Published in Prion on January 30, 2010
Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila. PLoS One (2014) 0.96
Drosophila models of proteinopathies: the little fly that could. Curr Pharm Des (2012) 0.89
Molluscan neurons in culture: shedding light on synapse formation and plasticity. J Mol Histol (2012) 0.83
Prion protein facilitates synaptic vesicle release by enhancing release probability. Hum Mol Genet (2014) 0.79
A Drosophila model for genetic analysis of influenza viral/host interactions. Genetics (2011) 0.78
Prion protein as a mediator of synaptic transmission. Commun Integr Biol (2015) 0.75
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature (1998) 72.56
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (1993) 58.26
Genetic transformation of Drosophila with transposable element vectors. Science (1982) 27.36
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics (2004) 8.40
A Drosophila model of Parkinson's disease. Nature (2000) 7.82
Spatiotemporal rescue of memory dysfunction in Drosophila. Science (2003) 7.72
In vitro generation of infectious scrapie prions. Cell (2005) 6.86
Modulation of neurodegeneration by molecular chaperones. Nat Rev Neurosci (2005) 5.00
Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila. Cell (1998) 4.07
Identification of genes that modify ataxin-1-induced neurodegeneration. Nature (2000) 4.02
SUMO modification of Huntingtin and Huntington's disease pathology. Science (2004) 3.85
Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein. Nat Methods (2007) 3.74
Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron (1998) 3.72
Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet (2005) 3.45
Genetic suppression of polyglutamine toxicity in Drosophila. Science (2000) 3.23
The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource. Genetics (2007) 3.08
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. Cell (2003) 2.50
Emerging technologies for gene manipulation in Drosophila melanogaster. Nat Rev Genet (2005) 2.49
Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice. Neuron (2003) 2.39
Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes. EMBO J (2002) 2.16
The cellular prion protein (PrP(C)): its physiological function and role in disease. Biochim Biophys Acta (2007) 2.09
Expression of the molecular chaperone Hsp70 in detergent-resistant microdomains correlates with its membrane delivery and release. J Biol Chem (2003) 2.02
Transgenesis upgrades for Drosophila melanogaster. Development (2007) 1.86
Gene expression systems in Drosophila: a synthesis of time and space. Trends Genet (2004) 1.83
Applications of high-throughput RNA interference screens to problems in cell and developmental biology. Genetics (2007) 1.82
Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome. J Neurosci (2006) 1.69
Drosophila models of neurodegenerative diseases. Annu Rev Pathol (2009) 1.67
Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila. PLoS Genet (2007) 1.66
Research resources for Drosophila: the expanding universe. Nat Rev Genet (2005) 1.34
In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms. PLoS Genet (2009) 1.29
The mechanism of Hsp70 chaperones: (entropic) pulling the models together. Trends Biochem Sci (2007) 1.28
Tetracycline-inducible systems for Drosophila. Proc Natl Acad Sci U S A (2001) 1.25
Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP. Mol Biol Cell (2006) 1.25
Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proc Natl Acad Sci U S A (2008) 1.20
Expression of polyubiquitin and heat-shock protein 70 genes increases in the later stages of disease progression in scrapie-infected mouse brain. J Neurochem (1994) 1.19
Molecular evolution of the mammalian prion protein. Mol Biol Evol (2003) 1.18
Hsp104 and prion propagation. Protein Pept Lett (2009) 1.16
Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases. Hum Mol Genet (2007) 1.13
Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in Drosophila. Genetics (2008) 1.11
Chaperone effects on prion and nonprion aggregates. Prion (2007) 1.06
The consequences of pathogenic mutations to the human prion protein. Protein Eng Des Sel (2009) 0.98
Expression and targeting of Syrian hamster prion protein induced by heat shock in transgenic Drosophila melanogaster. Mech Dev (1995) 0.87
Prominent stress response of Purkinje cells in Creutzfeldt-Jakob disease. Neurobiol Dis (2001) 0.84
Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons. J Neurochem (2003) 0.82
Evolution and differentiation of the prion protein gene (PRNP) among species. J Hered (2008) 0.79
Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. Dev Cell (2010) 2.84
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. Cell (2003) 2.50
The ER stress factor XBP1s prevents amyloid-beta neurotoxicity. Hum Mol Genet (2011) 1.40
Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition. Dev Cell (2010) 1.36
In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms. PLoS Genet (2009) 1.29
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain. J Biol Chem (2011) 1.22
Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases. Hum Mol Genet (2007) 1.13
Activation of JNK signaling mediates amyloid-ß-dependent cell death. PLoS One (2011) 0.96
Sequence-dependent prion protein misfolding and neurotoxicity. J Biol Chem (2010) 0.95
Drosophila models of proteinopathies: the little fly that could. Curr Pharm Des (2012) 0.89
Cell types and coincident synapses in the ellipsoid body of Drosophila. Eur J Neurosci (2014) 0.84
Differential activation of the ER stress factor XBP1 by oligomeric assemblies. Neurochem Res (2012) 0.80
FoxK mediates TGF-beta signalling during midgut differentiation in flies. J Cell Biol (2008) 0.78
p∆TubHA4C, a new versatile vector for constitutive expression in Drosophila. Mol Biol Rep (2013) 0.77
Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking. Hum Mol Genet (2013) 0.76
Purification of transcripts and metabolites from Drosophila heads. J Vis Exp (2013) 0.75
Lessons from Anti-Amyloid-β Immunotherapies in Alzheimer Disease: Aiming at a Moving Target. Neurodegener Dis (2017) 0.75