Published in Nature on October 24, 2012
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Germline mutations in shelterin complex genes are associated with familial glioma. J Natl Cancer Inst (2014) 2.23
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Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells. PLoS One (2013) 0.86
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Telomerase enzymatic component hTERT shortens long telomeres in human cells. Cell Cycle (2014) 0.84
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Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions. Nat Commun (2015) 0.83
Essential role for the TRF2 telomere protein in adult skin homeostasis. Aging Cell (2014) 0.83
A homozygous telomerase T-motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome. Blood (2013) 0.83
Cdc13 at a crossroads of telomerase action. Front Oncol (2013) 0.82
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Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase. J Mol Biol (2015) 0.82
The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres. PLoS Genet (2015) 0.82
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POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis. PLoS Genet (2014) 0.80
The Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner. Mol Cell Biol (2015) 0.80
Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance. J Cell Sci (2014) 0.79
Coordinated interactions of multiple POT1-TPP1 proteins with telomere DNA. J Biol Chem (2013) 0.79
Multiple facets of TPP1 in telomere maintenance. Biochim Biophys Acta (2014) 0.79
Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Res (2015) 0.79
Cold-inducible RNA-binding protein CIRP/hnRNP A18 regulates telomerase activity in a temperature-dependent manner. Nucleic Acids Res (2015) 0.78
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Surprises from the chromosome front: lessons from Arabidopsis on telomeres and telomerase. Cold Spring Harb Symp Quant Biol (2013) 0.78
The 3' overhangs at Tetrahymena thermophila telomeres are packaged by four proteins, Pot1a, Tpt1, Pat1, and Pat2. Eukaryot Cell (2013) 0.78
The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7. J Biol Chem (2014) 0.78
POT1-TPP1 Binding and Unfolding of Telomere DNA Discriminates against Structural Polymorphism. J Mol Biol (2016) 0.77
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Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces. Elife (2016) 0.77
Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles. Nucleic Acids Res (2015) 0.77
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Structure and function of the telomeric CST complex. Comput Struct Biotechnol J (2016) 0.77
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Solving the Telomere Replication Problem. Genes (Basel) (2017) 0.76
Minishelterins separate telomere length regulation and end protection in fission yeast. Genes Dev (2015) 0.76
Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis. Oncogene (2016) 0.76
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MTV, an ssDNA Protecting Complex Essential for Transposon-Based Telomere Maintenance in Drosophila. PLoS Genet (2016) 0.76
Endogenous TERT N-terminal tagging affects human telomerase function at telomeres in vivo. Mol Cell Biol (2016) 0.75
Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol (2017) 0.75
The shelterin complex and hematopoiesis. J Clin Invest (2016) 0.75
Acute exercise activates p38 MAPK and increases the expression of telomere-protective genes in cardiac muscle. Exp Physiol (2017) 0.75
The OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifs. Biochimie (2015) 0.75
Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells. Open Biol (2017) 0.75
Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance. Nucleic Acids Res (2016) 0.75
Structural and functional consequences of a disease mutation in the telomere protein TPP1. Proc Natl Acad Sci U S A (2016) 0.75
A human artificial chromosome recapitulates the metabolism of native telomeres in mammalian cells. PLoS One (2014) 0.75
The telomeric protein Pot1 from Schizosaccharomyces pombe binds ssDNA in two modes with differing 3' end availability. Nucleic Acids Res (2014) 0.75
Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer. Nat Commun (2017) 0.75
Structural and functional analysis of the human POT1-TPP1 telomeric complex. Nat Commun (2017) 0.75
Modern genome editing meets telomeres: the many functions of TPP1. Genes Dev (2014) 0.75
Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes. Nucleus (2017) 0.75
Multiple Mechanisms Contribute to the Cell Growth Defects Imparted by Human Telomerase Insertion in Fingers Domain Mutations Associated with Premature Aging Diseases. J Biol Chem (2016) 0.75
Structural biology of telomerase and its interaction at telomeres. Curr Opin Struct Biol (2017) 0.75
A lentivirus-free inducible CRISPR-Cas9 system for efficient targeting of human genes. Anal Biochem (2017) 0.75
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature (1989) 13.18
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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature (2007) 6.82
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The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature (2007) 5.08
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature (2007) 4.23
Telomerase modulates Wnt signalling by association with target gene chromatin. Nature (2009) 3.96
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nat Struct Mol Biol (2004) 3.66
PTOP interacts with POT1 and regulates its localization to telomeres. Nat Cell Biol (2004) 3.33
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev (2004) 3.25
Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length. Science (2008) 2.97
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Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast. Genes Dev (2012) 1.15
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Visualization of human telomerase localization by fluorescence microscopy techniques. Methods Mol Biol (2011) 0.96
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