Published in Oncogene on February 15, 2010
β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. PLoS One (2011) 1.25
RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis. Mol Cancer Ther (2013) 1.21
Merlin-deficient human tumors show loss of contact inhibition and activation of Wnt/β-catenin signaling linked to the PDGFR/Src and Rac/PAK pathways. Neoplasia (2011) 1.02
The molecular biology of vestibular schwannomas and its association with hearing loss: a review. Genet Res Int (2012) 0.90
Proteomic screening identifies a YAP-driven signaling network linked to tumor cell proliferation in human schwannomas. Neuro Oncol (2014) 0.85
Role of Merlin/NF2 inactivation in tumor biology. Oncogene (2015) 0.85
Approaches of targeting Rho GTPases in cancer drug discovery. Expert Opin Drug Discov (2015) 0.84
FERM domain phosphoinositide binding targets merlin to the membrane and is essential for its growth-suppressive function. Mol Cell Biol (2011) 0.84
Neurofibromatosis type 2 tumor suppressor protein, NF2, induces proteasome-mediated degradation of JC virus T-antigen in human glioblastoma. PLoS One (2013) 0.84
p75NTR is highly expressed in vestibular schwannomas and promotes cell survival by activating nuclear transcription factor κB. Glia (2014) 0.83
The NF2 tumor suppressor regulates microtubule-based vesicle trafficking via a novel Rac, MLK and p38(SAPK) pathway. Oncogene (2012) 0.83
Merlin/NF2 Suppresses Pancreatic Tumor Growth and Metastasis by Attenuating the FOXM1-Mediated Wnt/β-Catenin Signaling. Cancer Res (2015) 0.79
Cancer Cell Fusion: Mechanisms Slowly Unravel. Int J Mol Sci (2016) 0.77
Nf2/Merlin controls spinal cord neural progenitor function in a Rac1/ErbB2-dependent manner. PLoS One (2014) 0.77
A splicing variant of Merlin promotes metastasis in hepatocellular carcinoma. Nat Commun (2015) 0.76
Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients. Croat Med J (2012) 0.75
Porf-2 Inhibits Neural Stem Cell Proliferation Through Wnt/β-Catenin Pathway by Its GAP Domain. Front Cell Neurosci (2016) 0.75
In Silico Approach for SAR Analysis of the Predicted Model of DEPDC1B: A Novel Target for Oral Cancer. Adv Bioinformatics (2016) 0.75
Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation. Cell Death Differ (2016) 0.75
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature (1999) 20.34
RHO-GTPases and cancer. Nat Rev Cancer (2002) 8.03
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell (2004) 4.98
Wnt signaling controls the phosphorylation status of beta-catenin. J Biol Chem (2002) 4.40
Rho GTPases are over-expressed in human tumors. Int J Cancer (1999) 3.70
The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes Dev (2001) 3.65
Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin. Genes Dev (2005) 3.59
Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell (2008) 3.02
Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. Genes Dev (2004) 2.99
Contact-dependent inhibition of EGFR signaling by Nf2/Merlin. J Cell Biol (2007) 2.89
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell (2001) 2.89
Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev (2000) 2.72
NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev (2003) 2.55
Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin. J Biol Chem (1996) 2.07
p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem (2001) 2.05
Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane. J Cell Biol (2005) 1.86
Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. J Biol Chem (2002) 1.82
Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors. Oncogene (1999) 1.82
Crystal structure of a beta-catenin/BCL9/Tcf4 complex. Mol Cell (2006) 1.61
Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma. Cancer Res (2008) 1.55
Role of Rho-family proteins in cell adhesion and cancer. Curr Opin Cell Biol (2003) 1.53
Merlin is a potent inhibitor of glioma growth. Cancer Res (2008) 1.47
Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells. Hum Mol Genet (2003) 1.47
Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation. Oncogene (2004) 1.35
Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. Proc Natl Acad Sci U S A (2006) 1.35
RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult. Nucleic Acids Res (2004) 1.33
Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation. Nat Cell Biol (2007) 1.31
Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading. Hum Mol Genet (1999) 1.27
Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity. Mol Endocrinol (2005) 1.25
Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene. Oncogene (2002) 1.23
Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology. Nat Genet (2002) 1.22
Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. J Neurosci (2006) 1.17
Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells. Eur J Haematol (2008) 1.14
Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling. Oncogene (2008) 1.07
Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas. Oncogene (2007) 1.04
REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell (1995) 6.43
Pericentrin and gamma-tubulin form a protein complex and are organized into a novel lattice at the centrosome. J Cell Biol (1998) 4.23
CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Nat Cell Biol (2000) 3.96
Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase. Science (1996) 3.85
Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran. Science (1999) 3.66
Rapid multi-element analysis of groundwater by high-resolution inductively coupled plasma mass spectrometry. Anal Bioanal Chem (2004) 3.50
The Dbl family of oncogenes. Curr Opin Cell Biol (1996) 3.50
Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev (1994) 3.40
A prospective randomised study of "covered" versus "uncovered" diamond stents for the management of distal malignant biliary obstruction. Gut (2004) 3.35
Inhibition of RhoA by p120 catenin. Nat Cell Biol (2000) 3.33
Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis. Cell (1992) 3.30
Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone. Science (1978) 3.15
Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. J Biol Chem (1994) 3.03
Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity. Neuroimage (1996) 2.98
5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex. Proc Natl Acad Sci U S A (2000) 2.98
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell (2001) 2.89
Characterization of two related Drosophila gamma-tubulin complexes that differ in their ability to nucleate microtubules. J Cell Biol (1999) 2.88
Intestinal lymphangiectasia markedly improved with antiplasmin therapy. Gastroenterology (1989) 2.88
Role of importin-beta in coupling Ran to downstream targets in microtubule assembly. Science (2001) 2.87
Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities. Nat Cell Biol (2001) 2.78
Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol (2000) 2.67
An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. J Immunol (2001) 2.62
Regulation of cortical actin cytoskeleton assembly during polarized cell growth in budding yeast. J Cell Biol (1995) 2.59
Flow-cytometric separation and enrichment of hepatic progenitor cells in the developing mouse liver. Hepatology (2000) 2.43
A new function for the gamma-tubulin ring complex as a microtubule minus-end cap. Nat Cell Biol (2000) 2.43
Recruitment of the gamma-tubulin ring complex to Drosophila salt-stripped centrosome scaffolds. J Cell Biol (1998) 2.42
Behavioural and functional anatomical correlates of deception in humans. Neuroreport (2001) 2.41
Responses of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery. Anesthesiology (1992) 2.35
Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast. J Cell Biol (1994) 2.29
Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness. Science (1999) 2.25
Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42. J Neurosci (2001) 2.20
Associations between drinking water and urinary arsenic levels and skin lesions in Bangladesh. J Occup Environ Med (2000) 2.20
Rac1 GTPase: a "Rac" of all trades. Cell Mol Life Sci (2009) 2.19
Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China. Infection (2013) 2.18
Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. J Biol Chem (1998) 2.17
Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. Blood (2000) 2.08
Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats. Hepatology (1999) 2.02
Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse. Nat Genet (1999) 1.84
Insulin secretion and insulin sensitivity at different stages of glucose tolerance: a cross-sectional study of Japanese type 2 diabetes. Metabolism (2004) 1.82
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization. Proc Natl Acad Sci U S A (2001) 1.80
Xgrip109: a gamma tubulin-associated protein with an essential role in gamma tubulin ring complex (gammaTuRC) assembly and centrosome function. J Cell Biol (1998) 1.79
Transcription factors control invasion: AP-1 the first among equals. Oncogene (2006) 1.78
Schwann cells from neurofibromin deficient mice exhibit activation of p21ras, inhibition of cell proliferation and morphological changes. Oncogene (1995) 1.78
Two Xylella fastidiosa Genotypes Associated with Almond Leaf Scorch Disease on the Same Location in California. Phytopathology (2005) 1.74
Increased oxygen consumption following activation of brain: theoretical footnotes using spectroscopic data from barrel cortex. Neuroimage (2001) 1.74
Concentric structure of thalamic lesions in acute necrotizing encephalopathy. Neuroradiology (2002) 1.73
Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation. J Biol Chem (2001) 1.72
5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence. Nucleic Acids Res (2000) 1.71
Investigating the functional anatomy of empathy and forgiveness. Neuroreport (2001) 1.69
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67
The effects of lebrikizumab in patients with mild asthma following whole lung allergen challenge. Clin Exp Allergy (2014) 1.65
Characterization and reconstitution of Drosophila gamma-tubulin ring complex subunits. J Cell Biol (2000) 1.64
Sex-related differences in bronchial epithelial changes associated with tobacco smoking. J Natl Cancer Inst (1999) 1.64
The role of Mg2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins. J Biol Chem (2000) 1.61
Mutant p53 in MDA-MB-231 breast cancer cells is stabilized by elevated phospholipase D activity and contributes to survival signals generated by phospholipase D. Oncogene (2006) 1.61
Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome P450 reductase and involvement of the bioactivation in the DNA damage. Free Radic Biol Med (1997) 1.57
Distribution and specific identification of papillomavirus major capsid protein epitopes by immunocytochemistry and epitope scanning of synthetic peptides. J Infect Dis (1990) 1.57
Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models. J Clin Invest (2000) 1.56
Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56
OX40L blockade and allergen-induced airway responses in subjects with mild asthma. Clin Exp Allergy (2014) 1.54
Cognitive function and academic performance in neurofibromatosis. 1: consensus statement from the NF1 Cognitive Disorders Task Force. Neurology (1997) 1.52
Gamma-tubulin complexes and their interaction with microtubule-organizing centers. Curr Opin Struct Biol (1999) 1.49
Flushing history as a hydrogeological control on the regional distribution of arsenic in shallow groundwater of the Bengal Basin. Environ Sci Technol (2008) 1.48
Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats. Biochem Biophys Res Commun (1988) 1.46
AP-1-mediated invasion requires increased expression of the hyaluronan receptor CD44. Mol Cell Biol (1997) 1.46
Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. J Biol Chem (2000) 1.41
Insulin sensitivity, insulin secretion, and glucose effectiveness in anorexia nervosa: a minimal model analysis. Metabolism (1993) 1.40
Rho proteins play a critical role in cell migration during the early phase of mucosal restitution. J Clin Invest (1997) 1.40
The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes. Neuron (1992) 1.39
Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells. Oncogene (1998) 1.38
CD44 enhances neuregulin signaling by Schwann cells. J Cell Biol (2000) 1.38
Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors. J Biol Chem (2001) 1.37
Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide]. J Biol Chem (1999) 1.35
Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin. Proc Natl Acad Sci U S A (2000) 1.35
Na,K-ATPase activity is required for formation of tight junctions, desmosomes, and induction of polarity in epithelial cells. Mol Biol Cell (2001) 1.34
The role of Xgrip210 in gamma-tubulin ring complex assembly and centrosome recruitment. J Cell Biol (2000) 1.34
Both the N- and the C-terminal domains of the nominal phosphoprotein of rabies virus are involved in binding to the nucleoprotein. Virology (1994) 1.34
Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase. Mol Cell Biol (1997) 1.33
Detection of JC virus-specific cytotoxic T lymphocytes in healthy individuals. J Virol (2004) 1.32
Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts. J Biol Chem (2000) 1.32
Salmonella typhimurium has two homologous but different umuDC operons: cloning of a new umuDC-like operon (samAB) present in a 60-megadalton cryptic plasmid of S. typhimurium. J Bacteriol (1991) 1.32
The transcription factor AP-1 is required for EGF-induced activation of rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells. J Cell Biol (1998) 1.32
Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines. Mol Cell Biol (1998) 1.30
Endoscopic ultrasound-guided rendezvous for biliary access after failed cannulation. Endoscopy (2011) 1.29
Associated factors for age related maculopathy in the adult population in China: the Beijing eye study. Br J Ophthalmol (2006) 1.29
Angiogenic and invasive properties of neurofibroma Schwann cells. J Cell Biol (1990) 1.28
Effect of 5-hydroxytryptophan (5-HTP) on plasma prolactin levels in man. J Clin Endocrinol Metab (1974) 1.28
Overexpression of 5-methylcytosine DNA glycosylase in human embryonic kidney cells EcR293 demethylates the promoter of a hormone-regulated reporter gene. Proc Natl Acad Sci U S A (2001) 1.28
Spectroscopic analysis of neural activity in brain: increased oxygen consumption following activation of barrel cortex. Neuroimage (2000) 1.28
Arsenic migration to deep groundwater in Bangladesh influenced by adsorption and water demand. Nat Geosci (2011) 1.26
Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity. Cell Death Dis (2012) 1.26
A neuronal cell surface heparan sulfate proteoglycan is required for dorsal root ganglion neuron stimulation of Schwann cell proliferation. J Cell Biol (1985) 1.25
Vestibular endolymph-producing epithelium. Electron microscopic study of the development and histochemistry of the dark cells of the crista ampullaris. Acta Otolaryngol (1969) 1.25
Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1. J Neurosci (2001) 1.24
Cell and tissue distribution and developmental change of neuron specific 14 kDa protein (phosphoneuroprotein 14). Brain Res (1993) 1.24
Measurement of the electron charge asymmetry in inclusive W production in pp collisions at sqrt[s]=7 TeV. Phys Rev Lett (2012) 1.23
Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3. Cancer Res (2000) 1.23
Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains. J Biol Chem (1997) 1.23