Published in Nature on November 13, 2003
Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal (2012) 1.96
Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem J (2010) 1.26
Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Mol Nutr Food Res (2011) 1.20
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52
Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr (2008) 3.84
Risk stratification in uncomplicated type 2 diabetes: prospective evaluation of the combined use of coronary artery calcium imaging and selective myocardial perfusion scintigraphy. Eur Heart J (2006) 2.74
Plasma antioxidants from chocolate. Nature (2003) 2.69
Determinants of progression of coronary artery calcification in type 2 diabetes role of glycemic control and inflammatory/vascular calcification markers. J Am Coll Cardiol (2007) 2.29
Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal (2012) 1.96
Plant foods and herbal sources of resveratrol. J Agric Food Chem (2002) 1.87
Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. Am J Clin Nutr (2012) 1.78
Increased volume of epicardial fat is an independent risk factor for accelerated progression of sub-clinical coronary atherosclerosis. Atherosclerosis (2011) 1.48
Flavan-3-ol-enriched dark chocolate and white chocolate improve acute measures of platelet function in a gender-specific way--a randomized-controlled human intervention trial. Mol Nutr Food Res (2012) 1.43
Tea prepared from Anastatica hirerochuntica seeds contains a diversity of antioxidant flavonoids, chlorogenic acids and phenolic compounds. Phytochemistry (2010) 1.41
Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur J Nutr (2003) 1.40
Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-tracer study. Am J Clin Nutr (2013) 1.39
Caffeine and related purine alkaloids: biosynthesis, catabolism, function and genetic engineering. Phytochemistry (2007) 1.34
How should we assess the effects of exposure to dietary polyphenols in vitro? Am J Clin Nutr (2004) 1.33
The relationship between plasma osteoprotegerin levels and coronary artery calcification in uncomplicated type 2 diabetic subjects. J Am Coll Cardiol (2006) 1.32
Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera L. (horseradish tree) and Moringa stenopetala L. J Agric Food Chem (2003) 1.30
HPLC-MSn analysis of phenolic compounds and purine alkaloids in green and black tea. J Agric Food Chem (2004) 1.29
Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5. J Endocrinol (2010) 1.28
Osteoprotegerin as a predictor of coronary artery disease and cardiovascular mortality and morbidity. J Am Coll Cardiol (2010) 1.25
Relative impact of flavonoid composition, dose and structure on vascular function: a systematic review of randomised controlled trials of flavonoid-rich food products. Mol Nutr Food Res (2012) 1.20
Berry flavonoids and phenolics: bioavailability and evidence of protective effects. Br J Nutr (2010) 1.20
The absorption, metabolism and excretion of flavan-3-ols and procyanidins following the ingestion of a grape seed extract by rats. Br J Nutr (2005) 1.13
Isolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert). Phytochemistry (2004) 1.12
Distribution and biosynthesis of flavan-3-ols in Camellia sinensis seedlings and expression of genes encoding biosynthetic enzymes. Phytochemistry (2010) 1.11
Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo. Drug Metab Dispos (2003) 1.10
Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion. Br J Nutr (2009) 1.10
Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. Br J Nutr (2006) 1.07
Analysis of ellagitannins and conjugates of ellagic acid and quercetin in raspberry fruits by LC-MSn. Phytochemistry (2003) 1.07
Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity. Biochem Pharmacol (2007) 1.07
Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update. Arch Toxicol (2014) 1.06
Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties. Free Radic Biol Med (2011) 1.06
The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products. Mol Nutr Food Res (2009) 1.03
Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. Arch Biochem Biophys (2010) 1.02
Bioavailability of polyphenon E flavan-3-ols in humans with an ileostomy. J Nutr (2008) 1.02
Ontogenic profiling of glucosinolates, flavonoids, and other secondary metabolites in Eruca sativa (salad rocket), Diplotaxis erucoides (wall rocket), Diplotaxis tenuifolia (wild rocket), and Bunias orientalis (Turkish rocket). J Agric Food Chem (2006) 1.01
Absorption, metabolism and excretion of Choladi green tea flavan-3-ols by humans. Mol Nutr Food Res (2009) 1.00
Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli. Mol Nutr Food Res (2012) 1.00
Flavonoid metabolites in human plasma and urine after the consumption of red onions: analysis by liquid chromatography with photodiode array and full scan tandem mass spectrometric detection. J Chromatogr A (2004) 0.98
Coffee: biochemistry and potential impact on health. Food Funct (2014) 0.98
Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties. J Agric Food Chem (2002) 0.98
Identification of proanthocyanidin dimers and trimers, flavone C-Glycosides, and antioxidants in Ficus deltoidea , a malaysian herbal tea. J Agric Food Chem (2011) 0.97
Absorption, metabolism, and excretion of green tea flavan-3-ols in humans with an ileostomy. Mol Nutr Food Res (2010) 0.97
Espresso coffees, caffeine and chlorogenic acid intake: potential health implications. Food Funct (2011) 0.97
Bioavailability and metabolism of orange juice flavanones in humans: impact of a full-fat yogurt. J Agric Food Chem (2008) 0.96
A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids. Br J Pharmacol (2010) 0.96
Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: identification of biomarkers of coffee consumption. Drug Metab Dispos (2009) 0.95
Green tea flavan-3-ols: colonic degradation and urinary excretion of catabolites by humans. J Agric Food Chem (2010) 0.95
Evaluation of phenolic compounds in commercial fruit juices and fruit drinks. J Agric Food Chem (2007) 0.94
Identification of flavonoid and phenolic antioxidants in black currants, blueberries, raspberries, red currants, and cranberries. J Agric Food Chem (2010) 0.94
Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. J Agric Food Chem (2010) 0.93
Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides. Eur J Biochem (2002) 0.93
Rapid characterization of anthocyanins in red raspberry fruit by high-performance liquid chromatography coupled to single quadrupole mass spectrometry. J Chromatogr A (2002) 0.92
Occurrence of proteinaceous endoxylanase inhibitors in cereals. Biochim Biophys Acta (2004) 0.92
Identification of isomeric flavonoid glucuronides in urine and plasma by metal complexation and LC-ESI-MS/MS. J Mass Spectrom (2006) 0.92
On-line high-performance liquid chromatography analysis of the antioxidant activity of phenolic compounds in green and black tea. Mol Nutr Food Res (2005) 0.92
The effect of black tea on risk factors of cardiovascular disease in a normal population. Prev Med (2011) 0.91
Impact of dietary polyphenols on human platelet function--a critical review of controlled dietary intervention studies. Mol Nutr Food Res (2010) 0.91
Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2). Drug Metab Dispos (2007) 0.90
The influence of moderate red wine consumption on antioxidant status and indices of oxidative stress associated with CHD in healthy volunteers. Br J Nutr (2005) 0.90
Homocysteine-induced endothelin-1 release is dependent on hyperglycaemia and reactive oxygen species production in bovine aortic endothelial cells. J Vasc Res (2006) 0.90
Substrate (aglycone) specificity of human cytosolic beta-glucosidase. Biochem J (2003) 0.90
The biological responses to resveratrol and other polyphenols from alcoholic beverages. Alcohol Clin Exp Res (2009) 0.90
Determination of flavonol metabolites in plasma and tissues of rats by HPLC-radiocounting and tandem mass spectrometry following oral ingestion of [2-(14)C]quercetin-4'-glucoside. J Agric Food Chem (2002) 0.90
The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase. J Mol Biol (2007) 0.90
Regulation of vascular endothelial function by procyanidin-rich foods and beverages. J Agric Food Chem (2010) 0.90
Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells. Atherosclerosis (2007) 0.89
Colonic catabolism of ellagitannins, ellagic acid, and raspberry anthocyanins: in vivo and in vitro studies. Drug Metab Dispos (2011) 0.89
Identification of (poly)phenolic compounds in concord grape juice and their metabolites in human plasma and urine after juice consumption. J Agric Food Chem (2011) 0.89
Black tea reduces uric acid and C-reactive protein levels in humans susceptible to cardiovascular diseases. Toxicology (2009) 0.89
Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism. J Endocrinol (2011) 0.89
Deconjugation kinetics of glucuronidated phase II flavonoid metabolites by beta-glucuronidase from neutrophils. Drug Metab Pharmacokinet (2010) 0.89
Severe, acute liver injury and khat leaves. N Engl J Med (2010) 0.89
Rapid and comprehensive evaluation of (poly)phenolic compounds in pomegranate (Punica granatum L.) juice by UHPLC-MSn. Molecules (2012) 0.89
Oligomeric procyanidins inhibit cell migration and modulate the expression of migration and proliferation associated genes in human umbilical vascular endothelial cells. Mol Nutr Food Res (2009) 0.88
A role for increased mRNA stability in the induction of endothelin-1 synthesis by lipopolysaccharide. Biochem Pharmacol (2003) 0.88
In vitro anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations. Mol Nutr Food Res (2011) 0.88
Flavonoids in tropical citrus species. J Agric Food Chem (2011) 0.87
Phytochemical profile of a Japanese black-purple rice. Food Chem (2013) 0.87
Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta. Atherosclerosis (2008) 0.87
Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase. Life Sci (2009) 0.87
Consumption of mixed fruit-juice drink and vitamin C reduces postprandial stress induced by a high fat meal in healthy overweight subjects. Curr Pharm Des (2014) 0.87
Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans. Am J Clin Nutr (2009) 0.87
Assessment of the polyphenolic composition of the organic extracts of Mauritian black teas: a potential contributor to their antioxidant functions. Biofactors (2006) 0.87
Bioavailability of pelargonidin-3-O-glucoside and its metabolites in humans following the ingestion of strawberries with and without cream. J Agric Food Chem (2008) 0.87
The effects of dietary phenolic compounds on cytokine and antioxidant production by A549 cells. J Med Food (2008) 0.86
Quercetin and its in vivo metabolites inhibit neutrophil-mediated low-density lipoprotein oxidation. J Agric Food Chem (2008) 0.86
Potassium deficiency induces the biosynthesis of oxylipins and glucosinolates in Arabidopsis thaliana. BMC Plant Biol (2010) 0.86
Absorption, Conjugation and Efflux of the Flavonoids, Kaempferol and Galangin, Using the Intestinal CACO-2/TC7 Cell Model. J Funct Foods (2009) 0.85
High contents of nonextractable polyphenols in fruits suggest that polyphenol contents of plant foods have been underestimated. J Agric Food Chem (2009) 0.85
Characterization of metabolites of hydroxycinnamates in the in vitro model of human small intestinal epithelium caco-2 cells. J Agric Food Chem (2003) 0.85
Effect of freezing and storage on the phenolics, ellagitannins, flavonoids, and antioxidant capacity of red raspberries. J Agric Food Chem (2002) 0.85
Procyanidin effects on oesophageal adenocarcinoma cells strongly depend on flavan-3-ol degree of polymerization. Mol Nutr Food Res (2008) 0.84
Functional identification of the cDNA coding for a wheat endo-1,4-beta-D-xylanase inhibitor. FEBS Lett (2002) 0.84
The bioavailability of raspberry anthocyanins and ellagitannins in rats. Mol Nutr Food Res (2007) 0.84
Distribution, biosynthesis and catabolism of methylxanthines in plants. Handb Exp Pharmacol (2011) 0.84
Berry (poly)phenols and cardiovascular health. J Agric Food Chem (2013) 0.84
Absorption, metabolism, and excretion of cider dihydrochalcones in healthy humans and subjects with an ileostomy. J Agric Food Chem (2009) 0.83
Bioavailability of coffee chlorogenic acids and green tea flavan-3-ols. Nutrients (2010) 0.83