| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
|
Nature
|
2009
|
19.56
|
|
2
|
Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis.
|
JAMA
|
2003
|
7.42
|
|
3
|
Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability.
|
JAMA
|
2006
|
6.93
|
|
4
|
Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults.
|
Circulation
|
2005
|
6.89
|
|
5
|
Effects of Testosterone Treatment in Older Men.
|
N Engl J Med
|
2016
|
6.66
|
|
6
|
Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study.
|
J Gerontol A Biol Sci Med Sci
|
2006
|
6.61
|
|
7
|
Prognostic value of usual gait speed in well-functioning older people--results from the Health, Aging and Body Composition Study.
|
J Am Geriatr Soc
|
2005
|
6.54
|
|
8
|
Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial.
|
Arthritis Rheum
|
2004
|
6.46
|
|
9
|
Inflammatory markers and onset of cardiovascular events: results from the Health ABC study.
|
Circulation
|
2003
|
4.67
|
|
10
|
Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study.
|
J Gerontol A Biol Sci Med Sci
|
2002
|
4.00
|
|
11
|
Inflammatory markers and physical performance in older persons: the InCHIANTI study.
|
J Gerontol A Biol Sci Med Sci
|
2004
|
3.96
|
|
12
|
Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study.
|
Lancet
|
2002
|
3.88
|
|
13
|
Anemia is associated with disability and decreased physical performance and muscle strength in the elderly.
|
J Am Geriatr Soc
|
2004
|
3.48
|
|
14
|
Added value of physical performance measures in predicting adverse health-related events: results from the Health, Aging And Body Composition Study.
|
J Am Geriatr Soc
|
2009
|
3.12
|
|
15
|
The effects of cognitive impairment on mortality among hospitalized patients with heart failure.
|
Am J Med
|
2003
|
2.83
|
|
16
|
The lifestyle interventions and independence for elders (LIFE) pilot study: design and methods.
|
Contemp Clin Trials
|
2005
|
2.79
|
|
17
|
Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study.
|
Biol Psychiatry
|
2003
|
2.77
|
|
18
|
Measures of physical performance and risk for progressive and catastrophic disability: results from the Women's Health and Aging Study.
|
J Gerontol A Biol Sci Med Sci
|
2005
|
2.59
|
|
19
|
Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study.
|
Am J Epidemiol
|
2004
|
2.49
|
|
20
|
Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study).
|
Am J Cardiol
|
2003
|
2.49
|
|
21
|
Sarcopenia, obesity, and inflammation--results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study.
|
Am J Clin Nutr
|
2005
|
2.44
|
|
22
|
Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial.
|
Am J Clin Nutr
|
2004
|
2.37
|
|
23
|
Inflammatory markers and incident mobility limitation in the elderly.
|
J Am Geriatr Soc
|
2004
|
2.29
|
|
24
|
Hemoglobin levels and skeletal muscle: results from the InCHIANTI study.
|
J Gerontol A Biol Sci Med Sci
|
2004
|
2.28
|
|
25
|
The Lifestyle Interventions and Independence for Elders Study: design and methods.
|
J Gerontol A Biol Sci Med Sci
|
2011
|
2.26
|
|
26
|
Exercise and depressive symptoms: a comparison of aerobic and resistance exercise effects on emotional and physical function in older persons with high and low depressive symptomatology.
|
J Gerontol B Psychol Sci Soc Sci
|
2002
|
2.22
|
|
27
|
Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study.
|
J Am Geriatr Soc
|
2004
|
2.21
|
|
28
|
Change in physical performance over time in older women: the Women's Health and Aging Study.
|
J Gerontol A Biol Sci Med Sci
|
2002
|
2.13
|
|
29
|
Physical function and self-rated health status as predictors of mortality: results from longitudinal analysis in the ilSIRENTE study.
|
BMC Geriatr
|
2008
|
2.08
|
|
30
|
Effects of physical activity on strength and skeletal muscle fat infiltration in older adults: a randomized controlled trial.
|
J Appl Physiol (1985)
|
2008
|
2.06
|
|
31
|
Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strength.
|
J Gerontol A Biol Sci Med Sci
|
2009
|
2.03
|
|
32
|
Chronic inflammation is associated with low physical function in older adults across multiple comorbidities.
|
J Gerontol A Biol Sci Med Sci
|
2009
|
2.02
|
|
33
|
Walking while talking: effect of task prioritization in the elderly.
|
Arch Phys Med Rehabil
|
2007
|
2.01
|
|
34
|
Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study.
|
Am J Clin Nutr
|
2006
|
1.97
|
|
35
|
Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training.
|
CMAJ
|
2005
|
1.90
|
|
36
|
Obese, older adults with knee osteoarthritis: weight loss, exercise, and quality of life.
|
Health Psychol
|
2002
|
1.88
|
|
37
|
Inflammation and race and gender differences in computerized tomography-measured adipose depots.
|
Obesity (Silver Spring)
|
2009
|
1.88
|
|
38
|
Lifestyle Interventions and Independence for Elders pilot study: recruitment and baseline characteristics.
|
J Am Geriatr Soc
|
2007
|
1.86
|
|
39
|
Skeletal muscle and mortality results from the InCHIANTI Study.
|
J Gerontol A Biol Sci Med Sci
|
2009
|
1.86
|
|
40
|
Reliability of the 400-m usual-pace walk test as an assessment of mobility limitation in older adults.
|
J Am Geriatr Soc
|
2004
|
1.84
|
|
41
|
Anemia in old age is associated with increased mortality and hospitalization.
|
J Gerontol A Biol Sci Med Sci
|
2006
|
1.83
|
|
42
|
Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study.
|
J Bone Miner Res
|
2007
|
1.79
|
|
43
|
Physical performance measures as predictors of mortality in a cohort of community-dwelling older French women.
|
Eur J Epidemiol
|
2006
|
1.76
|
|
44
|
Lifestyle interventions and independence for elders study: recruitment and baseline characteristics.
|
J Gerontol A Biol Sci Med Sci
|
2013
|
1.75
|
|
45
|
Consideration of insurance reimbursement for physical activity and exercise programs for patients with diabetes.
|
JAMA
|
2011
|
1.73
|
|
46
|
Diabetes mellitus, glycemic control, and incident depressive symptoms among 70- to 79-year-old persons: the health, aging, and body composition study.
|
Arch Intern Med
|
2007
|
1.73
|
|
47
|
Inflammatory markers and cardiovascular health in older adults.
|
Cardiovasc Res
|
2005
|
1.71
|
|
48
|
Anemia and decline in physical performance among older persons.
|
Am J Med
|
2003
|
1.70
|
|
49
|
Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study.
|
Am J Clin Nutr
|
2004
|
1.69
|
|
50
|
Effects of birth cohort and age on body composition in a sample of community-based elderly.
|
Am J Clin Nutr
|
2007
|
1.65
|
|
51
|
One- and two-year change in body composition as measured by DXA in a population-based cohort of older men and women.
|
J Appl Physiol (1985)
|
2003
|
1.64
|
|
52
|
Abdominal obesity is an independent risk factor for chronic heart failure in older people.
|
J Am Geriatr Soc
|
2006
|
1.63
|
|
53
|
Blood pressure and decline in kidney function: findings from the Systolic Hypertension in the Elderly Program (SHEP).
|
J Am Soc Nephrol
|
2002
|
1.61
|
|
54
|
Long-term physical activity and inflammatory biomarkers in older adults.
|
Med Sci Sports Exerc
|
2010
|
1.59
|
|
55
|
Comorbidity and physical function: results from the aging and longevity study in the Sirente geographic area (ilSIRENTE study).
|
Gerontology
|
2006
|
1.57
|
|
56
|
Anorexia, physical function, and incident disability among the frail elderly population: results from the ilSIRENTE study.
|
J Am Med Dir Assoc
|
2010
|
1.56
|
|
57
|
Exercise training and plasma C-reactive protein and interleukin-6 in elderly people.
|
J Am Geriatr Soc
|
2008
|
1.55
|
|
58
|
Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle.
|
Ageing Res Rev
|
2006
|
1.46
|
|
59
|
The Testosterone Trials: Seven coordinated trials of testosterone treatment in elderly men.
|
Clin Trials
|
2014
|
1.46
|
|
60
|
Plasminogen activator inhibitor-1 (PAI-1): a key factor linking fibrinolysis and age-related subclinical and clinical conditions.
|
Cardiovasc Ther
|
2010
|
1.46
|
|
61
|
Psychomotor speed and functional brain MRI 2 years after completing a physical activity treatment.
|
J Gerontol A Biol Sci Med Sci
|
2010
|
1.45
|
|
62
|
Use of angiotensin-converting enzyme inhibitors in elderly people with heart failure: prevalence and outcomes.
|
J Gerontol A Biol Sci Med Sci
|
2004
|
1.43
|
|
63
|
Relationship of alcohol intake with inflammatory markers and plasminogen activator inhibitor-1 in well-functioning older adults: the Health, Aging, and Body Composition study.
|
Circulation
|
2004
|
1.41
|
|
64
|
Metabolic syndrome and physical decline in older persons: results from the Health, Aging And Body Composition Study.
|
J Gerontol A Biol Sci Med Sci
|
2009
|
1.37
|
|
65
|
Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on Sarcopenia.
|
J Cachexia Sarcopenia Muscle
|
2012
|
1.37
|
|
66
|
Antihypertensive medications and differences in muscle mass in older persons: the Health, Aging and Body Composition Study.
|
J Am Geriatr Soc
|
2004
|
1.36
|
|
67
|
Effects of exercise adherence on physical function among overweight older adults with knee osteoarthritis.
|
Arthritis Rheum
|
2005
|
1.33
|
|
68
|
Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy.
|
Ageing Res Rev
|
2010
|
1.31
|
|
69
|
Inflammatory markers and physical function among older adults with knee osteoarthritis.
|
J Rheumatol
|
2004
|
1.29
|
|
70
|
The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals.
|
Aging Cell
|
2012
|
1.29
|
|
71
|
Disability, more than multimorbidity, was predictive of mortality among older persons aged 80 years and older.
|
J Clin Epidemiol
|
2010
|
1.28
|
|
72
|
Muscle strength in obese elderly women: effect of recreational physical activity in a cross-sectional study.
|
Am J Clin Nutr
|
2004
|
1.26
|
|
73
|
Designing clinical trials of interventions for mobility disability: results from the lifestyle interventions and independence for elders pilot (LIFE-P) trial.
|
J Gerontol A Biol Sci Med Sci
|
2007
|
1.25
|
|
74
|
Changes in cognitive function in a randomized trial of physical activity: results of the lifestyle interventions and independence for elders pilot study.
|
J Gerontol A Biol Sci Med Sci
|
2009
|
1.24
|
|
75
|
Muscle strength and BMI as predictors of major mobility disability in the Lifestyle Interventions and Independence for Elders pilot (LIFE-P).
|
J Gerontol A Biol Sci Med Sci
|
2011
|
1.22
|
|
76
|
Body mass index, weight change, and death in older adults: the systolic hypertension in the elderly program.
|
Am J Epidemiol
|
2002
|
1.22
|
|
77
|
Interleukin-6, C-reactive protein, and tumor necrosis factor-alpha as predictors of mortality in frail, community-living elderly individuals.
|
J Am Geriatr Soc
|
2011
|
1.20
|
|
78
|
Midarm muscle circumference, physical performance and mortality: results from the aging and longevity study in the Sirente geographic area (ilSIRENTE study).
|
Clin Nutr
|
2010
|
1.18
|
|
79
|
Psychosocial risk factors and the metabolic syndrome in elderly persons: findings from the Health, Aging and Body Composition study.
|
J Gerontol A Biol Sci Med Sci
|
2007
|
1.17
|
|
80
|
Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events: the health, aging, and body composition study.
|
Arch Intern Med
|
2006
|
1.16
|
|
81
|
Anemia is associated with depression in older adults: results from the InCHIANTI study.
|
J Gerontol A Biol Sci Med Sci
|
2005
|
1.16
|
|
82
|
Health-related quality of life in older adults at risk for disability.
|
Am J Prev Med
|
2007
|
1.16
|
|
83
|
Age-related differences in lower extremity tissue compartments and associations with physical function in older adults.
|
Exp Gerontol
|
2011
|
1.14
|
|
84
|
Executive control function, brain activation and white matter hyperintensities in older adults.
|
Neuroimage
|
2009
|
1.14
|
|
85
|
Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats.
|
J Gerontol A Biol Sci Med Sci
|
2004
|
1.14
|
|
86
|
Effects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial.
|
Clin Interv Aging
|
2011
|
1.12
|
|
87
|
Promoting physical activity for elders with compromised function: the lifestyle interventions and independence for elders (LIFE) study physical activity intervention.
|
Clin Interv Aging
|
2013
|
1.11
|
|
88
|
Effects of exercise on mobility in obese and nonobese older adults.
|
Obesity (Silver Spring)
|
2009
|
1.10
|
|
89
|
Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6.
|
J Gerontol A Biol Sci Med Sci
|
2006
|
1.07
|
|
90
|
Correlation between two markers of inflammation, serum C-reactive protein and interleukin 6, and indices of oxidative stress in patients with high risk of cardiovascular disease.
|
Biomarkers
|
2008
|
1.07
|
|
91
|
Physical activity in prefrail older adults: confidence and satisfaction related to physical function.
|
J Gerontol B Psychol Sci Soc Sci
|
2008
|
1.06
|
|
92
|
Angiotensin-converting enzyme inhibition intervention in elderly persons: effects on body composition and physical performance.
|
J Gerontol A Biol Sci Med Sci
|
2005
|
1.06
|
|
93
|
Physical performance and longevity in aged rats.
|
J Gerontol A Biol Sci Med Sci
|
2002
|
1.05
|
|
94
|
HDL-cholesterol and physical performance: results from the ageing and longevity study in the sirente geographic area (ilSIRENTE Study).
|
Age Ageing
|
2007
|
1.05
|
|
95
|
Free insulin-like growth factor-I and cognitive function in older persons living in community.
|
Growth Horm IGF Res
|
2007
|
1.02
|
|
96
|
Depression and physical function: results from the aging and longevity study in the Sirente geographic area (ilSIRENTE Study).
|
J Geriatr Psychiatry Neurol
|
2007
|
1.02
|
|
97
|
Physical exercise and comorbidity. Results from the Fitness and Arthritis in Seniors Trial (FAST).
|
Aging Clin Exp Res
|
2006
|
1.02
|
|
98
|
Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study.
|
PLoS One
|
2012
|
1.02
|
|
99
|
Angiotensin-converting enzyme insertion/deletion genotype, exercise, and physical decline.
|
JAMA
|
2005
|
1.01
|
|
100
|
Determinants of high and low attendance to diet and exercise interventions among overweight and obese older adults. Results from the arthritis, diet, and activity promotion trial.
|
Contemp Clin Trials
|
2006
|
1.01
|
|
101
|
Oxidative damage, platelet activation, and inflammation to predict mobility disability and mortality in older persons: results from the health aging and body composition study.
|
J Gerontol A Biol Sci Med Sci
|
2012
|
1.00
|
|
102
|
Indications, labeling, and outcomes assessment for drugs aimed at improving functional status in older persons: a conversation between aging researchers and FDA regulators.
|
J Gerontol A Biol Sci Med Sci
|
2009
|
0.99
|
|
103
|
Serum high-density lipoprotein cholesterol levels and mortality in frail, community-living elderly.
|
Gerontology
|
2007
|
0.99
|
|
104
|
Bone density and hemoglobin levels in older persons: results from the InCHIANTI study.
|
Osteoporos Int
|
2004
|
0.96
|
|
105
|
Daily pain and functional decline among old-old adults living in the community: results from the ilSIRENTE Study.
|
J Pain Symptom Manage
|
2009
|
0.96
|
|
106
|
Lipoprotein peroxidation and mobility limitation: results from the Health, Aging, and Body Composition Study.
|
Arch Intern Med
|
2005
|
0.96
|
|
107
|
The ilSIRENTE study: a prospective cohort study on persons aged 80 years and older living in a mountain community of Central Italy.
|
Aging Clin Exp Res
|
2005
|
0.95
|
|
108
|
Genetic influence on exercise-induced changes in physical function among mobility-limited older adults.
|
Physiol Genomics
|
2014
|
0.95
|
|
109
|
ACE-inhibition and physical function: results from the Trial of Angiotensin-Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study.
|
J Am Med Dir Assoc
|
2009
|
0.95
|
|
110
|
Relation of angiotensin-converting enzyme inhibitor treatment to insulin-like growth factor-1 serum levels in subjects >65 years of age (the InCHIANTI study).
|
Am J Cardiol
|
2006
|
0.95
|
|
111
|
Stopping to rest during a 400-meter walk and incident mobility disability in older persons with functional limitations.
|
J Am Geriatr Soc
|
2008
|
0.94
|
|
112
|
Association of sex hormones with sexual function, vitality, and physical function of symptomatic older men with low testosterone levels at baseline in the testosterone trials.
|
J Clin Endocrinol Metab
|
2014
|
0.92
|
|
113
|
Oxidative damage and platelet activation as new predictors of mobility disability and mortality in elders.
|
Antioxid Redox Signal
|
2006
|
0.91
|
|
114
|
Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exercise.
|
J Am Geriatr Soc
|
2012
|
0.91
|
|
115
|
Late-life depressed mood and weight change contribute to the risk of each other.
|
Am J Geriatr Psychiatry
|
2010
|
0.91
|
|
116
|
Evidence regarding the benefits of physical exercise.
|
Arch Intern Med
|
2010
|
0.91
|
|
117
|
Plasminogen activator inhibitor type 1 gene polymorphisms and haplotypes are associated with plasma plasminogen activator inhibitor type 1 levels but not with myocardial infarction or stroke.
|
Am Heart J
|
2006
|
0.90
|
|
118
|
Moderate alcohol intake and risk of functional decline: the Health, Aging, and Body Composition study.
|
J Am Geriatr Soc
|
2009
|
0.90
|
|
119
|
An exploratory analysis of the effects of a weight loss plus exercise program on cellular quality control mechanisms in older overweight women.
|
Rejuvenation Res
|
2011
|
0.90
|
|
120
|
Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging.
|
ScientificWorldJournal
|
2010
|
0.90
|
|
121
|
Angiotensin-converting enzyme inhibition and novel cardiovascular risk biomarkers: results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study.
|
Am Heart J
|
2009
|
0.89
|
|
122
|
Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the lifestyle interventions and independence for elders study.
|
J Am Heart Assoc
|
2013
|
0.89
|
|
123
|
Interaction of HDL cholesterol concentrations on the relationship between physical function and inflammation in community-dwelling older persons.
|
Age Ageing
|
2009
|
0.88
|
|
124
|
Anemia and recovery from disability in activities of daily living in hospitalized older persons.
|
J Am Geriatr Soc
|
2006
|
0.88
|
|
125
|
The impact of behavioral intervention on obesity mediated declines in mobility function: implications for longevity.
|
J Aging Res
|
2011
|
0.86
|
|
126
|
Physical function and its response to exercise: associations with cytokine gene variation in older adults with knee osteoarthritis.
|
J Gerontol A Biol Sci Med Sci
|
2005
|
0.86
|
|
127
|
Anemia and cognitive performance in hospitalized older patients: results from the GIFA study.
|
Int J Geriatr Psychiatry
|
2006
|
0.86
|
|
128
|
Total and abdominal adiposity are associated with inflammation in older adults using a factor analysis approach.
|
J Gerontol A Biol Sci Med Sci
|
2012
|
0.86
|
|
129
|
Impact of inappropriate drug use on physical performance among a frail elderly population living in the community.
|
Eur J Clin Pharmacol
|
2007
|
0.85
|
|
130
|
Depression and adverse drug reactions among hospitalized older adults.
|
Arch Intern Med
|
2003
|
0.85
|
|
131
|
Self-assessed health status, walking speed and mortality in older Mexican-Americans.
|
Gerontology
|
2008
|
0.85
|
|
132
|
Sexual satisfaction and risk of disability in older women.
|
J Clin Psychiatry
|
2003
|
0.85
|
|
133
|
The clinically meaningful change in physical performance scores in an elderly cohort.
|
Aging Clin Exp Res
|
2007
|
0.85
|
|
134
|
Effects of ACE inhibitors on skeletal muscle.
|
Curr Pharm Des
|
2006
|
0.84
|
|
135
|
Snoring, daytime sleepiness, and incident cardiovascular disease in the health, aging, and body composition study.
|
Sleep
|
2013
|
0.84
|
|
136
|
A cost analysis of a physical activity intervention for older adults.
|
J Phys Act Health
|
2009
|
0.83
|
|
137
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