classifiers for image-based high-throughput screening. BMC Bioinformatics (2014) 0.78
Cellular mechanisms of toll-like receptor-3 activation in the thalamus are associated with white matter injury in the developing brain. J Neuropathol Exp Neurol (2015) 0.77
Quantitative non-invasive cell characterisation and discrimination based on multispectral autofluorescence features. Sci Rep (2016) 0.75
Development of an image-based screening system for inhibitors of the plastidial MEP pathway and of protein geranylgeranylation. F1000Res (2015) 0.75
Bioimage classification with subcategory discriminant transform of high dimensional visual descriptors. BMC Bioinformatics (2016) 0.75
EXTRACTING BIOMEDICALLY IMPORTANT INFORMATION FROM LARGE, AUTOMATED IMAGING EXPERIMENTS. Proc IEEE Int Symp Biomed Imaging (2011) 0.75
Contribution of high-content imaging technologies to the development of anti-infective drugs. Cytometry A (2016) 0.75
CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol (2006) 32.51
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. Proc Natl Acad Sci U S A (2009) 5.15
High-throughput RNAi screening by time-lapse imaging of live human cells. Nat Methods (2006) 4.86
Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration. Cell (2008) 4.47
Foot and mouth: podosomes, invadopodia and circular dorsal ruffles. Nat Rev Mol Cell Biol (2004) 4.35
Analysis of cell-based RNAi screens. Genome Biol (2006) 3.99
Image-based multivariate profiling of drug responses from single cells. Nat Methods (2007) 3.90
Quantitative morphological signatures define local signaling networks regulating cell morphology. Science (2007) 3.76
CellProfiler Analyst: data exploration and analysis software for complex image-based screens. BMC Bioinformatics (2008) 2.99
Novel cell segmentation and online SVM for cell cycle phase identification in automated microscopy. Bioinformatics (2007) 2.54
Wndchrm - an open source utility for biological image analysis. Source Code Biol Med (2008) 2.37
Small molecule screening by imaging. Curr Opin Chem Biol (2006) 1.90
Fast automated cell phenotype image classification. BMC Bioinformatics (2007) 1.74
Image-based chemical screening. Nat Chem Biol (2007) 1.72
Salmonella type III secretion effectors: pulling the host cell's strings. Curr Opin Microbiol (2006) 1.70
Salmonella enterica serovar typhimurium pathogenicity island 1-encoded type III secretion system translocases mediate intimate attachment to nonphagocytic cells. Infect Immun (2009) 1.68
Role of the Salmonella pathogenicity island 1 (SPI-1) protein InvB in type III secretion of SopE and SopE2, two Salmonella effector proteins encoded outside of SPI-1. J Bacteriol (2003) 1.54
Cellular phenotype recognition for high-content RNA interference genome-wide screening. J Biomol Screen (2008) 1.47
A graphical model approach to automated classification of protein subcellular location patterns in multi-cell images. BMC Bioinformatics (2006) 1.47
Compound classification using image-based cellular phenotypes. Methods Enzymol (2006) 1.18
A reliable method for cell phenotype image classification. Artif Intell Med (2008) 1.16
A fast and efficient segmentation scheme for cell microscopic image. Cell Mol Biol (Noisy-le-grand) (2007) 1.07
An automatic method to discriminate malignant masses from normal tissue in digital mammograms. Phys Med Biol (2000) 0.96
Helicobacter pylori-related gastric histology classification using support-vector-machine-based feature selection. IEEE Trans Inf Technol Biomed (2008) 0.85
Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion. Microbiol Mol Biol Rev (2004) 7.93
Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota. PLoS Biol (2007) 7.58
Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host. Infect Immun (2003) 6.82
Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets. Nat Genet (2006) 6.74
Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity (2009) 5.43
Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science (2009) 4.45
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
Genome-scale RNAi profiling of cell division in human tissue culture cells. Nat Cell Biol (2007) 3.91
A curated compendium of phosphorylation motifs. Nat Biotechnol (2007) 3.79
An evaluation of human protein-protein interaction data in the public domain. BMC Bioinformatics (2006) 3.33
The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms. J Immunol (2005) 3.14
The role of microbiota in infectious disease. Trends Microbiol (2008) 3.11
Self-destructive cooperation mediated by phenotypic noise. Nature (2008) 3.07
The Salmonella enterica serotype typhimurium effector proteins SipA, SopA, SopB, SopD, and SopE2 act in concert to induce diarrhea in calves. Infect Immun (2002) 2.88
Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies. Nat Methods (2007) 2.83
Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteria. PLoS Pathog (2010) 2.79
Stabilization of cooperative virulence by the expression of an avirulent phenotype. Nature (2013) 2.47
Role of the Salmonella pathogenicity island 1 effector proteins SipA, SopB, SopE, and SopE2 in Salmonella enterica subspecies 1 serovar Typhimurium colitis in streptomycin-pretreated mice. Infect Immun (2004) 2.46
Flagella and chemotaxis are required for efficient induction of Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated mice. Infect Immun (2004) 2.41
Phosphoproteomic analysis of Her2/neu signaling and inhibition. Proc Natl Acad Sci U S A (2006) 2.30
Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria. PLoS Pathog (2009) 2.29
Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry. Cell (2011) 2.28
Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens. Proc Natl Acad Sci U S A (2014) 2.25
The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea. PLoS Pathog (2010) 2.17
A mouse model for S. typhimurium-induced enterocolitis. Trends Microbiol (2005) 2.09
Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis. J Exp Med (2008) 1.92
Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae. Proc Natl Acad Sci U S A (2012) 1.90
Mechanisms controlling pathogen colonization of the gut. Curr Opin Microbiol (2010) 1.88
Real-time imaging of type III secretion: Salmonella SipA injection into host cells. Proc Natl Acad Sci U S A (2005) 1.85
A Burkholderia pseudomallei type III secreted protein, BopE, facilitates bacterial invasion of epithelial cells and exhibits guanine nucleotide exchange factor activity. J Bacteriol (2003) 1.78
The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation. Cell Host Microbe (2009) 1.74
Salmonella type III secretion effectors: pulling the host cell's strings. Curr Opin Microbiol (2006) 1.70
Motility allows S. Typhimurium to benefit from the mucosal defence. Cell Microbiol (2008) 1.69
A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. Proc Natl Acad Sci U S A (2005) 1.67
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO J (2002) 1.64
The cost of virulence: retarded growth of Salmonella Typhimurium cells expressing type III secretion system 1. PLoS Pathog (2011) 1.60
Comparison of Salmonella enterica serovar Typhimurium colitis in germfree mice and mice pretreated with streptomycin. Infect Immun (2005) 1.59
Role of the Salmonella pathogenicity island 1 (SPI-1) protein InvB in type III secretion of SopE and SopE2, two Salmonella effector proteins encoded outside of SPI-1. J Bacteriol (2003) 1.54
Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems. Mol Microbiol (2002) 1.51
'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution. Nat Rev Microbiol (2013) 1.45
[Patients' view of melanoma follow-up]. J Dtsch Dermatol Ges (2004) 1.43
TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa. J Immunol (2010) 1.43
Salmonella Pathogenicity Island 4 encodes a giant non-fimbrial adhesin and the cognate type 1 secretion system. Cell Microbiol (2007) 1.39
A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export. PLoS Biol (2010) 1.39
The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen's virulence factors, and the host's mucosal immune response. Immunol Rev (2012) 1.30
A simple screen to identify promoters conferring high levels of phenotypic noise. PLoS Genet (2008) 1.28
RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. Mol Syst Biol (2011) 1.27
The SopEPhi phage integrates into the ssrA gene of Salmonella enterica serovar Typhimurium A36 and is closely related to the Fels-2 prophage. J Bacteriol (2003) 1.26
A classical NLS and the SUN domain contribute to the targeting of SUN2 to the inner nuclear membrane. EMBO J (2010) 1.26
Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes. Cell Host Microbe (2012) 1.26
Malignant melanoma S3-guideline "diagnosis, therapy and follow-up of melanoma". J Dtsch Dermatol Ges (2013) 1.25
Lack of mismatch correction facilitates genome evolution in mycobacteria. Mol Microbiol (2004) 1.21
Salmonella-induced mucosal lectin RegIIIβ kills competing gut microbiota. PLoS One (2011) 1.20
Bacteriophage-encoded type III effectors in Salmonella enterica subspecies 1 serovar Typhimurium. Infect Genet Evol (2005) 1.20
Chronic Salmonella enterica serovar Typhimurium-induced colitis and cholangitis in streptomycin-pretreated Nramp1+/+ mice. Infect Immun (2006) 1.19
Phage mediated horizontal transfer of the sopE1 gene increases enteropathogenicity of Salmonella enterica serotype Typhimurium for calves. FEMS Microbiol Lett (2002) 1.19
InvB is required for type III-dependent secretion of SopA in Salmonella enterica serovar Typhimurium. J Bacteriol (2004) 1.19
Caspase-1 has both proinflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1β and IL-18. J Immunol (2012) 1.19
Hierarchical effector protein transport by the Salmonella Typhimurium SPI-1 type III secretion system. PLoS One (2008) 1.18
Virulence of broad- and narrow-host-range Salmonella enterica serovars in the streptomycin-pretreated mouse model. Infect Immun (2006) 1.14
Near surface swimming of Salmonella Typhimurium explains target-site selection and cooperative invasion. PLoS Pathog (2012) 1.10
Molecular dissection of Salmonella-induced membrane ruffling versus invasion. Cell Microbiol (2009) 1.10
O-antigen-negative Salmonella enterica serovar Typhimurium is attenuated in intestinal colonization but elicits colitis in streptomycin-treated mice. Infect Immun (2009) 1.10
Two newly identified SipA domains (F1, F2) steer effector protein localization and contribute to Salmonella host cell manipulation. Mol Microbiol (2007) 1.09
Stromal IFN-γR-signaling modulates goblet cell function during Salmonella Typhimurium infection. PLoS One (2011) 1.08
Cullin-3 regulates late endosome maturation. Proc Natl Acad Sci U S A (2012) 1.05
Effect of the O-antigen length of lipopolysaccharide on the functions of Type III secretion systems in Salmonella enterica. Infect Immun (2009) 1.00
Lymph node colonization dynamics after oral Salmonella Typhimurium infection in mice. PLoS Pathog (2013) 1.00
Histone deacetylase 8 is required for centrosome cohesion and influenza A virus entry. PLoS Pathog (2011) 0.99
Accelerated type III secretion system 2-dependent enteropathogenesis by a Salmonella enterica serovar enteritidis PT4/6 strain. Infect Immun (2009) 0.96
Salmonella enterica serovar Typhimurium binds to HeLa cells via Fim-mediated reversible adhesion and irreversible type three secretion system 1-mediated docking. Infect Immun (2010) 0.96
High-content analysis of sequential events during the early phase of influenza A virus infection. PLoS One (2013) 0.94
The chaperone binding domain of SopE inhibits transport via flagellar and SPI-1 TTSS in the absence of InvB. Mol Microbiol (2006) 0.93
Characterization of effector proteins translocated via the SPI1 type III secretion system of Salmonella typhimurium. Int J Med Microbiol (2002) 0.93
Salmonella transiently reside in luminal neutrophils in the inflamed gut. PLoS One (2012) 0.92
In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin. PLoS One (2010) 0.91
Amino acids of the bacterial toxin SopE involved in G nucleotide exchange on Cdc42. J Biol Chem (2003) 0.91
The dual role of wild phages for horizontal gene transfer among Salmonella strains. Berl Munch Tierarztl Wochenschr (2002) 0.90
Salmonella typhimurium diarrhea: switching the mucosal epithelium from homeostasis to defense. Curr Opin Immunol (2011) 0.90
IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium. PLoS One (2010) 0.89
Bacterial colitis increases susceptibility to oral prion disease. J Infect Dis (2009) 0.89
Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not. Antimicrob Agents Chemother (2012) 0.89
Dangerous liaisons between a microbe and the prion protein. J Exp Med (2003) 0.89
Salmonella pathogenicity island 2-mediated overexpression of chimeric SspH2 proteins for simultaneous induction of antigen-specific CD4 and CD8 T cells. Infect Immun (2005) 0.88
S3-guideline "diagnosis, therapy and follow-up of melanoma" -- short version. J Dtsch Dermatol Ges (2013) 0.88
The bactericidal activity of the C-type lectin RegIIIβ against Gram-negative bacteria involves binding to lipid A. J Biol Chem (2012) 0.87
Substrate adhesion regulates sealing zone architecture and dynamics in cultured osteoclasts. PLoS One (2011) 0.87
Identification of Novel Phosphorylation Motifs Through an Integrative Computational and Experimental Analysis of the Human Phosphoproteome. J Proteomics Bioinform (2011) 0.87
Regulation of the activity and fatty acid specificity of lecithin-cholesterol acyltransferase by sphingomyelin and its metabolites, ceramide and ceramide phosphate. Biochemistry (2006) 0.86
Impact of Salmonella Typhimurium DT104 virulence factors invC and sseD on the onset, clinical course, colonization patterns and immune response of porcine salmonellosis. Vet Microbiol (2007) 0.86
PEGylation of bacteriophages increases blood circulation time and reduces T-helper type 1 immune response. Microb Biotechnol (2008) 0.86