Role of the endothelium during tumor cell metastasis: is the endothelium a barrier or a promoter for cell invasion and metastasis?

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Published in J Biophys on March 05, 2009

Authors

Claudia Tanja Mierke1

Author Affiliations

1: Biophysics Group, Center for Medical Physics and Technology, Friedrich-Alexander-University Erlangen-Nuremberg, 91052 Erlangen, Germany. claudia.mierke@t-online.de

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Integrins: bidirectional, allosteric signaling machines. Cell (2002) 36.25

Tissue cells feel and respond to the stiffness of their substrate. Science (2005) 23.42

Genetic instabilities in human cancers. Nature (1998) 22.76

Cell locomotion and focal adhesions are regulated by substrate flexibility. Proc Natl Acad Sci U S A (1997) 19.46

Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates. Nat Cell Biol (2001) 14.08

Tumor metastasis: mechanistic insights and clinical challenges. Nat Med (2006) 11.06

Stresses at the cell-to-substrate interface during locomotion of fibroblasts. Biophys J (1999) 10.71

Silicone rubber substrata: a new wrinkle in the study of cell locomotion. Science (1980) 9.81

Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell (1991) 9.73

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol (1991) 8.60

A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature (1983) 8.20

Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol (2003) 7.89

Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res (2007) 6.60

Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol (1993) 6.53

Traction fields, moments, and strain energy that cells exert on their surroundings. Am J Physiol Cell Physiol (2002) 6.39

The multiple uses of fluorescent proteins to visualize cancer in vivo. Nat Rev Cancer (2005) 5.83

Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence. Biophys J (2005) 4.91

Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am J Pathol (1998) 4.41

Paxillin and focal adhesion signalling. Nat Cell Biol (2000) 4.37

Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nat Med (2000) 4.36

Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. Invest New Drugs (1999) 4.32

Biological diversity in metastatic neoplasms: origins and implications. Science (1982) 3.95

High resolution traction force microscopy based on experimental and computational advances. Biophys J (2007) 3.89

Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis. J Cell Biol (2004) 3.47

Vinculin knockout results in heart and brain defects during embryonic development. Development (1998) 3.44

Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification whole-mouse imaging system. Cancer Res (2006) 3.42

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells. Oncogene (1997) 3.25

Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer. Int J Cancer (2005) 3.19

Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci U S A (2001) 3.07

Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis. Endocr Rev (2007) 2.78

A tumor-homing peptide with a targeting specificity related to lymphatic vessels. Nat Med (2002) 2.77

Focal adhesions - the cytoskeletal connection. Curr Opin Cell Biol (2000) 2.76

Cell migration--movin' on. Science (1999) 2.72

Color-coded fluorescence imaging of tumor-host interactions. Nat Protoc (2006) 2.38

Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target. Cancer Res (2008) 2.35

Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens. Proc Natl Acad Sci U S A (1991) 2.17

Insights into the mechanisms of lymph node metastasis. Cancer (2003) 2.15

Role of vinculin in regulating focal adhesion turnover. Eur J Cell Biol (2006) 2.03

Mapping local matrix remodeling induced by a migrating tumor cell using three-dimensional multiple-particle tracking. Biophys J (2008) 1.99

Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells. Proc Natl Acad Sci U S A (2003) 1.98

CD24 mediates rolling of breast carcinoma cells on P-selectin. FASEB J (1998) 1.95

Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery. Adv Drug Deliv Rev (2007) 1.94

Mechano-coupling and regulation of contractility by the vinculin tail domain. Biophys J (2007) 1.92

Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells. Proc Natl Acad Sci U S A (2003) 1.91

Independent prognostic value of eosinophil and mast cell infiltration in colorectal cancer tissue. J Pathol (1999) 1.86

Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity. Cancer Res (2000) 1.86

Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function. J Biol Chem (2005) 1.84

Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J Cell Biol (2004) 1.83

Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion. Proc Natl Acad Sci U S A (1995) 1.82

ADAM15 supports prostate cancer metastasis by modulating tumor cell-endothelial cell interaction. Cancer Res (2008) 1.82

In vivo color-coded imaging of the interaction of colon cancer cells and splenocytes in the formation of liver metastases. Cancer Res (2006) 1.76

Tumour angiogenesis and mast cell density in the prognostic assessment of colorectal carcinomas. Dig Liver Dis (2004) 1.75

ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain. Dev Biol (1995) 1.73

An intramolecular association between the head and tail domains of vinculin modulates talin binding. J Biol Chem (1994) 1.69

Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts. J Biol Chem (1991) 1.65

Nestin-linked green fluorescent protein transgenic nude mouse for imaging human tumor angiogenesis. Cancer Res (2005) 1.64

Identification of a talin binding site in the cytoskeletal protein vinculin. J Cell Biol (1989) 1.60

Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase. Int J Cancer (2000) 1.56

Involvement of integrin alpha(v)beta(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells. Mol Biol Cell (2001) 1.51

Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3. J Cell Biol (1996) 1.50

Cooperativity between cell contractility and adhesion. Phys Rev Lett (2004) 1.48

Induction of cancer metastasis by cyclophosphamide pretreatment of host mice: an opposite effect of chemotherapy. Cancer Res (2008) 1.46

Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1. J Cell Sci (1996) 1.42

Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors. Cancer Res (2004) 1.42

ADAMs in fertilization and development. Dev Biol (1996) 1.42

Complexity and specificity of integrin signalling. Nat Cell Biol (2000) 1.41

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Nude mouse metastatic models of human stomach cancer constructed using orthotopic implantation of histologically intact tissue. Cancer Res (1993) 1.37

Real-time in vivo dual-color imaging of intracapillary cancer cell and nucleus deformation and migration. Cancer Res (2005) 1.35

The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner. Mol Biol Cell (2001) 1.35

Regulation of transendothelial migration of colon cancer cells by E-selectin-mediated activation of p38 and ERK MAP kinases. Oncogene (2006) 1.35

Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response. Cancer Res (1991) 1.35

CXC-chemokines stimulate invasion and chemotaxis in prostate carcinoma cells through the CXCR2 receptor. Prostate (1999) 1.34

Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: changes during treatment. Cancer Res (1993) 1.34

Interaction between integrin alpha(5) and fibronectin is required for metastasis of B16F10 melanoma cells. Biochem Biophys Res Commun (2005) 1.34

High affinity interaction of integrin alpha4beta1 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) enhances migration of human melanoma cells across activated endothelial cell layers. J Cell Physiol (2007) 1.30

Stress fluctuations and motion of cytoskeletal-bound markers. Phys Rev E Stat Nonlin Soft Matter Phys (2007) 1.28

alpha3beta1 integrin modulates neuronal migration and placement during early stages of cerebral cortical development. Development (2004) 1.28

Dual-color imaging of nascent blood vessels vascularizing pancreatic cancer in an orthotopic model demonstrates antiangiogenesis efficacy of gemcitabine. J Surg Res (2006) 1.28

Transendothelial migration of colon carcinoma cells requires expression of E-selectin by endothelial cells and activation of stress-activated protein kinase-2 (SAPK2/p38) in the tumor cells. J Biol Chem (2001) 1.27

Role of cadherins in the transendothelial migration of melanoma cells in culture. Cell Motil Cytoskeleton (1997) 1.25

An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase. J Biol Chem (2001) 1.24

Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells. J Cell Sci (1999) 1.20

Analysis of the alpha4beta1 integrin-osteopontin interaction. Exp Cell Res (2000) 1.20

Lymphatic zip codes in premalignant lesions and tumors. Cancer Res (2006) 1.18

Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells. Toxicol Appl Pharmacol (2007) 1.17

Paxillin binding to a conserved sequence motif in the alpha 4 integrin cytoplasmic domain. J Biol Chem (2000) 1.14

Integrin alpha6 cleavage: a novel modification to modulate cell migration. Exp Cell Res (2007) 1.14

Enhancing effect of platelet-derived microvesicles on the invasive potential of breast cancer cells. Transfusion (2006) 1.13

A modified Boyden chamber assay for tumor cell transendothelial migration in vitro. Clin Exp Metastasis (1999) 1.12

Metastatic tumor cell interactions with endothelium, basement membrane and tissue. Curr Opin Cell Biol (1989) 1.12

ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease. Neoplasia (2006) 1.10

Motility of vinculin-deficient F9 embryonic carcinoma cells analyzed by video, laser confocal, and reflection interference contrast microscopy. Exp Cell Res (1995) 1.10

A test of the role of alpha5 integrin/fibronectin interactions in tumorigenesis. Cancer Res (1998) 1.09

Decreased number of mast cells infiltrating into needle biopsy specimens leads to a better prognosis of prostate cancer. Br J Cancer (2007) 1.09

Osteopontin and beta 3 integrin are coordinately expressed in regenerating endothelium in vivo and stimulate Arg-Gly-Asp-dependent endothelial migration in vitro. Circ Res (1995) 1.08

CD24 induces localization of beta1 integrin to lipid raft domains. Biochem Biophys Res Commun (2007) 1.08