Published in Mol Cell Biol on February 16, 2010
NF-κB addiction and its role in cancer: 'one size does not fit all'. Oncogene (2010) 2.56
Inhibiting NF-κB activation by small molecules as a therapeutic strategy. Biochim Biophys Acta (2010) 2.55
AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. J Mol Med (Berl) (2011) 2.26
Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway. Cell Signal (2010) 1.99
Deciphering a global network of functionally associated post-translational modifications. Mol Syst Biol (2012) 1.86
Hierarchies of NF-κB target-gene regulation. Nat Immunol (2011) 1.71
Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy. Invest Ophthalmol Vis Sci (2014) 1.52
Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA. Oncogene (2013) 1.44
SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity. PLoS One (2012) 1.23
SET for life: biochemical activities and biological functions of SET domain-containing proteins. Trends Biochem Sci (2013) 1.22
The atypical PKCs in inflammation: NF-κB and beyond. Immunol Rev (2012) 1.17
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The functional diversity of protein lysine methylation. Mol Syst Biol (2014) 1.11
The Roles of SIRT1 in Cancer. Genes Cancer (2013) 1.04
Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop. Mol Cell Biol (2012) 1.02
Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination. Oncogene (2011) 1.01
Epigenetic gene regulation in the adult mammalian brain: multiple roles in memory formation. Neurobiol Learn Mem (2011) 0.93
Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells. Acta Pharmacol Sin (2012) 0.93
Histone deacetylase inhibitor treatment attenuates MAP kinase pathway activation and pulmonary inflammation following hemorrhagic shock in a rodent model. J Surg Res (2011) 0.89
Epigenetic mechanisms in experience-driven memory formation and behavior. Epigenomics (2011) 0.88
Emerging roles of lysine methylation on non-histone proteins. Cell Mol Life Sci (2015) 0.87
The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury. Cell Death Dis (2010) 0.87
Bromodomain and extraterminal (BET) protein inhibition suppresses human T cell leukemia virus 1 (HTLV-1) Tax protein-mediated tumorigenesis by inhibiting nuclear factor κB (NF-κB) signaling. J Biol Chem (2013) 0.87
Epigenetic regulation of inflammatory gene expression in macrophages by selenium. J Nutr Biochem (2014) 0.82
1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-κB/RelA acetylation at Lys310. PLoS One (2012) 0.82
Identification of novel interacting partners of Sirtuin6. PLoS One (2012) 0.81
Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry. J Proteomics (2015) 0.80
Amelioration of LPS-induced inflammation response in microglia by AMPK activation. Biomed Res Int (2014) 0.79
Histone deacetylase inhibition enhances antimicrobial peptide but not inflammatory cytokine expression upon bacterial challenge. Proc Natl Acad Sci U S A (2016) 0.78
p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-κB subunit. J Cell Sci (2014) 0.77
Downregulation of angiotensin type 1 receptor and nuclear factor-κB by sirtuin 1 contributes to renoprotection in unilateral ureteral obstruction. Sci Rep (2016) 0.76
Involvement of adiponectin in the pathogenesis of dystrophinopathy. Skelet Muscle (2015) 0.76
Methods to detect NF-κB acetylation and methylation. Methods Mol Biol (2015) 0.75
Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells. PLoS One (2015) 0.75
Talking to histone: methylated RelA serves as a messenger. Cell Res (2011) 0.75
JMJD8 is a positive regulator of TNF-induced NF-κB signaling. Sci Rep (2016) 0.75
Diabetic retinopathy and transcriptional regulation of a small molecular weight G-Protein, Rac1. Exp Eye Res (2016) 0.75
The Ubiquitination of NF-κB Subunits in the Control of Transcription. Cells (2016) 0.75
NF-κBp50 and HDAC1 Interaction Is Implicated in the Host Tolerance to Infection Mediated by the Bacterial Quorum Sensing Signal 2-Aminoacetophenone. Front Microbiol (2017) 0.75
Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem (1987) 59.79
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Translating the histone code. Science (2001) 56.77
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Missing pieces in the NF-kappaB puzzle. Cell (2002) 17.83
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J (2004) 11.00
Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol (2007) 10.23
Histone and chromatin cross-talk. Curr Opin Cell Biol (2003) 8.69
Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell (2008) 6.93
Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol (2004) 6.88
Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol Cell (2000) 5.79
Regulation of p53 activity through lysine methylation. Nature (2004) 5.78
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev (2002) 5.43
Signaling to chromatin through histone modifications. Cell (2000) 5.36
IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J Biol Chem (1999) 5.16
Dynamic regulation of histone lysine methylation by demethylases. Mol Cell (2007) 5.14
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J (2002) 4.91
Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway. Oncogene (2006) 4.62
Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14. Mol Cell (2000) 4.05
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol (2008) 3.74
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell (2009) 3.71
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet (2006) 3.54
NF-kappaB RelA phosphorylation regulates RelA acetylation. Mol Cell Biol (2005) 3.50
C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB. Immunity (2007) 3.32
Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II. J Biol Chem (2000) 3.00
Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation. EMBO J (2003) 2.97
Crosstalk among Histone Modifications. Cell (2008) 2.70
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am J Physiol Lung Cell Mol Physiol (2006) 2.70
Is there a code embedded in proteins that is based on post-translational modifications? Nat Rev Mol Cell Biol (2008) 2.64
Snf1--a histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription. Science (2001) 2.58
Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol Cell (2008) 2.35
Structural basis for the methylation site specificity of SET7/9. Nat Struct Mol Biol (2006) 2.18
IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300. Mol Cell Biol (2006) 2.05
Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit. EMBO J (2009) 2.05
Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol Cell (2008) 1.99
Methylation-acetylation interplay activates p53 in response to DNA damage. Mol Cell Biol (2007) 1.75
TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation. EMBO J (2007) 1.49
Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation. Cancer Res (2009) 1.48
Nuclear ubiquitin ligases, NF-kappaB degradation, and the control of inflammation. Sci Signal (2008) 1.38
Histone modifying enzymes and cancer: going beyond histones. J Cell Biochem (2005) 1.38
Controlling histone methylation via trans-histone pathways. Epigenetics (2008) 1.06
Impact of protein acetylation in inflammatory lung diseases. Pharmacol Ther (2007) 1.05
Methylation, a new epigenetic mark for protein stability. Epigenetics (2009) 1.01
Scalable molecular dynamics with NAMD. J Comput Chem (2005) 59.49
NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J (2005) 4.35
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol (2008) 3.74
Structural mechanism of plant aquaporin gating. Nature (2005) 3.64
Energetics of glycerol conduction through aquaglyceroporin GlpF. Proc Natl Acad Sci U S A (2002) 3.60
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem (2005) 3.38
Pressure-induced water transport in membrane channels studied by molecular dynamics. Biophys J (2002) 2.78
Theory and simulation of water permeation in aquaporin-1. Biophys J (2004) 2.63
Collective diffusion model for water permeation through microscopic channels. Phys Rev Lett (2004) 2.53
Prostratin antagonizes HIV latency by activating NF-kappaB. J Biol Chem (2004) 2.47
Electrostatic tuning of permeation and selectivity in aquaporin water channels. Biophys J (2003) 2.31
Mechanisms of selectivity in channels and enzymes studied with interactive molecular dynamics. Biophys J (2003) 2.24
Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit. EMBO J (2009) 2.05
p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1. J Biol Chem (2004) 2.01
Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway. Cell Signal (2010) 1.99
NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway. J Biol Chem (2004) 1.97
Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel. Biophys J (2010) 1.87
What makes an aquaporin a glycerol channel? A comparative study of AqpZ and GlpF. Structure (2005) 1.80
Substrate binding and formation of an occluded state in the leucine transporter. Biophys J (2007) 1.77
Sustained induction of NF-kappa B is required for efficient expression of latent human immunodeficiency virus type 1. J Virol (2007) 1.74
Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination. EMBO Rep (2009) 1.63
Molecular dynamics simulations of proteins in lipid bilayers. Curr Opin Struct Biol (2005) 1.62
Molecular dynamics investigation of primary photoinduced events in the activation of rhodopsin. Biophys J (2002) 1.62
Molecular dynamics simulations of membrane channels and transporters. Curr Opin Struct Biol (2009) 1.58
Dynamics of K+ ion conduction through Kv1.2. Biophys J (2006) 1.54
Molecular basis of proton blockage in aquaporins. Structure (2004) 1.51
Ion-releasing state of a secondary membrane transporter. Biophys J (2009) 1.50
Structural basis for iron piracy by pathogenic Neisseria. Nature (2012) 1.50
The mechanism of proton exclusion in aquaporin channels. Proteins (2004) 1.49
Structural changes during the formation of early intermediates in the bacteriorhodopsin photocycle. Biophys J (2002) 1.49
TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation. EMBO J (2007) 1.49
Dynamics of the extracellular gate and ion-substrate coupling in the glutamate transporter. Biophys J (2008) 1.46
Color tuning in rhodopsins: the mechanism for the spectral shift between bacteriorhodopsin and sensory rhodopsin II. J Am Chem Soc (2006) 1.43
Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65. J Biol Chem (2004) 1.38
Exploring gas permeability of cellular membranes and membrane channels with molecular dynamics. J Struct Biol (2007) 1.37
Classical force field parameters for the heme prosthetic group of cytochrome c. J Comput Chem (2004) 1.36
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe (2008) 1.35
Electrostatic funneling of substrate in mitochondrial inner membrane carriers. Proc Natl Acad Sci U S A (2008) 1.34
Distinct structural and adhesive roles of Ca2+ in membrane binding of blood coagulation factors. Structure (2008) 1.33
Mechanics of force propagation in TonB-dependent outer membrane transport. Biophys J (2007) 1.30
Identification of the third Na+ site and the sequence of extracellular binding events in the glutamate transporter. Biophys J (2010) 1.25
Molecular dynamics simulation of bacteriorhodopsin's photoisomerization using ab initio forces for the excited chromophore. Biophys J (2003) 1.22
Modeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologue. PLoS Comput Biol (2010) 1.20
Sugar binding and protein conformational changes in lactose permease. Biophys J (2006) 1.20
CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt. Nat Commun (2012) 1.18
Mechanism of signal propagation upon retinal isomerization: insights from molecular dynamics simulations of rhodopsin restrained by normal modes. Biophys J (2008) 1.18
Transient formation of water-conducting states in membrane transporters. Proc Natl Acad Sci U S A (2013) 1.17
Sugar transport across lactose permease probed by steered molecular dynamics. Biophys J (2007) 1.16
Mechanism of gating and ion conductivity of a possible tetrameric pore in aquaporin-1. Structure (2006) 1.16
Diffusion of glycerol through Escherichia coli aquaglyceroporin GlpF. Biophys J (2007) 1.16
Characterizing the membrane-bound state of cytochrome P450 3A4: structure, depth of insertion, and orientation. J Am Chem Soc (2013) 1.15
Atomic view of calcium-induced clustering of phosphatidylserine in mixed lipid bilayers. Biochemistry (2011) 1.13
Blood clotting reactions on nanoscale phospholipid bilayers. Thromb Res (2008) 1.12
Structure and permeation mechanism of a mammalian urea transporter. Proc Natl Acad Sci U S A (2012) 1.11
Rapid parameterization of small molecules using the Force Field Toolkit. J Comput Chem (2013) 1.10
Accelerating membrane insertion of peripheral proteins with a novel membrane mimetic model. Biophys J (2012) 1.08
Dimer opening of the nucleotide binding domains of ABC transporters after ATP hydrolysis. Biophys J (2008) 1.08
Molecular determinants of phospholipid synergy in blood clotting. J Biol Chem (2011) 1.08
Mechanistic picture for conformational transition of a membrane transporter at atomic resolution. Proc Natl Acad Sci U S A (2013) 1.07
On the origin of large flexibility of P-glycoprotein in the inward-facing state. J Biol Chem (2013) 1.06
Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor. Oncogene (2002) 1.04
Molecular dynamics investigation of the ω-current in the Kv1.2 voltage sensor domains. Biophys J (2012) 1.03
Peptide aggregation and pore formation in a lipid bilayer: a combined coarse-grained and all atom molecular dynamics study. Biophys J (2008) 1.03
Synergistic activation of NF-kappaB by nontypeable H. influenzae and S. pneumoniae is mediated by CK2, IKKbeta-IkappaBalpha, and p38 MAPK. Biochem Biophys Res Commun (2006) 1.02
Unique conformer selection of human growth-regulatory lectin galectin-1 for ganglioside GM1 versus bacterial toxins. Biochemistry (2003) 1.02
Role of the Helicobacter pylori-induced inflammatory response in the development of gastric cancer. J Cell Biochem (2013) 1.02
Methylation, a new epigenetic mark for protein stability. Epigenetics (2009) 1.01
Potential cation and H+ binding sites in acid sensing ion channel-1. Biophys J (2008) 1.00
Conformational coupling of the nucleotide-binding and the transmembrane domains in ABC transporters. Biophys J (2011) 0.99
Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria. Am J Physiol Cell Physiol (2009) 0.98
Simulation of spontaneous substrate binding revealing the binding pathway and mechanism and initial conformational response of GlpT. Biochemistry (2010) 0.97
Visualizing functional motions of membrane transporters with molecular dynamics simulations. Biochemistry (2013) 0.96
Nitric oxide conduction by the brain aquaporin AQP4. Proteins (2010) 0.96
Capturing spontaneous partitioning of peripheral proteins using a biphasic membrane-mimetic model. J Phys Chem B (2011) 0.95
Structural basis of substrate selectivity in the glycerol-3-phosphate: phosphate antiporter GlpT. Biophys J (2009) 0.95
Developing an energy landscape for the novel function of a (beta/alpha)8 barrel: ammonia conduction through HisF. Proc Natl Acad Sci U S A (2003) 0.95
Photochemical reaction dynamics of the primary event of vision studied by means of a hybrid molecular simulation. Biophys J (2009) 0.94
Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase. Nucleic Acids Res (2013) 0.91
A gate-free pathway for substrate release from the inward-facing state of the Na⁺-galactose transporter. Biochim Biophys Acta (2011) 0.91
Movement of NH₃ through the human urea transporter B: a new gas channel. Am J Physiol Renal Physiol (2013) 0.90
Molecular mechanisms of conduction and selectivity in aquaporin water channels. J Nutr (2007) 0.90
Tracing cytoplasmic Ca(2+) ion and water access points in the Ca(2+)-ATPase. Biophys J (2012) 0.90
The many roads traveled by Helicobacter pylori to NFκB activation. Gut Microbes (2010) 0.90
Role of hydrogen-bond network in energy storage of bacteriorhodopsin's light-driven proton pump revealed by ab initio normal-mode analysis. J Am Chem Soc (2004) 0.90
Synergistic induction of nuclear factor-kappaB by transforming growth factor-beta and tumour necrosis factor-alpha is mediated by protein kinase A-dependent RelA acetylation. Biochem J (2009) 0.90
Structural and functional analysis of SoPIP2;1 mutants adds insight into plant aquaporin gating. J Mol Biol (2009) 0.89
Molecular basis for the activation of a catalytic asparagine residue in a self-cleaving bacterial autotransporter. J Mol Biol (2011) 0.89
Coupling of calcium and substrate binding through loop alignment in the outer-membrane transporter BtuB. J Mol Biol (2009) 0.88
Efficient Exploration of Membrane-Associated Phenomena at Atomic Resolution. J Membr Biol (2015) 0.87
Water access points and hydration pathways in CLC H+/Cl- transporters. Proc Natl Acad Sci U S A (2013) 0.87
Bromodomain and extraterminal (BET) protein inhibition suppresses human T cell leukemia virus 1 (HTLV-1) Tax protein-mediated tumorigenesis by inhibiting nuclear factor κB (NF-κB) signaling. J Biol Chem (2013) 0.87
Driven Metadynamics: Reconstructing Equilibrium Free Energies from Driven Adaptive-Bias Simulations. J Phys Chem Lett (2013) 0.87
Proliferation and phenotypic changes of stromal cells in response to varying estrogen/androgen levels in castrated rats. Asian J Androl (2009) 0.86
Exploring transmembrane diffusion pathways with molecular dynamics. Physiology (Bethesda) (2010) 0.85
Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori. Proc Natl Acad Sci U S A (2009) 0.84
Incorporation of antimicrobial peptides into membranes: a combined liquid-state NMR and molecular dynamics study of alamethicin in DMPC/DHPC bicelles. J Phys Chem B (2009) 0.84
Resolution enhancement in solid-state NMR of oriented membrane proteins by anisotropic differential linebroadening. J Am Chem Soc (2008) 0.84
Partitioning of amino acids into a model membrane: capturing the interface. J Phys Chem B (2014) 0.84
A microscopic view of phospholipid insertion into biological membranes. J Phys Chem B (2013) 0.83
Conformational dynamics at the inner gate of KcsA during activation. Biochemistry (2014) 0.83