1
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Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
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Nature
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2002
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37.66
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2
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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.
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Science
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2007
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7.61
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3
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RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.
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Cell
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2009
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6.89
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4
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The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.
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Cell
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2009
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5.96
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5
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The CRAPome: a contaminant repository for affinity purification-mass spectrometry data.
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Nat Methods
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2013
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4.34
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6
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A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.
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Nature
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2005
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4.33
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7
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A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.
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Mol Cell
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2013
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3.55
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8
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Regulation of DNA damage responses by ubiquitin and SUMO.
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Mol Cell
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2013
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3.43
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9
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Mitosis inhibits DNA double-strand break repair to guard against telomere fusions.
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Science
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2014
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3.31
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10
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A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.
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Cell
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2006
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2.71
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11
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53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.
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Nature
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2013
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2.64
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12
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Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
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Nature
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2010
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2.47
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13
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An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.
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Cell
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2011
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2.35
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14
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Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.
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EMBO J
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2004
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2.24
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15
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Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation.
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Curr Biol
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2005
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2.20
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16
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Regulatory ubiquitylation in response to DNA double-strand breaks.
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DNA Repair (Amst)
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2009
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2.17
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17
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PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint.
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EMBO Rep
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2008
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2.09
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18
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The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase.
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Mol Cell
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2005
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2.09
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19
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Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
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Proc Natl Acad Sci U S A
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2008
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2.01
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20
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Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.
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Mol Cell
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2002
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1.99
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21
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MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.
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Cell Cycle
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2011
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1.97
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22
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The ubiquitous role of ubiquitin in the DNA damage response.
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DNA Repair (Amst)
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2010
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1.94
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23
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Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability.
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Curr Biol
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2003
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1.88
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24
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Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.
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Nat Struct Mol Biol
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2010
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1.87
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25
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A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses.
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EMBO J
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2010
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1.75
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26
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Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.
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Mol Cell
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2012
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1.62
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27
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OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.
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Mol Cell
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2012
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1.58
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28
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Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
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Mol Cell
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2008
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1.51
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29
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Problems with co-funding in Canada.
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Science
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2005
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1.48
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30
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APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation.
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DNA Repair (Amst)
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2008
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1.44
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31
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A strategy for modulation of enzymes in the ubiquitin system.
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Science
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2013
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1.43
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32
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Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.
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J Exp Med
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2010
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1.40
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33
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The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae.
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Genetics
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2006
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1.33
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34
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The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.
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Mol Cell
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2010
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1.32
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35
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Push back to respond better: regulatory inhibition of the DNA double-strand break response.
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Nat Rev Mol Cell Biol
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2013
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1.29
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36
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The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination.
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Proc Natl Acad Sci U S A
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2009
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1.24
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37
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Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.
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PLoS Genet
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2011
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1.23
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38
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De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks.
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Genes Dev
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2010
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1.22
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39
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Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length.
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J Cell Sci
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2006
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1.11
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40
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Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.
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Cell
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2008
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1.10
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41
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A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions.
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PLoS Genet
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2007
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1.06
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42
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CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation.
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PLoS Biol
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2010
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1.05
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43
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Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.
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Nucleic Acids Res
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2013
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1.00
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44
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Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer.
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Sci Transl Med
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2011
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1.00
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45
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Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.
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Mol Cell Proteomics
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2012
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1.00
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46
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gammaH2AX as a checkpoint maintenance signal.
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Cell Cycle
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2006
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0.93
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47
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Chromatin and DNA repair: the benefits of relaxation.
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Nat Cell Biol
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2006
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0.90
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48
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Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin.
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DNA Repair (Amst)
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2011
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0.90
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49
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RMI1 promotes DNA replication fork progression and recovery from replication fork stress.
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Mol Cell Biol
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2012
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0.89
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50
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The structural basis of modified nucleosome recognition by 53BP1.
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Nature
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2016
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0.86
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51
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A siRNA-based screen for genes involved in chromosome end protection.
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PLoS One
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2011
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0.86
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52
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DNA repair pathway choice--a PTIP of the hat to 53BP1.
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EMBO Rep
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2013
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0.85
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53
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DNA repair has a new FAN1 club.
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Mol Cell
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2010
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0.82
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54
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DNA repair: DNA polymerase zeta and Rev1 break in.
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Curr Biol
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2006
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0.79
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55
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Dun1 counts on rad53 to be turned on.
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Mol Cell
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2008
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0.78
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56
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Telomere protection: an act of God.
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Curr Biol
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2006
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0.77
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57
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Bacterial signal transduction: a FHAscinating glimpse at the origins of phospho-dependent signal transduction.
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Trends Microbiol
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2003
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0.77
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58
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Engineering a DNA damage response without DNA damage.
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Genome Biol
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2008
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0.75
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