Published in J Biol Chem on April 28, 2003
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Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion. Microbiol Mol Biol Rev (2004) 7.93
Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota. PLoS Biol (2007) 7.58
GEFs and GAPs: critical elements in the control of small G proteins. Cell (2007) 7.32
Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host. Infect Immun (2003) 6.82
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science (2005) 5.99
Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell (2003) 5.44
Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity (2009) 5.43
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature (2013) 5.04
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Splicing regulates NAD metabolite binding to histone macroH2A. Nat Struct Mol Biol (2005) 3.40
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nat Struct Mol Biol (2009) 3.26
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Self-destructive cooperation mediated by phenotypic noise. Nature (2008) 3.07
Structural insight into filament formation by mammalian septins. Nature (2007) 2.90
The Salmonella enterica serotype typhimurium effector proteins SipA, SopA, SopB, SopD, and SopE2 act in concert to induce diarrhea in calves. Infect Immun (2002) 2.88
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Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteria. PLoS Pathog (2010) 2.79
Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis. Cancer Cell (2009) 2.73
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Role of the Salmonella pathogenicity island 1 effector proteins SipA, SopB, SopE, and SopE2 in Salmonella enterica subspecies 1 serovar Typhimurium colitis in streptomycin-pretreated mice. Infect Immun (2004) 2.46
Flagella and chemotaxis are required for efficient induction of Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated mice. Infect Immun (2004) 2.41
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Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria. PLoS Pathog (2009) 2.29
Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens. Proc Natl Acad Sci U S A (2014) 2.25
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The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea. PLoS Pathog (2010) 2.17
Structure and regulation of the cAMP-binding domains of Epac2. Nat Struct Biol (2003) 2.11
The regulation of mDia1 by autoinhibition and its release by Rho*GTP. EMBO J (2005) 2.10
A mouse model for S. typhimurium-induced enterocolitis. Trends Microbiol (2005) 2.09
Capturing cyclic nucleotides in action: snapshots from crystallographic studies. Nat Rev Mol Cell Biol (2007) 2.07
The GTPase-activating protein Rap1GAP uses a catalytic asparagine. Nature (2004) 2.06
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How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. Nature (2006) 1.92
Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis. J Exp Med (2008) 1.92
Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae. Proc Natl Acad Sci U S A (2012) 1.90
Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state. Nature (2006) 1.88
Mechanisms controlling pathogen colonization of the gut. Curr Opin Microbiol (2010) 1.88
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins. Nat Cell Biol (2011) 1.87
Real-time imaging of type III secretion: Salmonella SipA injection into host cells. Proc Natl Acad Sci U S A (2005) 1.85
A Burkholderia pseudomallei type III secreted protein, BopE, facilitates bacterial invasion of epithelial cells and exhibits guanine nucleotide exchange factor activity. J Bacteriol (2003) 1.78
Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element. EMBO J (2006) 1.75
The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization. Mol Cell (2004) 1.74
The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation. Cell Host Microbe (2009) 1.74
A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat Genet (2009) 1.71
Salmonella type III secretion effectors: pulling the host cell's strings. Curr Opin Microbiol (2006) 1.70
Motility allows S. Typhimurium to benefit from the mucosal defence. Cell Microbiol (2008) 1.69
Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy. Mol Cell (2007) 1.67
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex. EMBO J (2003) 1.67
The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nat Struct Mol Biol (2008) 1.64
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO J (2002) 1.64
A new family of RhoGEFs activates the Rop molecular switch in plants. Nature (2005) 1.64
Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. EMBO J (2008) 1.62
The cost of virulence: retarded growth of Salmonella Typhimurium cells expressing type III secretion system 1. PLoS Pathog (2011) 1.60
Comparison of Salmonella enterica serovar Typhimurium colitis in germfree mice and mice pretreated with streptomycin. Infect Immun (2005) 1.59
The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. Proc Natl Acad Sci U S A (2004) 1.57
Role of the Salmonella pathogenicity island 1 (SPI-1) protein InvB in type III secretion of SopE and SopE2, two Salmonella effector proteins encoded outside of SPI-1. J Bacteriol (2003) 1.54
Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac. J Biol Chem (2003) 1.53
Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems. Mol Microbiol (2002) 1.51
The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module. Proc Natl Acad Sci U S A (2008) 1.50
Mutations in SYNGAP1 cause intellectual disability, autism, and a specific form of epilepsy by inducing haploinsufficiency. Hum Mutat (2012) 1.50
RanGAP mediates GTP hydrolysis without an arginine finger. Nature (2002) 1.50
Structural insights into HypB, a GTP-binding protein that regulates metal binding. J Biol Chem (2006) 1.47
'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution. Nat Rev Microbiol (2013) 1.45
Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Science (2009) 1.44
TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa. J Immunol (2010) 1.43
Salmonella Pathogenicity Island 4 encodes a giant non-fimbrial adhesin and the cognate type 1 secretion system. Cell Microbiol (2007) 1.39
Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies. Acta Crystallogr D Biol Crystallogr (2006) 1.39
U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Nat Struct Mol Biol (2007) 1.38
Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis. EMBO J (2007) 1.38
Structural insights into the cyclin T1-Tat-TAR RNA transcription activation complex from EIAV. Nat Struct Mol Biol (2008) 1.36
GTP-induced conformational changes in septins and implications for function. Proc Natl Acad Sci U S A (2009) 1.35
Regulation of dynamic polarity switching in bacteria by a Ras-like G-protein and its cognate GAP. EMBO J (2010) 1.35
Nucleotide binding and filament assembly of recombinant yeast septin complexes. Biol Chem (2005) 1.34
The structure of the TrmE GTP-binding protein and its implications for tRNA modification. EMBO J (2004) 1.34
A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein. EMBO Rep (2006) 1.33
Structural insights into the target specificity of plant invertase and pectin methylesterase inhibitory proteins. Plant Cell (2004) 1.33
The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction. EMBO Rep (2008) 1.31
The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen's virulence factors, and the host's mucosal immune response. Immunol Rev (2012) 1.30
The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy. Proc Natl Acad Sci U S A (2008) 1.30
A simple screen to identify promoters conferring high levels of phenotypic noise. PLoS Genet (2008) 1.28
Rap-specific GTPase activating protein follows an alternative mechanism. J Biol Chem (2002) 1.28
Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins. J Biol Chem (2007) 1.28
The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. EMBO J (2008) 1.28
RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. Mol Syst Biol (2011) 1.27
Specificity of interactions between mDia isoforms and Rho proteins. J Biol Chem (2008) 1.27
The SopEPhi phage integrates into the ssrA gene of Salmonella enterica serovar Typhimurium A36 and is closely related to the Fels-2 prophage. J Bacteriol (2003) 1.26
Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes. Cell Host Microbe (2012) 1.26
Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes. Angew Chem Int Ed Engl (2010) 1.25
Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. Hum Mutat (2010) 1.24
Pyrophosphate-producing protein dephosphorylation by HPr kinase/phosphorylase: a relic of early life? Proc Natl Acad Sci U S A (2002) 1.23
GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins. J Biol Chem (2006) 1.22
Lack of mismatch correction facilitates genome evolution in mycobacteria. Mol Microbiol (2004) 1.21
Salmonella-induced mucosal lectin RegIIIβ kills competing gut microbiota. PLoS One (2011) 1.20
Structural evidence for a common intermediate in small G protein-GEF reactions. Mol Cell (2007) 1.20