Published in Eur J Immunol on May 01, 2010
Pharmacological modulation of GITRL/GITR system: therapeutic perspectives. Br J Pharmacol (2012) 0.91
Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions. Cytokine Growth Factor Rev (2013) 0.88
Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo. J Immunol (2011) 0.83
The glucocorticoid-induced TNF receptor family-related protein (GITR) is critical to the development of acute pancreatitis in mice. Br J Pharmacol (2011) 0.81
Autoimmune therapies targeting costimulation and emerging trends in multivalent therapeutics. Ther Deliv (2011) 0.81
Mechanisms of regulatory T cell counter-regulation by innate immunity. Transplant Rev (Orlando) (2013) 0.76
Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 29.42
An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol (2003) 19.16
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol (2001) 12.00
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol (2002) 9.18
TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol (2005) 7.44
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol (2008) 6.56
Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. J Immunol (2004) 3.15
Organ transplantation--how much of the promise has been realized? Nat Med (2005) 2.26
GITR/GITRL: more than an effector T cell co-stimulatory system. Eur J Immunol (2007) 1.53
GITR Blockade Facilitates Treg Mediated Allograft Survival. Transplantation (2009) 1.48
Promotion of allograft survival by CD4+CD25+ regulatory T cells: evidence for in vivo inhibition of effector cell proliferation. J Immunol (2004) 1.34
GITR ligation blocks allograft protection by induced CD25+CD4+ regulatory T cells without enhancing effector T-cell function. Am J Transplant (2007) 1.05
Proinflammatory role of glucocorticoid-induced TNF receptor-related gene in acute lung inflammation. J Immunol (2006) 1.04
The multiple facets of toll-like receptors in transplantation biology. Transplantation (2008) 0.99
GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice. Gut (2006) 0.99
Recombinant glucocorticoid induced tumor necrosis factor receptor (rGITR) induces NOS in murine macrophage. FEBS Lett (2002) 0.99
Requirements for induction and maintenance of peripheral tolerance in stringent allograft models. Proc Natl Acad Sci U S A (2005) 0.96
A major T cell determinant from the influenza virus hemagglutinin (HA) can be a cryptic self peptide in HA transgenic mice. Int Immunol (1997) 0.92
Glucocorticoid-induced tumor necrosis factor receptor-related (GITR)-Fc fusion protein inhibits GITR triggering and protects from the inflammatory response after spinal cord injury. Mol Pharmacol (2008) 0.91
Vulnerability of allografts to rejection by MHC class II-restricted T-cell receptor transgenic mice. Transplantation (2003) 0.88
Modulation of acute and chronic inflammation of the lung by GITR and its ligand. Ann N Y Acad Sci (2007) 0.82
An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol (2003) 8.23
Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature (2009) 8.09
Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J Immunol (2002) 5.10
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature (2011) 4.16
Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med (2003) 4.12
Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol (2011) 3.95
Distinct molecular mechanism for initiating TRAF6 signalling. Nature (2002) 3.82
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat Med (2006) 3.78
Osteoimmunology: interplay between the immune system and bone metabolism. Annu Rev Immunol (2006) 3.18
Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol (2004) 2.79
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood (2007) 2.65
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol (2007) 2.61
Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice. J Cell Biol (2010) 2.47
Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc Natl Acad Sci U S A (2010) 2.45
TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med (2006) 2.44
TRAF6 is a critical factor for dendritic cell maturation and development. Immunity (2003) 2.36
Osteoimmunology: interactions of the bone and immune system. Endocr Rev (2008) 2.32
Dendritic cell development and survival require distinct NF-kappaB subunits. Immunity (2002) 2.31
Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice. Nat Med (2002) 2.29
NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP). Mol Endocrinol (2007) 2.25
Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects. Diabetes (2004) 2.22
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med (2005) 2.21
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity (2002) 2.20
Predicting outcome after liver transplantation: utility of the model for end-stage liver disease and a newly derived discrimination function. Transplantation (2004) 2.13
A novel member of the leukocyte receptor complex regulates osteoclast differentiation. J Exp Med (2002) 2.04
The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity (2006) 2.04
Survival following liver transplantation from non-heart-beating donors. Ann Surg (2004) 1.96
The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells. Immunity (2002) 1.89
Renal function after orthotopic liver transplantation is predicted by duration of pretransplantation creatinine elevation. Liver Transpl (2005) 1.87
TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL. PLoS One (2008) 1.86
Stimulation by toll-like receptors inhibits osteoclast differentiation. J Immunol (2002) 1.82
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med (2009) 1.81
Cutting edge: self-peptides drive the peripheral expansion of CD4+CD25+ regulatory T cells. J Immunol (2003) 1.80
Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system. Cell Metab (2006) 1.76
Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity. Br J Haematol (2002) 1.74
Lack of benefit of pre-transplant locoregional hepatic therapy for hepatocellular cancer in the current MELD era. Liver Transpl (2006) 1.72
Geographic inequity in access to livers for transplantation. Transplantation (2011) 1.71
Insulin independence following isolated islet transplantation and single islet infusions. Ann Surg (2003) 1.67
Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. J Biol Chem (2005) 1.62
A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells. Blood (2011) 1.60
Medullary thymic epithelial cell depletion leads to autoimmune hepatitis. J Clin Invest (2013) 1.57
Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy. Diabetes (2003) 1.55
Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. J Immunol (2006) 1.51
Role of TCR specificity in CD4+ CD25+ regulatory T-cell selection. Immunol Rev (2006) 1.51
GITR Blockade Facilitates Treg Mediated Allograft Survival. Transplantation (2009) 1.48
Positive and negative regulation of the IL-27 receptor during lymphoid cell activation. J Immunol (2005) 1.48
Cutting edge: transplant tolerance induced by anti-CD45RB requires B lymphocytes. J Immunol (2007) 1.47
OX40 signaling favors the induction of T(H)9 cells and airway inflammation. Nat Immunol (2012) 1.43
Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development. Blood (2009) 1.42
CD4+ CD25+ regulatory T cells inhibit the maturation but not the initiation of an autoantibody response. J Immunol (2005) 1.42
Immune rejection after pancreatic islet cell transplantation: in vivo dual contrast-enhanced MR imaging in a mouse model. Radiology (2012) 1.41
Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation. Blood (2005) 1.38
OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J Clin Invest (2011) 1.38
Discovery of a human peptide sequence signaling islet neogenesis. Endocr Pract (2008) 1.38
Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J Immunol (2006) 1.37
Promotion of allograft survival by CD4+CD25+ regulatory T cells: evidence for in vivo inhibition of effector cell proliferation. J Immunol (2004) 1.34
B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection. J Immunol (2006) 1.34
Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity? Transplantation (2003) 1.32
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway. J Biol Chem (2008) 1.31
Strength of TRAF6 signalling determines osteoclastogenesis. EMBO Rep (2005) 1.30
The tec family tyrosine kinase Btk Regulates RANKL-induced osteoclast maturation. J Biol Chem (2008) 1.29
Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling. J Exp Med (2002) 1.29
Biology of the TRANCE axis. Cytokine Growth Factor Rev (2003) 1.29
Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis. Aging Cell (2007) 1.29
{beta}-Cell function following human islet transplantation for type 1 diabetes. Diabetes (2005) 1.28
TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development. J Immunol (2005) 1.27
CD4+CD25+ regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen. J Immunol (2008) 1.27
Magnetic resonance-defined periportal steatosis following intraportal islet transplantation: a functional footprint of islet graft survival? Diabetes (2003) 1.27
T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J Bone Miner Res (2006) 1.26
Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets. Diabetes (2003) 1.25
The role of TRAF6 in signal transduction and the immune response. Microbes Infect (2004) 1.23
Pretransplant model to predict posttransplant survival in liver transplant patients. Ann Surg (2002) 1.22
Allograft survival following adult-to-adult living donor liver transplantation. Am J Transplant (2004) 1.20
Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation. J Immunol (2009) 1.20
TRAF-mediated TNFR-family signaling. Curr Protoc Immunol (2009) 1.19
Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife (2013) 1.19
Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays. Clin Cancer Res (2003) 1.18