Published in Nat Struct Mol Biol on February 14, 2010
Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. Science (2011) 3.14
Revisiting the structures of several antibiotics bound to the bacterial ribosome. Proc Natl Acad Sci U S A (2010) 1.82
Following the intersubunit conformation of the ribosome during translation in real time. Nat Struct Mol Biol (2010) 1.56
Coordinated conformational and compositional dynamics drive ribosome translocation. Nat Struct Mol Biol (2013) 1.47
Crystal structure of release factor RF3 trapped in the GTP state on a rotated conformation of the ribosome. RNA (2011) 1.39
Structure of the ribosome with elongation factor G trapped in the pretranslocation state. Proc Natl Acad Sci U S A (2013) 1.23
Allosteric control of the ribosome by small-molecule antibiotics. Nat Struct Mol Biol (2012) 1.17
Visualization of two transfer RNAs trapped in transit during elongation factor G-mediated translocation. Proc Natl Acad Sci U S A (2013) 1.17
Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes. J Antimicrob Chemother (2012) 1.07
Conformational changes of elongation factor G on the ribosome during tRNA translocation. Cell (2015) 1.07
GTP hydrolysis by EF-G synchronizes tRNA movement on small and large ribosomal subunits. EMBO J (2014) 1.00
Messenger RNA interactions in the decoding center control the rate of translocation. Nat Struct Mol Biol (2011) 0.98
Probing translation with small-molecule inhibitors. Chem Biol (2010) 0.91
Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition. Nucleic Acids Res (2016) 0.91
Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin. Antimicrob Agents Chemother (2011) 0.90
Capreomycin susceptibility is increased by TlyA-directed 2'-O-methylation on both ribosomal subunits. Mol Microbiol (2012) 0.88
The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge B2a of the ribosome. J Mol Biol (2012) 0.88
The central role of protein S12 in organizing the structure of the decoding site of the ribosome. RNA (2013) 0.86
Antibiotics that bind to the A site of the large ribosomal subunit can induce mRNA translocation. RNA (2012) 0.84
Peptide release promoted by methylated RF2 and ArfA in nonstop translation is achieved by an induced-fit mechanism. RNA (2015) 0.83
The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation. Cell Rep (2014) 0.83
Molecular mechanism of viomycin inhibition of peptide elongation in bacteria. Proc Natl Acad Sci U S A (2016) 0.81
Interaction strengths between the ribosome and tRNA at various steps of translocation. Biophys J (2011) 0.81
Drug Resistance Mechanisms in Mycobacterium tuberculosis. Antibiotics (Basel) (2014) 0.80
Elongation factor G initiates translocation through a power stroke. Proc Natl Acad Sci U S A (2016) 0.79
Dynamic contact network between ribosomal subunits enables rapid large-scale rotation during spontaneous translocation. Nucleic Acids Res (2015) 0.78
tRNAs as antibiotic targets. Int J Mol Sci (2014) 0.78
Identification and characterization of the Thermus thermophilus 5-methylcytidine (m5C) methyltransferase modifying 23 S ribosomal RNA (rRNA) base C1942. J Biol Chem (2012) 0.78
In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatment. Antimicrob Agents Chemother (2015) 0.77
Increased bacterial hemolytic activity is conferred by expression of TlyA methyltransferase but not by its 2'-O-methylation of the ribosome. Curr Microbiol (2013) 0.76
Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase. RNA (2016) 0.76
Revealing -1 programmed ribosomal frameshifting mechanisms by single-molecule techniques and computational methods. Comput Math Methods Med (2012) 0.75
Crystallization and preliminary crystallographic analysis of the first condensation domain of viomycin synthetase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.75
A Novel Motif for S-adenosyl-L-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis. J Biol Chem (2016) 0.75
The development of peptide ligands that target helix 69 rRNA of bacterial ribosomes. Bioorg Med Chem (2016) 0.75
Similarity and diversity of translational GTPase factors EF-G, EF4, and BipA: From structure to function. RNA Biol (2016) 0.75
The antituberculosis antibiotic capreomycin inhibits protein synthesis by disrupting interaction between ribosomal proteins L12 and L10. Antimicrob Agents Chemother (2014) 0.75
Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii. Cell Res (2017) 0.75
Model of the pathway of -1 frameshifting: Kinetics. Biochem Biophys Rep (2016) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr D Biol Crystallogr (2002) 53.61
Version 1.2 of the Crystallography and NMR system. Nat Protoc (2007) 13.01
Structures of the bacterial ribosome at 3.5 A resolution. Science (2005) 12.63
Structure of the 70S ribosome complexed with mRNA and tRNA. Science (2006) 12.25
Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature (2000) 11.30
Recognition of cognate transfer RNA by the 30S ribosomal subunit. Science (2001) 8.68
Intermediate states in the movement of transfer RNA in the ribosome. Nature (1989) 7.30
Insights into translational termination from the structure of RF2 bound to the ribosome. Science (2008) 3.89
Spontaneous intersubunit rotation in single ribosomes. Mol Cell (2008) 3.77
Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis. Science (2009) 3.73
Visualization of the hybrid state of tRNA binding promoted by spontaneous ratcheting of the ribosome. Mol Cell (2008) 3.58
Structural basis for translation termination on the 70S ribosome. Nature (2008) 3.50
Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science (2009) 3.39
Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome. Nat Struct Mol Biol (2009) 3.25
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA. Nature (2005) 3.18
Structures of the ribosome in intermediate states of ratcheting. Science (2009) 2.96
Kinetically competent intermediates in the translocation step of protein synthesis. Mol Cell (2007) 2.89
Antibacterial natural products in medicinal chemistry--exodus or revival? Angew Chem Int Ed Engl (2006) 2.64
Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat Struct Mol Biol (2007) 2.54
Conformational changes of the small ribosomal subunit during elongation factor G-dependent tRNA-mRNA translocation. J Mol Biol (2004) 2.41
Crystal structure of a translation termination complex formed with release factor RF2. Proc Natl Acad Sci U S A (2008) 2.33
Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome. Science (2009) 2.33
The antibiotic viomycin traps the ribosome in an intermediate state of translocation. Nat Struct Mol Biol (2007) 2.17
Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs. Mol Cell (2006) 2.15
Fluctuations of transfer RNAs between classical and hybrid states. Biophys J (2007) 1.82
Deletion of a conserved, central ribosomal intersubunit RNA bridge. Mol Cell (2006) 1.80
Modeling a minimal ribosome based on comparative sequence analysis. J Mol Biol (2002) 1.58
Resistance to viomycin conferred by RNA of either ribosomal subunit. Nature (1978) 1.52
The inhibition of ribosomal translocation by viomycin. Eur J Biochem (1977) 1.48
Crystal structure of the ribosome recycling factor bound to the ribosome. Nat Struct Mol Biol (2007) 1.45
Deciphering tuberactinomycin biosynthesis: isolation, sequencing, and annotation of the viomycin biosynthetic gene cluster. Antimicrob Agents Chemother (2003) 1.42
Overproduction and purification of Escherichia coli tRNA(2Gln) and its use in crystallization of the glutaminyl-tRNA synthetase-tRNA(Gln) complex. J Mol Biol (1988) 1.38
Ribosomal translocation: one step closer to the molecular mechanism. ACS Chem Biol (2009) 1.33
New features of the ribosome and ribosomal inhibitors: non-enzymatic recycling, misreading and back-translocation. J Mol Biol (2008) 1.23
Structural basis for hygromycin B inhibition of protein biosynthesis. RNA (2008) 1.21
Ribosomal intersubunit bridge B2a is involved in factor-dependent translation initiation and translational processivity. J Mol Biol (2008) 1.10
Colicin E3 cleavage of 16S rRNA impairs decoding and accelerates tRNA translocation on Escherichia coli ribosomes. Mol Microbiol (2008) 0.98
Helix 69 in 23S rRNA modulates decoding by wild type and suppressor tRNAs. Mol Genet Genomics (2009) 0.94
Mutations in conserved helix 69 of 23S rRNA of Thermus thermophilus that affect capreomycin resistance but not posttranscriptional modifications. J Bacteriol (2008) 0.93
Managing TB in the 21st century: existing and novel drug therapies. Ther Adv Respir Dis (2008) 0.87
Conformational change of Escherichia coli initiator methionyl-tRNA(fMet) upon binding to methionyl-tRNA formyl transferase. Nucleic Acids Res (2002) 0.82
Chemical and physical characterization of capreomycin. Ann N Y Acad Sci (1966) 0.81
Chemical studies on tuberactinomycin. XIII. Modification of beta-ureidodehydroalanine residue in tuberactinomycin N. J Antibiot (Tokyo) (1977) 0.80
Activity of di-beta-lysyl-capreomycin IIA and palmitoyl tuberactinamine N against drug-resistant mutants with altered ribosomes. Antimicrob Agents Chemother (1981) 0.78
Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase. Science (2002) 3.61
Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell (2005) 3.46
The structural mechanism of translocation and helicase activity in T7 RNA polymerase. Cell (2004) 3.33
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA. Nature (2005) 3.18
The structures of four macrolide antibiotics bound to the large ribosomal subunit. Mol Cell (2002) 3.07
Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit. J Mol Biol (2003) 2.98
Structural insight into nascent polypeptide chain-mediated translational stalling. Science (2009) 2.89
Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction. Mol Cell (2005) 2.49
Structural insights into peptide bond formation. Proc Natl Acad Sci U S A (2002) 2.40
The hexameric helicase DnaB adopts a nonplanar conformation during translocation. Cell (2012) 2.37
A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits. Nat Struct Biol (2002) 2.36
Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome. Science (2009) 2.33
Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases. EMBO J (2007) 2.22
The contribution of metal ions to the structural stability of the large ribosomal subunit. RNA (2004) 2.17
Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29. Mol Cell (2004) 2.00
Dissection of the mechanism for the stringent factor RelA. Mol Cell (2002) 1.98
Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase. Science (2007) 1.97
Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit. J Med Chem (2008) 1.96
Revisiting the structures of several antibiotics bound to the bacterial ribosome. Proc Natl Acad Sci U S A (2010) 1.82
The structural basis of large ribosomal subunit function. Annu Rev Biochem (2003) 1.82
The structure of T. aquaticus DNA polymerase III is distinct from eukaryotic replicative DNA polymerases. Cell (2006) 1.79
Poly(A) tail recognition by a viral RNA element through assembly of a triple helix. Science (2010) 1.73
Structure of a synaptic gammadelta resolvase tetramer covalently linked to two cleaved DNAs. Science (2005) 1.73
The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex. Mol Cell (2013) 1.73
The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation. Science (2009) 1.70
The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together. Cell (2007) 1.70
Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation. Proc Natl Acad Sci U S A (2007) 1.65
Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template. Nature (2004) 1.62
Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit. RNA (2003) 1.58
How hibernation factors RMF, HPF, and YfiA turn off protein synthesis. Science (2012) 1.55
The structure of the ankyrin-binding site of beta-spectrin reveals how tandem spectrin-repeats generate unique ligand-binding properties. Blood (2009) 1.54
The involvement of RNA in ribosome function. Nature (2002) 1.42
The initiation of mammalian protein synthesis and mRNA scanning mechanism. Nature (2013) 1.40
Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol (2009) 1.40
U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome. J Mol Biol (2009) 1.39
The structure of a transcribing T7 RNA polymerase in transition from initiation to elongation. Science (2008) 1.39
Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP. Cell (2002) 1.38
Insights into the replisome from the structure of a ternary complex of the DNA polymerase III alpha-subunit. J Mol Biol (2008) 1.37
Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding. Proc Natl Acad Sci U S A (2009) 1.36
Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J Mol Biol (2008) 1.35
A specific subdomain in phi29 DNA polymerase confers both processivity and strand-displacement capacity. Proc Natl Acad Sci U S A (2005) 1.33
The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition. EMBO J (2006) 1.31
Insights into base selectivity from the 1.8 Å resolution structure of an RB69 DNA polymerase ternary complex. Biochemistry (2010) 1.29
Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome. Science (2012) 1.29
Correction of X-ray intensities from single crystals containing lattice-translocation defects. Acta Crystallogr D Biol Crystallogr (2004) 1.26
The structure of LepA, the ribosomal back translocase. Proc Natl Acad Sci U S A (2008) 1.19
Structure of the base of the L7/L12 stalk of the Haloarcula marismortui large ribosomal subunit: analysis of L11 movements. J Mol Biol (2007) 1.19
Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination. Proc Natl Acad Sci U S A (2006) 1.17
A story with a good ending: tRNA 3'-end maturation by CCA-adding enzymes. Curr Opin Struct Biol (2005) 1.14
Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes. Mol Cell (2003) 1.12
Protein synthesis at atomic resolution: mechanistics of translation in the light of highly resolved structures for the ribosome. Curr Protein Pept Sci (2002) 1.11
A structural view on the mechanism of the ribosome-catalyzed peptide bond formation. Biochim Biophys Acta (2009) 1.08
The crystal structure of the Thermus aquaticus DnaB helicase monomer. Nucleic Acids Res (2007) 1.04
Variation in mutation rates caused by RB69pol fidelity mutants can be rationalized on the basis of their kinetic behavior and crystal structures. J Mol Biol (2011) 1.03
Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors. Proc Natl Acad Sci U S A (2004) 1.03
The roles of RNA in the synthesis of protein. Cold Spring Harb Perspect Biol (2011) 1.03
Codon-anticodon interaction at the P site is a prerequisite for tRNA interaction with the small ribosomal subunit. J Biol Chem (2002) 1.01
Structure of the calmodulin alphaII-spectrin complex provides insight into the regulation of cell plasticity. J Biol Chem (2006) 1.00
The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases. Proc Natl Acad Sci U S A (2003) 0.98
Structural insights into complete metal ion coordination from ternary complexes of B family RB69 DNA polymerase. Biochemistry (2011) 0.97
The structures of antibiotics bound to the E site region of the 50 S ribosomal subunit of Haloarcula marismortui: 13-deoxytedanolide and girodazole. J Mol Biol (2007) 0.97
Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP to be inserted opposite 7,8-dihydro-8-oxoguanine . Biochemistry (2010) 0.96
Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui. Antimicrob Agents Chemother (2009) 0.95
Negamycin binds to the wall of the nascent chain exit tunnel of the 50S ribosomal subunit. Antimicrob Agents Chemother (2007) 0.94
Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertase. Nucleic Acids Res (2012) 0.94
Toward understanding phosphoseryl-tRNACys formation: the crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase. Proc Natl Acad Sci U S A (2007) 0.92
How the CCA-adding enzyme selects adenine over cytosine at position 76 of tRNA. Science (2010) 0.92
Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor. Proc Natl Acad Sci U S A (2013) 0.92
After the ribosome structures: how does peptidyl transferase work? RNA (2003) 0.91
The ribosome revealed. Trends Biochem Sci (2005) 0.91
Gene replacement in Haloarcula marismortui: construction of a strain with two of its three chromosomal rRNA operons deleted. Extremophiles (2005) 0.90
Initiation factor 2 crystal structure reveals a different domain organization from eukaryotic initiation factor 5B and mechanism among translational GTPases. Proc Natl Acad Sci U S A (2013) 0.90
The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge B2a of the ribosome. J Mol Biol (2012) 0.88
Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP and dGMP to be inserted opposite Guanidinohydantoin . Biochemistry (2010) 0.88
The E3 ubiquitin ligase XIAP restricts Anaplasma phagocytophilum colonization of Ixodes scapularis ticks. J Infect Dis (2013) 0.87
Elements of ribosomal drug resistance and specificity. Curr Opin Struct Biol (2012) 0.86
Structure of a helicase-helicase loader complex reveals insights into the mechanism of bacterial primosome assembly. Nat Commun (2013) 0.84
Structure of the PolIIIα-τc-DNA complex suggests an atomic model of the replisome. Structure (2013) 0.83
Cross-crystal averaging reveals that the structure of the peptidyl-transferase center is the same in the 70S ribosome and the 50S subunit. Proc Natl Acad Sci U S A (2008) 0.82
Rational design of 'water-soluble' bacteriorhodopsin variants. Protein Eng (2002) 0.81
Peptidyl-CCA deacylation on the ribosome promoted by induced fit and the O3'-hydroxyl group of A76 of the unacylated A-site tRNA. RNA (2008) 0.79
Assembly, purification and crystallization of an active HIV-1 reverse transcriptase initiation complex. Nucleic Acids Res (2002) 0.78
A novel method of determining the number of macromolecules per asymmetric unit from accurate crystal-volume measurements. Acta Crystallogr D Biol Crystallogr (2003) 0.75