Published in PLoS Biol on January 26, 2010
14-3-3 proteins as signaling integration points for cell cycle control and apoptosis. Semin Cell Dev Biol (2011) 1.65
Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair. Mol Cell Biol (2012) 1.13
Replication checkpoint: tuning and coordination of replication forks in s phase. Genes (Basel) (2013) 0.95
Type 2C protein phosphatases in fungi. Eukaryot Cell (2010) 0.91
Inhibition of the mitotic exit network in response to damaged telomeres. PLoS Genet (2013) 0.91
When genome integrity and cell cycle decisions collide: roles of polo kinases in cellular adaptation to DNA damage. Syst Synth Biol (2014) 0.89
The budding yeast polo-like kinase Cdc5 regulates the Ndt80 branch of the meiotic recombination checkpoint pathway. Mol Biol Cell (2011) 0.88
Reduced kinase activity of polo kinase Cdc5 affects chromosome stability and DNA damage response in S. cerevisiae. Cell Cycle (2016) 0.88
Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast. Mol Biol Cell (2015) 0.83
Rad53 downregulates mitotic gene transcription by inhibiting the transcriptional activator Ndd1. Mol Cell Biol (2013) 0.82
Dbf4: the whole is greater than the sum of its parts. Cell Cycle (2013) 0.80
Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer. F1000 Biol Rep (2011) 0.80
RAD53 is limiting in double-strand break repair and in protection against toxicity associated with ribonucleotide reductase inhibition. DNA Repair (Amst) (2012) 0.78
SCF(FBXW7α) modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability. Oncotarget (2014) 0.78
Pph3 dephosphorylation of Rad53 is required for cell recovery from MMS-induced DNA damage in Candida albicans. PLoS One (2012) 0.78
Deacetylase Rpd3 facilitates checkpoint adaptation by preventing Rad53 overactivation. Mol Cell Biol (2013) 0.77
The subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3: dynamics and interdependence. Cell Div (2014) 0.76
Cdc5 blocks in vivo Rad53 activity, but not in situ activity (ISA). Cell Cycle (2010) 0.76
Use of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo. Mol Cell Proteomics (2013) 0.76
The budding yeast Polo-like kinase localizes to distinct populations at centrosomes during mitosis. Mol Biol Cell (2017) 0.75
Multiplexed Imaging of Protein Phosphorylation on Membranes Based on Ti(IV) Functionalized Nanopolymers. Chembiochem (2016) 0.75
Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance. Biomolecules (2012) 0.75
Inhibition of Polo-like kinase 1 during the DNA damage response is mediated through loss of Aurora A recruitment by Bora. Oncogene (2016) 0.75
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29
Cell-cycle checkpoints and cancer. Nature (2004) 13.19
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
The DNA damage response: ten years after. Mol Cell (2007) 11.80
Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell (2004) 9.74
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science (1996) 8.71
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol (2005) 8.27
Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol (2004) 7.22
The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell (2003) 7.04
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature (2004) 6.94
Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation. Mol Cell Biol (1992) 5.71
Mrc1 transduces signals of DNA replication stress to activate Rad53. Nat Cell Biol (2001) 5.05
Targeting polo-like kinase 1 for cancer therapy. Nat Rev Cancer (2006) 4.99
Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev (1996) 4.98
Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase. EMBO J (1999) 4.64
Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science (1999) 4.61
Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science (1998) 4.59
Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev (2001) 4.28
A unified view of the DNA-damage checkpoint. Curr Opin Cell Biol (2002) 4.10
Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1. Dev Cell (2008) 4.01
Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci U S A (2003) 3.88
CDC5 and CKII control adaptation to the yeast DNA damage checkpoint. Cell (1997) 3.83
Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest. Mol Cell (2001) 3.74
A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol Cell (2001) 3.65
The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell (2000) 3.64
Polo-like kinase-1 is a target of the DNA damage checkpoint. Nat Cell Biol (2000) 3.49
Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA. PLoS Biol (2003) 3.29
The FHA domain is a modular phosphopeptide recognition motif. Mol Cell (1999) 3.16
Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science (2001) 3.13
The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage. EMBO J (1998) 3.09
EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants. Genes Dev (2002) 3.05
Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. Cell (2001) 2.99
The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae. Curr Biol (1998) 2.92
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro. Proc Natl Acad Sci U S A (2003) 2.80
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol Cell (2006) 2.75
Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. Cell (2004) 2.75
Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc Natl Acad Sci U S A (2003) 2.72
Budding yeast Rad9 is an ATP-dependent Rad53 activating machine. Mol Cell (2001) 2.70
MEC1-dependent phosphorylation of Rad9p in response to DNA damage. Mol Cell (1998) 2.55
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell (2006) 2.45
Polo-like kinases (Plks) and cancer. Oncogene (2005) 2.37
Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation. Curr Biol (2005) 2.20
Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. Curr Biol (2006) 2.02
Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol Cell (2008) 1.94
PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol Cell (2003) 1.88
DNA degradation at unprotected telomeres in yeast is regulated by the CDK1 (Cdc28/Clb) cell-cycle kinase. Mol Cell (2006) 1.73
Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization. Mol Cell (2009) 1.73
Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast. EMBO J (2005) 1.67
Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion. J Biol Chem (2001) 1.60
An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing. Proc Natl Acad Sci U S A (2002) 1.55
Checkpoint adaptation precedes spontaneous and damage-induced genomic instability in yeast. Mol Cell Biol (2001) 1.48
The BRCT domain of the S. cerevisiae checkpoint protein Rad9 mediates a Rad9-Rad9 interaction after DNA damage. Curr Biol (1999) 1.47
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. J Biol Chem (2002) 1.44
A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol (2007) 1.42
Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast. Genes Dev (2006) 1.35
The role of the polo kinase Cdc5 in controlling Cdc14 localization. Mol Biol Cell (2003) 1.30
The Polo-box domain: a molecular integrator of mitotic kinase cascades and Polo-like kinase function. Cell Cycle (2004) 1.23
FHA domain-mediated DNA checkpoint regulation of Rad53. Cell Cycle (2003) 1.19
Mechanisms of checkpoint kinase Rad53 inactivation after a double-strand break in Saccharomyces cerevisiae. Mol Cell Biol (2007) 1.12
Cdc5 interacts with the Wee1 kinase in budding yeast. Mol Cell Biol (2001) 1.10
Diverse but overlapping functions of the two forkhead-associated (FHA) domains in Rad53 checkpoint kinase activation. J Biol Chem (2003) 1.08
Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae. Mol Cell Biol (2004) 1.08
A domain of Rad9 specifically required for activation of Chk1 in budding yeast. J Cell Sci (2004) 1.06
A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1. Mol Cell Biol (2004) 0.99
A Ddc2-Rad53 fusion protein can bypass the requirements for RAD9 and MRC1 in Rad53 activation. Mol Biol Cell (2004) 0.95
Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1. J Biol Chem (2004) 0.94
The Plk1 Polo box domain mediates a cell cycle and DNA damage regulated interaction with Chk2. Cell Cycle (2005) 0.86
Methods for studying adaptation to the DNA damage checkpoint in yeast. Methods Enzymol (2006) 0.77
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell (2009) 6.89
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell (2009) 5.96
The CRAPome: a contaminant repository for affinity purification-mass spectrometry data. Nat Methods (2013) 4.34
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature (2005) 4.33
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol Cell (2013) 3.55
Regulation of DNA damage responses by ubiquitin and SUMO. Mol Cell (2013) 3.43
Mitosis inhibits DNA double-strand break repair to guard against telomere fusions. Science (2014) 3.31
Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4. Mol Cell (2006) 2.91
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell (2006) 2.71
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature (2013) 2.64
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature (2010) 2.47
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell (2011) 2.35
An architectural map of the anaphase-promoting complex. Genes Dev (2006) 2.27
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. EMBO J (2004) 2.24
Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation. Curr Biol (2005) 2.20
Regulatory ubiquitylation in response to DNA double-strand breaks. DNA Repair (Amst) (2009) 2.17
DNA breaks promote genomic instability by impeding proper chromosome segregation. Curr Biol (2004) 2.14
PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint. EMBO Rep (2008) 2.09
The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase. Mol Cell (2005) 2.09
Precise destruction: an emerging picture of the APC. Genes Dev (2006) 2.03
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Proc Natl Acad Sci U S A (2008) 2.01
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol Cell (2002) 1.99
MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks. Cell Cycle (2011) 1.97
The ubiquitous role of ubiquitin in the DNA damage response. DNA Repair (Amst) (2010) 1.94
Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability. Curr Biol (2003) 1.88
Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX. Nat Struct Mol Biol (2010) 1.87
Damage-induced phosphorylation of Sld3 is important to block late origin firing. Nature (2010) 1.86
Securin and B-cyclin/CDK are the only essential targets of the APC. Nat Cell Biol (2003) 1.84
A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses. EMBO J (2010) 1.75
Complicated tails: histone modifications and the DNA damage response. Cell (2005) 1.74
Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks. Mol Cell (2012) 1.62
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Mol Cell (2012) 1.58
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Mol Cell (2008) 1.51
Problems with co-funding in Canada. Science (2005) 1.48
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation. DNA Repair (Amst) (2008) 1.44
A strategy for modulation of enzymes in the ubiquitin system. Science (2013) 1.43
Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer. J Exp Med (2010) 1.40
The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae. Genetics (2006) 1.33
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. Mol Cell (2010) 1.32
Push back to respond better: regulatory inhibition of the DNA double-strand break response. Nat Rev Mol Cell Biol (2013) 1.29
The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. Proc Natl Acad Sci U S A (2009) 1.24
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet (2011) 1.23
De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks. Genes Dev (2010) 1.22
A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch. Nat Cell Biol (2007) 1.16
Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase. PLoS Genet (2007) 1.12
F-box protein specificity for g1 cyclins is dictated by subcellular localization. PLoS Genet (2012) 1.11
Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length. J Cell Sci (2006) 1.11
Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol (2011) 1.10
Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp. Cell (2008) 1.10
A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions. PLoS Genet (2007) 1.06
Taking it off: regulation of H3 K56 acetylation by Hst3 and Hst4. Cell Cycle (2006) 1.03
Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell (2009) 1.00
Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer. Sci Transl Med (2011) 1.00
Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Nucleic Acids Res (2013) 1.00
Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. Mol Cell Proteomics (2012) 1.00
gammaH2AX as a checkpoint maintenance signal. Cell Cycle (2006) 0.93
Cycling without the cyclosome: modeling a yeast strain lacking the APC. Cell Cycle (2004) 0.93
Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1. Curr Biol (2013) 0.91
Chromatin and DNA repair: the benefits of relaxation. Nat Cell Biol (2006) 0.90
Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin. DNA Repair (Amst) (2011) 0.90
RMI1 promotes DNA replication fork progression and recovery from replication fork stress. Mol Cell Biol (2012) 0.89
The structural basis of modified nucleosome recognition by 53BP1. Nature (2016) 0.86
A siRNA-based screen for genes involved in chromosome end protection. PLoS One (2011) 0.86
DNA repair pathway choice--a PTIP of the hat to 53BP1. EMBO Rep (2013) 0.85
Hst3 is turned over by a replication stress-responsive SCF(Cdc4) phospho-degron. Proc Natl Acad Sci U S A (2014) 0.84
Damage in transition. Trends Biochem Sci (2005) 0.84
DNA repair has a new FAN1 club. Mol Cell (2010) 0.82
Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo. Mol Biol Cell (2012) 0.82
Rad53 downregulates mitotic gene transcription by inhibiting the transcriptional activator Ndd1. Mol Cell Biol (2013) 0.82
DNA repair: DNA polymerase zeta and Rev1 break in. Curr Biol (2006) 0.79
Keeping it together in times of stress: checkpoint function at stalled replication forks. Mol Cell (2012) 0.79
Cdc20, an activator at last. Mol Cell (2008) 0.78
Dun1 counts on rad53 to be turned on. Mol Cell (2008) 0.78
Repair scaffolding reaches new heights at blocked replication forks. Mol Cell (2010) 0.77
Telomere protection: an act of God. Curr Biol (2006) 0.77
Bacterial signal transduction: a FHAscinating glimpse at the origins of phospho-dependent signal transduction. Trends Microbiol (2003) 0.77
Cdc5 blocks in vivo Rad53 activity, but not in situ activity (ISA). Cell Cycle (2010) 0.76
Ubiquitin ligases: Taming the APC. Nat Chem Biol (2012) 0.75
Engineering a DNA damage response without DNA damage. Genome Biol (2008) 0.75
Reflections on persons in petri dishes. Linacre Q (1997) 0.75