Published in Proc Natl Acad Sci U S A on September 27, 2010
Microbial ecology of the dark ocean above, at, and below the seafloor. Microbiol Mol Biol Rev (2011) 2.97
Resistance to linezolid caused by modifications at its binding site on the ribosome. Antimicrob Agents Chemother (2011) 1.70
A platform for the discovery of new macrolide antibiotics. Nature (2016) 1.64
Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center. Proc Natl Acad Sci U S A (2016) 1.40
RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift. Proc Natl Acad Sci U S A (2011) 1.23
Recruitment of a species-specific translational arrest module to monitor different cellular processes. Proc Natl Acad Sci U S A (2011) 1.16
High-resolution structure of the Escherichia coli ribosome. Nat Struct Mol Biol (2015) 1.14
The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin. Nat Struct Mol Biol (2015) 1.13
Role of antibiotic ligand in nascent peptide-dependent ribosome stalling. Proc Natl Acad Sci U S A (2011) 1.07
The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex. Nat Struct Mol Biol (2015) 1.06
Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket. J Am Chem Soc (2012) 1.06
The evolving role of chemical synthesis in antibacterial drug discovery. Angew Chem Int Ed Engl (2014) 1.05
(R)-β-lysine-modified elongation factor P functions in translation elongation. J Biol Chem (2012) 1.02
Macrolide antibiotics allosterically predispose the ribosome for translation arrest. Proc Natl Acad Sci U S A (2014) 0.98
Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain. Antimicrob Agents Chemother (2011) 0.98
Environmental macrolide-lincosamide-streptogramin and tetracycline resistant bacteria. Front Microbiol (2011) 0.96
Direct entry to erythronolides via a cyclic bis[allene]. J Am Chem Soc (2011) 0.96
Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Mol Cell (2015) 0.94
Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus. Proc Natl Acad Sci U S A (2015) 0.94
Sequence-dependent elongation dynamics on macrolide-bound ribosomes. Cell Rep (2014) 0.93
Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition. Nucleic Acids Res (2016) 0.91
Effect of codon adaptation on codon-level and gene-level translation efficiency in vivo. BMC Genomics (2014) 0.89
The chemistry of peptidyltransferase center-targeted antibiotics: enzymatic resistance and approaches to countering resistance. ACS Chem Biol (2011) 0.89
Capreomycin susceptibility is increased by TlyA-directed 2'-O-methylation on both ribosomal subunits. Mol Microbiol (2012) 0.88
Impact of ribosomal modification on the binding of the antibiotic telithromycin using a combined grand canonical monte carlo/molecular dynamics simulation approach. PLoS Comput Biol (2013) 0.88
The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge B2a of the ribosome. J Mol Biol (2012) 0.88
Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis. J Am Chem Soc (2012) 0.87
Antibiotics that bind to the A site of the large ribosomal subunit can induce mRNA translocation. RNA (2012) 0.84
Investigating the entire course of telithromycin binding to Escherichia coli ribosomes. Nucleic Acids Res (2012) 0.83
The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation. Cell Rep (2014) 0.83
Designer drugs for discerning bugs. Proc Natl Acad Sci U S A (2010) 0.82
The structural basis for substrate versatility of chloramphenicol acetyltransferase CATI. Protein Sci (2012) 0.82
Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome. Nucleic Acids Res (2016) 0.82
Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel. Nat Chem Biol (2017) 0.82
A global map of genetic diversity in Babesia microti reveals strong population structure and identifies variants associated with clinical relapse. Nat Microbiol (2016) 0.81
Conjugation with polyamines enhances the antibacterial and anticancer activity of chloramphenicol. Nucleic Acids Res (2014) 0.80
Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA. Nucleic Acids Res (2012) 0.80
Methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible. Antimicrob Agents Chemother (2013) 0.79
Insights into the mode of action of novel fluoroketolides, potent inhibitors of bacterial protein synthesis. Antimicrob Agents Chemother (2013) 0.79
Binding of Macrolide Antibiotics Leads to Ribosomal Selection against Specific Substrates Based on Their Charge and Size. Cell Rep (2016) 0.78
Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A. Nucleic Acids Res (2015) 0.78
Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides. Antimicrob Agents Chemother (2012) 0.77
Macrolide-peptide conjugates as probes of the path of travel of the nascent peptides through the ribosome. ACS Chem Biol (2014) 0.77
Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides. Proc Natl Acad Sci U S A (2015) 0.77
Complex long-distance effects of mutations that confer linezolid resistance in the large ribosomal subunit. Nucleic Acids Res (2015) 0.77
RNA-protein distance patterns in ribosomes reveal the mechanism of translational attenuation. Sci China Life Sci (2014) 0.76
Reduced ribosomes of the apicoplast and mitochondrion of Plasmodium spp. and predicted interactions with antibiotics. Open Biol (2014) 0.76
Influence of Two Bulge Loops on the Stability of RNA Duplexes. RNA (2016) 0.75
Exploiting translational stalling peptides in an effort to extend azithromycin interaction within the prokaryotic ribosome nascent peptide exit tunnel. Bioorg Med Chem (2015) 0.75
Ribosomal Antibiotics: Contemporary Challenges. Antibiotics (Basel) (2016) 0.75
From Erythromycin to Azithromycin and New Potential Ribosome-Binding Antimicrobials. Antibiotics (Basel) (2016) 0.75
Parametrization of macrolide antibiotics using the force field toolkit. J Comput Chem (2015) 0.75
Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium. J Antimicrob Chemother (2016) 0.75
A Numbers Game: Ribosome Densities, Bacterial Growth, and Antibiotic-Mediated Stasis and Death. MBio (2017) 0.75
Chloramphenicol Derivatives as Antibacterial and Anticancer Agents: Historic Problems and Current Solutions. Antibiotics (Basel) (2016) 0.75
Discovery of a Structurally Unique Small Molecule that Inhibits Protein Synthesis. Yale J Biol Med (2017) 0.75
Synthesis and evaluation of chloramphenicol homodimers: molecular target, antimicrobial activity, and toxicity against human cells. PLoS One (2015) 0.75
Reconstitution of Protein Translation of Mycobacterium Reveals Functional Conservation and Divergence with the Gram-Negative Bacterium Escherichia coli. PLoS One (2016) 0.75
The Macrolide Antibiotic Renaissance. Br J Pharmacol (2017) 0.75
Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD. PLoS One (2017) 0.75
A single active site mutation in the pikromycin thioesterase generates a more effective macrocyclization catalyst. J Am Chem Soc (2017) 0.75
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
XDS. Acta Crystallogr D Biol Crystallogr (2010) 67.46
PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Acta Crystallogr D Biol Crystallogr (2004) 23.86
The structural basis of ribosome activity in peptide bond synthesis. Science (2000) 18.82
Structure of the 70S ribosome complexed with mRNA and tRNA. Science (2006) 12.25
Structure of ribosomal RNA. Annu Rev Biochem (1984) 9.44
Erythromycin resistance by ribosome modification. Antimicrob Agents Chemother (1995) 9.40
Interaction of antibiotics with functional sites in 16S ribosomal RNA. Nature (1987) 8.96
Detection, delineation, measurement and display of cavities in macromolecular structures. Acta Crystallogr D Biol Crystallogr (1994) 7.53
Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature (2001) 6.40
Characterization of chloramphenicol acetyltransferase from chloramphenicol-resistant Staphylococcus aureus. J Bacteriol (1968) 6.28
Altered ribosomal RNA genes in mitochondria from mammalian cells with chloramphenicol resistance. Nature (1981) 4.65
Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA. Biochimie (1987) 4.47
Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell (2005) 3.46
Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome. Nat Struct Mol Biol (2009) 3.25
The structures of four macrolide antibiotics bound to the large ribosomal subunit. Mol Cell (2002) 3.07
Molecular mechanism of drug-dependent ribosome stalling. Mol Cell (2008) 2.62
The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA. Mol Microbiol (1999) 2.36
The A-Z of bacterial translation inhibitors. Crit Rev Biochem Mol Biol (2009) 2.34
Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome. Science (2009) 2.33
Identification of a site on 23S ribosomal RNA located at the peptidyl transferase center. Proc Natl Acad Sci U S A (1984) 2.22
The contribution of metal ions to the structural stability of the large ribosomal subunit. RNA (2004) 2.17
Molecular basis of bacterial resistance to chloramphenicol and florfenicol. FEMS Microbiol Rev (2004) 2.07
Mitochondrial DNA of chloramphenicol-resistant mouse cells contains a single nucleotide change in the region encoding the 3' end of the large ribosomal RNA. Proc Natl Acad Sci U S A (1981) 2.03
Antibiotics targeting ribosomes: resistance, selectivity, synergism and cellular regulation. Annu Rev Biochem (2005) 1.99
Macrolide-resistant Mycoplasma pneumoniae: characteristics of isolates and clinical aspects of community-acquired pneumonia. J Infect Chemother (2010) 1.92
Fine structure of the peptidyl transferase centre on 23 S-like rRNAs deduced from chemical probing of antibiotic-ribosome complexes. J Mol Biol (1995) 1.82
Different nucleotide changes in the large rRNA gene of the mitochondrial DNA confer chloramphenicol resistance on two human cell lines. Nucleic Acids Res (1981) 1.72
Structural basis for the antibiotic activity of ketolides and azalides. Structure (2003) 1.64
Structure of chloramphenicol acetyltransferase at 1.75-A resolution. Proc Natl Acad Sci U S A (1988) 1.61
Structural insight into the antibiotic action of telithromycin against resistant mutants. J Bacteriol (2003) 1.59
A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition. Proc Natl Acad Sci U S A (2001) 1.57
Increase in pneumococcus macrolide resistance, United States. Emerg Infect Dis (2009) 1.54
The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome. Nat Struct Mol Biol (2010) 1.42
Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J Mol Biol (2008) 1.35
Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA. J Bacteriol (2001) 1.33
Species-specific antibiotic-ribosome interactions: implications for drug development. Biol Chem (2005) 1.27
Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes: Binding of UACCA-Leu to 50 S subunits. FEBS Lett (1971) 1.25
Binding site of the bridged macrolides in the Escherichia coli ribosome. Antimicrob Agents Chemother (2005) 1.17
Macrolide resistance from the ribosome perspective. Curr Drug Targets Infect Disord (2004) 1.08
Structure-based drug design meets the ribosome. Biochem Pharmacol (2006) 1.07
Correlation between the peptidyl transferase activity of the 50 s ribosomal subunit and the ability of the subunit to interact with antibiotics. J Mol Biol (1971) 1.03
R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance. Antimicrob Agents Chemother (2008) 1.02
Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. J Med Chem (2000) 1.01
Molecular characterization of macrolide- and multidrug-resistant Streptococcus pyogenes isolated from adult patients in Barcelona, Spain (1993-2008). J Antimicrob Chemother (2010) 0.97
Effect of polyamines on the inhibition of peptidyltransferase by antibiotics: revisiting the mechanism of chloramphenicol action. Nucleic Acids Res (2003) 0.92
Cooperative binding of 3'-fragments of transfer ribonucleic acid to the peptidyltransferase center of Escherichia coli ribosomes. Arch Biochem Biophys (1978) 0.90
Methylation of minimalist 23S rRNA sequences in vitro by ErmSF (TlrA) N-methyltransferase. Biochemistry (1995) 0.89
Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics. Bioorg Med Chem Lett (2008) 0.88
Design, synthesis and ribosome binding of chloramphenicol nucleotide and intercalator conjugates. Bioorg Med Chem Lett (2005) 0.85
Mutational analysis of reduced telithromycin susceptibility of Streptococcus pneumoniae isolated clinically in Japan. FEMS Microbiol Lett (2010) 0.82
Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase. Science (2002) 3.61
Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell (2005) 3.46
The structural mechanism of translocation and helicase activity in T7 RNA polymerase. Cell (2004) 3.33
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA. Nature (2005) 3.18
The structures of four macrolide antibiotics bound to the large ribosomal subunit. Mol Cell (2002) 3.07
Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit. J Mol Biol (2003) 2.98
Structural insight into nascent polypeptide chain-mediated translational stalling. Science (2009) 2.89
Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction. Mol Cell (2005) 2.49
Structural insights into peptide bond formation. Proc Natl Acad Sci U S A (2002) 2.40
The hexameric helicase DnaB adopts a nonplanar conformation during translocation. Cell (2012) 2.37
A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits. Nat Struct Biol (2002) 2.36
Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome. Science (2009) 2.33
Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases. EMBO J (2007) 2.22
The contribution of metal ions to the structural stability of the large ribosomal subunit. RNA (2004) 2.17
Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29. Mol Cell (2004) 2.00
Dissection of the mechanism for the stringent factor RelA. Mol Cell (2002) 1.98
Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase. Science (2007) 1.97
Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit. J Med Chem (2008) 1.96
The structural basis of large ribosomal subunit function. Annu Rev Biochem (2003) 1.82
The structure of T. aquaticus DNA polymerase III is distinct from eukaryotic replicative DNA polymerases. Cell (2006) 1.79
Poly(A) tail recognition by a viral RNA element through assembly of a triple helix. Science (2010) 1.73
Structure of a synaptic gammadelta resolvase tetramer covalently linked to two cleaved DNAs. Science (2005) 1.73
The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex. Mol Cell (2013) 1.73
The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation. Science (2009) 1.70
The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together. Cell (2007) 1.70
Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation. Proc Natl Acad Sci U S A (2007) 1.65
Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template. Nature (2004) 1.62
Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit. RNA (2003) 1.58
How hibernation factors RMF, HPF, and YfiA turn off protein synthesis. Science (2012) 1.55
The structure of the ankyrin-binding site of beta-spectrin reveals how tandem spectrin-repeats generate unique ligand-binding properties. Blood (2009) 1.54
The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome. Nat Struct Mol Biol (2010) 1.42
The involvement of RNA in ribosome function. Nature (2002) 1.42
The initiation of mammalian protein synthesis and mRNA scanning mechanism. Nature (2013) 1.40
Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol (2009) 1.40
U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome. J Mol Biol (2009) 1.39
The structure of a transcribing T7 RNA polymerase in transition from initiation to elongation. Science (2008) 1.39
Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP. Cell (2002) 1.38
Insights into the replisome from the structure of a ternary complex of the DNA polymerase III alpha-subunit. J Mol Biol (2008) 1.37
Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding. Proc Natl Acad Sci U S A (2009) 1.36
Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J Mol Biol (2008) 1.35
A specific subdomain in phi29 DNA polymerase confers both processivity and strand-displacement capacity. Proc Natl Acad Sci U S A (2005) 1.33
The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition. EMBO J (2006) 1.31
Insights into base selectivity from the 1.8 Å resolution structure of an RB69 DNA polymerase ternary complex. Biochemistry (2010) 1.29
Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome. Science (2012) 1.29
Correction of X-ray intensities from single crystals containing lattice-translocation defects. Acta Crystallogr D Biol Crystallogr (2004) 1.26
The structure of LepA, the ribosomal back translocase. Proc Natl Acad Sci U S A (2008) 1.19
Structure of the base of the L7/L12 stalk of the Haloarcula marismortui large ribosomal subunit: analysis of L11 movements. J Mol Biol (2007) 1.19
Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination. Proc Natl Acad Sci U S A (2006) 1.17
A story with a good ending: tRNA 3'-end maturation by CCA-adding enzymes. Curr Opin Struct Biol (2005) 1.14
Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes. Mol Cell (2003) 1.12
Protein synthesis at atomic resolution: mechanistics of translation in the light of highly resolved structures for the ribosome. Curr Protein Pept Sci (2002) 1.11
A structural view on the mechanism of the ribosome-catalyzed peptide bond formation. Biochim Biophys Acta (2009) 1.08
The crystal structure of the Thermus aquaticus DnaB helicase monomer. Nucleic Acids Res (2007) 1.04
Variation in mutation rates caused by RB69pol fidelity mutants can be rationalized on the basis of their kinetic behavior and crystal structures. J Mol Biol (2011) 1.03
Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors. Proc Natl Acad Sci U S A (2004) 1.03
The roles of RNA in the synthesis of protein. Cold Spring Harb Perspect Biol (2011) 1.03
Codon-anticodon interaction at the P site is a prerequisite for tRNA interaction with the small ribosomal subunit. J Biol Chem (2002) 1.01
Structure of the calmodulin alphaII-spectrin complex provides insight into the regulation of cell plasticity. J Biol Chem (2006) 1.00
The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases. Proc Natl Acad Sci U S A (2003) 0.98
Structural insights into complete metal ion coordination from ternary complexes of B family RB69 DNA polymerase. Biochemistry (2011) 0.97
The structures of antibiotics bound to the E site region of the 50 S ribosomal subunit of Haloarcula marismortui: 13-deoxytedanolide and girodazole. J Mol Biol (2007) 0.97
Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP to be inserted opposite 7,8-dihydro-8-oxoguanine . Biochemistry (2010) 0.96
Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui. Antimicrob Agents Chemother (2009) 0.95
Negamycin binds to the wall of the nascent chain exit tunnel of the 50S ribosomal subunit. Antimicrob Agents Chemother (2007) 0.94
Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertase. Nucleic Acids Res (2012) 0.94
Toward understanding phosphoseryl-tRNACys formation: the crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase. Proc Natl Acad Sci U S A (2007) 0.92
How the CCA-adding enzyme selects adenine over cytosine at position 76 of tRNA. Science (2010) 0.92
Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor. Proc Natl Acad Sci U S A (2013) 0.92
After the ribosome structures: how does peptidyl transferase work? RNA (2003) 0.91
The ribosome revealed. Trends Biochem Sci (2005) 0.91
Gene replacement in Haloarcula marismortui: construction of a strain with two of its three chromosomal rRNA operons deleted. Extremophiles (2005) 0.90
Initiation factor 2 crystal structure reveals a different domain organization from eukaryotic initiation factor 5B and mechanism among translational GTPases. Proc Natl Acad Sci U S A (2013) 0.90
The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge B2a of the ribosome. J Mol Biol (2012) 0.88
Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP and dGMP to be inserted opposite Guanidinohydantoin . Biochemistry (2010) 0.88
The E3 ubiquitin ligase XIAP restricts Anaplasma phagocytophilum colonization of Ixodes scapularis ticks. J Infect Dis (2013) 0.87
Elements of ribosomal drug resistance and specificity. Curr Opin Struct Biol (2012) 0.86
Structure of a helicase-helicase loader complex reveals insights into the mechanism of bacterial primosome assembly. Nat Commun (2013) 0.84
Structure of the PolIIIα-τc-DNA complex suggests an atomic model of the replisome. Structure (2013) 0.83
Cross-crystal averaging reveals that the structure of the peptidyl-transferase center is the same in the 70S ribosome and the 50S subunit. Proc Natl Acad Sci U S A (2008) 0.82
Rational design of 'water-soluble' bacteriorhodopsin variants. Protein Eng (2002) 0.81
Peptidyl-CCA deacylation on the ribosome promoted by induced fit and the O3'-hydroxyl group of A76 of the unacylated A-site tRNA. RNA (2008) 0.79
Assembly, purification and crystallization of an active HIV-1 reverse transcriptase initiation complex. Nucleic Acids Res (2002) 0.78
A novel method of determining the number of macromolecules per asymmetric unit from accurate crystal-volume measurements. Acta Crystallogr D Biol Crystallogr (2003) 0.75