Myocardial infarction and stroke associated with diuretic based two drug antihypertensive regimens: population based case-control study.

Fixed-dose combination therapy for the prevention of cardiovascular disease. Cochrane Database Syst Rev (2014) 2.24

Comparing marginal structural models to standard methods for estimating treatment effects of antihypertensive combination therapy. BMC Med Res Methodol (2012) 0.78

Intervention for control of hypertension in Catalonia, Spain (INCOTECA Project): results of a multicentric, non-randomised, quasi-experimental controlled intervention study. BMJ Open (2012) 0.75

Case-control study of second-line therapies for type 2 diabetes in combination with metformin and the comparative risks of myocardial infarction and stroke. Diabetes Obes Metab (2015) 0.75

The use of diuretics plus calcium channel blockers for hypertension may be associated with a higher risk of myocardial infarction but not stroke compared with the combination of diuretics plus beta blockers. Evid Based Med (2010) 0.75

Antihypertensive regimens. Should beta blockers be second line treatment? BMJ (2010) 0.75

Case-control study of oral glucose-lowering drugs in combination with long-acting insulin and the risks of incident myocardial infarction and incident stroke. Pharmacoepidemiol Drug Saf (2015) 0.75

Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension (2003) 63.78

Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med (2008) 47.90

Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA (2002) 36.26

Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med (2008) 25.70

Treatment of hypertension in patients 80 years of age or older. N Engl J Med (2008) 21.04

Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet (2005) 12.92

Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med (2008) 11.61

Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet (2004) 11.13

Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists' Collaboration. Lancet (2000) 9.78

Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group. JAMA (2000) 7.73

Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study. Lancet (1999) 7.65

Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial. Lancet (1999) 7.56

Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis. JAMA (2003) 7.42

The risk of myocardial infarction associated with antihypertensive drug therapies. JAMA (1995) 7.31

Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet (2002) 6.87

Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. Lancet (2007) 6.80

Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis. Lancet (2005) 6.59

A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial. JAMA (2003) 5.67

Much ado about nothing: A comparison of missing data methods and software to fit incomplete data regression models. Am Stat (2007) 5.53

Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients. ACE-Inhibitor Myocardial Infarction Collaborative Group. Lancet (2000) 5.00

Management of elderly patients with sustained hypertension. BMJ (1992) 4.92

Clinical effects of beta-adrenergic blockade in chronic heart failure: a meta-analysis of double-blind, placebo-controlled, randomized trials. Circulation (1998) 2.35

Recent trials in hypertension: compelling science or commercial speech? JAMA (2006) 2.30

Meta-analysis of trials comparing beta-blockers, calcium antagonists, and nitrates for stable angina. JAMA (1999) 1.43

Major clinical trials of hypertension: what should be done next? Hypertension (2005) 0.95

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med (2005) 15.30

Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med (2007) 14.90

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19

Opioid prescriptions for chronic pain and overdose: a cohort study. Ann Intern Med (2010) 11.99

Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07

Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med (2003) 10.06

Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52

The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. BMC Med Genomics (2011) 9.20

Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89

Outcomes ascertainment and adjudication methods in the Women's Health Initiative. Ann Epidemiol (2003) 8.64

From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation (2003) 8.61

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

A pragmatic-explanatory continuum indicator summary (PRECIS): a tool to help trial designers. J Clin Epidemiol (2009) 7.86

Walking compared with vigorous exercise for the prevention of cardiovascular events in women. N Engl J Med (2002) 7.77

Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA (2008) 7.46

Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis. JAMA (2003) 7.42

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66

Calcium/vitamin D supplementation and cardiovascular events. Circulation (2007) 6.63

The Group Health medical home at year two: cost savings, higher patient satisfaction, and less burnout for providers. Health Aff (Millwood) (2010) 6.60

Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. Ann Intern Med (2006) 6.58

C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31

Risk of serious adverse cardiovascular events associated with varenicline: a systematic review and meta-analysis. CMAJ (2011) 6.19

Effectiveness of home blood pressure monitoring, Web communication, and pharmacist care on hypertension control: a randomized controlled trial. JAMA (2008) 6.04

Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA (2008) 6.00

Dementia and Alzheimer disease incidence: a prospective cohort study. Arch Neurol (2002) 5.69

Patient-centered medical home demonstration: a prospective, quasi-experimental, before and after evaluation. Am J Manag Care (2009) 5.65

New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48

Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47

Genomewide association studies of stroke. N Engl J Med (2009) 5.29

Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol (2006) 5.28

Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet (2009) 5.20

New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet (2009) 5.12

Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. JAMA (2007) 5.02

Inflammation as a risk factor for atrial fibrillation. Circulation (2003) 4.95

Glucose levels and risk of dementia. N Engl J Med (2013) 4.95

Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials. BMJ (2011) 4.88

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat Biotechnol (2013) 4.85

Quality control and quality assurance in genotypic data for genome-wide association studies. Genet Epidemiol (2010) 4.83

Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet (2009) 4.78

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73

Potential for conflict of interest in the evaluation of suspected adverse drug reactions: use of cerivastatin and risk of rhabdomyolysis. JAMA (2004) 4.71

Temporal trends in the prevalence of diabetic kidney disease in the United States. JAMA (2011) 4.70

Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet (2010) 4.65

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63

Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med (2005) 4.57

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56

Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. JAMA (2003) 4.54

Pathological correlates of dementia in a longitudinal, population-based sample of aging. Ann Neurol (2007) 4.47

Impact of endoscopic surveillance on mortality from Barrett's esophagus-associated esophageal adenocarcinomas. Gastroenterology (2013) 4.43

Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology. Am J Med (2004) 4.38

The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med (2013) 4.37

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37

Association between acute care and critical illness hospitalization and cognitive function in older adults. JAMA (2010) 4.36

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28